CN101979053A - Medicament for treating infantile uterus and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating infantile uterus. The medicament is prepared from Chinese angelica, nutgrass galingale rhizome, rhizoma corydalis, plantain seed, dried longan pulp, deer fetus, cornu cervi pantotrichum, himalayan teasel root, thinleaf milkwort root-bark and ladybell root according to a certain weight proportion. The medicament can be prepared into any common medicament for oral administration. The medicament of the invention has the effects of nourishing liver and kidney, promoting blood circulation by removing blood stasis, supplementing qi, nourishing blood, nourishing yin and strengthening yang and has quick response to the infantile uterus and high curative rate.

Description

A kind of medicine for the treatment of uterine hypoplasia and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of uterine hypoplasia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Uterine hypoplasia is that gynecological often runs into one of the most thorny disease kind, also be a kind of gynaecopathia that can't cure in the world at present, in case ill, cause great misery will for people's physical and mental health and family, the patient is often unhappy with mood, fidgety, emaciation and sallow complexion, limbs fatigue, inappetence, insomnia and dreamful sleep, bitter taste in the mouth and dry throat, spontaneous perspiration, night sweat, waist abdomen pain or abdominal part are afraid of cold, menstruation 1 year or half a year once, amenorrhea often or do not have through, breast dysplasia, the pubes rareness, aplasia of ultrasound diagnosis uterus or dysplasia, Western medicine can't be cured.

Therefore a lot of infertile families to curative effect preferably Chinese medicine have great demand, up to now, also do not find relevant report, the woman with a hypoplastic vagina's of this sick subordination traditional Chinese medical science disease relevant for medicine of the present invention.

The inventor is according to the theory of the traditional Chinese medical science: " kidney is that human body is congenital basic; by becoming thoroughly decomposed of the taste day after tomorrow; the luxuriant foster the congenital foundation kidney of foodstuff essence ", parallel in the hope of the kidney yin kidney yang, through research and clinical trial repeatedly, finally finding has better curative effect to cure the medicine of uterine hypoplasia, thereby has finished the present invention.

Purpose of the present invention just provides has the composition of medicine that specially good effect is cured uterine hypoplasia.

Another object of the present invention just provides the preparation method of this composition of medicine.

Medicament selection Radix Angelicae Sinensis of the present invention, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica 38 flavor medicines make up, make each efficacy of drugs produce association's effect of withering these drug regimens, thereby can effectively cure the recurrence of uterine hypoplasia.Wherein selecting Radix Angelicae Sinensis for use is that temperature is gone into the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged because of the sweet suffering of its nature and flavor, menstruction regulating and pain relieving, and the function of moisturizing laxation is controlled menoxenia, and amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, the dryness of the intestine dyschezia is heavy after the bloody dysentery; Ulcer sores, traumatic injury.Select for use Herba Leonuri to be because its nature and flavor are arduous, cold.Go into pericardium, Liver Channel.Invigorate blood circulation blood stasis dispelling, regulating menstruation, the function of the water that disappears.Control menoxenia, the vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria is rushed down blood, the carbuncle skin infection.Select for use Rhizoma Cyperi to be because the hot little hardship of its nature and flavor is sweet, flat, go into liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Selecting Pericarpium Citri Reticulatae Viride for use is because of its nature and flavor toil, tepor, goes into liver, gallbladder meridian, and soothing the liver dispelling the stagnated QI is arranged, and the function of eliminating stagnation expectorant is controlled breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction piece.Select for use Rhizoma Corydalis to be because its nature and flavor are arduous, temperature is gone into liver, spleen channel, invigorate blood circulation, and promoting the circulation of QI, the analgesic function is controlled the breast side of body, epigastric pain, the amenorrhea dysmenorrhea, postpartum stagnation, tumbling down swells and ache.Select for use Fructus Ligustri Lucidi to be because its property bitter but sweet flavor, flat is gone into liver, kidney channel, invigorating the liver and kidney is arranged, strong waist knee joint function is controlled interior-heat caused by deficiency of YIN, dizziness, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Select for use Semen Plantaginis to be because its nature and flavor are sweet, cold, go into kidney, urinary bladder channel has diuretic, and heat clearing away makes eye bright, and the expectorant function is controlled urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Wherein selecting Flos Carthami for use is because of its nature and flavor suffering, temperature.Go into the heart, Liver Channel.Promoting blood circulation to restore menstrual flow is arranged, and blood stasis removing analgesic function is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, traumatic injury.Select for use Radix Salviae Miltiorrhizae to be because its nature and flavor hardship is slightly cold, go into the heart, Liver Channel, stasis-dispelling and pain-killing is arranged, promoting blood circulation to restore menstrual flow, the function of the relieving restlessness that clears away heart-fire is controlled menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Select for use flower of Radix Notoginseng to be because its nature and flavor are sweet, cold has heat clearing away, suppressing the hyperactive liver, and the function of blood pressure lowering is controlled hypertension, and giddy is dizzy, tinnitus, acute pharyngolaryngitis.Select for use Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor is gone into liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Selecting Fructus Corni for use is that tepor is gone into liver, kidney channel, and invigorating the liver and kidney is arranged because of its nature and flavor acid, and arresting seminal emission gas is dizzy Gu the function of collapse is controlled soreness of waist and knee joint, tinnitus, and sexual impotence, seminal emission, frequent micturition, the deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Select for use Arillus Longan to be because its nature and flavor are sweet, temperature is gone into the heart, spleen channel, and heart-spleen boosting is arranged, fill blood, and the function of calming the nerves, it is thin and weak to control asthenia, and insomnia is forgetful, palpitation with fear, severe palpitation.Selecting Colla cornus cervi for use is that temperature is gone into liver, kidney channel because of its property sweet-salty, enriches blood, and the function that benefit is smart is controlled deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, women's deficiency-cold of uterus, metrorrhagia, leukorrhagia.Select for use Colla Plastri Testudinis to be because its property sweet-salty is flat, YIN nourishing is arranged, enrich blood, the hemostatic function is controlled deficiency of YIN anemia, and the consumptive fever hectic fever due to YIN-deficiency is spitted blood, epistaxis, dysphoria with smothery sensation palpitation with fear, lumbago due to renal deficiency, flaccidity of feet and knees, metrorrhagia, leukorrhagia.Select for use Colla Corii Asini to be because its nature and flavor are sweet, flat, go into lung, liver, kidney channel, nourishing YIN and supplementing blood is arranged, antiabortive function is controlled blood deficiency, and cough due to consumptive disease, is had blood in stool menoxenia, metrorrhagia, vaginal bleeding during pregnancy at haematemesis, epistaxis.Selecting Caulis Spatholobi for use is because its property bitter but sweet flavor, and temperature is gone into the heart, spleen two warps, have invigorate blood circulation, the function of Shujin, control waist urushic acid pain, paralysis and numbness, menoxenia.Selecting Herba Ecliptae for use is that liver, kidney channel are gone in cold, and removing heat from blood is arranged because of the sweet acid of its nature and flavor, hemostasis, and the kidney invigorating, the function of tonifying YIN is controlled haematemesis, hemoptysis, epistaxis, hematuria is had blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, dysentery, pudendum pruritus due to damp pathogen.Select for use Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, go into lung, spleen, kidney channel, spleen invigorating is arranged, tonifying the lung is reinforced the kidney, and the function that benefit is smart is controlled diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease is quenched one's thirst, seminal emission, leukorrhagia, frequent micturition.Selecting Radix Adenophorae for use is that lung, Liver Channel are gone in cold, and nourishing YIN and clearing away lung-heat is arranged because of its property sweet and slightly bitter taste, and the function of expelling phlegm for arresting cough is controlled lung-heat type cough, and chronic consumptive disease chronic cough, the moon are hindered the dry pharynx laryngalgia.Select for use Herba Dendrobii to be because its property slightly sweet flavor is little salty, cold, go into stomach, lung, kidney channel, the stomach reinforcing of promoting the production of body fluid is arranged, the function of clearing away heat and nourishing YIN is controlled consumption of body fluid caused by febrile disease, the xerostomia excessive thirst, deficiency-heat after being ill, it is dark that the moon is hindered order.Select for use the Radix Aucklandiae to be because its nature and flavor are arduous, temperature is gone into lung, liver, spleen channel, and promoting the circulation of QI to relieve pain are arranged, and the function of warming middle-JIAO for easing the stomach is controlled the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, and dysentery tenesmus, colic of cold type are had loose bowels in vomiting.Select for use Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating middle warmer is arranged, QI invigorating, the function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Selecting Radix Pseudostellariae for use is that tepor is gone into the heart, spleen, lung three warps, and tonifying the lung is arranged because of its nature and flavor sweetness and bitterness, and the function of spleen invigorating is controlled the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, and the cardiopalmus spontaneous perspiration, spirit is tired.Select for use Semen Cuscutae to be because its property acrid-sweet flavor is flat, go into liver, kidney channel, invigorating the liver and kidney is arranged, beneficial marrow, the function that makes eye bright is controlled soreness of waist and knee joint, and seminal emission is quenched one's thirst, dripping urination, order is dark.Select for use Fructus Rubi to be because the sweet acid of its nature and flavor is flat, go into liver, kidney two warps, invigorating the liver and kidney is arranged, urine reducing, supporing yang, controlling nocturnal emission with astringent drugs, the function that makes eye bright is controlled sexual impotence, seminal emission, frequency of micturition, incontinence of urine, asthenia, order is dark.Select for use Fructus Cnidii to be because its nature and flavor are arduous, temperature is gone into kidney, and spleen channel has warming the kidney to activate YANG, dispel the wind, and dampness, parasiticidal function is controlled man's sexual impotence, the scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema.Selecting Embryo cervi for use is that temperature is gone into liver, kidney, the heart three warps, and kidney-reinforcing Yang-strengthening is arranged because of its property sweet-salty, and the function of tonify deficiency spermatogenesis is controlled deficient tuberculosis, asthenia of essence and blood, women's deficiency and coldness, bleeding not during menses.Selecting Cornu Cervi Pantotrichum for use is that temperature is gone into liver, kidney channel, and kidney-Yang invigorating is arranged because of its property sweet-salty, fill blood, and beneficial marrow, the function of bone and muscle strengthening is controlled the asthenia weakness and emaciation, and spirit is tired weary, dizzy, deafness, order is dark, soreness of waist and knee joint, sexual impotence, spermatorrhea, deficiency-cold of uterus, metrorrhagia, leukorrhagia.Selecting Herba Epimedii for use is that temperature is gone into liver, kidney channel, and kidney invigorating and YANG supporting is arranged because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled the sexual impotence erectile problem, dribbling urination, and the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.Select for use Semen Vaccariae to be because its nature and flavor hardship is flat, go into liver, stomach warp, have promoting the circulation of blood to stimulate the menstrual flow, expedite the emergence of stimulating milk secretion, the function of skin ulcer is held back in detumescence, controls women's amenorrhea, galactostasis, and difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.Selecting Radix Dipsaci for use is that tepor is gone into liver, kidney channel, and invigorating the liver and kidney is arranged because of its nature and flavor toil, reuniting the fractured tendons and bones, and the function of blood circulation regulating is controlled aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia, leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, the carbuncle skin ulcer is swollen.Select for use Poria cum Radix Pini to be because its nature and flavor are sweet, light, flat, go into the heart, spleen two warps, mind tranquilizing and the heart calming is arranged, the function of diuretic is controlled the palpitation with fear of having a guilty conscience, and is forgetful, insomnia, infantile convulsion, dysuria.Selecting Radix Polygalae for use is that temperature is gone into the heart, kidney channel, and the Fructus Alpiniae Oxyphyllae of calming the nerves is arranged, and eliminates the phlegm because of its nature and flavor toil, and the function of resolving depression is controlled palpitation with fear, and is forgetful, nocturnal emission, and insomnia, cough ant phlegm, the carbuncle skin ulcer is swollen.Select for use Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature is gone into spleen, stomach warp, and spleen invigorating is arranged, dampness, and resolving depression is warded off dirty function, control wet the Sheng and be stranded spleen, the asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, dysentery is had loose bowels in vomiting, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, sufficient fistula, nyctalopia.Select Ovum Zaocys for use, the different name snake egg is the ovum of Colubridae animal Zaocys, can control strong wind leprosy disease.Select for use Medulla Bovis seu Bubali to be because its nature and flavor are sweet, temperature, nontoxic, go into the heart, spleen two warps, lung moistening is arranged, the kidney invigorating, the function of filling out marrow are controlled the chronic consumptive disease weakness and emaciation, and profit is let out in the essence and blood loss, quenches one's thirst injury from falling down, hand and foot from chapping.Select for use Medulla sus domestica to be because its nature and flavor are sweet, cold, poisonous, control wind syndrome of head, dizzy, be coated with chilblain, chap.

The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range:

Radix Angelicae Sinensis 8-15 gram Herba Leonuris 15-20 gram Rhizoma Cyperis 10-15 grams

Pericarpium Citri Reticulatae Viride 10-15 gram Rhizoma Corydalis 10-15 gram Fructus Ligustri Lucidi 15-20 grams

Semen Plantaginis 15-20 gram Flos Carthamis 10-15 gram Radix Salviae Miltiorrhizaes 15-20 grams

Flower of Radix Notoginseng 2-8 gram Radix Rehmanniae Preparata 10-15 Keshan Fructus Evodiaes 8-12 grams

Arillus Longan 6-10 gram Colla cornus cervis 6-12 gram Colla Plastri Testudinis 6-12 grams

Colla Corii Asini 6-12 gram Caulis Spatholobis 15-30 gram Herba Ecliptaes 15-30 grams

Rhizoma Dioscoreae 15-20 gram Radix Adenophoraes 10-15 gram Herba Dendrobiis 10-15 grams

The Radix Aucklandiae 10-15 gram Radix Codonopsis 10-15 gram Radix Pseudostellariaes 10-15 grams

Semen Cuscutae 15-20 gram Fructus Rubies 10-15 gram Fructus Cnidiis 10-15 grams

Embryo cervi 10-15 gram Cornu Cervi Pantotrichums 2-8 gram Herba Epimedii 10-15 grams

Semen Vaccariae 15-20 gram Radix Dipsacis 10-15 gram Poria cum Radix Pinis 10-15 grams

Radix Polygalae 10-15 gram Rhizoma Atractylodis 10-15 gram Ovum Zaocyss 1-3 grams

Medulla Bovis seu Bubali 20-30 gram Medulla sus domestica 20-30 grams

Be preferably:

Radix Angelicae Sinensis 12 gram Herba Leonuris 18 gram Rhizoma Cyperis 12 grams

Pericarpium Citri Reticulatae Viride 12 gram Rhizoma Corydalis 12 gram Fructus Ligustri Lucidi 18 grams

Semen Plantaginis 18 gram Flos Carthamis 12 gram Radix Salviae Miltiorrhizaes 18 grams

The flower of Radix Notoginseng 4 gram Radix Rehmanniae Preparata 12 Keshan Fructus Evodiaes 10 grams

Arillus Longan 8 gram Colla cornus cervis 10 gram Colla Plastri Testudinis 10 grams

Colla Corii Asini 10 gram Caulis Spatholobis 20 gram Herba Ecliptaes 20 grams

Rhizoma Dioscoreae 18 gram Radix Adenophoraes 12 gram Herba Dendrobiis 12 grams

The Radix Aucklandiae 12 gram Radix Codonopsis 12 gram Radix Pseudostellariaes 12 grams

Semen Cuscutae 18 gram Fructus Rubies 12 gram Fructus Cnidiis 12 grams

Embryo cervi 12 gram Cornu Cervi Pantotrichums 4 gram Herba Epimedii 12 grams

Semen Vaccariae 18 gram Radix Dipsacis 12 gram Poria cum Radix Pinis 12 grams

Radix Polygalae 12 gram Rhizoma Atractylodis 12 gram Ovum Zaocyss 2 grams

Medulla Bovis seu Bubali 15 gram Medulla sus domestica 15 grams

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the uniform tablet of powder mixes, capsule, granule and decocting liquid or water boiling concentration paste making agent.

Preparation method of the present invention is as follows:

One, get the raw materials ready:

1, Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried;

2, Herba Leonuri: choose decontamination, clean vexed one night, run through, cutting is dried;

3, Rhizoma Cyperi: get clean Rhizoma Cyperi grain, mix thoroughly, put to fry in the pot and do with vinegar, rare black speck, 100 jin of every Rhizoma Cyperis are with 20 jin of vinegar;

4, Pericarpium Citri Reticulatae Viride: get the Pericarpium Citri Reticulatae Viride sheet, mix thoroughly, treat that vinegar exhausts, put a pot interior slow fire stir-fry and do rare black speck, 100 jin on every Pericarpium Citri Reticulatae Viride, 15 jin of vinegar with vinegar;

5, Rhizoma Corydalis: get Rhizoma Corydalis and mix infiltration thoroughly, exhaust to vinegar, put to fry in the pot and do, rare black speck, 100 jin of every Rhizoma Corydalis, 20 jin of vinegar with vinegar;

6, Fructus Ligustri Lucidi: choose decontamination, clean, dry;

7, Semen Plantaginis: choose decontamination, sieve removes spare;

8, Flos Carthami: choose decontamination, remove that stem is told, base of a fruit head, dry;

9, Radix Salviae Miltiorrhizae: get crude drug, remove residual stem, impurity, clean, run through, cut sheet, drying, sieve removes chip;

10, flower of Radix Notoginseng: choose decontamination and stalk, dedust soil;

11, Radix Rehmanniae Preparata: select high-quality Radix Rehmanniae Preparata pornographic movie, the flush away dust;

12, Fructus Corni: clean, remove removal core and impurity, dry;

13, Arillus Longan: get crude drug, choose decontamination;

14, Colla cornus cervi: Cornu Cervi is sawn into segment, long 10-15 centimetres, to put to soak in the water and float, stir also and change water 1-2 times every day, floats to water clearly, takes out, and puts and take glue in the pot, fries in shallow oil repeatedly to colloid to go out to the greatest extent, till the cutin shortcake melts when frangible;

15, Colla Plastri Testudinis: get the clean Carapax et Plastrum Testudinis that floats behind the bubble, put in the pot decocting for several times, fry in shallow oil to colloid to the greatest extent, go dregs;

16, Colla Corii Asini: smash to pieces, with boiling of enamelled vessel usefulness;

17, Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

18, Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;

19, Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

20, Radix Adenophorae: choose clean impurity, go reed, wash, slightly profit is cut into slices, and well sifted dries;

21, Herba Dendrobii: get exsiccant Herba Dendrobii, approximately to eighty per cant saturating, stewing profit is removed undesirable root and black branch with blister, and the thin film is hit in cutting, dries;

22, the Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;

23, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

24, Radix Pseudostellariae: clean earth, go into to soak boiling hotly in the boiling water, take out after about 3-5 minutes and tan by the sun;

25, Semen Cuscutae: cross square-bottomed bamboo basket and remove clean impurity, clean, dry;

26, Fructus Rubi: sieve dedust bits, choose clean impurity, remove handle;

27, Fructus Cnidii: choose decontamination, sieve removes silt, cleans, and dries;

28, Embryo cervi: it is interior with steaming 20 minutes to place iron pan with yellow wine and Embryo cervi, and per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine;

29, Cornu Cervi Pantotrichum: get exsiccant piece of antler, fine grinding;

30, Herba Epimedii: choose decontamination, destemming, shredding, sieve removes chip;

31, Semen Vaccariae: the decontamination of winnowing with a dustpan, put in the pot, fry with slow fire and spend six to popping in vain, took out in seventy percent o'clock, cool;

32, Radix Dipsaci: get the Radix Dipsaci sheet and go in the pot, add saline and stir to parching, 100 jin of every Radix Dipsaci sheets with 2 jin of Sal, add boiled water and change water in right amount;

33, Poria cum Radix Pini: get Poria cum Radix Pini's piece or sheet, remove impurity, or get crude drug, remove impurity, clean, run through, be cut into foursquare sheet or piece, dry in the shade;

34, Radix Polygalae: add boiled water and even, vexed slightly with furnacing honey, when stir-fry was extremely tack-free slightly, taking-up cooled, and per 100 jin of Cortex et Radix Polygalae (processed) are with 20 jin of furnacing honeys;

35, Rhizoma Atractylodis: choose decontamination,, pull out, run through the back section, dry with blister to seven, most probably saturating;

36, Ovum Zaocys: choosing is individual big, shells and converts yellow wine with steaming 15 minutes, and per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine;

37, Medulla Bovis seu Bubali: with steaming 30 minutes, per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine with yellow wine;

38, Medulla sus domestica: with steaming 30 minutes, per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine with yellow wine.

Two, preparation

1, the preparation of capsule

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, add decocting twice, each amount of water is advisable to cover powder, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrated, dry down at 45-50 ℃, it is ground into powder, incapsulates.

2, the preparation of tablet:

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merge decoction liquor twice, be condensed into proportion and be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45-50 ℃, be ground into powder, add the adjuvant compacting in flakes.

3, the preparation of decocting liquid:

(1) with the Radix Angelicae Sinensis of described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water, add for the first time 2 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling;

(2) medicinal residues after will filtering for the first time add 1.5 times of amounts of water, decoct boiling reuse slow fire boiling 20 minutes, promptly get the decoction liquor second time, the liquid of taking medicine the evening that is the patient.

4, particulate preparation:

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45-50 ℃, add adjuvant, make granule.

5, the preparation of unguentum:

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum.

The active component of medicine of the present invention can add preparation required various conventional adjuvant during different dosage form, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as tablet, capsule, oral liquid, granule, unguentum etc.

Medicine of the present invention has nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, and nourishing blood and invigorating qi, invigorating the spleen to benefit the lung, YIN nourishing and YANG strengthening, in the hope of reaching functions such as tonify without causing stagnation, YIN and YANG in a relative equilibrium, it is fast to be used for the treatment of the uterine hypoplasia curative effect, the cure rate height.

Below further set forth effective achievement of medicine of the present invention by testing example, these tests comprise that medicine of the present invention (to call gynecological in the following text---uterine hypoplasia health) animal toxicity test and clinical observation test.

[test example 1] gets 60 of West Germany does, and body weight 2.0-2.5kg divides two groups, and 30 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, once a day, serve on January, observes administration reaction every day, and the result shows that two groups of rabbit activities, diet are normal, and medicine does not have bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data:

Accept out-patient's 580 examples for medical treatment, 18-20 years old 360 age example, 20-26 years old 120 example, 100 examples more than 26 years old.

2, diagnostic criteria:

Light-duty uterine hypoplasia morbidity 1-3 years, pain during patient's waist abdomen, the time acid, the tenesmus of time sense lower abdomen, menstrual period random rate, sometimes monthly and extremely, often postpone or amenorrhea, scarlet sometimes through color, purple sometimes dark, rare sometimes as yellow fluid, more or less mensis in amount or nothing, leucorrhea is based on stench, and more or less, B ultrasonic or color ultrasound examination find that the uterus is less than normal a little.Heavy uterine hypoplasia medical history 3-8 years, the patient not only possesses above symptom, and more with the face tarnish, diet is relatively poor, and extremity are tired, and amenorrhea often a year is surplus, through B ultrasonic or color ultrasonic diagnosis, belongs to the standard type uterine hypoplasia.

3, Therapeutic Method:

Decocting liquid: every day secondary, by measure uterine hypoplasia health crude drug, put into boil medicine container routinely herbal decoction decoct, sooner or later service once, two months is a course of treatment, a light-duty course of treatment, heavy three courses of treatment.Tablet: oral three times of every day, each 10, two months is a course of treatment, a light-duty course of treatment, heavy three courses of treatment.Capsule: oral three times of every day, each 12, two months is a course of treatment, a light-duty course of treatment, heavy three courses of treatment.Granule: oral three times of every day, each 1 bag (12g), two months is a course of treatment, a light-duty course of treatment, heavy three courses of treatment.Unguentum: oral three times of every day, each 15ml, two months one courses of treatment, a light-duty course of treatment, heavy three courses of treatment.

4, efficacy assessment standard:

Produce effects: light, heavy uterine hypoplasia after treatment, this transference cure of patient, it is normal that body constitution is recovered, through B ultrasonic or color ultrasound examination, it is normal that uterine hypoplasia recovers, and follows up a case by regular visits to and do not have recurrence in 1-3 years.

Take a turn for the better: the uterine hypoplasia symptom progressively alleviates or normally, the patient feels good, and it is normal that body constitution is recovered substantially.

Invalid: as not reach improvement standard person.

5, therapeutic outcome: (seeing the following form)

After a course of therapy, with light-duty uterine hypoplasia patient 480 examples of Drug therapy of the present invention, produce effects 460 examples, 20 examples that take a turn for the better, total effective rate 100%; In three course of therapy, with the heavy uterine hypoplasia patient of Drug therapy of the present invention 100 examples, produce effects 95 examples, 3 examples that take a turn for the better, invalid 2 examples, total effective rate is 98%.

Claims (3)

1. medicine for the treatment of uterine hypoplasia, it is characterized in that: it is to be made by the crude drug in the following weight range:

Radix Angelicae Sinensis 8-15 gram Herba Leonuris 15-20 gram Rhizoma Cyperis 10-15 grams

Pericarpium Citri Reticulatae Viride 10-15 gram Rhizoma Corydalis 10-15 gram Fructus Ligustri Lucidi 15-20 grams

Semen Plantaginis 15-20 gram Flos Carthamis 10-15 gram Radix Salviae Miltiorrhizaes 15-20 grams

Flower of Radix Notoginseng 2-8 gram Radix Rehmanniae Preparata 10-15 Keshan Fructus Evodiaes 8-12 grams

Arillus Longan 6-10 gram Colla cornus cervis 6-12 gram Colla Plastri Testudinis 6-12 grams

Colla Corii Asini 6-12 gram Caulis Spatholobis 15-30 gram Herba Ecliptaes 15-30 grams

Rhizoma Dioscoreae 15-20 gram Radix Adenophoraes 10-15 gram Herba Dendrobiis 10-15 grams

The Radix Aucklandiae 10-15 gram Radix Codonopsis 10-15 gram Radix Pseudostellariaes 10-15 grams

Semen Cuscutae 15-20 gram Fructus Rubies 10-15 gram Fructus Cnidiis 10-15 grams

Embryo cervi 10-15 gram Cornu Cervi Pantotrichums 2-8 gram Herba Epimedii 10-15 grams

Semen Vaccariae 15-20 gram Radix Dipsacis 10-15 gram Poria cum Radix Pinis 10-15 grams

Radix Polygalae 10-15 gram Rhizoma Atractylodis 10-15 gram Ovum Zaocyss 1-3 grams

Medulla Bovis seu Bubali 20-30 gram Medulla sus domestica 20-30 grams.

2. the medicine of treatment uterine hypoplasia according to claim 1, wherein the consumption of each crude drug is:

Radix Angelicae Sinensis 12 gram Herba Leonuris 18 gram Rhizoma Cyperis 12 grams

Pericarpium Citri Reticulatae Viride 12 gram Rhizoma Corydalis 12 gram Fructus Ligustri Lucidi 18 grams

Semen Plantaginis 18 gram Flos Carthamis 12 gram Radix Salviae Miltiorrhizaes 18 grams

The flower of Radix Notoginseng 4 gram Radix Rehmanniae Preparata 12 Keshan Fructus Evodiaes 10 grams

Arillus Longan 8 gram Colla cornus cervis 10 gram Colla Plastri Testudinis 10 grams

Colla Corii Asini 10 gram Caulis Spatholobis 20 gram Herba Ecliptaes 20 grams

Rhizoma Dioscoreae 18 gram Radix Adenophoraes 12 gram Herba Dendrobiis 12 grams

The Radix Aucklandiae 12 gram Radix Codonopsis 12 gram Radix Pseudostellariaes 12 grams

Semen Cuscutae 18 gram Fructus Rubies 12 gram Fructus Cnidiis 12 grams

Embryo cervi 12 gram Cornu Cervi Pantotrichums 4 gram Herba Epimedii 12 grams

Semen Vaccariae 18 gram Radix Dipsacis 12 gram Poria cum Radix Pinis 12 grams

Radix Polygalae 12 gram Rhizoma Atractylodis 12 gram Ovum Zaocyss 2 grams

Medulla Bovis seu Bubali 15 gram Medulla sus domestica 15 grams.

3. according to the preparation method of claim 1 or 2 described medicines, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready:

(1) Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air slightly to inside and outside humidity when suitable, and section is dried;

(2) Herba Leonuri: choose decontamination, clean vexed one night, run through, cutting is dried;

(3) Rhizoma Cyperi: get clean Rhizoma Cyperi grain, mix thoroughly, put to fry in the pot and do with vinegar, rare black speck, 100 jin of every Rhizoma Cyperis are with 20 jin of vinegar;

(4) Pericarpium Citri Reticulatae Viride: get the Pericarpium Citri Reticulatae Viride sheet, mix thoroughly, treat that vinegar exhausts, put a pot interior slow fire stir-fry and do rare black speck, 100 jin on every Pericarpium Citri Reticulatae Viride, 15 jin of vinegar with vinegar;

(5) Rhizoma Corydalis: get Rhizoma Corydalis and mix infiltration thoroughly, exhaust to vinegar, put to fry in the pot and do, rare black speck, 100 jin of every Rhizoma Corydalis, 20 jin of vinegar with vinegar;

(6) Fructus Ligustri Lucidi: choose decontamination, clean, dry;

(7) Semen Plantaginis: choose decontamination, sieve removes spare;

(8) Flos Carthami: choose decontamination, remove that stem is told, base of a fruit head, dry;

(9) Radix Salviae Miltiorrhizae: get crude drug, remove residual stem, impurity, clean, run through, cut sheet, drying, sieve removes chip;

(10) flower of Radix Notoginseng: choose decontamination and stalk, dedust soil;

(11) Radix Rehmanniae Preparata: select high-quality Radix Rehmanniae Preparata pornographic movie, the flush away dust;

(12) Fructus Corni: clean, remove removal core and impurity, dry;

(13) Arillus Longan: get crude drug, choose decontamination;

(14) Colla cornus cervi: Cornu Cervi is sawn into segment, long 10-15 centimetres, to put to soak in the water and float, stir also and change water 1-2 times every day, floats to water clearly, takes out, and puts and take glue in the pot, fries in shallow oil repeatedly to colloid to go out to the greatest extent, till the cutin shortcake melts when frangible;

(15) Colla Plastri Testudinis: get the clean Carapax et Plastrum Testudinis that floats behind the bubble, put in the pot decocting for several times, fry in shallow oil to colloid to the greatest extent, go dregs;

(16) Colla Corii Asini: smash to pieces, with boiling of enamelled vessel usefulness;

(17) Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

(18) Herba Ecliptae: choose clean impurity, remove undesirable root, clean vexed, cutting is dried;

(19) Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

(20) Radix Adenophorae: choose clean impurity, go reed, wash, slightly profit is cut into slices, and well sifted dries;

(21) Herba Dendrobii: get exsiccant Herba Dendrobii, approximately to eighty per cant saturating, stewing profit is removed undesirable root and black branch with blister, and the thin film is hit in cutting, dries;

(22) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;

(23) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

(24) Radix Pseudostellariae: clean earth, go into to soak boiling hotly in the boiling water, take out after about 3-5 minutes and tan by the sun;

(25) Semen Cuscutae: cross square-bottomed bamboo basket and remove clean impurity, clean, dry;

(26) Fructus Rubi: sieve dedust bits, choose clean impurity, remove handle;

(27) Fructus Cnidii: choose decontamination, sieve removes silt, cleans, and dries;

(28) Embryo cervi: it is interior with steaming 20 minutes to place iron pan with yellow wine and Embryo cervi, and per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine;

(29) Cornu Cervi Pantotrichum: get exsiccant piece of antler, fine grinding;

(30) Herba Epimedii: choose decontamination, destemming, shredding, sieve removes chip;

(31) Semen Vaccariae: the decontamination of winnowing with a dustpan, put in the pot, fry with slow fire and spend six to popping in vain, took out in seventy percent o'clock, cool;

(32) Radix Dipsaci: get the Radix Dipsaci sheet and go in the pot, add saline and stir to parching, 100 jin of every Radix Dipsaci sheets with 2 jin of Sal, add boiled water and change water in right amount;

(33) Poria cum Radix Pini: get Poria cum Radix Pini's piece or sheet, remove impurity, or get crude drug, remove impurity, clean, run through, be cut into foursquare sheet or piece, dry in the shade;

(34) Radix Polygalae: add boiled water and even, vexed slightly with furnacing honey, when stir-fry was extremely tack-free slightly, taking-up cooled, and per 100 jin of Cortex et Radix Polygalae (processed) are with 20 jin of furnacing honeys;

(35) Rhizoma Atractylodis: choose decontamination,, pull out, run through the back section, dry with blister to seven, most probably saturating;

(36) Ovum Zaocys: choosing is individual big, shells and converts yellow wine with steaming 15 minutes, and per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine;

(37) Medulla Bovis seu Bubali: with steaming 30 minutes, per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine with yellow wine;

(38) Medulla sus domestica: with steaming 30 minutes, per 100 kilograms of clean medical materials are with 10 kilograms of yellow wine with yellow wine;

(2) preparation

(1) preparation of capsule

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, add decocting twice, each amount of water is advisable to cover powder, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrated, dry down at 45-50 ℃, it is ground into powder, incapsulates;

(2) preparation of tablet:

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merge decoction liquor twice, be condensed into proportion and be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45-50 ℃, be ground into powder, add the adjuvant compacting in flakes;

(3) preparation of decocting liquid:

1. with the Radix Angelicae Sinensis of described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water, add for the first time 2 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling;

2. the medicinal residues after will filtering for the first time add 1.5 times of amounts of water, decoct boiling reuse slow fire boiling 20 minutes, promptly get the decoction liquor second time, the liquid of taking medicine the evening that is the patient;

(4) particulate preparation:

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45-50 ℃, add adjuvant, make granule;

(5) preparation of unguentum:

Radix Angelicae Sinensis with described weight, Herba Leonuri, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, Fructus Ligustri Lucidi, Semen Plantaginis, Flos Carthami, Radix Salviae Miltiorrhizae, flower of Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Corni, Arillus Longan, Colla cornus cervi, Colla Plastri Testudinis, Colla Corii Asini, Caulis Spatholobi, Herba Ecliptae, Rhizoma Dioscoreae, Radix Adenophorae, Herba Dendrobii, the Radix Aucklandiae, Radix Codonopsis, Radix Pseudostellariae, Semen Cuscutae, Fructus Rubi, Fructus Cnidii, Embryo cervi, Cornu Cervi Pantotrichum, Herba Epimedii, Semen Vaccariae, Radix Dipsaci, Poria cum Radix Pini, Radix Polygalae, Rhizoma Atractylodis, Ovum Zaocys, Medulla Bovis seu Bubali, Medulla sus domestica, decoct with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum.