CN101595884B - Flutriafol and thiophanate-methyl containing sterilizing composition - Google Patents
Flutriafol and thiophanate-methyl containing sterilizing composition Download PDFInfo
- Publication number
- CN101595884B CN101595884B CN 200910023309 CN200910023309A CN101595884B CN 101595884 B CN101595884 B CN 101595884B CN 200910023309 CN200910023309 CN 200910023309 CN 200910023309 A CN200910023309 A CN 200910023309A CN 101595884 B CN101595884 B CN 101595884B
- Authority
- CN
- China
- Prior art keywords
- flutriafol
- thiophanate
- methyl
- composition
- powdery mildew
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The invention discloses a sterilizing composition. The active ingredient of the composition contains flutriafol and thiophanate-methyl; wherein the weight percentage of the flutriafol and thiophanate-methyl is 1-15:80-1, the active ingredient can be prepared into wet powder, water dispersible granules, suspending agents by adding with assistants and excipients for preventing and treating powdery mildew and cladosporium cucumerinum of vegetables and fruit trees.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on the vegetables fruit diseases that contains Flutriafol and thiophanate-methyl.
Technical background
Flutriafol (flutriafol) is the triazole bactericidal agent that American Cyanamid Company produces.Molecular formula: C16H13F2N30, chemical name: α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol.
Flutriafol belongs to triazole bactericidal agent, has interior absorption, conducts in plant corpus, and disease is had protection and therapeutic action.Can prevent and treat the cereal crop powdery mildew, Helminthosporium, Puccinia, shell pin Pseudomonas pathogen also can be cooked seed treatment, prevents and treats soil-borne disease and seed-borne disease.The cereal powdery mildew there is special efficacy.
Thiophanate-methyl (thiophanate-methyl), structural formula are 1,2-pair-(3-carbethoxyl group-α-ghiourea group) benzene, molecular formula: C
12H
14N
4O
4S
2
Thiophanate-methyl is wide spectrum, interior absorption benzimidazole germicide, has prevention and the effect such as treatment, and it by being converted into first carbendazim, disturbing the formation of spindle in the mitosis of bacterium again, and then affect cell division in plant corpus.
On the one hand, the use of organic solvent on agricultural chemicals is restricted day by day, and need not or lack with organic solvent has been the inexorable trend of Agrochemicals as far as possible.The formulation of agricultural chemicals needs constantly to upgrade, thereby impels agricultural chemicals along the good future development of efficient, low toxicity, safety and Environmental compatibility.The present composition does not contain organic solvent, is difficult for producing poisoning, to crop safety, can effectively overcome Current problems.On the other hand, the long-term single doses such as thiophanate-methyl, carbendazim of using, plant disease is developed immunity to drugs and therapeutic purposes can not be reached, adopt composite bactericidal composition can obviously improve control and result for the treatment of, reduced the usage amount of agricultural chemicals, reduce cost, become the important means of the various diseases of integrated control.
According to repeatedly the test of pesticide effectiveness, prescription screening report draw, Flutriafol and thiophanate-methyl be composite to have good synergistic function, obviously improved control efficiency, and dosage and medication number of times have been reduced, thereby greatly having delayed the generation of disease drug resistance, is the important means of integrated control powdery mildew, scab.
There is not yet up to now the report of the composite bactericidal composition of relevant Flutriafol and thiophanate-methyl.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic effect, use cost is low, preventive effect the is good bactericidal composition that contains Flutriafol and thiophanate-methyl.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Flutriafol and thiophanate-methyl, wherein Flutriafol and thiophanate-methyl percentage by weight are 1～15: 80～1.
The described bactericidal composition that contains Flutriafol and thiophanate-methyl, wherein the percentage by weight of Flutriafol and thiophanate-methyl is 1～10: 70～10.
The described bactericidal composition that contains Flutriafol and thiophanate-methyl, wherein the percentage by weight of Flutriafol and thiophanate-methyl is 1～5: 60～20.
The described bactericidal composition that contains Flutriafol and thiophanate-methyl can be made into wetting powder, water dispersible granules, suspending agent.
When making wetting powder, composition comprises following constituent content: Flutriafol 1～15%, thiophanate-methyl 1～80%, dispersant 3～15%, wetting agent 2～12%, filler 10～83%.
Flutriafol, thiophanate-methyl, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, namely can be made into Flutriafol thiophanate-methyl wetting powder product.
Comprise following constituent content when composition is made water dispersible granules: Flutriafol 1～15%, thiophanate-methyl 1～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%,, filler 8～83%.
Flutriafol, thiophanate-methyl, dispersant, wetting agent, disintegrant, filler etc. are obtained together the particle diameter of needs through air-flow crushing, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make Flutriafol thiophanate-methyl water dispersible granules product.
When making suspending agent, composition comprises following constituent content: Flutriafol 1～10%, thiophanate-methyl 1～40%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water surplus.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add Flutriafol, thiophanate-methyl, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes Flutriafol thiophanate-methyl suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, aluminium-magnesium silicate, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating powdery mildew, the scab of vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition Flutriafol and thiophanate-methyl belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition within the specific limits the antagonism disease have good synergistic effect, preventive effect is higher than single dose, dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, scab.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial again.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% Flutriafol thiophanate-methyl wetting powder
Flutriafol 15%, thiophanate-methyl 65%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, kaolin 10%, mixture carries out air-flow crushing, makes 80% Flutriafol thiophanate-methyl wetting powder.
Embodiment 2 60% Flutriafol thiophanate-methyl wetting powders
Flutriafol 5%, thiophanate-methyl 55%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 24%, and mixture carries out air-flow crushing, makes 60% Flutriafol thiophanate-methyl wetting powder.
Embodiment 3 30% Flutriafol thiophanate-methyl wetting powders
Flutriafol 3%, thiophanate-methyl 27%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F 3%, white carbon 10%, bentonite 52%, mixture carries out air-flow crushing, makes 30% Flutriafol thiophanate-methyl wetting powder.
Embodiment 4 15% Flutriafol thiophanate-methyl wetting powders
Flutriafol 2%, thiophanate-methyl 13%, lignosulfonates 2%, silkworm excrement 3%, white carbon 5%, attapulgite 75%, mixture carries out air-flow crushing, makes 15% Flutriafol thiophanate-methyl wetting powder.
Embodiment 5 80% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 10%, thiophanate-methyl 70%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 8% mix making 80% Flutriafol thiophanate-methyl water dispersible granules.
Embodiment 6 65% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 8%, thiophanate-methyl 57%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 22% mix making 65% Flutriafol thiophanate-methyl water dispersible granules.
Embodiment 7 55% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 6%, thiophanate-methyl 49%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 6%, succinic acid 3%, citric acid 1%, starch 30% mix making 55% Flutriafol thiophanate-methyl water dispersible granules.
Embodiment 8 40% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 5%, thiophanate-methyl 35%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, starch 20%, diatomite 33%, mix making 40% Flutriafol thiophanate-methyl water dispersible granules.
Embodiment 9 50% Flutriafol thiophanate-methyl suspending agents
Flutriafol 5%, thiophanate-methyl 45%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, mixes to make 50% Flutriafol thiophanate-methyl suspending agent.
Embodiment 10 35% Flutriafol thiophanate-methyl suspending agents
Flutriafol 4%, thiophanate-methyl 31%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 35% Flutriafol thiophanate-methyl suspending agent.
Embodiment 11 25% Flutriafol thiophanate-methyl suspending agents
Flutriafol 2%, thiophanate-methyl 23%, polyoxyethylene carboxylate 4%, spaonin powder 5%, silicone compound 0.1%, polyvinyl alcohol 0.4%, propane diols 2%, deionized water add to 100%, mix to make 25% Flutriafol thiophanate-methyl suspending agent.
Embodiment 12 10% Flutriafol thiophanate-methyl suspending agents
Flutriafol 1%, thiophanate-methyl 9%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 10% Flutriafol thiophanate-methyl suspending agent.
Implementation of an application example two Flutriafols and thiophanate-methyl are mixed to the wheat powdery mildew Toxicity Determination
This experimental establishment is in plant protection institute of Shandong Agricultural University; wheat breed is Yangmai No.158, is 8 centimetres cuvette with diameter, 10 in the seed of the full stalwartness of every glass of sowing vernalization; for subsequent use when waiting to grow to 3 leaves, the wheat powdery mildew germ is picked up from Shandong Agricultural University wheat cultivation greenhouse.Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is arranged respectively 5 dose concentrations to be processed, if contrast without medicine, each concentration is processed and is repeated 4 times, carry out with reference to " farm-chemical indoor determination test rule bactericide ", in culturing room, evenly shake off to receive on the cultured 3 leaf phase wheat seedlings with the fresh spore of Powdery Mildew in advance inoculation and the wheat seedling of fully falling ill.When treating that wheat has slightly been fallen ill, process with the medicine liquid spray of above-mentioned concentration.Every processing repeats 4 times, 2 glasss of every repetitions, 4 every glass, put into 20 ℃, 16L:8D cultivates in the illumination box of 60% relative moisture, the incidence of routine observation inoculation blade and newborn blade, after control treatment was fully fallen ill approximately 8-10 days, begin to put down in writing an incidence of processing, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Computing formula is as follows:
Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 is for picking up anti-effect, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.
Wherein: a, b are respectively Flutriafol and thiophanate-methyl shared ratio in combination
A is Flutriafol;
B is thiophanate-methyl;
Result of the test is as shown in the table:
Table 1 Flutriafol, thiophanate-methyl and composite to the wheat powdery mildew toxicity test
As shown in Table 1, Flutriafol and thiophanate-methyl are composite to the wheat powdery mildew toxicity test, the Flutriafol virulence is lower than the thiophanate-methyl virulence, its proportioning is that 1: 1,1: 4,1: 7,1: 11,1: 14 o'clock synergy ratio is respectively 1.15,1.59,1.74,1.86,1.50, wherein proportioning is all to show as synergistic effect in 1: 4,1: 7,1: 11,1: 14, so Flutriafol and thiophanate-methyl had synergistic effect at 1: 4 to 1: 11 in the scope.
Implementation of an application example three Flutriafols, thiophanate-methyl and composite control wheat powdery mildew field efficacy thereof
This experimental establishment is at the Shaanxi Changan District, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 2 times, observes disease index behind the last medicine after 10 days, 20 days and calculates preventive effect.Result of the test is as follows:
Table 2 Flutriafol, thiophanate-methyl and the composite control wheat powdery mildew test of pesticide effectiveness thereof
Result of the test shows, the complex composition of Flutriafol and thiophanate-methyl is compared with two single doses and to be had following advantages: (1) has significantly improved the control efficiency to wheat powdery mildew; (2) have concurrently quick-actingly and long-acting, bactericidal effect is significantly higher than each single dose after the dispenser.
Implementation of an application example four Flutriafols, thiophanate-methyl and the composite pear scab field trial of preventing and treating thereof
This experimental establishment is closed the town at the county town, Pucheng, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 4 times, checks disease index and calculates preventive effect in 7 days, 20 days behind the last medicine.Result of the test is as follows:
Table 3 Flutriafol, thiophanate-methyl and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
Result of the test shows, Flutriafol and thiophanate-methyl are composite to have obvious synergistic effect afterwards to pear scab, have quick-acting and long-acting, crop safety in this experimental drug scope.
Claims (3)
1. bactericidal composition that contains Flutriafol, its effective active composition contains Flutriafol and thiophanate-methyl, and wherein the weight ratio of Flutriafol and thiophanate-methyl is 1: 1～1: 14.
2. the formulation that contains the bactericidal composition of Flutriafol according to claim 1 is wetting powder, water dispersible granules, suspending agent.
3. the bactericidal composition of Flutriafol that contains according to claim 1 is for preventing and treating vegetables and the powdery mildew of fruit tree, the purposes of scab.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910023309 CN101595884B (en) | 2009-07-13 | 2009-07-13 | Flutriafol and thiophanate-methyl containing sterilizing composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910023309 CN101595884B (en) | 2009-07-13 | 2009-07-13 | Flutriafol and thiophanate-methyl containing sterilizing composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101595884A CN101595884A (en) | 2009-12-09 |
| CN101595884B true CN101595884B (en) | 2013-01-23 |
Family
ID=41417625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910023309 Expired - Fee Related CN101595884B (en) | 2009-07-13 | 2009-07-13 | Flutriafol and thiophanate-methyl containing sterilizing composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101595884B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR102013030596A2 (en) * | 2013-11-28 | 2015-09-22 | Rotam Agrochem Int Co Ltd | method of treating fungicidal infections, fungicidal compositions and their use |
-
2009
- 2009-07-13 CN CN 200910023309 patent/CN101595884B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 严海昌等.三氮唑类杀菌剂——粉唑醇的合成.《浙江化工》.2003,第34卷(第10期),7-8. * |
| 汪国平等.70%甲基硫菌灵水分散粒剂(WG)的研制.《农药科学与管理》.2007,第28卷(第9期),40-42. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101595884A (en) | 2009-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101601388B (en) | Sterilization composite containing flutriafol and triflumizole | |
| CN101601386B (en) | Sterilization composite containing triflumizole and chlorothalonil | |
| CN101595884B (en) | Flutriafol and thiophanate-methyl containing sterilizing composition | |
| CN101601397B (en) | Sterilization composite containing flutriafol and zineb | |
| CN102017966B (en) | Kasugamycin and propineb-containing bactericidal composition | |
| CN101731226B (en) | Bactericidal composition containing ethirimol and penconazole | |
| CN101601389B (en) | Sterilization composite containing triflumizole and difenoconazole | |
| CN101731248B (en) | Penconazole-containing and thioneb-containing sterilizing composition | |
| CN101999380B (en) | Difenoconazole- and propineb-containing pesticidal composition | |
| CN101578985A (en) | Sterilization composition containing kresoxim-methyl and triflumizole | |
| CN102037972B (en) | Sterilization composition containing mycophenolic ketone and hexaconazole | |
| CN101617669B (en) | Sterilization composite containing triflumizole and tebuconazole | |
| CN101731247B (en) | Penconazole-containing and thioneb-containing sterilizing composition | |
| CN101595878A (en) | A kind of bactericidal composition that contains Flutriafol and cyprodinil | |
| CN101720774B (en) | Bactericide composition containing penconazole and propineb | |
| CN101601398B (en) | Sterilization composite containing triflumizole and carbendazim | |
| CN102084865B (en) | Bactericidal composition containing flutriafol and propineb | |
| CN102172239A (en) | Flutriafol.tebuconazole sterilization composition | |
| CN101715772B (en) | Bactericidal composition containing carbendazim and ethirimol | |
| CN101617667B (en) | Sterilization composition containing flutriafol and kresoxim-methyl | |
| CN101755781B (en) | Fungicidal composition containing penconazole and carbendazim | |
| CN101731246B (en) | Cyprodinil and propineb-containing sterilizing composition | |
| CN101897336A (en) | Bactericidal composition containing imazalil and penconazole | |
| CN101627760B (en) | Sterilization composition containing triflumizole and hexaconazole | |
| CN101617666B (en) | Sterilization composite containing flutriafol and myclobutanil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130123 Termination date: 20150713 |
|
| EXPY | Termination of patent right or utility model |