CN101971812A - Eugenol-containing germicidal composition - Google Patents
Eugenol-containing germicidal composition Download PDFInfo
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Abstract
The invention discloses a eugenol-containing germicidal composition, and the effective ingredient of the eugenol-containing germicidal composition is one of eugenol (A) and methacrylic acid ester bactericide (B). The methacrylic acid ester bactericide comprises azoxystrobin, kresoxim-methyl, pyraclostrobin, trifloxystrobin, enestroburin, SYP-1620, ZJ0712, and the like, and the ratio of the parts by weight of the two active ingredients A to B is 1-80:1-50. The composition of the invention has an obvious synergistic effect, can prevent various diseases, has good safety to crops, and has the advantages of rain wash resistance and lasting pesticide effect, etc.
Description
Technical field
The invention belongs to the disinfectant use in agriculture field, relate to a kind of preparation and application that contains the bactericidal composition of eugenol.
Background technology
Sustainable development along with agricultural development; the mankind constantly strengthen environmental protection consciousness; the influence that agricultural chemicals cause environment extremely people is paid close attention to, because a large amount of chemical pesticides that use, and the pollution in various degree that all arrived of air, water source, soil and crops.Therefore, reduce the use of chemical pesticide, adopt the biopesticide prevention and elimination of disease and pests of environmental protection to become the inexorable trend that agricultural chemicals is researched and developed.
Eugenol (eugenol), molecular formula: C
19H
12O
2, chemical name: 4-pi-allyl-2-metoxyphenol.The botanical fungicide eugenol is the active component of extract from Chinese medicine a kind of natural, green, environmental protection,, noresidue nontoxic, free from environmental pollution to the person poultry safety when corps diseases is played preventive and therapeutic effect.Powdery mildew, gray mold, downy mildew, leaf mold, anthracnose, rust, fusarium wilt, eqpidemic disease there is favorable effect.
But the agent of the long-term eugenol of use separately list makes disease produce resistance easily, causes problems such as dosage increase, preventive effect reduction, lasting period shortening, is unfavorable for sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, makes to delay the common method that disease develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The objective of the invention is to propose a kind of generation of disease drug resistance or delaying drug resistance of preventing and produce speed, the bactericidal composition that use cost is low, preventive effect is good.
The resistance that may bring at the long-term use of eugenol list agent takes place, degradation problem under the drug effect.The inventor finds by a large amount of indoor biometricses and field control effectiveness test: eugenol and methoxy acrylic bactericide use after being mixed with certain proportion, have obvious synergistic effect.
Methoxy acrylic (strobilurins) bactericide is the new type bactericide that in these years occurs, and the sterilization mechanism uniqueness has and permeates in systemic action, low toxicity, efficient, broad spectrum activity.This series bactericidal agent all is the cell mitochondrial respiration inhibitor of pathogen, shifts by the electronics in the pathogen physiological activity and suppresses mitochondrial respiratory, and the supply of interference cell energy, make the pathogen cell death.Sac fungi, pityrosporion ovale, oomycetes and Fungi Imperfecti all there is good preventive effect.Good to white powder, black star, eqpidemic disease, downy mildew control efficiency.This series bactericidal agent mainly contains Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, ZJ0712 etc. at present.
Fluoxastrobin (azoxystrobin) is the heterocyclic nitrogen-group fungicide of Britain ICI company exploitation.Molecular formula: C
24H
17N
3O
5, chemical name: (E)-2-{2-[6 (2-cyano-benzene oxygen) pyrimidine-4-base oxygen] phenyl }-the 3-methoxy acrylate.Fluoxastrobin belongs to the mitochondrial respiratory inhibitor, promptly passes through to shift to the electronics of cromoci at cytochrome B cl, thereby suppresses mitochondrial breathing.The bacterial strain that 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole is produced resistance is effective.Have protection, root out, infiltration, systemic activity.Suppress spore germination and mycelial growth and produce spore always.
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic new type bactericide of BASF Aktiengesellschaft.Molecular formula: C
18H
19NO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.Kresoxim-methyl belongs to the cell mitochondrial respiration inhibitor, shifts by electronics between cytochrome b and C1 and suppresses mitochondrial respiratory, and the supply of interference cell energy makes the pathogen cell death.Tool is protected, treats, is rooted out, infiltration, systemic activity, and fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has the better prevention effect.
Pyraclostrobin (Pyraclostrobin) molecular formula: C
19H
18CIN
3O
4, chemical name: N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] and the oxygen methyl] phenyl]-N-methoxyl group methyl carbamate.Be the efficient mitochondrial respiratory inhibitor after improving on the kresoxim-methyl basis, have protection, treatment, blade infiltration conduction.
Alkene oxime amine was found by Shenyang Chemical Engineering Inst in 1999, molecular formula: C
21H
20CI
2N
3O
3, chemical name: (E, E, E)-N-methyl-2-[((((1-methyl-3-(2,, 6 ,-dichlorophenyl)-the 2-acrylic) imino group) the oxygen base) methyl) phenyl]-the 2-methoxyimino acetic amide.Alkene oxime amine acts on the mitochondrial respiratory of fungi, medicament by with the mitochondria electron transport chain in the combining of composite I II (Cyt bc1 compound), to Cyt c, the ATP that destroys fungi is synthetic by Cyt bc1 complex logistics for the blocking-up electronics, thereby plays the effect of inhibition or kill fungi.
Oxime bacterium ester (Trifloxystrobin) molecular formula: C
20H
19F
3N
2O
4, chemical name: (2Z)-2-methoxyimino-2-[2-[[1-[3-(trifluoromethyl) phenyl] ethyleneimino] the oxygen methyl] phenyl] methyl acetate.It is capable of being fast degraded in the water at soil, so environmentally safe.
Enestroburin (Enestroburin), molecular formula: C
22H
27ClNO
4, chemical name: 3-methoxyl group-2-[2-((((1-methyl-3-(4-chlorphenyl)-2-acrylic fork) amino) oxygen)-methyl) phenyl] and methyl acrylate
ZJ0712 (kresoxim-methyl) is the novel methoxy acrylic new type bactericide by the exploitation of Zhejiang chemical research institute.Molecular formula: C
20H
22O
4, chemical name: (E) 2-[2-(2,5-dimethyl phenoxy toluene)-phenyl]-the 3-methoxy-methyl acrylate.Protection of ZJ0712 tool and therapeutic action, toxicity is low, and active high, fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has the better prevention effect, particularly powdery mildew of cucumber and downy mildew of garpe is had very excellent preventive effect.
The bactericidal composition that the present invention proposes contains two kinds of active components of A, B, and an amount of surfactant adjuvant and carrier.
Active component A is selected from a kind of in the above-mentioned methoxy acrylic bactericide:
Comparatively preferred active components A is a kind of in Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, the ZJ0712.
Active component B is selected from eugenol.
The ratio of weight and number of A, two kinds of active components of B is 1～80: 1～50, is preferably 1～60: 1～30, more preferably 1～50: 1～10.
Amount of application when the content of active component depends on independent use in the present composition also depends on the mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target fungi.Usually active weight percentage is 1～90% of a gross weight in the composition, and preferable is 5%～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5～40% of a total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from dispersant, wetting agent, binding agent or the defoamer one or more.According to different dosage form, can also contain disintegrant known in those skilled in the art, antifreeze etc. in the preparation.
Composition of the present invention can be by the user before use through dilution or directly use.Its preparation can be by the preparation of common processing method, is about to active substance and after liquid flux or solid carrier mix, and adds in surfactant such as dispersant, stabilizing agent, wetting agent, adhesive, the defoamer etc. one or more again.
Bactericidal composition of the present invention can be processed into acceptable forms on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent.
When making wetting powder, composition comprises following constituent content: active components A 1～80%, eugenol 1～50%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
Active components A, eugenol, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: active components A 1～80%, eugenol 1～50%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
Active components A, eugenol, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, add other auxiliary agents such as adhesive again, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes the water dispersible granules product of the present composition.
Comprise following constituent content when composition is made suspending agent: active components A 1～50%, eugenol 1～30%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, binding agent 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add active components A, eugenol, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes the suspending agent product of the present composition.
Microbicide compositions of the present invention has protection concurrently, treats and roots out activity; available and various crop be as fruit tree, wheat, paddy rice, tomato, grape, cucumber, capsicum, pimento, eggplant, strawberry, vegetables and some flower plants, prevent and treat young Oomycete, Phycomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny as: powdery mildew, gray mold, downy mildew, leaf mold, anthracnose, rust, fusarium wilt, eqpidemic disease etc. have preventive effect preferably.
Composition of the present invention has following advantage: the mechanism of action difference of active ingredient in (one) present composition, and being mixed mutually can not produce conflict; (2) present composition shows significant synergistic effect in certain ratio range, has both improved protection effect, has reduced mu dosage and cost, has enlarged fungicidal spectrum again; (3) present composition helps avoid the drug-fast generation of germ and slows down drug-fast generation speed, thereby has solved resistance and cost problem in the present agricultural chemicals list agent application process; (4) present composition not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage, and being mixed will be lower to the influence of environment, safer.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
After different active ingredients are mixed, show three kinds of type of action usually, summation action, synergistic effect and antagonism.But be specially which kind of effect, unpredictable, have only by a large amount of experiments and just can know.The prescription that compound synergic is good owing to obviously improved actual preventive effect, has reduced the agricultural chemicals usage amount, thereby has delayed the drug-fast generation speed of germ greatly, is the important means of scientific prevention and cure disease.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Implementation of an application example one: active component (A) methoxy acrylic bactericide is with (B) eugenol is composite to the powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament powdery mildew of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component (A) methoxy acrylic bactericide and (B) eugenol shared ratio in combination;
A is selected from methoxy acrylic bactericide: a kind of in Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, the ZJ0712;
B is an eugenol.
It is as shown in the table for result of the test:
Toxicity test result one
Table 1 Fluoxastrobin, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 1, Fluoxastrobin, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.381mg/L and 0.011mg/L.The virulence of Fluoxastrobin is lower than the virulence of eugenol.1: 1,10: 1,30: 1,50: 1,70: 1 synergy ratio of Fluoxastrobin and eugenol proportioning is respectively 1.527,1.806,2.125,1.996,1.596, illustrating that Fluoxastrobin and eugenol were mixed in the scope at 1: 1 to 70: 1 all shows synergistic effect, synergy ratio SR maximum when Fluoxastrobin and eugenol weight ratio are 30: 1 wherein, synergistic effect is the most obvious.
Toxicity test result two
Table 2 kresoxim-methyl, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 2, kresoxim-methyl, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.213mg/L and 0.011mg/L.The virulence of kresoxim-methyl is lower than the virulence of eugenol.1: 1,10: 1,20: 1,40: 1,60: 1 synergy ratio of kresoxim-methyl and eugenol proportioning is respectively 1.609,1.900,2.228,1.839,1.544, illustrating that kresoxim-methyl and eugenol were mixed in the scope at 1: 1 to 60: 1 all shows synergistic effect, synergy ratio SR maximum when kresoxim-methyl and eugenol weight ratio are 20: 1 wherein, synergistic effect is the most obvious.
Toxicity test result three
Table 3 pyraclostrobin, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 3, pyraclostrobin, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.211mg/L and 0.011mg/L.The virulence of pyraclostrobin is lower than the virulence of eugenol.1: 1,10: 1,20: 1,40: 1,60: 1 synergy ratio of pyraclostrobin and eugenol proportioning is respectively 1.608,1.894,2.217,1.827,1.533, illustrating that pyraclostrobin and eugenol were mixed in the scope at 1: 1 to 60: 1 all shows synergistic effect, synergy ratio SR maximum when pyraclostrobin and eugenol weight ratio are 20: 1 wherein, synergistic effect is the most obvious.
Toxicity test result four
Table 4 oxime bacterium ester, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 4, pyraclostrobin, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.206mg/L and 0.012mg/L.The virulence of pyraclostrobin is far below the virulence of eugenol.1: 1,10: 1,20: 1,40: 1,60: 1 synergy ratio of pyraclostrobin and eugenol proportioning is respectively 1.512,1.940,2.238,1.824,1.551, illustrating that pyraclostrobin and eugenol were mixed in the scope at 1: 1 to 60: 1 all shows synergistic effect, synergy ratio SR maximum when pyraclostrobin and eugenol weight ratio are 20: 1 wherein, synergistic effect is the most obvious.
Toxicity test result five
Table 5 Enestroburin, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 5, Enestroburin, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.208mg/L and 0.011mg/L.The virulence of Enestroburin is far below the virulence of eugenol.1: 1,10: 1,20: 1,40: 1,60: 1 synergy ratio of Enestroburin and eugenol proportioning is respectively 1.513,1.947,2.250,1.836,1.563, illustrating that Enestroburin and eugenol were mixed in the scope at 1: 1 to 60: 1 all shows synergistic effect, synergy ratio SR maximum when Enestroburin and eugenol weight ratio are 20: 1 wherein, synergistic effect is the most obvious.
Toxicity test result six
Table 6 alkene oxime amine, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 6, alkene oxime amine, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.169mg/L and 0.012mg/L.The virulence of alkene oxime amine is far below the virulence of eugenol.1: 1,5: 1,10: 1,20: 1,40: 1 synergy ratio of alkene oxime amine and eugenol proportioning is respectively 1.601,1.832,2.205,1.893,1.544, illustrating that alkene oxime amine and eugenol were mixed in the scope at 1: 1 to 40: 1 all shows synergistic effect, synergy ratio SR maximum when alkene oxime amine and eugenol weight ratio are 10: 1 wherein, synergistic effect is the most obvious.
Toxicity test result seven
Table 7 ZJ0712, eugenol and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
As shown in Table 7, ZJ0712, eugenol are to the EC of powdery mildew of cucumber
50Be respectively 0.057mg/L and 0.011mg/L.The virulence of ZJ0712 is far below the virulence of eugenol.1: 10,1: 1,10: 1,20: 1,40: 1 synergy ratio of ZJ0712 and eugenol proportioning is respectively 1.696,2.049,2.294,1.828,1.521, illustrating that ZJ0712 and eugenol were mixed in the scope at 1: 10 to 40: 1 all shows synergistic effect, synergy ratio SR maximum when ZJ0712 and eugenol weight ratio are 10: 1 wherein, synergistic effect is the most obvious.
Exemplary application example two:
1, the preparation of water dispersible granules
Embodiment 1 Fluoxastrobin 50%, eugenol 1%, methyl naphthalene sulfonate formaldehyde condensate 10%, epoxidized polyether 5%, starch 14%, white carbon 5%, kaolin 15%, the mixed 51% Fluoxastrobin eugenol water dispersible granules that gets.
Embodiment 2 kresoxim-methyls 30%, eugenol 1%, sodium lignin sulfonate 5%, methanonaphthalene sodium sulfonate 5%, epoxidized polyether 5%, starch 14%, aluminium-magnesium silicate 2%, bentonite 38%, the mixed 31% kresoxim-methyl eugenol water dispersible granules that gets.
Embodiment 3 pyraclostrobins 33%, eugenol 2%, polycarboxylate 4%, lignosulfonates 4%, lauryl sodium sulfate 4%, ammonium sulfate 3%, starch 15%, white carbon 5%, diatomite 30%, the mixed 35% pyraclostrobin eugenol water dispersible granules that gets.
Embodiment 4 alkene oxime amines 50%, eugenol 5%, Negel 4%, sodium lignin sulfonate 3%, lauryl sodium sulfate 3%, ammonium sulfate 2%, white carbon 10%, precipitated calcium carbonate 28%, the mixed 55% alkene oxime amine eugenol water dispersible granules that gets.
Embodiment 5 oxime bacterium esters 60%, eugenol 20%, calcium lignosulfonate 3%, the withered powder 5% of tea, white carbon 7%, diatomite 5%, the mixed 80% oxime bacterium ester eugenol water dispersible granules that gets.
Embodiment 6 Enestroburins 48%, eugenol 2%, polycarboxylate 5%, soapberry powder 3%, sodium phosphate trimer 2%, aluminium-magnesium silicate 5%, calcium chloride 8%, attapulgite 27%, the mixed 50% Enestroburin eugenol water dispersible granules that gets.
Embodiment 7 ZJ0712 20%, eugenol 10%, ethoxylated dodecyl alcohol 2%, sodium lignin sulfonate 3%, urea 10%, white carbon 20%, diatomite 35%, the mixed 30% ZJ0712 eugenol water dispersible granules that gets.
2, the preparation of wetting powder
Embodiment 8 Fluoxastrobins 60%, eugenol 6%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, white carbon 10%, kaolin 14%, mixture carries out comminution by gas stream, makes 66% Fluoxastrobin eugenol wetting powder.
Embodiment 9 kresoxim-methyls 40%, eugenol 2%, tea are withered 3%, sodium lignin sulfonate 7%, aluminium-magnesium silicate 10%, talcum powder 38%, and mixture carries out comminution by gas stream, makes 42% kresoxim-methyl eugenol wetting powder.
Embodiment 10 pyraclostrobins 37%, eugenol 3%, sldium lauryl sulfate 2%, sodium lignin sulfonate 3%, attapulgite 55%, mixture carries out comminution by gas stream, makes 40% pyraclostrobin eugenol wetting powder.
Embodiment 11 alkene oxime amines 20%, eugenol 1%, lauryl sodium sulfate 4%, polyaryl phenol polyethenoxy ether 5%, white carbon 10%, diatomite 21%, mixture carries out comminution by gas stream, makes 40% alkene oxime amine eugenol wetting powder.
Embodiment 12 oxime bacterium esters 45%, eugenol 5%, draw back powder 3%, Negel 5%, aluminium-magnesium silicate 12%, kaolin 40%, mixture carries out comminution by gas stream, makes 50% oxime bacterium ester eugenol wetting powder.
Embodiment 13 Enestroburins 10%, eugenol 1%, soapberry powder 3%, calcium lignosulfonate 4%, white carbon 2%, attapulgite 80%, mixture carries out comminution by gas stream, makes 11% Enestroburin eugenol wetting powder.
Embodiment 14 ZJ0712 10%, eugenol 10%, neopelex 3%, sodium lignin sulfonate 3%, diatomite 74%, mixture carries out comminution by gas stream, makes 20% ZJ0712 eugenol wetting powder.
3, the preparation of suspending agent
Embodiment 15 Fluoxastrobins 43%, eugenol 7%, polyoxyethylene carboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed 50% Fluoxastrobin eugenol suspending agent that gets.
Embodiment 16 kresoxim-methyls 15%, eugenol 1%, polycarboxylate 2%, lauryl sodium sulfate 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, the mixed 16% kresoxim-methyl eugenol suspending agent that gets.
Embodiment 17 pyraclostrobins 28%, eugenol 2%, naphthalene sulfonic acid-formaldehyde condensation product 2%, draw back powder 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water and add to 100%, mixed 30% pyraclostrobin eugenol suspending agent.
Embodiment 18 alkene oxime amines 50%, eugenol 10%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthans 2%, agricultural newborn 600# phosphate 3%, glycerine 4%, deionized water add to 100%, the mixed 60% alkene oxime amine eugenol suspending agent that gets.
Embodiment 19 oxime bacterium esters 34%, eugenol 6%, sodium lignin sulfonate 4%, silkworm excrement 2%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, the mixed 40% oxime bacterium ester eugenol suspending agent that gets.
Embodiment 20 Enestroburins 20%, eugenol 2%, methyl naphthalene sulfonate formaldehyde condensate 10%, gelatin 2%, polyethylene glycol 2%, silicone oil 0.2%, deionized water add to 100%, the mixed 22 Enestroburin eugenol suspending agents that get.
Embodiment 21 ZJ0712 5%, eugenol 5%, polyoxyethylene nonylphenol ether phosphate 5%, aluminium-magnesium silicate 1%, ethylene glycol 4%, white carbon 3%, organosilicon 0.2%, deionized water adds to 100%, the mixed 10% ZJ0712 eugenol suspending agent that gets.
Embodiment uses three: the bactericidal composition that contains eugenol is prevented and treated the powdery mildew of cucumber test of pesticide effectiveness
This experimental establishment is in suburb, Liquan County, Shaanxi Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 0.3% eugenol soluble liquid agent (commercial).
The investigation powdery mildew of cucumber state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the powdery mildew of cucumber disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 8 contains the bactericidal composition of eugenol and prevents and treats the powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 8, can effectively prevent and treat powdery mildew of cucumber after eugenol and methoxy acrylic bactericide are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.Find that simultaneously also there is preventive effect preferably the composite back of eugenol and methoxy acrylic bactericide to cucumber downy mildew, anthracnose, all reaches more than 90%.
Embodiment uses four: the bactericidal composition control graw mold of tomato test of pesticide effectiveness that contains eugenol
This experimental establishment is in suburb, county, Tai'an, Gansu Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 0.3% eugenol soluble liquid agent (commercial).
The investigation graw mold of tomato state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated the graw mold of tomato disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the third time.Experimental result is as follows:
Table 9 contains the bactericidal composition control graw mold of tomato test of pesticide effectiveness of eugenol
As can be seen from Table 9, can effectively prevent and treat graw mold of tomato after eugenol and methoxy acrylic bactericide are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.Find that simultaneously also there is preventive effect preferably the composite back of eugenol and methoxy acrylic bactericide to tomato blight, all reaches more than 90%.
Embodiment uses five: the bactericidal composition that contains eugenol is prevented and treated the wheat rust test of pesticide effectiveness
This experimental establishment is in Bai Gang village, Miyang County, Henan Province, and test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 0.3% eugenol soluble liquid agent (commercial).
The investigation wheat rust state of an illness before the medicine, in their early stage dispenser for the first time, dispenser in per 7 days once is total to dispenser 2 times.Investigated the wheat rust disease index respectively and calculated preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
Table 10 contains the bactericidal composition of eugenol and prevents and treats the wheat rust test of pesticide effectiveness
As can be seen from Table 10, can effectively prevent and treat wheat rust after eugenol and methoxy acrylic bactericide are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.
Claims (7)
1. bactericidal composition that contains eugenol is characterized in that: active ingredient is (A) eugenol and (B) a kind of in the methoxy acrylic bactericide.
2. a kind of bactericidal composition according to claim 1 is characterized in that: described (A) methoxy acrylic bactericide is selected from Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, ZJ0712.
3. a kind of bactericidal composition according to claim 1 is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 1～80: 1～50.
4. a kind of bactericidal composition according to claim 3 is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 1～60: 1～30.
5. a kind of bactericidal composition according to claim 4 is characterized in that: the ratio of weight and number of A, two kinds of active components of B is 1～50: 1～10.
6. a kind of bactericidal composition according to claim 1 is characterized in that: bactericidal composition is made wetting powder, suspending agent or water dispersible granules.
7. a kind of bactericidal composition according to claim 1 is characterized in that: bactericidal composition is used for the young Oomycete of control control, Phycomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103125485A (en) * | 2011-12-03 | 2013-06-05 | 深圳诺普信农化股份有限公司 | Sterilization composition containing fenhexamid |
| CN103688936A (en) * | 2013-08-15 | 2014-04-02 | 山东省农业科学院植物保护研究所 | Compound bactericide containing eugenol and cyazofamid and application thereof |
| CN104322576A (en) * | 2014-10-13 | 2015-02-04 | 句容市满园春家庭农场 | Grape downy mildew prevention and treatment medicine |
| CN104886055A (en) * | 2015-06-27 | 2015-09-09 | 响水县智诚知识产权信息服务有限公司 | Plant growth regulator |
| KR101625599B1 (en) * | 2014-05-07 | 2016-05-30 | 경기도 | Composition and method of environment friendly controlling agent for cucumber powdery mildew and cucumber downy mildew |
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| CN106973898A (en) * | 2017-04-21 | 2017-07-25 | 广西南宁益土生物科技有限责任公司 | A kind of bactericidal composition |
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| CN109287677A (en) * | 2018-11-15 | 2019-02-01 | 云南中医学院 | The purposes of flos caryophylli volatile oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004095926A2 (en) * | 2003-04-28 | 2004-11-11 | Monsanto Technology, Llc | Treatment of plants and plant propagation materials with an antioxidant to improve plant health and/or yield |
| CN101036461A (en) * | 2007-04-26 | 2007-09-19 | 江苏省农业科学院 | Eugenol, osthol complex biological bactericide |
| CN101584316A (en) * | 2009-05-27 | 2009-11-25 | 江苏省农业科学院 | Soluble eugenol solvent, preparation method and application thereof |
-
2010
- 2010-11-08 CN CN 201010534352 patent/CN101971812B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004095926A2 (en) * | 2003-04-28 | 2004-11-11 | Monsanto Technology, Llc | Treatment of plants and plant propagation materials with an antioxidant to improve plant health and/or yield |
| CN101036461A (en) * | 2007-04-26 | 2007-09-19 | 江苏省农业科学院 | Eugenol, osthol complex biological bactericide |
| CN101584316A (en) * | 2009-05-27 | 2009-11-25 | 江苏省农业科学院 | Soluble eugenol solvent, preparation method and application thereof |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103125485A (en) * | 2011-12-03 | 2013-06-05 | 深圳诺普信农化股份有限公司 | Sterilization composition containing fenhexamid |
| CN103688936A (en) * | 2013-08-15 | 2014-04-02 | 山东省农业科学院植物保护研究所 | Compound bactericide containing eugenol and cyazofamid and application thereof |
| CN103688936B (en) * | 2013-08-15 | 2016-02-03 | 山东省农业科学院植物保护研究所 | A kind of composite bactericide and application thereof containing eugenol and cyazofamid |
| KR101625599B1 (en) * | 2014-05-07 | 2016-05-30 | 경기도 | Composition and method of environment friendly controlling agent for cucumber powdery mildew and cucumber downy mildew |
| CN104322576A (en) * | 2014-10-13 | 2015-02-04 | 句容市满园春家庭农场 | Grape downy mildew prevention and treatment medicine |
| CN104886055A (en) * | 2015-06-27 | 2015-09-09 | 响水县智诚知识产权信息服务有限公司 | Plant growth regulator |
| CN104886055B (en) * | 2015-06-27 | 2017-05-24 | 王东强 | Plant growth regulator |
| CN106508910A (en) * | 2016-10-31 | 2017-03-22 | 山东省农业科学院植物保护研究所 | Bactericide composite capable of aiming at phytophthora and Pythium, and application thereof |
| CN106973898A (en) * | 2017-04-21 | 2017-07-25 | 广西南宁益土生物科技有限责任公司 | A kind of bactericidal composition |
| CN107853304A (en) * | 2017-12-22 | 2018-03-30 | 佛山市普尔玛农化有限公司 | A kind of composition pesticide of the Evil bacterium azoles of Lv containing Er and eugenol |
| CN109287677A (en) * | 2018-11-15 | 2019-02-01 | 云南中医学院 | The purposes of flos caryophylli volatile oil |
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