CN102696645B - A kind of composition pesticide containing pyraclostrobin and Metalaxyl-M - Google Patents
A kind of composition pesticide containing pyraclostrobin and Metalaxyl-M Download PDFInfo
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- CN102696645B CN102696645B CN201210141557.8A CN201210141557A CN102696645B CN 102696645 B CN102696645 B CN 102696645B CN 201210141557 A CN201210141557 A CN 201210141557A CN 102696645 B CN102696645 B CN 102696645B
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Abstract
The present invention relates to a kind of composition pesticide containing pyraclostrobin and Metalaxyl-M, comprise usual auxiliaries, pyraclostrobin and Metalaxyl-M, the ratio of quality and the number of copies of pyraclostrobin and Metalaxyl-M is 6:1 ~ 1:15, preferably than being 4:1 ~ 3:25.Pyraclostrobin and Metalaxyl-M composite after have obvious synergistic effect, delay phytopathogen pesticide resistance and produce, the lasting period is long, decreases dosage and access times, cost-saving, easy to use, time and labour saving, and the pollution of minimizing to environment.Composition pesticide of the present invention is applicable to control crops epidemic disease.
Description
Technical field
The composition pesticide that the present invention relates to, be with pyraclostrobin and Metalaxyl-M for active ingredient, be mainly applicable to control crops epidemic disease and downy mildew.
Background technology
Pyraclostrobin, english common name: pyraclostrobin, chemical formula: C
19h
18clN
3o
4, chemical name: N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] oxygen methyl] phenyl]-N-methoxy carbamate methyl esters.Belong to methoxy acrylic bactericide, its fungicidal spectrum is wide, active high, there is preventive and therapeutic action and have good compatibility with environment, good control efficiency is had, especially to powdery mildew, anthracnose, epidemic disease to the plurality of plant diseases that mastigomycetes, zygomycete, sac fungi, basidiomycetes, imperfect fungus cause.Activity is high, consumption is few, is widely used in preventing and treating corps diseases.But because this series bactericidal agent action site is single, germ produces very fast to the pesticide resistance of medicament.
Metalaxyl-M, english common name: metalaxyl-M, chemical formula C
15h
21nO, chemical name N-(2,6-xylyl)-N-(Methoxyacetyl)-D-alanine methyl esters.Metalaxyl-M is the systemic fungicide with protection and therapeutic action; the synthetic inhibitor of rRNA I; can be absorbed by the root of plant, stem, leaf; and each organ of plant is transferred to moisture content running in plant corpus; cauline leaf process can be done; seed treatment and soil treatment are effective to the downy mildew caused caused by Oomycete fungal, epidemic disease disease.Meanwhile, this prescription agent uses for a long time in a large number, easily develops immunity to drugs.
The problem such as pesticide resistance generation, drug effect reduction brought in order to avoid using single medicament, the present invention proposes the composition pesticide containing pyraclostrobin and Metalaxyl-M.
Have no pyraclostrobin and the composite report of Metalaxyl-M at present.
Summary of the invention
The object of this invention is to provide a kind of efficient, low toxicity, low-residual, the composition pesticide that good, lower-cost to Environmental compatibility, active ingredient is pyraclostrobin and Metalaxyl-M.
The present invention is achieved through the following technical solutions.
Contain a composition pesticide for pyraclostrobin and Metalaxyl-M, pyraclostrobin and the Metalaxyl-M ratio of weight and number in composition pesticide is 6:1 ~ 1:15, and preferred proportion is 4:1 ~ 3:25.
Described composition pesticide adds the pesticidal preparations such as auxiliary agent and excipients auxiliary element, and the production technology all known according to those skilled in the art makes suspending agent, water dispersible granules, wetting powder.
The pesticidal preparations auxiliary elements such as described auxiliary agent and excipients comprise antifreeze, defoamer, dispersant, solvent, filler etc., and be all various compositions that are conventional in pesticidal preparations or permission use, concrete composition and consumption are determined by test according to recipe requirements.
Beneficial effect of the present invention is: compared with single product, there is the feature of binary bactericidal composition, expand effective active scope, to crop downy mildew, epidemic disease, there is notable synergistic effect, also have powdery mildew simultaneously and doublely preferably control effect, and having delayed drug-fast generation, the lasting period is long, decreases dosage and access times, cost-saving, easy to use, time and labour saving, and reduce the pollution to environment.
Embodiment
Be described in further detail content of the present invention below in conjunction with embodiment, content mentioned in embodiment is not limitation of the invention, and material prescription is selected to suit measures to local conditions, and on result without substantial impact.In these embodiments, unless otherwise indicated, all percentage is all weight percentage.
example of formulations 1: 20% pyraclostrobin Metalaxyl-M suspending agent.
Pyraclostrobin 8%, Metalaxyl-M 12%, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 3%, calcium dodecyl benzene sulfonate 3%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 2%, ethylene glycol 0.2%, xanthan gum 0.1%, organosilicon 0.4%, glycerine 5%, gum Arabic 0.1%, deionized water complements to 100%.Above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 20% pyraclostrobin Metalaxyl-M suspending agent of allotment after high shear mixing.
example of formulations 2: 25% pyraclostrobin Metalaxyl-M suspending agent.
Pyraclostrobin 15%, Metalaxyl-M 10%, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 3%, calcium dodecyl benzene sulfonate 3%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 2%, ethylene glycol 0.2%, xanthan gum 0.1%, organosilicon 0.4%, glycerine 5%, gum Arabic 0.1%, deionized water complements to 100%.Above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 25% pyraclostrobin Metalaxyl-M suspending agent of allotment after high shear mixing.
example of formulations 3: 60% pyraclostrobin Metalaxyl-M water dispersible granules.
Pyraclostrobin 45%, Metalaxyl-M 15%, lauryl sodium sulfate 6%, dispersant polycarboxylate 4% disintegrant sodium chloride 2%, binding agent polyethylene glycol 3%, stable meltable starch 3%, kaolin complements to 100%.By above-mentioned formula, 60% pyraclostrobin Metalaxyl-M water dispersible granules is made and is obtained in dry pulverization process, granulation, drying, screening in proportion.
example of formulations 4: 50% pyraclostrobin Metalaxyl-M water dispersible granules.
Pyraclostrobin 25%, Metalaxyl-M 25%, lauryl sodium sulfate 6%, dispersant polycarboxylate 4% disintegrant sodium chloride 2%, binding agent polyethylene glycol 3%, stable meltable starch 3%, kaolin complements to 100%.By above-mentioned formula, 50% pyraclostrobin Metalaxyl-M water dispersible granules is made and is obtained in dry pulverization process, granulation, drying, screening in proportion.
example of formulations 5: 50% pyraclostrobin Metalaxyl-M wetting powder.
Pyraclostrobin 35%, Metalaxyl-M 15%, pulls open powder 3%, naphthalenesulfonate formaldehyde condensation compound 6%, and talcum powder 15%, kaolin complements to 100%.Mix entering in blender after above-mentioned formula in proportion coarse crushing, more namely obtain 50% pyraclostrobin Metalaxyl-M wetting powder after air-flow crushing.
example of formulations 6: 40% pyraclostrobin Metalaxyl-M wetting powder.
Pyraclostrobin 28%, Metalaxyl-M 12%, pulls open powder 3%, naphthalenesulfonate formaldehyde condensation compound 6%, and talcum powder 15%, kaolin complements to 100%.Mix entering in blender after above-mentioned formula in proportion coarse crushing, more namely obtain 40% pyraclostrobin Metalaxyl-M wetting powder after air-flow crushing.
assays Example 1: pyraclostrobin and Metalaxyl-M mixture are to the Toxicity Determination of P. capsici.
Mycelial growth rate method is adopted to measure.Under aseptic technique, the PDA medium according to test process the sterilizing of melting in advance being cooled to about 45 DEG C quantitatively adds in conical flask, quantitatively draws liquid successively, add respectively in above-mentioned conical flask, fully shake up from low concentration to high concentration.Then equivalent pours 3 diameters into is in the culture dish of 9cm, and the pastille making respective concentration is dull and stereotyped, and establishes not containing the process blank of medicament.Often process repetition 3 times.By cultured pathogen, aseptically use the sterilizing card punch of diameter 5cm, cut bacterium cake from colony edge, with inoculator, pure culture biscuits involvng inoculation is dull and stereotyped central in pastille, mycelia faces up, and covers ware lid, moves in (27 ± 1 DEG C) insulating box and cultivates.After culture dish cultivates 4 days in insulating box, use kind of calliper colony diameter, each bacterium colony cross method vertical survey diameter is each once, gets its mean value.
According to survey data, calculate as follows: bacterium colony increases diameter=colony diameter-bacterium cake diameter.
Be independent variable x with the logarithm value of drug concentration (mg/L), with the probit value of inhibiting rate for dependent variable y, set up virulence regression equation formula respectively, adopt DPS software to calculate the EC of single dose and each proportioning mixture
50the co-toxicity coefficient (CTC) of (95% confidence limit) and mixture, compares synergy situation.
According to the NY/T1156.6-2006 bactericide synergy criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
As can be seen from result of the test table 1, the mixture composition of pyraclostrobin and Metalaxyl-M is between 6:1 ~ 1:15 at weight amount portion rate, co-toxicity coefficient (CTC value) is all greater than 120, namely all showing obvious synergistic effect, is that between 4:1 ~ 3:25, synergistic effect is the most obvious at weight amount portion rate.Pyraclostrobin and Metalaxyl-M mixture have reasonability and feasibility, are worth carrying out field experiment popularization.
Table 1, pyraclostrobin and Metalaxyl-M mixture are to the Toxicity Determination result of P. capsici.
assays Example 2:the field control effectiveness test of control capsicum epidemic disease.
Test and carry out in Lingshui, Hainan Province autonomous county on February 12nd, 2011, being watered 45kg by every mu carries out even spraying in earlier stage in capsicum epidemic disease morbidity, dispenser twice altogether, 7 days, dispenser interval, 5 days, 14 days investigation prevention effects after last medicine.
The field control effectiveness test result of table 2, control capsicum epidemic disease.
As can be seen from Table 2, the composite bactericidal composition of pyraclostrobin Metalaxyl-M of the present invention has good control efficiency to capsicum epidemic disease, and after last medicine, the preventive effect of 5 days, 14 days is all better than the single dose contrasted.Do not find in process of the test that poisoning phenomenon occurs, to capsicum safety.
assays Example 3:the field control effectiveness test of control cucumber downy mildew.
Test and carry out in Chen Jiang town, Huizhou on March 15th, 2011, being watered 45kg by every mu carries out even spraying in earlier stage in cucumber downy mildew morbidity, dispenser twice altogether, 7 days, dispenser interval, 5 days, 15 days investigation prevention effects after last medicine.
The field control effectiveness test result of table 3, control cucumber downy mildew.
As can be seen from Table 3, the composition pesticide of pyraclostrobin of the present invention and Metalaxyl-M mixture has good control efficiency to cucumber downy mildew, and after last medicine, the preventive effect of 5 days, 15 days is all better than the single dose contrasted.Meanwhile, composition pesticide of the present invention also has powdery mildew of cucumber and good doublely controls effect.Do not find in process of the test that poisoning phenomenon occurs, to cucumber safety.
As can be seen from above field control effectiveness test result, the composition pesticide containing pyraclostrobin and Metalaxyl-M of the present invention all has good preventive effect to epidemic disease, downy mildew etc., is obviously better than single dose, quick-acting is good, lasting effect is long, to crop safety, environmentally friendly.Compared with single dose, reduce times for spraying, saved drug cost, this is so R&D and promotion of the present invention is significant.
Claims (1)
1. one kind contains the composition pesticide of pyraclostrobin and Metalaxyl-M, it is characterized in that active ingredient is pyraclostrobin and Metalaxyl-M, the percetage by weight of pyraclostrobin and Metalaxyl-M is: pyraclostrobin 8%, Metalaxyl-M 12%, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 3%, calcium dodecyl benzene sulfonate 3%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 2%, ethylene glycol 0.2%, xanthan gum 0.1%, organosilicon 0.4%, glycerine 5%, gum Arabic 0.1%, deionized water complements to 100%, above-mentioned formula is pulverized in proportion in advance, add in sand mill again and grind, the obtained 20% pyraclostrobin Metalaxyl-M suspending agent of allotment after high shear mixing.
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| CN103975935B (en) * | 2014-05-28 | 2016-08-24 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition preventing and treating crops soil-borne disease |
| CN105409990A (en) * | 2015-12-19 | 2016-03-23 | 青岛奥迪斯生物科技有限公司 | Sterilization composition containing pyraclostrobin and efficient metalaxyl-M |
| CN108849990A (en) * | 2018-06-27 | 2018-11-23 | 四川福思达生物技术开发有限责任公司 | A kind of agricultural medicine fertilizer composition of pyraclostrobin-containing and its application |
| CN112889834B (en) * | 2019-06-06 | 2021-12-14 | 上海明德立达生物科技有限公司 | Preparation method and application of metalaxyl-M-pyraclostrobin microcapsule suspending agent |
| CN111011390A (en) * | 2019-10-23 | 2020-04-17 | 安徽辉隆集团银山药业有限责任公司 | Seed treatment agent containing thiamethoxam, metalaxyl-M and pyraclostrobin and application thereof |
| CN113598166A (en) * | 2021-08-13 | 2021-11-05 | 石家庄农信生物科技集团有限公司 | Bactericidal granules and preparation method and application thereof |
| CN114230395B (en) * | 2021-12-16 | 2022-12-06 | 河北安格诺农化有限公司 | Slow-release pesticide-fertilizer composition and application thereof |
| CN114451420A (en) * | 2022-03-14 | 2022-05-10 | 河南豫之星作物保护有限公司 | Bactericidal composition for preventing and treating root rot |
| CN114532334B (en) * | 2022-03-31 | 2023-01-03 | 山东汤普乐作物科学有限公司 | Azole ether and fine nail cream granules and preparation method thereof |
| WO2024130462A1 (en) * | 2022-12-18 | 2024-06-27 | 张子勇 | Mancozeb nanosuspension containing metalaxyl-m, and preparation method therefor |
| CN117441738B (en) * | 2023-12-26 | 2024-09-27 | 山东科赛基农生物工程有限公司 | Seed treatment suspending agent containing metalaxyl-M, pyraclostrobin and fluxapyroxad and application thereof |
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Effective date of registration: 20190823 Address after: 225400 West of Daiwang Road, Taixing High-tech Industrial Development Zone, Taizhou City, Jiangsu Province Patentee after: Jiangsu yuan Qing Environmental Protection Technology Co., Ltd. Address before: 516000 Guangdong province Huizhou Zhongkai hi tech Development Zone No. 24 District Patentee before: Guangdong Zhongxun Agricultural Technology Co., Ltd. |
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Effective date of registration: 20201209 Address after: Room 315, No.8 Nujiang Road, Hexi District, Tianjin 300202 Patentee after: Nantong Zhonggao (Tianjin) Intellectual Property Management Co., Ltd Address before: 225400 west side of Dai Wang Road, Taixing hi tech Industrial Development Zone, Taizhou, Jiangsu Patentee before: Jiangsu yuan Qing Environmental Protection Technology Co.,Ltd. |