CN101731246B - Cyprodinil and propineb-containing sterilizing composition - Google Patents
Cyprodinil and propineb-containing sterilizing composition Download PDFInfo
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- CN101731246B CN101731246B CN 201010001563 CN201010001563A CN101731246B CN 101731246 B CN101731246 B CN 101731246B CN 201010001563 CN201010001563 CN 201010001563 CN 201010001563 A CN201010001563 A CN 201010001563A CN 101731246 B CN101731246 B CN 101731246B
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- cyprodinil
- propineb
- dispersible granules
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Abstract
The invention relates to a cyprodinil and propineb-containing sterilizing composition, the weight ratio of the active ingredients of the cyprodinil and the propineb is 5-80:80-5; and added with an auxiliary agent and an excipient, the effective active components can be prepared into wettable powder, water dispersible granules and suspending agent. The sterilizing composition is used for preventing and controlling diseases on fruit trees and cereals and has obvious synergism on the prevention and treatment of gray mold, alternaria leaf spot, peronospora tabacina and anthracnose of crops.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of composite application of bactericidal composition on fruit tree and vegetable disease of cyprodinil and Propineb that contain.
Technical background
Cyprodinil (cyprodinil) is that sterling is powdery solid by the aminopyrimidine bactericide of Syngenta Co.,Ltd's exploitation.Molecular formula: C
14H
15N
3, chemical name: 4-cyclopropyl-6-methyl-N-phenyl pyrimidine-2-amine.
Cyprodinil is the methionine biosynthesis inhibitor.Same triazole type, imidazoles, morpholine class, phenylpyrrole class etc. are without cross resistance.Cyprodinil Main Function mode is to suppress the biosynthesis of methionine moral, suppresses the secretion of hydrolase.Absorbed rapidly by blade in plant corpus, be penetrated into more than 30% in the tissue, protected sediment is stored in the blade; transmit in xylem, also transmit between blade, at high temperature metabolism is relatively rapid; sediment quite stable under the low temperature in blade, the metabolite inanimate object is active.Be mainly used in preventing and treating gray mold, powdery mildew, scab of wheat, barley, grape, strawberry, fruit tree, vegetables, ornamental plants etc. etc.
Propineb (propineb), molecular formula: (C
5H
8N
2S
4Zn)
x, chemical name: acrylic bisdithiocarbamic zinc.
Propineb is a kind of protective fungicide of quick-acting, long residual, wide spectrum, and its bactericidal mechanism is fixing, and site of action is many, mainly suppresses the oxidation of pyruvic acid in the cause of disease thalline.The downy mildew of the crops such as vegetables, grape, tobacco and morning, the late blight of tomato and potato all there are good protective effect, and the disease of powdery mildew, rust and Botrytis is also had fixed inhibitory action.Such as alternaria leaf spot of apple, Chinese cabbage downy mildew, cucumber downy mildew, downy mildew of garpe, early blight of tomato and late blight, target and late blight, mango anthracnose, Alternaria alternate.
In the real process of agricultural production, prevent and treat disease the problem of easy generation be the drug-fast generation of germ.Important disease such as gray mold, spot defoliation, leaf spot etc. are because its spread speed is fast on the agricultural, and host range is wide, often occurs in the plant growth later stage, produces especially easily resistance.In some diseases serious place occurs, common bactericide such as tpn, thiophanate-methyl, tmtd, Propineb etc. separately use have caused very serious resistance, and cyprodinil etc. can large tracts of land use because of the higher section of price.At present, adopt composite bactericidal composition can obviously improve control and result for the treatment of, reduced the usage amount of agricultural chemicals, reduced cost, become the important means of the various diseases of integrated control.
So far not yet see the relevant report of relevant cyprodinil and the composite product of Propineb on domestic and international magazine and the related media.
Summary of the invention
The purpose of this invention is to provide the bactericidal composition that contains cyprodinil and Propineb that a kind of antagonism germ has synergistic effect.
The present invention is achieved through the following technical solutions:
The bactericidal composition that contains cyprodinil and Propineb, cyprodinil and Propineb percentage by weight are 5～80: 80～5, percentage by weight after wherein preferred is 10～60: 70～10, preferred percentage by weight is 20～50: 60～20, effective active composition weight percentage is 10% to 80%, adds auxiliary agent and excipients and makes wetting powder, water dispersible granules, suspending agent.
When making wetting powder, composition comprises following constituent content: cyprodinil 5～80%, Propineb 5～80%, dispersant 3～15%, wetting agent 2～12%, filler 5～84%.
Cyprodinil, Propineb, dispersant, wetting agent, filler are mixed in mixed cylinder, after airslide disintegrating mill is pulverized, mix again, namely can be made into the cyprodinil Wettable propineb powder.
When making water dispersible granules, composition comprises following constituent content: cyprodinil 5～80%, Propineb 5～80%, dispersant 3～12%, wetting agent 2～8%, disintegrant 0～8%, filler 5～84%.
Cyprodinil, Propineb, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through air-flow crushing together, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make cyprodinil Propineb water dispersible granules product.
When making suspending agent, composition comprises following constituent content: cyprodinil 5～50%, Propineb 5～50%, dispersant 3～12%, wetting agent 2～10%, emulsifier 1～6%, defoamer 0.1～0.5%, thickener 0～2%, antifreeze 0～8%, deionized water surplus.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add cyprodinil, Propineb, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes cyprodinil Propineb suspending agent product.
Described dispersant, wetting agent, emulsifier, disintegrant, defoamer, thickener, antifreeze, filler are the conventional auxiliary agent of the art.
Described bactericidal composition is used for the disease on control fruit tree and the cereal, is mainly used in preventing and treating gray mold, spot defoliation, downy mildew, anthracnose.
The invention has the advantages that: (1) cyprodinil has the different mechanisms of action from Propineb, and is mutual composite without antagonism; The agricultural chemicals of (2) two kinds of different mechanisms of action carries out composite, has both enlarged fungicidal spectrum, has saved again production cost; (3) composition does not contain organic solvent, and environmental pollution is little, and use cost is low; (4) be used for preventing and treating gray mold, spot defoliation, downy mildew, anthracnose and have good synergistic effect.
Embodiment
To further instruction of the present invention, but the scope of application of the present invention is not limited to following illustrated embodiment below in conjunction with embodiment.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Embodiment 1 80% cyprodinil Wettable propineb powder
Cyprodinil 10%, Propineb 70%, sodium lignin sulfonate 5%, bay alcohol radical sodium sulphate 5%, white carbon 10%, mixture carries out air-flow crushing, makes 80% cyprodinil Wettable propineb powder.
Embodiment 2 70% cyprodinil Wettable propineb powders
Cyprodinil 60%, Propineb 10%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 4%, silkworm excrement 4%, white carbon 8%, kaolin 14%, mixture carries out air-flow crushing, makes 70% cyprodinil Wettable propineb powder.
Embodiment 3 55% cyprodinil Wettable propineb powders
Cyprodinil 15%, Propineb 40%, alkyl benzene sulfonate calcium salt 5%, lauryl sodium sulfate 6%, white carbon 8%, bentonite 26%, mixture carries out air-flow crushing, makes 55% cyprodinil Wettable propineb powder.
Embodiment 4 20% cyprodinil Wettable propineb powders
Cyprodinil 8%, Propineb 12%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4%, spaonin powder 3%, kaolin 63%, mixture carries out air-flow crushing, makes 20% cyprodinil Wettable propineb powder.
Embodiment 5 80% cyprodinil Propineb water dispersible granules
Cyprodinil 20%, Propineb 60%, alkylphenol polyoxyethylene 5%, tea are withered 4%, soapberry powder 2%, urea 3%, starch 6%, make 80% cyprodinil Propineb water dispersible granules.
Embodiment 6 75% cyprodinil Propineb water dispersible granules
Cyprodinil 25%, Propineb 50%, fatty acid glyceride APEO 7%, pull open powder 4%, ammonium sulfate 2%, starch 12%, make 75% cyprodinil Propineb water dispersible granules.
Embodiment 7 60% cyprodinil Propineb water dispersible granules
Cyprodinil 50%, Propineb 10%, alkylphenol polyoxyethylene 5%, spaonin powder 4%, succinic acid 3%, starch 12%, attapulgite 16% mix making 60% cyprodinil Propineb water dispersible granules.
Embodiment 8 36% cyprodinil Propineb water dispersible granules
Cyprodinil 9%, Propineb 27%, aliphatic acid polyethenoxy ether 6%, wetting and penetrating agent F4%, urea 3%, starch 17%, attapulgite 34% mix making 36% cyprodinil Propineb water dispersible granules.
Embodiment 9 50% cyprodinil Propineb suspending agents
Cyprodinil 20%, Propineb 30%, sodium lignin sulfonate 4%, lauryl sodium sulfate 3%, farming breast 1600
#3%, silicone compound 0.1%, polyvinyl alcohol 0.1%, deionized water add to 100%, mix to make 50% cyprodinil Propineb suspending agent.
Embodiment 10 40% cyprodinil Propineb suspending agents
Cyprodinil 30%, Propineb 10%, alkyl benzene sulfonate calcium salt 4%, pull open powder 3%, Nongru-700
#2%, silicone compound 0.1%, polyethylene glycol 0.1%, second triol 3%, deionized water add to 100%, mix to make 40% cyprodinil Propineb suspending agent.
Embodiment 11 30% cyprodinil Propineb suspending agents
Cyprodinil 10%, Propineb 20%, fatty acid glyceride APEO 4%, farming breast 400
#3%, silicone oil 0.1%, aluminium-magnesium silicate 0.8%, propane diols 4%, deionized water add to 100%, mix to make 30% cyprodinil Propineb suspending agent.
Embodiment 12 10% cyprodinil Propineb suspending agents
Cyprodinil 5%, Propineb 5%, sodium lignin sulfonate 4%, silicone oil 0.1%, xanthans 0.2%, ethylene glycol 5%, deionized water add to 100%, mix to make 10% cyprodinil Propineb suspending agent.
Implementation of an application example one: cyprodinil and Propineb and be mixed to the downy mildew of garpe Toxicity Determination
Reagent agent is provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation.Test strain picks up from Luochuan County suburb, Shaanxi Province, the cyprodinil that obtains, Propineb and mix ratio thereof to the virulence regression equation of downy mildew of garpe, suppress in concentration and synergy ratio (SR) such as following table:
Table 1 cyprodinil, Propineb and be mixed to the downy mildew of garpe Toxicity Determination
As shown in Table 1, cyprodinil of the present invention and Propineb are composite, to the downy mildew of garpe Toxicity Determination, when cyprodinil and Propineb proportioning are that 6: 1,2: 1,2: 6,1: 5,1: 7 synergy ratio is respectively 1.60,1.72,1.96,1.79,1.62, cyprodinil and Propineb proportioning all showed as synergistic effect at 6: 1 to 1: 7, and it is comparatively reasonable to illustrate that cyprodinil and Propineb were mixed in the scope at 6: 1～1: 7.
Implementation of an application example two: the composite control alternaria leaf spot of apple of cyprodinil and the Propineb test of pesticide effectiveness
This experimental establishment is at Shaanxi Province's Luochuan County, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 50% cyprodinil water dispersible granules (commercial), 70% Wettable propineb powder (commercial).
In the alternaria leaf spot of apple initial stage of origination, dispenser in per 7 days once is total to dispenser 3 times, and investigation state of an illness radix before the medicine was investigated disease indexs in 7 days, 20 days behind the last medicine and calculated preventive effect, and the result is as shown in the table:
Table 2 cyprodinil, Propineb and the control alternaria leaf spot of apple test of pesticide effectiveness that is mixed thereof
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 80% cyprodinil Wettable propineb powder | 1000 times | 90.34 | 88.26 |
| 60% cyprodinil Propineb water dispersible granules | 1000 times | 92.75 | 89.72 |
| 40% cyprodinil Propineb suspending agent | 800 times | 91.26 | 90.12 |
| 50% cyprodinil water dispersible granules | 1000 times | 85.13 | 81.36 |
| 70% Wettable propineb powder | 500 times | 67.26 | 65.00 |
As shown in Table 2, can effectively prevent and treat alternaria leaf spot of apple after cyprodinil and Propineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long, the test scope of medication in to crop safety.
Implementation of an application example three cyprodinils, Propineb and the composite control cucumber anthracnose test of pesticide effectiveness thereof
Reagent agent: the composite product of cyprodinil Propineb is provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation; 50% cyprodinil water dispersible granules (commercial), 70% Wettable propineb powder (commercial).
Test arrangement is in area just outside a city gate town, Pucheng County, Shaanxi Province, and dispenser in per 7 days once is total to dispenser 2 times, and investigation disease index before the medicine was investigated disease indexs in 7 days, 14 days behind the last medicine and calculated preventive effect.Result of the test is as follows:
Table 3 cyprodinil, Propineb and composite control cucumber anthracnose field control effectiveness test thereof
| Treatment agent | The preparation dosage | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine |
| 70% cyprodinil Wettable propineb powder | 50 g/acres | 83.49 | 89.00 |
| 36% cyprodinil Propineb water dispersible granules | 120 g/acres | 85.77 | 91.57 |
| 10% cyprodinil Propineb suspending agent | 400 g/acres | 86.19 | 90.42 |
| 50% cyprodinil water dispersible granules | 70 g/acres | 81.02 | 85.14 |
| 70% Wettable propineb powder | 120 g/acres | 74.33 | 79.34 |
Found out that by table 3 can effectively prevent and treat the generation of cucumber anthracnose after cyprodinil and Propineb are composite, control efficiency is better than all contrasting medicament, in trial stretch to the target crop safety.
Implementation of an application example four: the composite downy mildew of garpe test of pesticide effectiveness of preventing and treating of cyprodinil and Propineb
This experimental establishment is in area just outside a city gate, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 50% cyprodinil water dispersible granules (commercial), 70% Wettable propineb powder (commercial).
In the downy mildew of garpe initial stage of origination, dispenser in per 7 days once is total to dispenser 2 times, and investigation state of an illness radix before the medicine was investigated disease indexs in 7 days, 20 days behind the last medicine and calculated preventive effect, and the result is as shown in the table:
Table 4 cyprodinil, Propineb and be mixed and prevent and treat the downy mildew of garpe test of pesticide effectiveness
| Treatment agent | Extension rate | 7 days preventive effects (%) behind the last medicine | 20 days preventive effects (%) behind the last medicine |
| 55% cyprodinil Wettable propineb powder | 800 times | 87.64 | 91.37 |
| 75% cyprodinil Propineb water dispersible granules | 1000 times | 88.09 | 92.55 |
| 30% cyprodinil Propineb suspending agent | 500 times | 86.43 | 92.07 |
| 50% cyprodinil water dispersible granules | 800 times | 80.16 | 84.30 |
| 70% Wettable propineb powder | 500 times | 74.23 | 77.28 |
As shown in Table 4, can effectively prevent and treat downy mildew of garpe after cyprodinil and Propineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long, the test scope of medication in to crop safety.
Implementation of an application example five: the composite control gray mold of cucumber of cyprodinil and the Propineb test of pesticide effectiveness
This experimental establishment is in area just outside a city gate, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 50% cyprodinil water dispersible granules (commercial), 70% Wettable propineb powder (commercial).
In the gray mold of cucumber initial stage of origination, dispenser in per 7 days once is total to dispenser 4 times, and investigation state of an illness radix before the medicine was investigated disease indexs in 7 days, 15 days behind the last medicine and calculated preventive effect, and the result is as shown in the table:
Table 5 cyprodinil, Propineb and the control gray mold of cucumber test of pesticide effectiveness that is mixed thereof
| Treatment agent | The preparation dosage | 7 days preventive effects (%) behind the last medicine | 15 days preventive effects (%) behind the last medicine |
| 20% cyprodinil Wettable propineb powder | 250 g/acres | 86.17 | 90.14 |
| 80% cyprodinil Propineb water dispersible granules | 50 g/acres | 85.92 | 91.22 |
| 50% cyprodinil Propineb suspending agent | 80 g/acres | 85.36 | 93.76 |
| 50% cyprodinil water dispersible granules | 70 g/acres | 79.23 | 82.70 |
| 70% Wettable propineb powder | 120 g/acres | 70.22 | 75.27 |
As shown in Table 5, can effectively prevent and treat gray mold of cucumber after cyprodinil and Propineb are composite, control efficiency all is better than contrasting medicament, and the lasting period is long, the test scope of medication in to crop safety.
Claims (4)
1. bactericidal composition, it is characterized in that: composition effective active composition contains cyprodinil and Propineb, and wherein the weight ratio of cyprodinil and Propineb is 2: 3～3: 8 or 6: 1～2: 1 or 1: 5.
2. the bactericidal composition that contains cyprodinil and Propineb according to claim 1 is characterized in that the effective active composition weight content of cyprodinil and Propineb is 10～80%.
3. the bactericidal composition that contains cyprodinil and Propineb according to claim 1, the formulation that it is characterized in that composition is wetting powder, water dispersible granules, suspending agent.
4. according to claim 1ly contain the purposes that cyprodinil and Propineb bactericidal composition are used for control crop gray mold, spot defoliation, downy mildew, anthracnose.
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| CN101583270A (en) * | 2006-11-15 | 2009-11-18 | 杜邦公司 | Fungicidal mixtures |
| CN101755782A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing cyprodinil |
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| CN101583270A (en) * | 2006-11-15 | 2009-11-18 | 杜邦公司 | Fungicidal mixtures |
| CN101755782A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing cyprodinil |
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