CN101970645B - 呼肠弧病毒家族病毒的疫苗病毒株的制造方法 - Google Patents

呼肠弧病毒家族病毒的疫苗病毒株的制造方法 Download PDF

Info

Publication number
CN101970645B
CN101970645B CN200880125535.4A CN200880125535A CN101970645B CN 101970645 B CN101970645 B CN 101970645B CN 200880125535 A CN200880125535 A CN 200880125535A CN 101970645 B CN101970645 B CN 101970645B
Authority
CN
China
Prior art keywords
virus
btv
cell
ssrna
segment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880125535.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN101970645A (zh
Inventor
P·罗伊
M·博伊斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
London School of Hygiene and Tropical Medicine
Original Assignee
London School of Hygiene and Tropical Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by London School of Hygiene and Tropical Medicine filed Critical London School of Hygiene and Tropical Medicine
Priority to CN201811285310.7A priority Critical patent/CN109825517B/zh
Publication of CN101970645A publication Critical patent/CN101970645A/zh
Application granted granted Critical
Publication of CN101970645B publication Critical patent/CN101970645B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4216—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-viral Ig
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12111—Orbivirus, e.g. bluetongue virus
    • C12N2720/12123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12111—Orbivirus, e.g. bluetongue virus
    • C12N2720/12134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12111—Orbivirus, e.g. bluetongue virus
    • C12N2720/12151—Methods of production or purification of viral material
    • C12N2720/12152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12111—Orbivirus, e.g. bluetongue virus
    • C12N2720/12161—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880125535.4A 2007-11-26 2008-11-26 呼肠弧病毒家族病毒的疫苗病毒株的制造方法 Expired - Fee Related CN101970645B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811285310.7A CN109825517B (zh) 2007-11-26 2008-11-26 呼肠弧病毒家族病毒的疫苗病毒株的制造方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US98999107P 2007-11-26 2007-11-26
US60/989991 2007-11-26
US5871608P 2008-06-04 2008-06-04
US61/058716 2008-06-04
PCT/GB2008/003945 WO2009068870A1 (en) 2007-11-26 2008-11-26 Method for producing vaccinal viral strain of a virus of the reoviridae family

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811285310.7A Division CN109825517B (zh) 2007-11-26 2008-11-26 呼肠弧病毒家族病毒的疫苗病毒株的制造方法

Publications (2)

Publication Number Publication Date
CN101970645A CN101970645A (zh) 2011-02-09
CN101970645B true CN101970645B (zh) 2018-11-30

Family

ID=40290782

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880125535.4A Expired - Fee Related CN101970645B (zh) 2007-11-26 2008-11-26 呼肠弧病毒家族病毒的疫苗病毒株的制造方法
CN201811285310.7A Active CN109825517B (zh) 2007-11-26 2008-11-26 呼肠弧病毒家族病毒的疫苗病毒株的制造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811285310.7A Active CN109825517B (zh) 2007-11-26 2008-11-26 呼肠弧病毒家族病毒的疫苗病毒株的制造方法

Country Status (9)

Country Link
US (2) US8673315B2 (enExample)
EP (2) EP3037526B1 (enExample)
JP (2) JP5619614B2 (enExample)
KR (2) KR101749130B1 (enExample)
CN (2) CN101970645B (enExample)
CA (1) CA2706603C (enExample)
MX (1) MX2010005701A (enExample)
WO (1) WO2009068870A1 (enExample)
ZA (1) ZA201004531B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ702145A (en) * 2010-03-12 2016-03-31 Merial Inc Bluetongue virus recombinant vaccines and uses thereof
JP6347257B2 (ja) 2012-06-13 2018-06-27 メリアル インコーポレイテッド 再集合体ｂｔｖおよびａｈｓｖワクチン
WO2014185784A1 (en) * 2013-05-16 2014-11-20 Stichting Dienst Landbouwkundig Onderzoek Vaccines for diseases caused by viruses of the family of reoviridae
EP3449003B1 (en) * 2016-04-26 2021-03-17 London School Of Hygiene & Tropical Medicine Reoviridae vaccine
US11707516B2 (en) 2016-09-27 2023-07-25 Osaka University Method for producing artificial recombinant rotavirus
CN109321583B (zh) * 2018-09-29 2023-08-15 福建省农业科学院畜牧兽医研究所 一种构建番鸭呼肠孤病毒反向遗传系统的方法
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
CN116732246A (zh) * 2023-04-25 2023-09-12 佛山科学技术学院 一种检测流行性出血热病毒的试剂盒及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951754B2 (en) * 2000-04-28 2005-10-04 St. Jude Children's Research Hospital DNA transfection system for the generation of infectious influenza virus
ES2330309T3 (es) * 2002-06-20 2009-12-09 Institut Pasteur Adnc infeccioso de una cepa de vacuna aprobada de virus del sarampion. uso para composiciones inmunogenicas.
CN1563383A (zh) * 2004-03-17 2005-01-12 云南出入境检验检疫局检验检疫技术中心 蓝舌病病毒vp7基因重组表达质粒载体、vp7表达抗原以及制备方法
JP2007215466A (ja) 2006-02-16 2007-08-30 Fujita Gakuen レオウイルス科ウイルス由来の組換えウイルスを調製する方法、及び組換えロタウイルス調製用のｄｎａコンストラクト

Also Published As

Publication number Publication date
EP2215221B1 (en) 2016-02-17
US20140134209A1 (en) 2014-05-15
JP5908948B2 (ja) 2016-04-26
EP3037526B1 (en) 2018-03-14
JP2014239683A (ja) 2014-12-25
WO2009068870A1 (en) 2009-06-04
KR20160003896A (ko) 2016-01-11
US9457076B2 (en) 2016-10-04
CN109825517A (zh) 2019-05-31
MX2010005701A (es) 2010-08-31
US20100322971A1 (en) 2010-12-23
CA2706603C (en) 2021-02-09
ZA201004531B (en) 2011-03-30
KR101718497B1 (ko) 2017-03-22
EP3037526A2 (en) 2016-06-29
CN101970645A (zh) 2011-02-09
EP2215221A1 (en) 2010-08-11
EP3037526A3 (en) 2016-10-05
KR20100108356A (ko) 2010-10-06
CA2706603A1 (en) 2009-06-04
US8673315B2 (en) 2014-03-18
JP2011504367A (ja) 2011-02-10
JP5619614B2 (ja) 2014-11-05
KR101749130B1 (ko) 2017-06-20
CN109825517B (zh) 2023-04-14
AU2008331293A1 (en) 2009-06-04

Similar Documents

Publication Publication Date Title
CN101970645B (zh) 呼肠弧病毒家族病毒的疫苗病毒株的制造方法
JP5758632B2 (ja) 蚊において複製不可能な弱毒化組み換えアルファウイルス属及びそれらの使用
CN103266091B (zh) A型口蹄疫重组疫苗株及其制备方法和应用
US10206994B2 (en) RNA virus attenuation by alteration of mutational robustness and sequence space
US11033617B2 (en) Duck hepatitis A virus type 3 mutant CH-P60-117C and construction thereof
CN101586120B (zh) 狂犬病病毒Flury-LEP疫苗株反向遗传操作系统及LEP绿色荧光蛋白重组病毒载体
CN109136200A (zh) 一种重组传染性造血器官坏死病毒及其构建方法与应用
JPH05503634A (ja) ｃＤＮＡからＲＮＡウイルスを産生する方法
CN106916832A (zh) O型口蹄疫病毒重组核酸、重组疫苗株及其制备方法和应用
AU2014201189B2 (en) Method for producing vaccinal viral strain of a virus of the Reoviridae family
EP3149158B1 (en) Live attenuated african horsesickness virus
CN113897376B (zh) 一种hn蛋白突变的基因vii型新城疫病毒重组疫苗株
AU2008331293B2 (en) Method for producing vaccinal viral strain of a virus of the Reoviridae family
Boyce Bluetongue virus reverse genetics
Lee et al. Murine neurovirulence studies with a chimeric poliovirus: in vivogeneration of a mutant base-paired stable attenuated poliovirus
CN101942418A (zh) 狂犬病病毒Flury-LEP糖蛋白第333位氨基酸突变株
CN109312351A (zh) 呼肠孤病毒科疫苗

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20181130

Termination date: 20201126