CN102919244B - Fungicide composition containing tridemorph - Google Patents
Fungicide composition containing tridemorph Download PDFInfo
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- CN102919244B CN102919244B CN201210396154.8A CN201210396154A CN102919244B CN 102919244 B CN102919244 B CN 102919244B CN 201210396154 A CN201210396154 A CN 201210396154A CN 102919244 B CN102919244 B CN 102919244B
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Abstract
The invention discloses a fungicide composition with synergistic effect. Active ingredients of the fungicide composition contain (A) tridemorph and one of (B) methoxy acrylate fungicides, wherein the weight ratio of the active ingredient A to the active ingredient B is (32:1)-(1:32). Auxiliaries and excipients are added to the active ingredients to prepare suspension emulsion, suspending agents and the like. The fungicide composition is used for controlling the diseases caused by ascomycetes, basidiomycetes and imperfect fungi germs.
Description
The application is divisional application, the patent application " a kind of bactericidal composition containing tridemorph " that original application is Shaanxi Meibang Pesticide Co., Ltd., and the application number of original application is ︰ 201010579234.8, and original application day is 2010.12.8.
Technical field
The invention belongs to disinfectant use in agriculture field, relate to a kind of preparation and application of the bactericidal composition that contains tridemorph.
Background technology
Along with the sustainable development of agricultural development; the mankind constantly strengthen environmental protection consciousness; the impact that agricultural chemicals cause environment extremely people is paid close attention to, and due to a large amount of chemical pesticides that use, air, water source, soil and crops are all subject to the pollution arriving in various degree.Therefore, reduce the use of chemical pesticide, release that preventive effect is good, consumption is low, environmental protection, and the Pesticidal products that can delaying drug resistance produces speed become the trend of agricultural chemicals research and development.
Tridemorph (tridemorph) is morpholine series bactericidal agent.Molecular formula is C
19h
39nO (approximately), chemical name: 2,6-dimethyl-4-tridecyl morpholine.
Tridemorph is a kind of broad spectrum activity systemic fungicide with protection and therapeutic action, can be absorbed by the root of plant, stem, leaf, and the plurality of plant diseases that basidiomycetes, sac fungi and imperfect fungus are caused is effective, is mainly the biosynthesis that suppresses the ergosterol of germ.
But the long-term tridemorph single dose that uses separately, easily makes disease produce resistance, causes the problems such as dosage increase, preventive effect reduction, lasting period shortening, is unfavorable for sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, make to delay the common method that disease develops immunity to drugs, and according to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can expand fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The object of the invention is to propose a kind of generation or delaying drug resistance generation speed that can prevent disease drug resistance, the bactericidal composition containing tridemorph that use cost is low, preventive effect is good.
Long-term use may bring for tridemorph single dose resistance occurs, degradation problem under drug effect.Inventor finds by a large amount of indoor biometricses and field control effectiveness test: tridemorph and methoxy acrylic bactericide use after with certain proportion mixture, have obvious synergistic effect.
Described methoxy acrylic (strobilurins) bactericide is the new type bactericide in these years occurring, sterilization mechanism uniqueness, has and permeate in systemic action, low toxicity, efficient, broad spectrum activity.This series bactericidal agent is all the cell mitochondrial respiration inhibitor of pathogen, shifts to suppress mitochondrial respiratory by the electronics in pathogen physiological activity, and interference cell energy supply, makes pathogen cell death.Sac fungi, pityrosporion ovale, oomycetes and Fungi Imperfecti are had to good preventive effect.Good to white powder, anthracnose, scab, epidemic disease, downy mildew control efficiency.
Inventor is by further research discovery, and in described methoxy acrylic bactericide, comparatively preferred composition has: Fluoxastrobin, kresoxim-methyl, pyraclostrobin, ZJ0712, oxime bacterium ester, Enestroburin, alkene oxime amine etc.
Fluoxastrobin (azoxystrobin) is the heterocyclic nitrogen-group fungicide of ICI company of Britain exploitation.Molecular formula: C
24h
17n
3o
5, chemical name: (E)-2-{2-[6 (2-cyano-benzene oxygen) pyrimidine-4-yl oxygen] and phenyl }-3-methoxy acrylate.Fluoxastrobin belongs to mitochondrial respiratory inhibitor, by shifting to the electronics of cromoci at cytochrome B cl, thereby suppresses mitochondrial breathing.The bacterial strain that 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole is produced to resistance is effective.There is protection, root out, infiltration, systemic activity.Suppress spore germination and mycelial growth and produce spore always.
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic new type bactericide of BASF Aktiengesellschaft.Molecular formula: C
18h
19nO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.Kresoxim-methyl belongs to cell mitochondrial respiration inhibitor, shifts to suppress mitochondrial respiratory by electronics between cytochrome b and C1, and interference cell energy supply, makes pathogen cell death.Tool is protected, treats, is rooted out, infiltration, systemic activity, and fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has good control efficiency.
Pyraclostrobin (Pyraclostrobin) molecular formula: C
19h
18cIN
3o
4, chemical name: N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] and oxygen methyl] phenyl]-N-methoxyl group methyl carbamate.Be the efficient mitochondrial respiratory inhibitor after improving on kresoxim-methyl basis, there is protection, treatment, blade infiltration conduction.
Alkene oxime amine is found by Shenyang Chemical Engineering Inst for 1999, molecular formula: C
21h
20cI
2n
3o
3, chemical name: (E, E, E)-N-methyl-2-[((((1-methyl-3-(2,, 6 ,-dichlorophenyl)-2-acrylic) imino group) oxygen base) methyl) phenyl]-2-methoxyimino acetic amide.Alkene oxime amine acts on the mitochondrial respiratory of fungi, medicament by with mitochondria electron transport chain in the combination of compound III (Cyt bc1 compound), blocking-up electronics is by Cyt bc1 complex logistics to Cyt c, and the ATP that destroys fungi is synthetic, thereby plays the effect of inhibition or kill fungi.
Oxime bacterium ester (Trifloxystrobin) molecular formula: C
20h
19f
3n
2o
4, chemical name: (2Z)-2-methoxyimino-2-[2-[[1-[3-(trifluoromethyl) phenyl] and ethyleneimino] oxygen methyl] phenyl] methyl acetate.It is capable of being fast degraded in water at soil, therefore environmentally safe.
Enestroburin (Enestroburin), molecular formula: C
22h
27clNO
4, chemical name: 3-methoxyl group-2-[2-((((1-methyl-3-(4-chlorphenyl) and-2-acrylic fork) amino) oxygen)-methyl) phenyl] methyl acrylate
ZJ0712 (kresoxim-methyl) is the novel methoxy acrylic new type bactericide of being developed by Zhejiang chemical research institute.Molecular formula: C
20h
22o
4, chemical name: (E) 2-[2-(2,5-dimethyl phenoxy toluene)-phenyl] and-3-methoxy-methyl acrylate.The protection of ZJ0712 tool and therapeutic action, toxicity is low, and active high, fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has good control efficiency, particularly powdery mildew of cucumber and downy mildew of garpe is had to very excellent preventive effect.
The bactericidal composition that the present invention proposes contains A, two kinds of active components of B, and appropriate surfactant adjuvant and carrier.
Active component A is selected from tridemorph.
Active component B is selected from the one in above-mentioned methoxy acrylic bactericide:
Comparatively preferred active component is the one in Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, ZJ0712.
The ratio of weight and number of A, two kinds of active components of B is 32 ︰ 1～1 ︰ 32, is preferably 16 ︰ 1～1 ︰ 16.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and Fluoxastrobin is 16 ︰ 1～1 ︰ 8, is preferably 8 ︰ 1～1 ︰ 8.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and kresoxim-methyl is 16 ︰ 1～1 ︰ 8, is preferably 8 ︰ 1～1 ︰ 8.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and pyraclostrobin is 16 ︰ 1～1 ︰ 8, is preferably 8 ︰ 1～1 ︰ 8.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and oxime bacterium ester is 16 ︰ 1～1 ︰ 8, is preferably 8 ︰ 1～1 ︰ 8.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and Enestroburin is 16 ︰ 1～1 ︰ 8, is preferably 8 ︰ 1～1 ︰ 8.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and alkene oxime amine is 16 ︰ 1～1 ︰ 8, is preferably 16 ︰ 1～1 ︰ 4.
Described bactericidal composition, is characterized in that: in bactericidal composition, the ratio of weight and number of tridemorph and ZJ0712 is .16 ︰ 1～1 ︰ 8, is preferably 16 ︰ 1～1 ︰ 1.
The amount of application when content of active component depends on independent use in the present composition, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target fungi.Conventionally in composition, active weight percentage is gross weight 1～80%, is preferably 10%～50%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5～40% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, emulsifier, binding agent or defoamer.According to different dosage form, in preparation, can also contain disintegrant known in those skilled in the art, antifreeze etc.
Composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by common processing method, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, adhesive, defoamer etc. by active substance with liquid flux or solid carrier.
Bactericidal composition of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein more preferably formulation as water dispersible granules, suspension emulsion, suspending agent, aqueous emulsion or microemulsion.
Microbicide compositions of the present invention has protection concurrently, treats and roots out activity; available and various crop be as fruit tree, wheat, paddy rice, tomato, grape, cucumber, capsicum, pimento, eggplant, strawberry, vegetables and some flower plants, prevent and treat young Oomycete, Phycomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny as: powdery mildew, gray mold, rot, leaf mold, anthracnose, rust, fusarium wilt, epidemic disease etc. have good preventive effect.
Composition of the present invention has following advantage: the mechanism of action difference of two kinds of active ingredients in (one) present composition, and mixture can not produce conflict mutually; (2) present composition shows significant synergistic effect in certain ratio range, has both improved protection effect, has reduced mu dosage and cost, has expanded again fungicidal spectrum; (3) present composition helps avoid the drug-fast generation of germ and slows down drug-fast generation speed, thereby has solved resistance and Cost Problems in current agricultural chemicals single dose application process; (4) present composition is difficult for producing poisoning, is convenient to transport and storage, and mixture will be lower on the impact of environment, safer.
Embodiment
After different active ingredient mixtures, conventionally show three kinds of type of action, summation action, synergistic effect and antagonism.But be specially which kind of effect, unpredictable, only have by great many of experiments and just can know.The formula that compound synergic is good, owing to obviously having improved actual preventive effect, has reduced agricultural chemicals usage amount, thereby has greatly delayed the drug-fast generation speed of germ, is the important means of scientific prevention and cure disease.
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Implementation of an application example one: active component (A) tridemorph is with (B) methoxy acrylic bactericide is composite to powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi Meibang Pesticide Co., Ltd..
After the effective inhibition concentration scope of each medicament is determined in prerun, each medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to powdery mildew of cucumber.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50value.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component (A) tridemorph and (B) methoxy acrylic bactericide shared ratio in combination;
A is selected from tridemorph;
B is methoxy acrylic bactericide: the one in Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, ZJ0712.
It is as shown in the table for result of the test:
Toxicity test result one
Table 1 Fluoxastrobin, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 1, tridemorph, the EC of Fluoxastrobin to powdery mildew of cucumber
50be respectively 12.34mg/L and 6.02mg/L.The virulence of Fluoxastrobin is higher than the virulence of tridemorph.Tridemorph and Fluoxastrobin proportioning mixture in 32 ︰ 1 to 1 ︰ 32 scopes all shows synergistic effect, and wherein, both mixed synergies in 16 ︰ 1 to 1 ︰ 16 scopes are comparatively desirable, and in 8 ︰ 1 to 1 ︰ 8 scopes, mixed synergies is particularly outstanding.
Toxicity test result two
Table 2 kresoxim-methyl, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 2, tridemorph, the EC of kresoxim-methyl to powdery mildew of cucumber
50be respectively 12.34mg/L and 1.35mg/L.The virulence of kresoxim-methyl is higher than the virulence of tridemorph.Tridemorph and kresoxim-methyl proportioning mixture in 32 ︰ 1 to 1 ︰ 32 scopes all shows synergistic effect, and wherein, both mixed synergies in 16 ︰ 1 to 1 ︰ 16 scopes are comparatively desirable, and in 16 ︰ 1 to 1 ︰ 8 scopes, mixed synergies is particularly outstanding.
Toxicity test result three
Table 3 pyraclostrobin, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 3, tridemorph, the EC of kresoxim-methyl to powdery mildew of cucumber
50be respectively 12.34mg/L and 1.32mg/L.The virulence of kresoxim-methyl is higher than the virulence of tridemorph.Tridemorph and kresoxim-methyl proportioning mixture in 32 ︰ 1 to 1 ︰ 32 scopes all shows synergistic effect, and wherein, both mixed synergies in 16 ︰ 1 to 1 ︰ 16 scopes are comparatively desirable, and in 16 ︰ 1 to 1 ︰ 8 scopes, mixed synergies is particularly outstanding.
Toxicity test result four
Table 4 oxime bacterium ester, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 4, tridemorph, the EC of oxime bacterium ester to powdery mildew of cucumber
50be respectively 12.34mg/L and 1.51mg/L.The virulence of oxime bacterium ester is higher than the virulence of tridemorph.Tridemorph and oxime bacterium ester proportioning mixture in 32 ︰ 1 to 1 ︰ 32 scopes all shows synergistic effect, and wherein, both mixed synergies in 16 ︰ 1 to 1 ︰ 16 scopes are comparatively desirable, and in 16 ︰ 1 to 1 ︰ 8 scopes, mixed synergies is particularly outstanding.
Toxicity test result five
Table 5 Enestroburin, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 5, tridemorph, the EC of Enestroburin to powdery mildew of cucumber
50be respectively 12.34mg/L and 1.54mg/L.The virulence of Enestroburin is higher than the virulence of tridemorph.Tridemorph and Enestroburin proportioning mixture in 32 ︰ 1 to 1 ︰ 32 scopes all shows synergistic effect, and wherein, both mixed synergies in 16 ︰ 1 to 1 ︰ 16 scopes are comparatively desirable, and in 16 ︰ 1 to 1 ︰ 8 scopes, mixed synergies is particularly outstanding.
Toxicity test result six
Table 6 alkene oxime amine, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 6, tridemorph, the EC of Enestroburin to powdery mildew of cucumber
50be respectively 12.34mg/L and 0.83mg/L.The virulence of Enestroburin is higher than the virulence of tridemorph.Tridemorph and Enestroburin proportioning mixture in 32 ︰ 1 to 1 ︰ 32 scopes all shows synergistic effect, and wherein, both mixed synergies in 16 ︰ 1 to 1 ︰ 8 scopes are comparatively desirable, and in 16 ︰ 1 to 1 ︰ 4 scopes, mixed synergies is particularly outstanding.
Toxicity test result seven
Table 7 ZJ0712, tridemorph and the composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 7, tridemorph, the EC of ZJ0712 to powdery mildew of cucumber
50be respectively 12.34mg/L and 0.16mg/L.The virulence of ZJ0712 is higher than the virulence of tridemorph.Tridemorph and ZJ0712 proportioning mixture in 64 ︰ 1 to 1 ︰ 16 scopes all shows synergistic effect, and wherein, both mixed synergies in 32 ︰ 1 to 1 ︰ 8 scopes are comparatively desirable, and in 16 ︰ 1 to 1 ︰ 1 scopes, mixed synergies is particularly outstanding.
Exemplary application example two:
1, the preparation of suspension emulsion
When making suspension emulsion, composition comprises following constituent content: active components A 1 ~ 40%, active component B 1 ~ 40%, emulsifier 2 ~ 12%, disperse wetting agent 2 ~ 10%, defoamer 0.1 ~ 2%, thickener 0.1 ~ 2%, antifreeze 0.1 ~ 8%, stabilizing agent 0.05 ~ 3%, water to add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in above-mentioned formulation material are mixed through high speed shear, add the former medicine of active components A, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make suspension, then by former active component B medicine, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.
Embodiment 1 Fluoxastrobin 20%, tridemorph 30%, OP-10 phosphate 8%, polyoxyethylene carboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix and make 50% Fluoxastrobin tridemorph suspension emulsion.
Embodiment 2 kresoxim-methyls 20%, tridemorph 25%, polycarboxylate 2%, alkyl benzene sulfonate calcium salt 5%, lauryl sodium sulfate 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix and make 45% kresoxim-methyl tridemorph suspension emulsion.
Embodiment 3 pyraclostrobins 10%, tridemorph 30%, alkylphenol-formaldehyde resin polyoxy ethyl ether 4%, naphthalene sulfonic acid-formaldehyde condensation product 2%, pull open powder 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water and add to 100%, mix and make 40% pyraclostrobin tridemorph suspension emulsion.
Embodiment 4 alkene oxime amines 10%, tridemorph 25%, castor oil polyoxyethylene ether 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthans 2%, agriculture breast 600# phosphate 3%, glycerine 4%, deionized water add to 100%, mix and make 35% alkene oxime amine tridemorph suspension emulsion.
Embodiment 5 oxime bacterium esters 5%, tridemorph 25%, triethanolamine salt 5%, sodium lignin sulfonate 4%, silkworm excrement 2%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix and make 30% oxime bacterium ester tridemorph suspension emulsion.Embodiment 6 Enestroburins 15%, tridemorph 10%, Tween 80 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, gelatin 2%, polyethylene glycol 2%, silicone oil 0.2%, deionized water add to 100%, mix and make 25 Enestroburin tridemorph suspension emulsions.
Embodiment 7 ZJ0712 10%, tridemorph 10%, alkyl biphenyl ether disulfonic acid magnesium salts 4%, polyoxyethylene nonylphenol ether phosphate 5%, aluminium-magnesium silicate 1%, ethylene glycol 4%, white carbon 3%, organosilicon 0.2%, deionized water adds to 100%, mixes and makes 20% ZJ0712 tridemorph suspension emulsion.
2, the preparation of suspending agent
When making suspending agent, composition comprises following constituent content: active components A 1 ~ 40%, active component B 1 ~ 40%, dispersant 2 ~ 10%, wetting agent 2 ~ 10%, defoamer 0.1 ~ 1%, thickener 0.1 ~ 2%, antifreeze 0.1 ~ 8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add the former medicine of active components A, the former medicine of active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.
Embodiment 8 Fluoxastrobins 10%, tridemorph 40%, polyoxyethylene carboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix and make 50% Fluoxastrobin tridemorph suspending agent.
Embodiment 9 kresoxim-methyls 10%, tridemorph 35%, polycarboxylate 2%, lauryl sodium sulfate 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix and make 45% kresoxim-methyl tridemorph suspending agent.
Embodiment 10 pyraclostrobins 30%, tridemorph 10%, naphthalene sulfonic acid-formaldehyde condensation product 2%, pull open powder 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water and add to 100%, mix and make 40% pyraclostrobin tridemorph suspending agent.Embodiment 11 alkene oxime amines 15%, tridemorph 20%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthans 2%, agriculture breast 600# phosphate 3%, glycerine 4%, deionized water add to 100%, mix and make 35% alkene oxime amine tridemorph suspending agent.
Embodiment 12 oxime bacterium esters 25%, tridemorph 5%, sodium lignin sulfonate 4%, silkworm excrement 2%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix and make 30% oxime bacterium ester tridemorph suspending agent.
Embodiment 13 Enestroburins 20%, tridemorph 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, gelatin 2%, polyethylene glycol 2%, silicone oil 0.2%, deionized water add to 100%, mix and make 25 Enestroburin tridemorph suspending agents.
Embodiment 14 ZJ0712 5%, tridemorph 15%, polyoxyethylene nonylphenol ether phosphate 5%, aluminium-magnesium silicate 1%, ethylene glycol 4%, white carbon 3%, organosilicon 0.2%, deionized water adds to 100%, mixes and makes 20% ZJ0712 tridemorph suspending agent.
3, the preparation of aqueous emulsion
When making aqueous emulsion, composition comprises following constituent content: active components A 1 ~ 40%, active component B 1 ~ 40%, solvent 1 ~ 30%, emulsifier 1 ~ 15%, co-emulsifier 0 ~ 8%, antifreeze 0 ~ 10%, thickener 0.1 ~ 2%, defoamer 0.01 ~ 2%, deionized water are supplied surplus.
Above-mentioned formulation material is mixed, effective active composition, solvent, emulsifier, co-emulsifier are added together, make to be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.
Embodiment 15 tridemorphs 5%, kresoxim-methyl 40%, ethyl acetate 20%, acetonitrile 5%, castor oil polyoxyethylene ether 5%, polyvinyl alcohol 1%, propane diols 5%, lauric acid 0.5%, deionized water adds to 100%, mixes and makes 45% tridemorph kresoxim-methyl aqueous emulsion.
Embodiment 16 tridemorphs 30%, Fluoxastrobin 8%, methyl alcohol 18%, acetone 8%, alkylphenol polyoxyethylene 5%, polyvinyl alcohol 1%, glycerine 5%, silicone oil 0.5%, deionized water adds to 100%, mixes and makes 38% tridemorph azoxystrobin water emulsion.
Embodiment 17 tridemorphs 30%, pyraclostrobin 5%, methyl alcohol 15%, dimethyl sulfoxide (DMSO) 8%, fatty alcohol-polyoxyethylene ether 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, mixes and makes 35% tridemorph pyraclostrobin aqueous emulsion.
Embodiment 18 tridemorphs 20%, ZJ0712 10%, ethanol 15%, ether 8%, sapn 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, mixes and makes 30% tridemorph ZJ0712 aqueous emulsion.
Embodiment 19 tridemorphs 8%, alkene oxime amine 20%, cyclohexane 12%, dimethyl sulfoxide (DMSO) 8%, tween 5%, gelatin 1%, olive oil 5%, polyethylene glycol 0.5%, deionized water adds to 100%, mixes and makes 28% tridemorph alkene oxime amine aqueous emulsion.
Embodiment 20 tridemorphs 15%, Enestroburin 10%, methyl alcohol 15%, ether 8%, fatty alcohol-polyoxyethylene ether 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, mixes and makes 25% tridemorph Enestroburin aqueous emulsion.Embodiment 21 tridemorphs 10%, oxime bacterium ester 5%, methyl alcohol 15%, dimethyl sulfoxide (DMSO) 8%, fatty alcohol-polyoxyethylene ether 5%, polyvinyl alcohol 2%, glycerine 1%, laruyl alcohol 0.3%, deionized water adds to 100%, mixes and makes 15% tridemorph trifloxystrobin water emulsion.
4, the preparation of microemulsion
When making microemulsion, composition comprises following constituent content: active components A 1 ~ 40%, active component B1 ~ 40%, solvent 1 ~ 30%, emulsifier 3 ~ 20%, co-emulsifier 0 ~ 12%, antifreeze 0 ~ 10%, thickener 0.1 ~ 2%, defoamer 0.01 ~ 2%, stabilizing agent 0 ~ 4%, deionized water is supplied surplus.
Former active components A medicine and the former medicine of active component B are dissolved in the homogenizer that solvent and cosolvent are housed; After emulsifier, stabilizing agent and antifreeze, water being joined in the homogenizer that above-mentioned solution is housed, give strong mixing and homogenize, finally obtain the as clear as crystal microemulsion product of the present invention of outward appearance.
Embodiment 22 tridemorphs 5%, kresoxim-methyl 50%, ether 18%, alkylphenol-formaldehyde resin polyoxy ethyl ether 8%, butanols 5%, hydroxyethylcellulose 3%, sodium salicylate 2%, organosilicon 0.5%, deionized water adds to 100%, mixes and makes 55% tridemorph kresoxim-methyl microemulsion.
Embodiment 23 tridemorphs 10%, Fluoxastrobin 40%, olive oil 12%, phenethyl phenol polyethenoxy ether 8%, tetradecanol-15%, polyvinyl alcohol 2%, sodium sorbate 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes and makes 50% tridemorph Fluoxastrobin microemulsion.
Embodiment 24 tridemorphs 32%, pyraclostrobin 2%, cyclohexane 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, salicylic acid 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes and makes 34% tridemorph pyraclostrobin microemulsion.
Embodiment 25 tridemorphs 40%, oxime bacterium ester 8%, acetonitrile 20%, alkylphenol-formaldehyde resin polyoxy ethyl ether 8%, butanols 5%, hydroxyethylcellulose 2%, sodium sorbate 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes and makes 48% tridemorph oxime bacterium ester microemulsion.
Embodiment 26 tridemorphs 40%, Enestroburin 5%, methyl alcohol 15%, phenethyl phenol polyethenoxy ether 8%, tetradecanol-15%, polyvinyl alcohol 2%, sodium salicylate 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes and makes 45% tridemorph Enestroburin microemulsion.
Embodiment 27 tridemorphs 25%, alkene oxime amine 5%, ethyl acetate 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, sodium sorbate 2%, silicone oil 0.3%, deionized water adds to 100%, mixes and makes 30% tridemorph alkene oxime amine microemulsion.
Embodiment 28 tridemorphs 16%, ZJ0712 2%, ethanol 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, salicylate hydrochlorate 2%, organosilicon 0.5%, deionized water adds to 100%, mixes and makes 18% tridemorph ZJ0712 microemulsion.
One in active components A in above-mentioned the implementation of Formulation Example (tridemorph) and B(Fluoxastrobin, kresoxim-methyl, pyraclostrobin, ZJ0712, oxime bacterium ester, Enestroburin, alkene oxime amine) ratio can within the scope of the synergy of 32 ︰ 1 ~ 1 ︰ 32, adjust, thereby form new the implementation of Formulation Example.
Embodiment applies three: the bactericidal composition containing tridemorph is prevented and treated the powdery mildew of cucumber test of pesticide effectiveness
This experimental establishment is in suburb, Tai'an county, Gansu Province, and test medicine is researched and developed, provided by Shaanxi Meibang Pesticide Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation powdery mildew of cucumber state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively powdery mildew of cucumber disease index and calculate preventive effect.Experimental result is as follows:
Table 8 is prevented and treated the powdery mildew of cucumber test of pesticide effectiveness containing the bactericidal composition of tridemorph
As can be seen from Table 8, after tridemorph and methoxy acrylic bactericide are composite, can effectively prevent and treat powdery mildew of cucumber, control efficiency is all better than contrasting medicament, and the lasting period is long.In test scope of medication, target crop is had no adverse effects, preventive effect reaches more than 90%.Find, tridemorph and methoxy acrylic bactericide are composite also has good preventive effect afterwards to cucumber anthracnose, downy mildew, all reaches more than 90% simultaneously.
Embodiment applies four: the bactericidal composition containing tridemorph is prevented and treated the apple mildew test of pesticide effectiveness
This experimental establishment is in Qian Dong town, Liquan County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi Meibang Pesticide Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation apple mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.Within after dispenser 7 days, 14 days for the third time, investigate respectively apple mildew disease index and calculate preventive effect.Experimental result is as follows:
Table 9 is prevented and treated the apple mildew test of pesticide effectiveness containing the bactericidal composition of tridemorph
As can be seen from Table 9, after tridemorph and methoxy acrylic bactericide are composite, can effectively prevent and treat apple mildew, control efficiency is all better than contrasting medicament, and the lasting period is long.In test scope of medication, target crop is had no adverse effects, preventive effect reaches more than 90%.Find, tridemorph and methoxy acrylic bactericide are composite also has good preventive effect afterwards to apple canker, all reaches more than 90% simultaneously.
Embodiment applies five: the bactericidal composition containing tridemorph is prevented and treated the wheat rust test of pesticide effectiveness
This experimental establishment is at Hua County, Henan Province Cui Jiacun, and test medicine is researched and developed, provided by Shaanxi Meibang Pesticide Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation wheat rust state of an illness before medicine, in their early stage dispenser for the first time, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days for the second time, investigate respectively wheat rust disease index and calculate preventive effect.Experimental result is as follows:
Table 10 is prevented and treated the wheat rust test of pesticide effectiveness containing the bactericidal composition of tridemorph
As can be seen from Table 10, after tridemorph and methoxy acrylic bactericide are composite, can effectively prevent and treat wheat rust, control efficiency is all better than contrasting medicament, and the lasting period is long.In test scope of medication, target crop is had no adverse effects, preventive effect reaches more than 90%.Find, tridemorph and methoxy acrylic bactericide are composite also has good preventive effect afterwards to wheat powdery mildew simultaneously.
Embodiment applies six: the bactericidal composition containing tridemorph is prevented and treated the sigatoka test of pesticide effectiveness
This experimental establishment is in LongXi county of Fujian Province, and test medicine is researched and developed, provided by Shaanxi Meibang Pesticide Co., Ltd.; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation sigatoka state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 3 times.Within after dispenser 7 days, 14 days for the third time, investigate respectively sigatoka disease index and calculate preventive effect.Experimental result is as follows:
Table 9 is prevented and treated the sigatoka test of pesticide effectiveness containing the bactericidal composition of tridemorph
As can be seen from Table 9, after tridemorph and methoxy acrylic bactericide are composite, can effectively prevent and treat sigatoka, control efficiency is all better than contrasting medicament, and the lasting period is long.In test scope of medication, target crop is had no adverse effects, preventive effect reaches more than 90%.
Claims (6)
1. containing a bactericidal composition for tridemorph, it is characterized in that: the effective active composition tridemorph of bactericidal composition and the weight ratio of Enestroburin are 32 ︰ 1～1 ︰ 32.
2. the bactericidal composition containing tridemorph according to claim 1, is characterized in that: the weight ratio of effective active composition tridemorph and Enestroburin is 16 ︰ 1～1 ︰ 16.
3. the bactericidal composition containing tridemorph according to claim 2, is characterized in that: the weight ratio of effective active composition tridemorph and Enestroburin is 16 ︰ 1～1 ︰ 8.
4. the bactericidal composition containing tridemorph according to claim 1, is characterized in that: effective active component content accounts for 1～80% of gross weight.
5. the bactericidal composition containing tridemorph according to claim 4, is characterized in that: effective active component content accounts for 10～50% of gross weight.
6. the bactericidal composition containing tridemorph according to claim 1 is for preventing and treating the application of powdery mildew, rust, rot, anthracnose, leaf spot, downy mildew.
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| CN1191670A (en) * | 1998-02-10 | 1998-09-02 | 化工部沈阳化工研究院 | Pesticide and fungicide of unsaturated oximido ethers |
| WO2000036917A1 (en) * | 1998-12-19 | 2000-06-29 | Basf Aktiengesellschaft | Fungicide mixtures which are based on derivatives of morpholine or piperidine and derivatives of oxime ether |
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| CN1191670A (en) * | 1998-02-10 | 1998-09-02 | 化工部沈阳化工研究院 | Pesticide and fungicide of unsaturated oximido ethers |
| WO2000036917A1 (en) * | 1998-12-19 | 2000-06-29 | Basf Aktiengesellschaft | Fungicide mixtures which are based on derivatives of morpholine or piperidine and derivatives of oxime ether |
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