CN101601397B - Sterilization composite containing flutriafol and zineb - Google Patents
Sterilization composite containing flutriafol and zineb Download PDFInfo
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- CN101601397B CN101601397B CN 200910023376 CN200910023376A CN101601397B CN 101601397 B CN101601397 B CN 101601397B CN 200910023376 CN200910023376 CN 200910023376 CN 200910023376 A CN200910023376 A CN 200910023376A CN 101601397 B CN101601397 B CN 101601397B
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- flutriafol
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- bactericidal composition
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Abstract
The invention discloses a sterilization composite whose effective activity components comprise flutriafol and zineb in a weight ratio of 1-15 to 80-1. Auxiliary agent and excipient are added into the effective activity components to prepare wettability powder, water-dispersion granule and suspending agent. The sterilization composite is mainly used for preventing and curing powdery mildew, cladosporium cucumerinum and alternaria leaf spot of grain, vegetable and fruit trees.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on the vegetables fruit diseases that contains Flutriafol and zineb.
Technical background
Flutriafol (flutriafol) is the triazole bactericidal agent that American Cyanamid Company produces.Molecular formula: C16H13F2N30, chemical name: α-(2-fluorophenyl)-α-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol.
Flutriafol belongs to triazole bactericidal agent, has interior absorption, conducts in plant corpus, and disease is had protection and therapeutic action.Can prevent and treat the cereal crop powdery mildew, Helminthosporium, Puccinia, shell pin Pseudomonas pathogen also can be cooked seed treatment, prevents and treats soil-borne disease and seed-borne disease.The cereal powdery mildew there is special efficacy.
Zineb (zineb), structural formula are zinc ethylenebisdithiocarbamate, molecular formula: C
4H
6N
2S
4Zn.
Zineb is to be the protectant that a kind of foliage spray is used, and many germs such as Pseudoperonospora cubensis, late disease bacteria and anthrax bacteria etc. are had stronger action of contace poison.To plant safety, the active ingredient chemical property is more active, in water, easily be oxidized to different thiocyanation compound, to the cause of disease thalline contain-enzyme of SH base has strong inhibitory action, and the direct kill pathogens spore of energy, suppress the germination of spore, stop in the germ invaded plants body, but very little to the mycelial lethal effect of cause of disease in the invaded plants body.Therefore, use zineb to prevent and treat disease and should rest in the disease phase of beginning to see and carry out, just can obtain preferably effect.The drug effect phase of zineb is short, decomposes comparatively fast about 7 days of its longevity of residure behind the moisture in solar radiation and absorbing air.
Because the long-term single doses such as zineb, thiophanate-methyl, carbendazim of using, plant disease is developed immunity to drugs and therapeutic purposes can not be reached, adopt composite bactericidal composition can obviously improve control and result for the treatment of, reduce the usage amount of agricultural chemicals, reduce cost, become the important means of the various diseases of integrated control.
According to repeatedly the test of pesticide effectiveness, prescription screening report draw, Flutriafol and zineb be composite to have good synergistic function, obviously improved control efficiency, and dosage and medication number of times have been reduced, thereby greatly having delayed the generation of disease drug resistance, is the important means of integrated control powdery mildew, scab, spot defoliation.
There is not yet up to now the report of the composite bactericidal composition of relevant Flutriafol and zineb.
Summary of the invention
Purpose of the present invention proposes a kind of have synergistic effect, use cost is low, preventive effect the is good bactericidal composition that contains Flutriafol and zineb.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains Flutriafol and zineb, wherein Flutriafol and zineb percentage by weight are 1～15: 80～1.
The described bactericidal composition that contains Flutriafol and zineb, wherein the percentage by weight of Flutriafol and zineb is 1～10: 70～10.
The described bactericidal composition that contains Flutriafol and zineb, wherein the percentage by weight of Flutriafol and zineb is 1～5: 60～20.
The described bactericidal composition that contains Flutriafol and zineb can be made into wetting powder, water dispersible granules, suspending agent.
The described bactericidal composition effective active component content that contains Flutriafol and zineb is 2～80%.
The described bactericidal composition effective active component content that contains Flutriafol and zineb is 5～70%.
The described bactericidal composition effective active component content that contains Flutriafol and zineb is 10～50%.
When making wetting powder, composition comprises following constituent content: Flutriafol 1～15%, zineb 1～80%, dispersant 3～15%, wetting agent 2～12%, filler 10～83%.
Flutriafol, zineb, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, namely can be made into Flutriafol Zineb wettable powder product.
When making water dispersible granules, composition comprises following constituent content: Flutriafol 1～15%, zineb 1～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%, filler 8～83%.
Flutriafol, zineb, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through air-flow crushing together, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make Flutriafol water dispersion granules agent of dithane product.
When making suspending agent, composition comprises following constituent content: Flutriafol 1～10%, zineb 1～40%, dispersant 3～12%, wetting agent 2～10%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water surplus.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add Flutriafol, zineb, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes Flutriafol zineb suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, fatty acid glyceride polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, aluminium-magnesium silicate, polyvinyl alcohol, the polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating powdery mildew, scab, the spot defoliation of cereal, vegetables and fruit tree.
Beneficial effect of the present invention: (1) present composition effective active composition Flutriafol and zineb belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition within the specific limits the antagonism disease have good synergistic effect, preventive effect is higher than single dose, dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio after clear and definite two kinds of medicaments are composite by a certain percentage on this basis, carries out field trial again.
Implementation of an application example one the implementation of Formulation Example
Embodiment 1 80% Flutriafol Zineb wettable powder
Flutriafol 13%, zineb 67%, sodium lignin sulfonate 5%, moistening bleeding agent F 4%, white carbon 11%, mixture carries out air-flow crushing, makes 80% Flutriafol Zineb wettable powder.
Embodiment 2 60% Flutriafol Zineb wettable powders
Flutriafol 5%, zineb 55%, lignosulfonates 4%, tea are withered 4%, white carbon 8%, kaolin 24%, and mixture carries out air-flow crushing, makes 60% Flutriafol Zineb wettable powder.
Embodiment 3 20% Flutriafol Zineb wettable powders
Flutriafol 2%, zineb 18%, alkyl benzene sulfonate calcium salt 5%, wetting and penetrating agent F 3%, white carbon 10%, bentonite 52%, mixture carries out air-flow crushing, makes 20% Flutriafol Zineb wettable powder.
Embodiment 4 75% Flutriafol water dispersion granules agent of dithane
Flutriafol 10%, zineb 65%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch 13% mix making 75% Flutriafol water dispersion granules agent of dithane.
Embodiment 5 65% Flutriafol water dispersion granules agent of dithane
Flutriafol 7%, zineb 58%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 22% mix making 65% Flutriafol water dispersion granules agent of dithane.
Embodiment 6 55% Flutriafol water dispersion granules agent of dithane
Flutriafol 5%, zineb 50%, alkyl benzene sulfonate calcium salt 5%, Nekal BX 6%, succinic acid 3%, citric acid 1%, starch 30% mix making 55% Flutriafol water dispersion granules agent of dithane.
Embodiment 7 50% Flutriafol zineb suspending agents
Flutriafol 4%, zineb 46%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, mixes to make 50% Flutriafol zineb suspending agent.
Embodiment 8 35% Flutriafol zineb suspending agents
Flutriafol 3%, zineb 32%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 35% Flutriafol zineb suspending agent.
Embodiment 9 10% Flutriafol zineb suspending agents
Flutriafol 1%, zineb 9%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 10% Flutriafol zineb suspending agent.
Implementation of an application example two Flutriafols and zineb are mixed to the wheat powdery mildew Toxicity Determination
This experimental establishment is in plant protection institute of Shandong Agricultural University; wheat breed is Yangmai No.158, is 8 centimetres cuvette with diameter, 10 in the seed of the full stalwartness of every glass of sowing vernalization; for subsequent use when waiting to grow to 3 leaves, the wheat powdery mildew germ is picked up from Shandong Agricultural University wheat cultivation greenhouse.Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Test medicine is arranged respectively 5 dose concentrations to be processed, if contrast without medicine, each concentration is processed and is repeated 4 times, carry out with reference to " farm-chemical indoor determination test rule bactericide ", in culturing room, evenly shake off to receive on the cultured 3 leaf phase wheat seedlings with the fresh spore of Powdery Mildew in advance inoculation and the wheat seedling of fully falling ill.When treating that wheat has slightly been fallen ill, process with the medicine liquid spray of above-mentioned concentration.Every processing repeats 4 times, 2 glasss of every repetitions, 4 every glass, put into 20 ℃, 16L:8D cultivates in the illumination box of 60% relative moisture, the incidence of routine observation inoculation blade and newborn blade, after control treatment was fully fallen ill about 8-10 days, begin to put down in writing an incidence of processing, and calculate disease index and protection effect thereof.Concentration-preventive effect is converted into corresponding logarithm-probit value, obtains virulence regression equation, calculate EC
50Value.
Computing formula is as follows:
Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.
Wherein: a, b are respectively Flutriafol and zineb shared ratio in combination
A is Flutriafol;
B is zineb;
Result of the test is as shown in the table:
Table 1 Flutriafol, zineb and composite to the wheat powdery mildew toxicity test
As shown in Table 1, Flutriafol and zineb are composite to the wheat powdery mildew toxicity test, the Flutriafol virulence is higher than the zineb virulence, its proportioning is that 1: 2,1: 5,1: 8,1: 11,1: 14 o'clock synergy ratio is respectively 1.40,1.94,2.28,1.85,1.55, wherein proportioning is all to show as synergistic effect in 1: 5,1: 8,1: 11,1: 14, so Flutriafol and zineb had synergistic effect at 1: 5 to 1: 14 in the scope.
Implementation of an application example three Flutriafols, zineb and composite control wheat powdery mildew field efficacy thereof
This experimental establishment is at the Shaanxi Changan District, and test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 2 times, observes disease index behind the last medicine after 10 days, 20 days and calculates preventive effect.Result of the test is as follows:
Table 2 Flutriafol, zineb and the composite control wheat powdery mildew test of pesticide effectiveness thereof
| Treatment agent | The preparation dosage | 10 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 80% Flutriafol Zineb wettable powder | 30 g/acres | 80.29 | 91.00 |
| 55% Flutriafol water dispersion granules agent of dithane | 50 g/acres | 81.62 | 90.72 |
| 35% Flutriafol zineb suspending agent | 80 g/acres | 83.44 | 92.36 |
| 12.5% Flutriafol suspending agent | 50 g/acres | 77.29 | 83.36 |
| 65% Zineb wettable powder | 120 g/acres | 60.39 | 65.02 |
Result of the test shows, the complex composition of Flutriafol and zineb is compared with two single doses and to be had following advantages: (1) has significantly improved the control efficiency to wheat powdery mildew; (2) have concurrently quick-actingly and long-acting, bactericidal effect is significantly higher than each single dose after the dispenser.
Implementation of an application example four Flutriafols, zineb and the composite pear scab field trial of preventing and treating thereof
This experimental establishment is closed the town at the county town, Pucheng, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., and dispenser in per seven days once is total to dispenser 4 times, checks disease index and calculates preventive effect in 7 days, 14 days, 30 days behind the last medicine.Result of the test is as follows:
Table 3 Flutriafol, zineb and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 60% Flutriafol Zineb wettable powder | 3000 times | 80.32 | 87.16 | 90.22 |
| 75% Flutriafol water dispersion granules agent of dithane | 4000 times | 79.22 | 88.36 | 89.14 |
| 10% Flutriafol zineb suspending agent | 500 times | 84.07 | 89.77 | 93.00 |
| 12.5% Flutriafol suspending agent | 3500 times | 67.35 | 74.06 | 76.47 |
| 65% Zineb wettable powder | 500 times | 52.44 | 69.45 | 60.04 |
Result of the test shows that the composite rear control to pear scab of Flutriafol and zineb has obvious synergistic effect, have quick-acting and long-acting, crop safety in this experimental drug scope.Implementation of an application example five Flutriafols, zineb and the test of composite control alternaria leaf spot of apple thereof
This experimental establishment is at Shaanxi Province's Luochuan County, test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd., begins dispenser in the alternaria leaf spot of apple their early stage, and dispenser in per seven days once, dispenser is 5 times altogether, checks disease index and calculates preventive effect in 7 days, 14 days, 30 days behind the last medicine.Result of the test is as follows:
Table 4 Flutriafol, zineb and the composite control alternaria leaf spot of apple test of pesticide effectiveness thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 20% Flutriafol Zineb wettable powder | 800 times | 79.36 | 88.77 | 94.37 |
| 65% Flutriafol water dispersion granules agent of dithane | 3000 times | 82.04 | 89.62 | 95.18 |
| 50% Flutriafol zineb suspending agent | 2000 times | 84.66 | 90.40 | 93.45 |
| 12.5% Flutriafol suspending agent | 3000 times | 67.45 | 80.02 | 80.17 |
| 65% Zineb wettable powder | 500 times | 52.66 | 60.54 | 58.43 |
Result of the test shows that the composite rear control to alternaria leaf spot of apple of Flutriafol and zineb has obvious synergistic effect, have quick-acting and long-acting, crop safety in this experimental drug scope, and to apple mildew after 14 days preventive effect reach more than 80%.
Claims (6)
1. bactericidal composition that contains Flutriafol and zineb, its effective active composition is Flutriafol and zineb, wherein the weight ratio of Flutriafol and zineb is 1: 5～1: 14.
2. the bactericidal composition that contains Flutriafol and zineb according to claim 1, it is characterized in that: the formulation of composition is wetting powder, water dispersible granules, suspending agent.
3. the bactericidal composition that contains Flutriafol and zineb according to claim 1, it is characterized in that: effective active composition weight content is 2～80% in the composition.
4. the bactericidal composition that contains Flutriafol and zineb according to claim 3, it is characterized in that: effective active composition weight content is 5～70% in the composition.
5. the bactericidal composition that contains Flutriafol and zineb according to claim 4, it is characterized in that: effective active composition weight content is 10～50% in the composition.
6. the bactericidal composition of Flutriafol and zineb that contains according to claim 1 is for the purposes of the powdery mildew of preventing and treating cereal, vegetables and fruit tree, scab, spot defoliation.
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| CN102084865B (en) * | 2011-03-25 | 2013-10-30 | 陕西先农生物科技有限公司 | Bactericidal composition containing flutriafol and propineb |
| CN114423289A (en) * | 2019-06-24 | 2022-04-29 | Upl有限公司 | Synergistic fungicidal compositions |
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Non-Patent Citations (4)
| Title |
|---|
| 代森锌可湿性粉剂防治葡萄炭疽病应用技术研究.《农药科学与管理》.2006,第27卷(第1期),14-15. |
| 吴光远等.代森锌多菌灵防止茶白星病的效果初报.《福建农业科技》.1996,(第5期),12. * |
| 尤庆伟等.70%百菌清• |
| 尤庆伟等.70%百菌清•代森锌可湿性粉剂防治葡萄炭疽病应用技术研究.《农药科学与管理》.2006,第27卷(第1期),14-15. * |
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