CN102177903A - Antibacterial composition containing pyraclostrobin and amide compounds - Google Patents
Antibacterial composition containing pyraclostrobin and amide compounds Download PDFInfo
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- CN102177903A CN102177903A CN2011100689646A CN201110068964A CN102177903A CN 102177903 A CN102177903 A CN 102177903A CN 2011100689646 A CN2011100689646 A CN 2011100689646A CN 201110068964 A CN201110068964 A CN 201110068964A CN 102177903 A CN102177903 A CN 102177903A
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- metalaxyl
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Abstract
The invention discloses an antibacterial composition containing pyraclostrobin and amide compounds, which contains synergistic effective dose of pyraclostrobin and one of amide compounds including flumorph, pyrimorph, metalaxyl and benalaxyl, and the weight part ratio of two active components in the antibacterial composition is (32:1)-(1:32). The antibacterial composition provided by the invention at least contains one surfactant which is beneficial to the dispersion of the active components in water during application. The antibacterial composition provided by the invention also has the effects of protection, treatment and activity eradication.
Description
Technical field
The invention belongs to the disinfectant use in agriculture field, relate to a kind of preparation and application that contains the binary built bactericidal composition of pyraclostrobin.
Background technology
Pyraclostrobin (pyraclostrobin), molecular formula: C
20H
23N
3O
2, chemical name: methyl (N)-[[[1-(4-chlorobenzene) pyrazoles-3 base)-oxygen]-the 0-methoxyl group]-the N-methoxymethyl carbamate.
Pyraclostrobin is the bactericide of BASF AG's latest model methoxy acrylic.Pure product are that white is to the tasteless crystalline solid of oldlace.The mechanism of action is the mitochondrial respiratory inhibitor.Make mitochondria can not produce and provide cell eubolism institute energy requirement, finally cause cell death.It can control most of diseases such as Ascomycetes, Basidiomycetes, deuteromycetes, Oomycete.Growth to spore germination and leaf intramatrical mycelium has very strong inhibitory action, has protection and therapeutic activity.Have permeability and local systemic activity, the lasting period is long, resistance of rainwater washing against.Be widely used in preventing and treating the disease on wheat, paddy rice, peanut, grape, vegetables, potato, banana, lemon, coffee, fruit tree, walnut, tea tree, tobacco and ornamental plants, lawn and other field crops.This compound not only toxicity is low, to non-target organism safety, and also all friendly safely to user and environment, classified as " the candidate's medicament that reduces risk " by U.S. EPA.In addition, pyraclostrobin can be to making the positive physiological regulatory action of deposits yields, and the generation of its energy ethene suppressing can help crop to have longer time deposit bio-energy to guarantee maturity like this; Can significantly improve the activity of the restore nitrification enzyme of crop, mean the use that can reduce nitrogenous fertilizer in the soil, thereby further reduce phreatic influence; When crop was subjected to viral attack, it can quicken to resist the formation of albumen---and identical with crop self salicylic acid synthetic to the synthesis of degeneration-resistant albumen.
The agent of pyraclostrobin list is used for a long time, and disease is developed immunity to drugs, and causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The objective of the invention is to propose a kind of generation or delaying drug resistance speed that can prevent disease drug resistance, the bactericidal composition of the pyraclostrobin-containing that use cost is low, preventive effect is good.
The inventor is by a large amount of indoor biometricses and field control effectiveness test, unexpected find the use that is mixed within the specific limits of pyraclostrobin and amides compound flumorph, fourth pyrrole morpholine, metalaxyl, M 9834, the disease that Erysiphe is caused has good synergistic activity.Further experiment finds, the use that is mixed within the specific limits of pyraclostrobin and flumorph, fourth pyrrole morpholine, metalaxyl, M 9834 also has good preventive effect to Puccinia, nuclear cavity Pseudomonas, septoria musiva Pseudomonas.
The bactericidal composition that the present invention proposes contains two kinds of active components of A, B.
Active component A is selected from a kind of in flumorph, fourth pyrrole morpholine, metalaxyl or Metalaxyl-M, M 9834 or the efficient M 9834.
Described flumorph (flumorph), molecular formula are C
21H
22FNO
4, chemical name: (E, Z) 4-[3-(3 ', 4 '-Dimethoxyphenyl)-3-(4-fluorophenyl) acryloyl] morpholine.This medicine is the acryloyl morpholine series bactericidal agent, have that efficient, low toxicity, low-residual, the longevity of residure are long, protection and therapeutic action is had both, to characteristics such as crop safeties.Cucumber downy mildew had good control efficiency.
Described fourth pyrrole morpholine (Pyrimorph), molecular formula: C
22H
25N
2C
1O
2, chemical name: (E)-3-(2-chloropyridine-4-yl)-3-(4-tert-butyl-phenyl)-acryloyl morpholine.Fourth pyrrole morpholine is one of domestic novel pesticide that has China's independent intellectual property right few in number, and its mechanism of action causes protoplasm seepage in the cell for by changing the permeability of cell wall, and it is synthetic to suppress mycelium protein matter simultaneously, thereby suppresses mycelial growth.Fourth pyrrole morpholine has excellent preventive effect to oomycetes order fungi, and fungicidal spectrum is wide, can be used for preventing and treating various crop diseases such as cucumber downy mildew, tomato late blight and capsicum epidemic disease, and damping off, melon gray mold are also had good effect.
Described M 9834 (benalaxyl) or efficient M 9834 (benalaxyl-M), molecular formula is C
14H
16ClN
3O
2, chemical name: N-phenylacetyl group-N-(2, the 6-3,5-dimethylphenyl)-DL-α-An Jibingsuan methyl esters.Be mainly used in the microbial disease of the various oomycetes cause of diseases of control.
Described metalaxyl (metalaxyl) or Metalaxyl-M (metalaxyl-M), molecular formula is C
15H
21NO
4The systemic fungicide of protection of metalaxyl tool and therapeutic action; can be absorbed by the root of plant, stem, leaf; and transfer to each organ of plant with moisture content in the plant corpus; can make cauline leaf handles; seed treatment and soil treatment are effective to downy mildew, phytophthora, the caused disease of pythium spp.
Active component B is a pyraclostrobin.
The ratio of weight and number of A, two kinds of active components of B is 32: 1～1: 32, and preferred ratio of weight and number is 16: 1～1: 16.
The bactericidal composition of described pyraclostrobin-containing is characterized in that: the percentage by weight of active component fourth pyrrole morpholine and pyraclostrobin is 8: 1～1: 8, and further preferred ratio of weight and number is 4: 1～1: 4.
The bactericidal composition of described pyraclostrobin-containing is characterized in that: the percentage by weight of active component flumorph and pyraclostrobin is 8: 1～1: 8, and further preferred ratio of weight and number is 4: 1～1: 4.
The bactericidal composition of described pyraclostrobin-containing is characterized in that: the percentage by weight of active component metalaxyl and pyraclostrobin is 16: 1～1: 4, and further preferred ratio of weight and number is 16: 1～2: 1.
The bactericidal composition of described pyraclostrobin-containing is characterized in that: the percentage by weight of active component M 9834 and pyraclostrobin is 16: 1～1: 4, and further preferred ratio of weight and number is 8: 1～1: 1.
Amount of application when the content of active component depends on independent use in the present composition also depends on the mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target fungi.Usually active weight percentage is 1～90% of a gross weight in the composition, and preferable is 10%～80%.According to different preparation types, the active component content scope is different.Usually, liquid preparation contains 1～70% active substance by weight, preferably is 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, preferably is 10～80%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5～30% of a total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from dispersant, wetting agent, emulsifier or the defoamer one or more.According to different dosage form, can also contain disintegrant known in those skilled in the art, antifreeze etc. in the preparation.
Composition of the present invention can be by the user before use through dilution or directly use.Its preparation can be by common processing method preparation known in those skilled in the art, be about to active substance and after liquid flux or solid carrier mix, add in surfactant such as dispersant, stabilizing agent, wetting agent, binding agent, the defoamer etc. one or more again.
Bactericidal composition of the present invention can be processed into acceptable forms on any agricultural chemicals on demand, and the wherein excellent formulation of selecting is: wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, seed treatment.
When making wetting powder, composition comprises following constituent content: active components A 1～80%, pyraclostrobin 1～80%, dispersant 2～10%, wetting agent 2～10%, filler 8～90%.
Active components A, pyraclostrobin, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into wetting powder product of the present invention.
When making water dispersible granules, composition comprises following constituent content: active components A 1～80%, pyraclostrobin 1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
Active components A, pyraclostrobin, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, add other auxiliary agents such as binding agent again, obtain the materials of granulating.It is interior through after granulation and the drying to expect that product are quantitatively sent the fluidized bed granulation dryer to, makes water dispersible granules product of the present invention.
Comprise following constituent content when composition is made suspending agent: active components A 1～40%, pyraclostrobin 1～40%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add active components A, pyraclostrobin, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes suspending agent product of the present invention.
Comprise following constituent content when composition is made suspension emulsion: active components A 1～50%, active component B 1～50%, emulsifier 2～12%, dispersant 2～10%, defoamer 0.1～2%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05～3%, water add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in the above-mentioned formulation material are mixed through high speed shear, add pyraclostrobin, ball milling is 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make the pyraclostrobin suspending agent, then with active components A, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.
Comprise following constituent content when composition is made aqueous emulsion: active components A 1～40%, pyraclostrobin 1～40%, solvent 1～30%, emulsifier 1～15%, co-emulsifier 0～8%, antifreeze 0～10%, thickener 0.1～2%, defoamer 0.01～2%, deionized water are supplied surplus.
Above-mentioned formulation material is mixed, active ingredient, solvent, emulsifier, co-emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, make aqueous emulsion product of the present invention.
Comprise following constituent content when composition is made microemulsion: active components A 1～40%, pyraclostrobin 1～40%, solvent 1～30%, emulsifier 3～20%, co-emulsifier 0～12%, antifreeze 0～10%, thickener 0.1～2%, defoamer 0.01～2%, stabilizing agent 0～4%, deionized water is supplied surplus.
Active components A and the former medicine of pyraclostrobin are dissolved in the homogenizer that solvent and cosolvent are housed; Mix strongly after joining emulsifier, stabilizing agent and antifreeze, water in the homogenizer that above-mentioned solution is housed and homogenize, obtain the as clear as crystal microemulsion product of the present invention of outward appearance at last.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, the naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, during the ester polyoxyethylene is phonetic one or more.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, glucose, the aluminium chloride.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10Aliphatic alcohols, C
10～20In saturated fat acids (as capric acid) and acid amides, silicone oil, the silicone compound one or more.
Described emulsifier is selected from one or more among alkyl benzene sulfonate calcium salt, styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, phenethyl phenol polyethenoxy ether, 506#, 600#, 700#, NP-10 phosphate, OP-10 phosphate, castor oil polyoxyethylene ether, sorbester p17, Tween 80, the 602#;
Described co-emulsifier is one or more in butanols, isobutanol, dodecanol-1, tetradecanol-1, the octadecanol-1;
Described solvent is selected from one or more in toluene, dimethylbenzene, methyl alcohol, ethanol, acetone, ether, cyclohexanone, vegetable oil, dimethyl formamide, acetonitrile, polyethylene glycol, pyrrolidones, the solvent N-chain alkyl pyrrolidones;
Described preservative is selected from one or more in formaldehyde, sodium salicylate, Sodium Benzoate, the dichlorophen;
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Microbicide compositions of the present invention has protection concurrently, treats and roots out activity, for example can be used for various crop: vegetables, fruit tree, wheat, paddy rice etc., mainly prevent and treat the microbial plant disease of oomycetes order cause of disease.Downy mildew, eqpidemic disease, banded sclerotial blight, damping off etc. there is special efficacy.
Composition of the present invention has following advantage:
(1) said composition shows significant synergistic effect in certain ratio range, has both improved protection effect, has reduced mu dosage and cost, has enlarged fungicidal spectrum again;
(2) since in the said composition each active component do not have the problem of cross resistance, so the application of said composition can reach and delay drug-fast generation of pathogen and development, the result of use that helps to prolong this medicament reduces pesticide resistance and produces probability;
(3) improved safety, being mixed will be lower to the influence of environment, safer.
Embodiment
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Implementation of an application example one: Toxicity Determination
Active components A (A be selected from active components A flumorph, fourth pyrrole morpholine, metalaxyl, the M 9834 a kind of) is composite to target germ Toxicity Determination with pyraclostrobin
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament the target germ.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A (flumorph, fourth pyrrole morpholine, metalaxyl, M 9834) and pyraclostrobin shared ratio in composition;
A is a kind of in active components A flumorph, fourth pyrrole morpholine, metalaxyl, the M 9834;
B is a pyraclostrobin.
Test results and analysis:
Toxicity test result one
Fourth pyrrole morpholine, pyraclostrobin and composite toxicity test thereof to cucumber downy mildew
Table 1 fourth pyrrole morpholine, pyraclostrobin and composite toxicity test analysis of results table thereof to cucumber downy mildew
As shown in Table 1, fourth pyrrole morpholine, pyraclostrobin are to the EC of cucumber downy mildew
50Be respectively 0.65mg/L and 0.73mg/L.Fourth pyrrole morpholine and pyraclostrobin were mixed in the scope at 32: 1～1: 32 and all show obvious synergistic effect.Wherein, both mixed synergies in 16: 1～1: 16 scope are comparatively desirable, and mixed synergies is particularly outstanding in 8: 1～1: 8 scope.
Toxicity test result two
Flumorph, pyraclostrobin and composite toxicity test thereof to cucumber downy mildew
Table 2 flumorph, pyraclostrobin and composite toxicity test analysis of results table thereof to cucumber downy mildew
As shown in Table 2, flumorph, pyraclostrobin are to the EC of cucumber downy mildew
50Be respectively 0.62mg/L and 0.76mg/L.Flumorph and pyraclostrobin were mixed in the scope at 32: 1～1: 32 and all show obvious synergistic effect.Wherein, both mixed synergies in 16: 1～1: 16 scope are comparatively desirable, and mixed synergies is particularly outstanding in 8: 1～1: 8 scope.
Toxicity test result three
Metalaxyl, pyraclostrobin and composite toxicity test thereof to rice sheath blight disease
Table 3 metalaxyl, pyraclostrobin and composite toxicity test analysis of results table thereof to rice sheath blight disease
As shown in Table 3, metalaxyl, pyraclostrobin are to the EC of rice sheath blight disease
50Be respectively 15.49mg/L and 0.75mg/L.Metalaxyl and pyraclostrobin were mixed in the scope at 32: 1～1: 32 and all show obvious synergistic effect.Wherein, both mixed synergies in 16: 1～1: 2 scope are comparatively desirable, and mixed synergies is particularly outstanding in 16: 1～2: 1 scopes.
Toxicity test result four
M 9834, pyraclostrobin and composite toxicity test thereof to capsicum epidemic disease
Table 4 M 9834, pyraclostrobin and composite toxicity test analysis of results table thereof to capsicum epidemic disease
As shown in Table 4, M 9834, pyraclostrobin are to the EC of capsicum epidemic disease
50Be respectively 10.53mg/L and 0.66mg/L.M 9834 and pyraclostrobin were mixed in the scope at 32: 1～1: 32 and all show obvious synergistic effect.Wherein, both mixed synergies in 16: 1～1: 4 scope are comparatively desirable, and mixed synergies is particularly outstanding in 8: 1～1: 1 scope.
Implementation of an application example two: the implementation of Formulation Example
Embodiment 1:30% pyraclostrobin flumorph wetting powder
Pyraclostrobin 10%, flumorph 20%, lignosulfonates 3%, polycarboxylate 3%, neopelex 4%, white carbon 12%, kaolin adds to 100%, the mixed 40% pyraclostrobin flumorph wetting powder that gets.
Embodiment 2:40% pyraclostrobin fourth pyrrole morpholine wetting powder
Pyraclostrobin 20%, fourth pyrrole morpholine 20%, alkyl sulfate 3%, polycarboxylate 4%, white carbon 10%, kaolin adds to 100%, the mixed 40% pyraclostrobin fourth pyrrole morpholine wetting powder that gets.
Embodiment 3:50% pyraclostrobin Metalaxyl-M wetting powder
Pyraclostrobin 5%, Metalaxyl-M 45%, alkyl sulfate 3%, lignosulfonates 3%, white carbon 10%, kaolin adds to 100%, the mixed 50% pyraclostrobin Metalaxyl-M wetting powder that gets.
Embodiment 4:66% pyraclostrobin M 9834 wetting powder
Pyraclostrobin 2%, M 9834 64%, lignosulfonates 3%, polycarboxylate 3%, alkyl benzene sulfonate calcium salt 4%, white carbon 5%, kaolin adds to 100%, the mixed 66% pyraclostrobin M 9834 wetting powder that gets.
Embodiment 5 80% pyraclostrobin flumorph water dispersible granules
Pyraclostrobin 20%, flumorph 60%, alkylphenol-polyethenoxy are phonetic 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, white carbon add to 100%, mixed 80% pyraclostrobin flumorph water dispersible granules.
Embodiment 6 68% pyraclostrobin metalaxyl water dispersible granules
Pyraclostrobin 4%, metalaxyl 64%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, diatomite add to 100%, the mixed 68% pyraclostrobin metalaxyl water dispersible granules that gets.
Embodiment 7 60% pyraclostrobin fourth pyrrole morpholine water dispersible granules
Pyraclostrobin 5%, fourth pyrrole morpholine 55%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, urea 3%, white carbon 8%, kaolin add to 100%, mixed 60% pyraclostrobin fourth pyrrole morpholine water dispersible granules.
The efficient M 9834 water dispersible granules of embodiment 8 50% pyraclostrobins
Pyraclostrobin 10%, efficient M 9834 40%, polycarboxylate 3%, sodium lignin sulfonate 2%, lauryl sodium sulfate 4%, urea 3%, white carbon 20%, diatomite add to 100%, the mixed efficient M 9834 water dispersible granules of 50% pyraclostrobin that gets.
Embodiment 9 40% pyraclostrobin flumorph suspending agents
Pyraclostrobin 30%, flumorph 10%, polycarboxylate 3%, sodium lignin sulfonate 4%, DBSA 4%, silicone 0.2%, glycerine 0.3%, aluminium-magnesium silicate 0.5%, deionized water add to 100%, the mixed 40% pyraclostrobin flumorph suspending agent that gets.
Embodiment 10 40% pyraclostrobin M 9834 suspending agents
Pyraclostrobin 20%, M 9834 20%, alkyl benzene sulfonate calcium salt 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, phenyl phenol polyoxy ethyl ether 2%, deionized water adds to 100%, the mixed 40% pyraclostrobin M 9834 suspending agent that gets.
Embodiment 11 30% pyraclostrobin Metalaxyl suspending agents
Pyraclostrobin 20%, metalaxyl 10%, alkyl benzene sulfonate calcium salt 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, gelatin 0.3%, polyethylene glycol 2%, deionized water add to 100%, the mixed 30% pyraclostrobin Metalaxyl suspending agent that gets.
Embodiment 12 20% pyraclostrobin fourth pyrrole morpholine suspending agents
Pyraclostrobin 5%, fourth pyrrole morpholine 15%, sodium lignin sulfonate 4%, DBSA 3%, silicone 0.2%, polyethylene glycol 0.4%, polyvinyl alcohol 2%, aluminium-magnesium silicate 0.5% deionized water add to 100%, the mixed 20% pyraclostrobin fourth pyrrole morpholine suspending agent that gets.
Embodiment 13 48% pyraclostrobin fourth pyrrole morpholine suspension emulsions
Pyraclostrobin 40%, flumorph 8%, alkylbenzenesulfonate 8%, polycarboxylate 4%, soapberry powder 5%, organosilicon 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, alkyl benzene calcium sulfonate 2%, deionized water adds to 100%, the mixed 48% pyraclostrobin flumorph suspension emulsion that gets.
Embodiment 14 45% pyraclostrobin flumorph suspension emulsions
Pyraclostrobin 5%, flumorph 40%, phenethyl phenol polyethenoxy ether 4.5%, alkylnaphthalene sulfonate 4%, silicone 1.5%, Sodium Benzoate 2%, ethylene glycol 0.3%, gum Arabic 0.5%, deionized water adds to 100%, the mixed 45% pyraclostrobin flumorph suspension emulsion that gets.
Embodiment 15 30% pyraclostrobin Metalaxyl-M suspension emulsions
Pyraclostrobin 20%, Metalaxyl-M 10%, castor oil polyoxyethylene ether 6%, polycarboxylate 2%, Nekal BX 2%, C
10-20Saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, ethylene glycol 4%, deionized water adds to 100%, the mixed 30% pyraclostrobin Metalaxyl-M suspension emulsion that gets.
The efficient M 9834 suspension emulsion of embodiment 16 25% pyraclostrobins
Pyraclostrobin 5%, efficient M 9834 20%, castor oil polyoxyethylene ether 6%, polycarboxylate 2%, Nekal BX 2%, C
10-20Saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water adds to 100%, the mixed efficient M 9834 suspension emulsion of 25% pyraclostrobin that gets.
Embodiment 17 40% pyraclostrobin fourth pyrrole morpholine aqueous emulsions
Pyraclostrobin 10%, fourth pyrrole morpholine 30%, ethyl acetate 20%, acetonitrile 5%, castor oil polyoxyethylene ether 5%, polyvinyl alcohol 1%, propane diols 5%, lauric acid 0.5%, deionized water adds to 100%, the mixed 40% pyraclostrobin fourth pyrrole morpholine aqueous emulsion that gets.
Embodiment 18 36% pyraclostrobin flumorph aqueous emulsions
Pyraclostrobin 6%, flumorph 30%, methyl alcohol 18%, acetone 8%, alkylphenol polyoxyethylene 5%, polyvinyl alcohol 1%, glycerine 5%, silicone oil 0.5%, deionized water adds to 100%, the mixed 36% pyraclostrobin flumorph aqueous emulsion that gets.
Embodiment 19 30% pyraclostrobin Metalaxyl-M aqueous emulsions
Pyraclostrobin 20%, Metalaxyl-M 10%, methyl alcohol 15%, dimethyl sulfoxide (DMSO) 8%, fatty alcohol-polyoxyethylene ether 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, the mixed 30% pyraclostrobin Metalaxyl-M aqueous emulsion that gets.
The efficient M 9834 aqueous emulsion of embodiment 20 20% pyraclostrobins
Pyraclostrobin 5%, efficient M 9834 15%, methyl alcohol 15%, toluene 8%, fatty alcohol-polyoxyethylene ether 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, the mixed efficient M 9834 aqueous emulsion of 20% pyraclostrobin that gets.
Embodiment 21 50% pyraclostrobin fourth pyrrole morpholine microemulsions
Pyraclostrobin 15%, fourth pyrrole morpholine 35%, acetonitrile 20%, alkylphenol-formaldehyde resin polyoxy ethyl ether 8%, butanols 5%, hydroxyethylcellulose 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, the mixed 50% pyraclostrobin fourth pyrrole morpholine microemulsion that gets.
Embodiment 22 25% pyraclostrobin metalaxyl microemulsions
Pyraclostrobin 10%, metalaxyl 15%, methyl alcohol 15%, phenethyl phenol polyethenoxy ether 8%, tetradecanol-15%, polyvinyl alcohol 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, the mixed 25% pyraclostrobin metalaxyl microemulsion that gets.
Embodiment 23 20% pyraclostrobin flumorph microemulsions
Pyraclostrobin 10%, flumorph 10%, ethyl acetate 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, the mixed 20% pyraclostrobin pyraclostrobin microemulsion that gets.
Embodiment 24 30% pyraclostrobin M 9834 microemulsions
Pyraclostrobin 5%, M 9834 25%, acetone 18%, alkylphenol-formaldehyde resin polyoxy ethyl ether 8%, butanediol 5%, hydroxyethylcellulose 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, the mixed 30% pyraclostrobin M 9834 microemulsion that gets.
The ratio of pyraclostrobin and flumorph, fourth pyrrole morpholine, M 9834 or efficient M 9834, metalaxyl or smart M 9834 can be adjusted in 32: 1～1: 32 synergy scope in the above-mentioned the implementation of Formulation Example, thereby forms new the implementation of Formulation Example.
Embodiment uses the three bactericidal compositions control tomato late blight test of pesticide effectiveness
This experimental establishment is in Zhang Jiachuan county, Tianshui, Gansu Province, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 25% metalaxyl wetting powder (commercial), 20% M 9834 wetting powder (commercial), 20% flumorph wetting powder (commercial), 20% fourth pyrrole morpholine suspending agent (commercial), 25% pyraclostrobin missible oil (commercial).
The investigation tomato late blight state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigate the tomato late blight disease index respectively in 7 days, 14 days, 30 days after the last dispenser and calculate preventive effect.Experimental result is as follows:
The bactericidal composition control tomato late blight test of pesticide effectiveness of table 3 pyraclostrobin-containing
As can be seen from Table 3, can effectively prevent and treat tomato late blight after pyraclostrobin and flumorph, M 9834, metalaxyl or fourth pyrrole morpholine are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Embodiment uses the four bactericidal compositions control cucumber downy mildew test of pesticide effectiveness
This experimental establishment is at Baoji, Shaanxi province city Chencang District, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 25% metalaxyl wetting powder (commercial), 20% M 9834 wetting powder (commercial), 20% flumorph wetting powder (commercial), 20% fourth pyrrole morpholine suspending agent (commercial), 25% pyraclostrobin missible oil (commercial).
The investigation cucumber downy mildew state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigate the cucumber downy mildew disease index respectively in 7 days, 14 days, 30 days after the last dispenser and calculate preventive effect.Experimental result is as follows:
The bactericidal composition control cucumber downy mildew test of pesticide effectiveness of table 3 pyraclostrobin-containing
As can be seen from Table 3, can effectively prevent and treat cucumber downy mildew after pyraclostrobin and flumorph, M 9834, metalaxyl or fourth pyrrole morpholine are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, and cucumber downy mildew is had good preventive effect, preventive effect reaches more than 90%.
Claims (7)
1. bactericidal composition that contains pyraclostrobin and amides compound is characterized in that: the ratio of weight and number of two kinds of active component A and B is 32: 1～1: 32 in the bactericidal composition.
2. bactericidal composition according to claim 1 is characterized in that: described active component A is selected from a kind of in the flumorph, fourth pyrrole morpholine, metalaxyl (or Metalaxyl-M), M 9834 (or efficient M 9834).
3. bactericidal composition according to claim 1 is characterized in that: the percentage by weight of two kinds of active component A and B is 16: 1～1: 16.
4. bactericidal composition according to claim 4 is characterized in that: the percentage by weight of active component flumorph and pyraclostrobin is .8 in the bactericidal composition: 1～1: 8;
The percentage by weight of fourth pyrrole morpholine and pyraclostrobin is 8: 1～1: 8;
Metalaxyl (or Metalaxyl-M) is 16: 1～1: 2 with the percentage by weight of pyraclostrobin;
M 9834 (or efficient M 9834) is 16: 1～1: 2 with the percentage by weight of pyraclostrobin.
5. bactericidal composition according to claim 1 is characterized in that: the weight percentage of active component is 10%～80% of a gross weight in the composition.
6. bactericidal composition according to claim 1 is characterized in that: composition can be made into wetting powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion.
7. bactericidal composition according to claim 1 is used to prevent and treat the microbial plant disease of oomycetes purpose cause of disease.
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| CN102696645A (en) * | 2012-05-09 | 2012-10-03 | 广东中迅农科股份有限公司 | Pesticide composition containing pyraclostrobin and metalaxyl |
| CN103704230A (en) * | 2013-12-13 | 2014-04-09 | 广西田园生化股份有限公司 | Ultralow volume liquid containing pyraclostrobin and benzamide bactericidal composition |
| CN103719123A (en) * | 2013-12-13 | 2014-04-16 | 广西田园生化股份有限公司 | Ultra-low volume liquid containing composite of pyraclostrobin and morpholine bactericide |
| CN105409990A (en) * | 2015-12-19 | 2016-03-23 | 青岛奥迪斯生物科技有限公司 | Sterilization composition containing pyraclostrobin and efficient metalaxyl-M |
| CN105994324A (en) * | 2016-08-03 | 2016-10-12 | 顾爱国 | Bactericidal composition containing pyraclostrobin, metalaxyl and fludioxonil |
| CN109006851A (en) * | 2018-08-22 | 2018-12-18 | 惠州市银农科技股份有限公司 | Composition pesticide suspending agent and preparation method thereof containing flumorph and pyraclostrobin |
| CN111567540A (en) * | 2020-06-01 | 2020-08-25 | 沈阳化工研究院（南通）化工科技发展有限公司 | Bactericide agent composition containing flumorph and pyraclostrobin |
| CN115943952A (en) * | 2022-12-20 | 2023-04-11 | 惠州市银农科技股份有限公司 | Suspending agent containing pyraclostrobin and flumorph and preparation method thereof |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102696645A (en) * | 2012-05-09 | 2012-10-03 | 广东中迅农科股份有限公司 | Pesticide composition containing pyraclostrobin and metalaxyl |
| CN102696645B (en) * | 2012-05-09 | 2015-10-21 | 广东中迅农科股份有限公司 | A kind of composition pesticide containing pyraclostrobin and Metalaxyl-M |
| CN103704230A (en) * | 2013-12-13 | 2014-04-09 | 广西田园生化股份有限公司 | Ultralow volume liquid containing pyraclostrobin and benzamide bactericidal composition |
| CN103719123A (en) * | 2013-12-13 | 2014-04-16 | 广西田园生化股份有限公司 | Ultra-low volume liquid containing composite of pyraclostrobin and morpholine bactericide |
| CN105409990A (en) * | 2015-12-19 | 2016-03-23 | 青岛奥迪斯生物科技有限公司 | Sterilization composition containing pyraclostrobin and efficient metalaxyl-M |
| CN105994324A (en) * | 2016-08-03 | 2016-10-12 | 顾爱国 | Bactericidal composition containing pyraclostrobin, metalaxyl and fludioxonil |
| CN109006851A (en) * | 2018-08-22 | 2018-12-18 | 惠州市银农科技股份有限公司 | Composition pesticide suspending agent and preparation method thereof containing flumorph and pyraclostrobin |
| CN109006851B (en) * | 2018-08-22 | 2019-10-25 | 惠州市银农科技股份有限公司 | Composition pesticide suspending agent and preparation method thereof containing flumorph and pyraclostrobin |
| CN111567540A (en) * | 2020-06-01 | 2020-08-25 | 沈阳化工研究院（南通）化工科技发展有限公司 | Bactericide agent composition containing flumorph and pyraclostrobin |
| CN115943952A (en) * | 2022-12-20 | 2023-04-11 | 惠州市银农科技股份有限公司 | Suspending agent containing pyraclostrobin and flumorph and preparation method thereof |
| CN115943952B (en) * | 2022-12-20 | 2023-08-22 | 惠州市银农科技股份有限公司 | Suspending agent containing pyraclostrobin and flumorph and preparation method thereof |
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Address after: 715500 middle section of North Ring Road, Pucheng County, Shaanxi Applicant after: Shanxi Thompson Biological Technology Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Applicant before: Shanxi Thompson Biological Technology Co., Ltd. |
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Application publication date: 20110914 |