CN101595884A - A kind of bactericidal composition that contains Flutriafol and thiophanate-methyl - Google Patents
A kind of bactericidal composition that contains Flutriafol and thiophanate-methyl Download PDFInfo
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- CN101595884A CN101595884A CNA2009100233091A CN200910023309A CN101595884A CN 101595884 A CN101595884 A CN 101595884A CN A2009100233091 A CNA2009100233091 A CN A2009100233091A CN 200910023309 A CN200910023309 A CN 200910023309A CN 101595884 A CN101595884 A CN 101595884A
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- thiophanate
- methyl
- flutriafol
- bactericidal composition
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Abstract
The invention discloses a kind of bactericidal composition, its effective active composition contains Flutriafol and thiophanate-methyl, wherein the percentage by weight of Flutriafol and thiophanate-methyl is 1～15: 80～1, the effective active composition adds auxiliary agent and excipients is made wetting powder, water dispersible granules, suspending agent, is mainly used in powdery mildew, the scab of control vegetables and fruit tree.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on the vegetables fruit diseases that contains Flutriafol and thiophanate-methyl.
Technical background
Flutriafol (flutriafol) is the triazole bactericidal agent that American Cyanamid Company produces.Molecular formula: C16H13F2N30, chemical name: α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol.
Flutriafol belongs to triazole bactericidal agent, has interior absorption, conducts in plant corpus, and disease is had protection and therapeutic action.Can prevent and treat the cereal crop powdery mildew, Helminthosporium, Puccinia, shell pin Pseudomonas pathogen also can be cooked seed treatment, prevents and treats soil-borne disease and seed-borne disease.The cereal powdery mildew there is special efficacy.
Thiophanate-methyl (thiophanate-methyl), structural formula are 1,2-pair-(3-carbethoxyl group-α-ghiourea group) benzene, and molecular formula: C
12H
14N
4O
4S
2
Thiophanate-methyl is wide spectrum, interior absorption benzimidazole germicide, has prevention and effect such as treatment, and it by being converted into carbendazim earlier, disturbing the formation of spindle in the mitosis of bacterium again, and then influence cell division in plant corpus.
On the one hand, the use of organic solvent on agricultural chemicals is restricted day by day, and need not or lack with organic solvent has been the inexorable trend of agricultural chemicals development as far as possible.The formulation of agricultural chemicals needs constantly to upgrade, thereby impels agricultural chemicals to develop along the good direction of efficient, low toxicity, safety and Environmental compatibility.The present composition does not contain organic solvent, is difficult for producing poisoning, to crop safety, can effectively overcome existing problem.On the other hand, single agent such as long-term use thiophanate-methyl, carbendazim, plant disease is developed immunity to drugs and therapeutic purposes can not be reached, adopt composite bactericidal composition can obviously improve control and result of treatment, reduced the usage amount of agricultural chemicals, reduce cost, become the important means of the various diseases of integrated control.
According to repeatedly the test of pesticide effectiveness, prescription screening report draw, Flutriafol and thiophanate-methyl be composite to have good synergistic effects, obviously improved control efficiency, and dosage and medication number of times have been reduced, thereby having delayed the generation of disease drug resistance greatly, is the important means of integrated control powdery mildew, scab.
Do not see the report of the bactericidal composition that relevant Flutriafol and thiophanate-methyl are composite up to now as yet.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic effect, use cost is low, preventive effect the is good bactericidal composition that contains Flutriafol and thiophanate-methyl.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Flutriafol and thiophanate-methyl, wherein Flutriafol and thiophanate-methyl percentage by weight are 1～15: 80～1.
The described bactericidal composition that contains Flutriafol and thiophanate-methyl, wherein the percentage by weight of Flutriafol and thiophanate-methyl is 1～10: 70～10.
The described bactericidal composition that contains Flutriafol and thiophanate-methyl, wherein the percentage by weight of Flutriafol and thiophanate-methyl is 1～5: 60～20.
The described bactericidal composition that contains Flutriafol and thiophanate-methyl can be made into wetting powder, water dispersible granules, suspending agent.
When making wetting powder, composition comprises following constituent content: Flutriafol 1～15%, thiophanate-methyl 1～80%, dispersant 3～15%, wetting agent 2～12%, filler 10～83%.
Flutriafol, thiophanate-methyl, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into Flutriafol thiophanate-methyl wetting powder product.
Comprise following constituent content when composition is made water dispersible granules: Flutriafol 1～15%, thiophanate-methyl 1～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%,, filler 8～83%.
Flutriafol, thiophanate-methyl, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes Flutriafol thiophanate-methyl water dispersible granules product.
When making suspending agent, composition comprises following constituent content: Flutriafol 1～10%, thiophanate-methyl 1～40%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water surplus.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add Flutriafol, thiophanate-methyl, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes Flutriafol thiophanate-methyl suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, aluminium-magnesium silicate, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, the scab of control vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition Flutriafol and thiophanate-methyl belong to the bactericide of two kinds of different mechanisms of action, and both are mixed mutually and can produce conflict; (2) present composition within the specific limits the antagonism disease have good synergistic effect, preventive effect is higher than single agent, dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, scab.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.By Toxicity Determination, the synergy ratio after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial more earlier.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% Flutriafol thiophanate-methyl wetting powder
Flutriafol 15%, thiophanate-methyl 65%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, kaolin 10%, mixture carries out comminution by gas stream, makes 80% Flutriafol thiophanate-methyl wetting powder.
Embodiment 2 60% Flutriafol thiophanate-methyl wetting powders
Flutriafol 5%, thiophanate-methyl 55%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 24%, and mixture carries out comminution by gas stream, makes 60% Flutriafol thiophanate-methyl wetting powder.
Embodiment 3 30% Flutriafol thiophanate-methyl wetting powders
Flutriafol 3%, thiophanate-methyl 27%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F 3%, white carbon 10%, bentonite 52%, mixture carries out comminution by gas stream, makes 30% Flutriafol thiophanate-methyl wetting powder.
Embodiment 4 15% Flutriafol thiophanate-methyl wetting powders
Flutriafol 2%, thiophanate-methyl 13%, lignosulfonates 2%, silkworm excrement 3%, white carbon 5%, attapulgite 75%, mixture carries out comminution by gas stream, makes 15% Flutriafol thiophanate-methyl wetting powder.
Embodiment 5 80% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 10%, thiophanate-methyl 70%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 8%, the mixed 80% Flutriafol thiophanate-methyl water dispersible granules that gets.
Embodiment 6 65% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 8%, thiophanate-methyl 57%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 22%, the mixed 65% Flutriafol thiophanate-methyl water dispersible granules that gets.
Embodiment 7 55% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 6%, thiophanate-methyl 49%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 6%, succinic acid 3%, citric acid 1%, starch 30%, the mixed 55% Flutriafol thiophanate-methyl water dispersible granules that gets.
Embodiment 8 40% Flutriafol thiophanate-methyl water dispersible granules
Flutriafol 5%, thiophanate-methyl 35%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, starch 20%, diatomite 33%, mixed 40% Flutriafol thiophanate-methyl water dispersible granules.
Embodiment 9 50% Flutriafol thiophanate-methyl suspending agents
Flutriafol 5%, thiophanate-methyl 45%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, the mixed 50% Flutriafol thiophanate-methyl suspending agent that gets.
Embodiment 10 35% Flutriafol thiophanate-methyl suspending agents
Flutriafol 4%, thiophanate-methyl 31%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed 35% Flutriafol thiophanate-methyl suspending agent that gets.
Embodiment 11 25% Flutriafol thiophanate-methyl suspending agents
Flutriafol 2%, thiophanate-methyl 23%, polyoxyethylene carboxylate 4%, spaonin powder 5%, silicone compound 0.1%, polyvinyl alcohol 0.4%, propane diols 2%, deionized water add to 100%, the mixed 25% Flutriafol thiophanate-methyl suspending agent that gets.
Embodiment 12 10% Flutriafol thiophanate-methyl suspending agents
Flutriafol 1%, thiophanate-methyl 9%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, the mixed 10% Flutriafol thiophanate-methyl suspending agent that gets.
Implementation of an application example two Flutriafols and thiophanate-methyl are mixed to the wheat powdery mildew Toxicity Determination
This experimental establishment is in plant protection institute of Shandong Agricultural University; wheat breed is for raising wheat 158, is 8 centimetres cuvette with diameter, 10 in the seed of the full stalwartness of every glass of sowing vernalization; standby when waiting to grow to 3 leaves, the wheat powdery mildew germ is picked up from Shandong Agricultural University wheat cultivation greenhouse.Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is provided with 5 dose concentrations respectively to be handled, if there is not the medicine contrast, each concentration is handled and is repeated 4 times, carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", in culturing room, evenly shake off to receive on the cultured 3 leaf phase wheat seedlings with the fresh spore of white powder germ on the wheat seedling of inoculation in advance and fully morbidity.When treating that wheat has slightly been fallen ill, handle with the medicine liquid spray of above-mentioned concentration.Every processing repeats 4 times, 2 glasss of every repetitions, 4 every glass, put into 20 ℃, 16L:8D cultivates in the illumination box of 60% relative moisture, the incidence of routine observation inoculation blade and newborn blade, after treating that control treatment was fully fallen ill about 8-10 days, begin to put down in writing an incidence of handling, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Computing formula is as follows:
Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.
Wherein: a, b are respectively Flutriafol and thiophanate-methyl shared ratio in combination
A is a Flutriafol;
B is a thiophanate-methyl;
Result of the test is as shown in the table:
Table 1 Flutriafol, thiophanate-methyl and composite to the wheat powdery mildew toxicity test
As shown in Table 1, Flutriafol and thiophanate-methyl are composite to the wheat powdery mildew toxicity test, the Flutriafol virulence is lower than the thiophanate-methyl virulence, its proportioning is that 1: 1,1: 4,1: 7,1: 11,1: 14 o'clock synergy ratio is respectively 1.15,1.59,1.74,1.86,1.50, wherein proportioning is all to show as synergistic effect in 1: 4,1: 7,1: 11,1: 14, so Flutriafol and thiophanate-methyl had synergistic effect at 1: 4 to 1: 11 in the scope.
Implementation of an application example three Flutriafols, thiophanate-methyl and composite control wheat powdery mildew field efficacy thereof
This experimental establishment is at the Shaanxi Changan District, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 2 times, observes disease index behind the last medicine after 10 days, 20 days and calculates preventive effect.Result of the test is as follows:
Table 2 Flutriafol, thiophanate-methyl and the composite control wheat powdery mildew test of pesticide effectiveness thereof
Result of the test shows, the complex composition of Flutriafol and thiophanate-methyl is compared with two single agent and to be had following advantage: (1) has significantly improved the control efficiency to wheat powdery mildew; (2) have concurrently quick-actingly and long-acting, bactericidal effect is significantly higher than each single agent after the dispenser.
Implementation of an application example four Flutriafols, thiophanate-methyl and the composite pear scab field trial of preventing and treating thereof
This experimental establishment is closed the town at the county town, Pucheng, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 4 times, checks disease index and calculates preventive effect in 7 days, 20 days behind the last medicine.Result of the test is as follows:
Table 3 Flutriafol, thiophanate-methyl and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
Result of the test shows, the composite back of Flutriafol and thiophanate-methyl has obvious synergistic effect to pear scab, have quick-acting and long-acting, crop safety in this experimental drug scope.
Claims (5)
1, a kind of bactericidal composition that contains Flutriafol, its effective active composition contains Flutriafol and thiophanate-methyl, and wherein the percentage by weight of Flutriafol and thiophanate-methyl is 1～15: 80～1.
2, the bactericidal composition that contains Flutriafol and thiophanate-methyl according to claim 1 is characterized in that: the percentage by weight of Flutriafol and thiophanate-methyl is 1～10: 70～10.
3, the bactericidal composition that contains Flutriafol and thiophanate-methyl according to claim 1 is characterized in that: the percentage by weight of Flutriafol and thiophanate-methyl is 1～5: 60～20.
4, the bactericidal composition that contains Flutriafol and thiophanate-methyl according to claim 1 can be made into wetting powder, water dispersible granules, suspending agent.
5, the bactericidal composition that contains Flutriafol and thiophanate-methyl according to claim 1 is mainly used in powdery mildew, the scab of control vegetables and fruit tree.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910023309 CN101595884B (en) | 2009-07-13 | 2009-07-13 | Flutriafol and thiophanate-methyl containing sterilizing composition |
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|---|---|---|---|
| CN 200910023309 CN101595884B (en) | 2009-07-13 | 2009-07-13 | Flutriafol and thiophanate-methyl containing sterilizing composition |
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| CN101595884A true CN101595884A (en) | 2009-12-09 |
| CN101595884B CN101595884B (en) | 2013-01-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015078216A1 (en) * | 2013-11-28 | 2015-06-04 | Rotam Agrochem International Company Limited | A method of treating fungicidal infections, fungicidal compositions and their use |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015078216A1 (en) * | 2013-11-28 | 2015-06-04 | Rotam Agrochem International Company Limited | A method of treating fungicidal infections, fungicidal compositions and their use |
| CN105792655A (en) * | 2013-11-28 | 2016-07-20 | 龙灯农业化工国际有限公司 | A method of treating fungicidal infections, fungicidal compositions and their use |
| TWI674842B (en) * | 2013-11-28 | 2019-10-21 | 香港商龍燈農業化工國際有限公司 | A method of treating fungicidal infections, fungicidal compositions and their use |
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