CN101637169A - Tebuconazole-thiram sterilizer composition - Google Patents
Tebuconazole-thiram sterilizer composition Download PDFInfo
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- CN101637169A CN101637169A CN200910023831A CN200910023831A CN101637169A CN 101637169 A CN101637169 A CN 101637169A CN 200910023831 A CN200910023831 A CN 200910023831A CN 200910023831 A CN200910023831 A CN 200910023831A CN 101637169 A CN101637169 A CN 101637169A
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- tebuconazole
- tmtd
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Abstract
The invention relates to a sterilizer composition consisting of tebuconazole and thiram which serve as effectively active components. The ebuconazole-thiram sterilizer composition contains 5-20% by weight of tebuconazole and 51-73% by weight of thiram. The composition is preferably in the form of water dispersible granule, suspending agent, oil suspending agent, emulsion in water, wettable powderand missible oil. The ebuconazole-thiram sterilizer composition can be applied for preventing and removing gibberellic disease, sphaerotheca fuliginea, banded sclerotial blight, rice blast, blight andverticillium wilt, alternaria leaf spot, cladosporium cucumerinum and anthracnose which happen to wheat, rice, cotton, apple treess and grape plants.
Description
Technical field
The present invention relates to a kind of bactericidal composition, particularly the bactericidal composition of being made up of effective active composition Tebuconazole and tmtd belongs to technical field of compounded pesticide.
Background technology
Tebuconazole belongs to triazole bactericidal agent, is that sterol takes off basic inhibitor early, is used for the seed treatment of important economic crops or the efficient protective fungicide of surface sprinkling.
Tmtd, English common name thiram belongs to protective fungicide, to various crop downy mildew, eqpidemic disease, anthracnose, cereal class smut, seedling stage yellow blight the better prevention effect is arranged.
At present, the pesticidal preparations that with the tmtd is effective ingredient in actual use, exists dust pollution seriously environment and health to be had very big harm based on 50%, 70%, 80% wetting powder, and availability is low, shortcomings such as the lasting period is short, the inventor finds tmtd and Tebuconazole active component be mixed and can improve its availability, compares the use of tmtd and the agent of Tebuconazole list, can reduce the pharmacy application amount, environmentally friendly, save cost, the generation that slows down pest resistance.
Summary of the invention
The object of the present invention is to provide and a kind ofly reduce the pharmacy application amount, and environment-friendly high-efficiency, the tmtd of high usage and the bactericidal composition of Tebuconazole.
In order to overcome the defective of existing single component formulations, technical scheme of the present invention is to solve like this:
Tebuconazole and tmtd bactericidal composition contain by weight percentage 5%～20% Tebuconazole and 45%～73% tmtd, are preferably the tmtd of 8%～16% Tebuconazole and 65%～73%.
The present composition can be prepared into by known method and be fit to any one formulation that agricultural is used, and reasonable formulation is water dispersible granules, suspending agent, oil-suspending agent, aqueous emulsion, wetting powder or missible oil.
The auxiliary agent that uses in the composition of the present invention comprises that solvent, dispersant, stabilizing agent, antifreezing agent, thickener etc. and other are of value to the known substance that active ingredient is stablized and drug effect is brought into play in preparation, all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited, concrete composition and consumption require to determine by test according to prescription.
Tebuconazole and tmtd bactericidal composition are preferably water dispersible granules, be 8%～16% Tebuconazole and 65%～73% tmtd by weight percentage, wetting agent 2%～10%, dispersant 3%～12%, disintegrant 4%～10%, binding agent 2%～10%, carrier are surplus;
Described wetting agent is alkyl sulfate, alkylsulfonate, draw back in powder or the naphthalene sulfonate one or more; Described dispersant is one or more in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate or the naphthalene sulfonic acid-formaldehyde condensation product sodium salt; Described disintegrant is one or more in modified starch, ammonium sulfate or the glucose; Described carrier is one or more in diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite or the potter's clay; Described binding agent is one or more in corn starch, Sodium Polyacrylate or the carboxymethyl cellulose class.
The preparation method of Tebuconazole tmtd water dispersible granules comprises the steps:
1. choose raw material according to the prescription of Tebuconazole and tmtd water dispersible granules, it is mixed.
2. morcel through air-flow and obtain female powder after machine carries out ultramicro grinding with above mixture
3. the female powder that obtains after the ultramicro grinding is mixed by prescription and binding agent
4. above mixture is carried out granulation on comminutor;
5. above grain dress thing is dried;
Below be advantage of the present invention: 1, composition shows fabulous synergistic effect in certain ratio range, composition after being mixed has obviously improved bactericidal effect than its single agent, thereby reduced using dosage, when reducing peasant's drug cost, reduced influence degree environment; 2, the application of said composition has delayed the generation and the development of single agent resistance.3, improved safety, being mixed will be lower to the influence of environment, safer.
The invention belongs to novel systemic fungicide, have prevention protection and outstanding therapeutic action; It prevents and treats drug effect and the lasting period is much higher than conventional varieties such as first holder, carbendazim.This product is outstanding to the disease result of treatment, and the control spectrum is extremely wide, and crop head blight, powdery mildew, banded sclerotial blight, rice blast, blight, spot defoliation, scab, anthracnose etc. such as wheat, paddy rice, cotton, apple, grape are had outstanding result of treatment.Safe in utilization, do not pollute the fruit face, and absorb soon resistance of rainwater washing against behind the spray medicine.
Embodiment
Below in conjunction with embodiment content of the present invention is described further.
Example of formulations 1
Take by weighing the former powder 9% of Tebuconazole, the former powder 73% of tmtd, dispersant naphthalene sulfonic acid-formaldehyde condensation product sodium salt 4%, wetting agent dodecyl sulphate hydrogen sodium 2% draws back powder 2%, disintegrant modified starch 4%, carrier kaolin 2%; It is pressed conventional method mix, after stirring, pulverize through airslide disintegrating mill and to obtain female powder, the binding agent Sodium Polyacrylate 80 of female powder and 4% is mixed, granulation is then dried, and sieving obtains about 96% 80% Tebuconazole, tmtd water dispersible granules.Through the check active constituent content is Tebuconazole 8.2% tmtd 72.4%, moisture≤2.5%, pH value 7.4 screenings (by the 75um sieve) 〉=8%, suspensibility 〉=65%, lasting foaming characteristic (1min)≤10mL, wetability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.
Example of formulations 2
Take by weighing the former powder 12% of Tebuconazole, the former powder 70% of tmtd, dispersant lignosulfonates 3%, wetting agent sodium butylnaphthalenesulfonate 3%, dodecyl sulphate hydrogen sodium 1%, disintegrant glucose 4%, carrier white carbon 3%; It is pressed conventional method mix, after stirring, pulverize through airslide disintegrating mill and to obtain female powder, the binding agent Sodium Polyacrylate 80 of female powder and 4% is mixed, granulation is then dried, and sieving obtains about 96% 80% Tebuconazole, tmtd water dispersible granules.Through the check active constituent content is Difenoconazole 11% tmtd 69%, moisture≤2.5%, pH value 7.2 screenings (by the 75um sieve) 〉=98%, suspensibility 〉=65%, lasting foaming characteristic (1min)≤10mL, wetability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.
Example of formulations 3
Take by weighing the former powder 16% of Tebuconazole, the former powder 66% of tmtd, dispersant naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, wetting agent dodecyl sulphate hydrogen sodium 1% draws back powder 2.5%, disintegrant ammonium sulfate 5.5%; It is pressed conventional method mix, after stirring, obtain female powder through the airslide disintegrating mill pulverizing, the binding agent carboxymethyl cellulose class of female powder and 6% is mixed, granulation then, oven dry, sieving obtains about 96% 80% Difenoconazole, tmtd water dispersible granules.Through the check active constituent content is Tebuconazole 15% tmtd 65%, moisture≤2.5%, pH value 7.6 screenings (by the 75um sieve) 〉=98%, suspensibility 〉=65%, lasting foaming characteristic (1min)≤10mL, wetability≤1min, dust≤3.0%, the acceleration heat storage stability is qualified.
Example of formulations 4
Tebuconazole 12%, tmtd 70%, sodium lignin sulfonate 8%, diffusant sodium methylene bis-naphthalene sulfonate 4%, white carbon black adds to 100%, and mixture carries out comminution by gas stream, makes wetting powder.
Example of formulations 5
Tebuconazole 13%, tmtd 68%, calcium lignosulfonate 5%, white carbon black 0.3%, ethylene glycol 4%, defoamer a little, water complements to 100%.
The present invention is the bactericidal property height in production application, through evidence multiple fruit tree and vegetable disease is prevented that effect from can reach more than 80%; Safety is good, and crops are not had poisoning.The water dispersible granules that the present invention makes the results showed, this product has good dispersiveness, and working substance suspends indefinite duration; Disintegration rate is fast; Heat storage stability is good, and the height of adhesion rate in use, lasting period are long.
The Toxicity Determination example:
1, test medicine
Tebuconazole (Carbendazim) 96% former medicine; Tmtd (Thiram) 96% former medicine.
2, test method
With reference to giving birth to the accurate method NY/T1156.2-2006 of mark, adopt the pastille medium therapy: get the soup 3mL of each single agent and mixture series concentration, add in the PDA medium of the 27mL that is cooled to 45 ℃, make the pastille culture medium flat plate of required final concentration.Produce 6mm diameter mycelia piece from the apple anthrax bacteria colony edge of cultivating 4 days then, move on each serial pastille medium, mycelia faces down, and every processing repeats for 4 times.Dispose, place 28 ℃ the biochemical incubator of constant temperature to cultivate, measure colony diameter after 4 days, calculate growth inhibition ratio.
3, interpretation of result
With reference to giving birth to the accurate method NY/T1156.6-2006 of mark, according to Sun﹠amp; The co-toxicity coefficient method (CTC) of Johnson (1960) is estimated the synergistic effect of pharmacy mix, and promptly CTC≤80 are antagonism, and 80＜CTC＜120 are summation action, and CTC 〉=120 are synergistic effect.
The percentage of A medicament in toxicity index * 100 mixtures of the theoretical toxicity index (TTI) of mixture=medicament A
The percentage composition of B medicament in the toxicity index of content+medicament B * 100 mixtures
Table 1 Tebuconazole and tmtd are mixed to the toxicity test result of apple anthrax bacteria
| Medicament and proportioning | Regression equation (Y=a+bx) | Correlation coefficient (r) | ??EC 50Value (mg/L) | 95% confidence limit (mg/L) | Co-toxicity coefficient (CTC) |
| Tebuconazole (A) | ??Y＝5.0433+1.0284x | ??0.9992 | ??0.91 | ??0.77～1.07 | ??- |
| Tmtd (B) | ??Y＝3.6293+1.0453x | ??0.9795 | ??20.48 | ??8.44～50.26 | ??- |
| ??A∶B＝1∶1 | ??Y＝4.8716+1.0258x | ??0.9987 | ??1.33 | ??1.06～3.99 | ??131.02 |
| ??A∶B＝1∶3 | ??Y＝4.6125+0.9978x | ??0.9938 | ??2.45 | ??1.50～3.99 | ??131.11 |
| ??A∶B＝1∶5 | ??Y＝4.5736+0.9894x | ??0.9942 | ??2.70 | ??1.67～4.36 | ??165.48 |
| ??A∶B＝1∶7 | ??Y＝4.4221+1.021x | ??0.9986 | ??3.68 | ??2.92～4.64 | ??150.92 |
| ??A∶B＝1∶9 | ??Y＝4.3299+1.0684x | ??0.9921 | ??4.24 | ??2.39～7.51 | ??153.35 |
Conclusion: the ratio of Tebuconazole and tmtd 1: 1,1: 3,1: 5,1: 7 and 1: 9 is mixed to the virulence of apple anthrax bacteria, and the result shows that Tebuconazole and tmtd are mixed with above-mentioned 5 ratios, apple anthrax bacteria are all shown as synergistic effect, its EC
50Value is respectively 1.33,2.45,2.70,3.68 and 4.24mg/L, and co-toxicity coefficient is respectively 131.02,131.11,165.48,150.92 and 153.35, and wherein the two is the most obvious with 1: 5 ratio mixed synergies.
The test of biological Examples control apple anthracnose
80% Tebuconazole tmtd water dispersible granules of the present invention (Tebuconazole 15%, tmtd 65%) has carried out the apple orchard field trial in 2006, test main points and result are as follows:
(1), materials and methods:
1, test medicine: 80% Tebuconazole tmtd water dispersible granules;
2, contrast medicament: 25% Tebuconazole missible oil, 70% thiram wettable powder
3, controlling object: apple anthracnose
4, experiment is handled and method:
(2), seven processing are established in experiment:
500 times of liquid of (1) 80% Tebuconazole tmtd water dispersible granules
1000 times of liquid of (2) 80% Tebuconazole tmtd water dispersible granules
1500 times of liquid of (3) 80% Tebuconazole tmtd water dispersible granules
2000 times of liquid of (4) 25% Tebuconazole missible oil
(the favorable to the people farmingization in Yancheng, Jiangsu Province Co., Ltd produces)
1000 times of liquid of (5) 70% thiram wettable powders
(Tai Yuan development in science and technology Co., Ltd in Qingdao, Shandong Province produces)
(6) blank (clear water)
Randomized arrangement, every processing sub-district 3-5 strain tree, 3 repetitions; Respectively on June 23rd, 2006, July 7, July 21 usefulness power driven sprayer (operating pressure 2.0-2.3kg/m
3, shower nozzle aperture 1.2mm) evenly spray five processing, blank does not spray medicine, and treatment measures such as other waters, fertilising are all identical.
(3), investigation method:
Investigation morbidity radix before the dispenser for the first time, 7 days investigation prevention results after each dispenser, each handles 2 trees in sub-district, and whole fruits are investigated in every strain.
(4), result and analysis
Table 2 80% Tebuconazole tmtd water dispersible granules control apple anthracnose result of the test
| Handle | Preventive effect |
| 1000 times of liquid of 80% Tebuconazole tmtd water dispersible granules | ??85.27 |
| 1500 times of liquid of 80% Tebuconazole tmtd water dispersible granules | ??89.12 |
| 600 times of liquid of 25% Tebuconazole missible oil | ??77.61 |
| 1000 times of liquid of 70% thiram wettable powder | ??79.97 |
| Blank (clear water) |
In sum, the water dispersible granules that composition of the present invention preferably adopts two kinds of active components to be re-dubbed, for the control apple anthracnose, its active and bactericidal effect all significantly strengthens than single agent result of use, and quick-acting height, lasting effect are long, slows down the generation of resistance, the preparation less residue, pollution-free to crop, safety is good, meets the security requirement of pesticidal preparations.
Claims (7)
1, Tebuconazole and tmtd bactericidal composition is characterized in that containing by weight percentage 5%～20% Tebuconazole and 45%～73% tmtd.
2, Tebuconazole according to claim 1 and tmtd bactericidal composition is characterized in that containing by weight percentage 8%～16% Tebuconazole and 65%～73% tmtd.
3, Tebuconazole according to claim 1 and 2 and tmtd bactericidal composition is characterized in that composition is water dispersible granules, suspending agent, oil-suspending agent, aqueous emulsion, wetting powder or missible oil.
4, Tebuconazole according to claim 3 and tmtd bactericidal composition is characterized in that composition is a water dispersible granules.
5, Tebuconazole according to claim 4 and tmtd bactericidal composition, it is characterized in that Tebuconazole 8%～16% by weight percentage, tmtd 65%～73%, wetting agent 2%～10%, dispersant 3%～12%, disintegrant 4%～10%, binding agent 2%～10%, carrier are surplus.
6, Tebuconazole according to claim 5 and tmtd bactericidal composition is characterized in that described wetting agent is alkyl sulfate, alkylsulfonate, draws back in powder or the naphthalene sulfonate one or more; Described dispersant is one or more in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate or the naphthalene sulfonic acid-formaldehyde condensation product sodium salt; Described disintegrant is one or more in modified starch, ammonium sulfate or the glucose; Described carrier is one or more in diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite or the potter's clay; Described binding agent is one or more in corn starch, Sodium Polyacrylate or the carboxymethyl cellulose class.
7, described Tebuconazole of claim 1 and the tmtd bactericidal composition application in preventing and kill off wheat, paddy rice, cotton, apple, grape crop head blight, powdery mildew, banded sclerotial blight, rice blast, blight, spot defoliation, scab, anthracnose.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102246771A (en) * | 2011-05-13 | 2011-11-23 | 中国农业大学 | Tebuconazole and thiodiazole-copper blended medicament for preventing and treating rice seed-borne fungal and bacterial diseases |
| CN102792952A (en) * | 2012-09-12 | 2012-11-28 | 山东棉花研究中心 | Bactericide composition for preventing and controlling cotton disease |
| CN103190423A (en) * | 2013-04-02 | 2013-07-10 | 南京南农农药科技发展有限公司 | Bactericidal composition containing triazole and thiram |
| CN103503897A (en) * | 2013-10-18 | 2014-01-15 | 雷玉明 | Special seed coating agent for potatoes |
| CN104267031A (en) * | 2014-09-25 | 2015-01-07 | 句容市农业技术推广中心 | Screening method of control agent for wheat scab |
| US20160270392A1 (en) * | 2013-12-05 | 2016-09-22 | Upl Limited | Agrochemical compositions having increased rainfastness |
| CN106577707A (en) * | 2016-12-14 | 2017-04-26 | 富源县农业技术推广中心 | Coix seed coating agent, coated coix seed, and preparation method thereof |
| CN107087593A (en) * | 2017-04-12 | 2017-08-25 | 江苏金凤凰农化有限公司 | A kind of composition and application process that rice blast is treated based on guaiacol |
| CN109644996A (en) * | 2018-12-10 | 2019-04-19 | 上海惠光环境科技有限公司 | Suspension agent composition containing jinggangmycin A and hexaconazole |
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2009
- 2009-09-08 CN CN200910023831A patent/CN101637169A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102246771A (en) * | 2011-05-13 | 2011-11-23 | 中国农业大学 | Tebuconazole and thiodiazole-copper blended medicament for preventing and treating rice seed-borne fungal and bacterial diseases |
| CN102792952A (en) * | 2012-09-12 | 2012-11-28 | 山东棉花研究中心 | Bactericide composition for preventing and controlling cotton disease |
| CN102792952B (en) * | 2012-09-12 | 2014-02-12 | 山东棉花研究中心 | Bactericide composition for preventing and controlling cotton disease |
| CN103190423A (en) * | 2013-04-02 | 2013-07-10 | 南京南农农药科技发展有限公司 | Bactericidal composition containing triazole and thiram |
| CN103503897A (en) * | 2013-10-18 | 2014-01-15 | 雷玉明 | Special seed coating agent for potatoes |
| US20160270392A1 (en) * | 2013-12-05 | 2016-09-22 | Upl Limited | Agrochemical compositions having increased rainfastness |
| US10694741B2 (en) * | 2013-12-05 | 2020-06-30 | Upl Limited | Agrochemical compositions having increased rainfastness |
| CN104267031A (en) * | 2014-09-25 | 2015-01-07 | 句容市农业技术推广中心 | Screening method of control agent for wheat scab |
| CN106577707A (en) * | 2016-12-14 | 2017-04-26 | 富源县农业技术推广中心 | Coix seed coating agent, coated coix seed, and preparation method thereof |
| CN107087593A (en) * | 2017-04-12 | 2017-08-25 | 江苏金凤凰农化有限公司 | A kind of composition and application process that rice blast is treated based on guaiacol |
| CN109644996A (en) * | 2018-12-10 | 2019-04-19 | 上海惠光环境科技有限公司 | Suspension agent composition containing jinggangmycin A and hexaconazole |
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Application publication date: 20100203 |