CN101959934B - 聚噁唑啉共聚物的多官能形式和包含它的药物组合物 - Google Patents

聚噁唑啉共聚物的多官能形式和包含它的药物组合物 Download PDF

Info

Publication number
CN101959934B
CN101959934B CN2009801062765A CN200980106276A CN101959934B CN 101959934 B CN101959934 B CN 101959934B CN 2009801062765 A CN2009801062765 A CN 2009801062765A CN 200980106276 A CN200980106276 A CN 200980106276A CN 101959934 B CN101959934 B CN 101959934B
Authority
CN
China
Prior art keywords
oxazoline
verivate
guan neng
assorted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2009801062765A
Other languages
English (en)
Chinese (zh)
Other versions
CN101959934A (zh
Inventor
J·米尔顿·哈里斯
迈克尔·大卫·本特利
尹君尚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serena Treatment Alabama Co
Original Assignee
Serina Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serina Therapeutics Inc filed Critical Serina Therapeutics Inc
Publication of CN101959934A publication Critical patent/CN101959934A/zh
Application granted granted Critical
Publication of CN101959934B publication Critical patent/CN101959934B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
CN2009801062765A 2008-01-11 2009-01-12 聚噁唑啉共聚物的多官能形式和包含它的药物组合物 Active CN101959934B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2068408P 2008-01-11 2008-01-11
US61/020,684 2008-01-11
US2933708P 2008-02-16 2008-02-16
US61/029,337 2008-02-16
PCT/US2009/030762 WO2009089542A2 (en) 2008-01-11 2009-01-12 Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same

Publications (2)

Publication Number Publication Date
CN101959934A CN101959934A (zh) 2011-01-26
CN101959934B true CN101959934B (zh) 2012-12-12

Family

ID=40853790

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801062765A Active CN101959934B (zh) 2008-01-11 2009-01-12 聚噁唑啉共聚物的多官能形式和包含它的药物组合物

Country Status (7)

Country Link
US (2) US8110651B2 (cg-RX-API-DMAC7.html)
EP (3) EP2669313B1 (cg-RX-API-DMAC7.html)
JP (1) JP5514736B2 (cg-RX-API-DMAC7.html)
KR (1) KR101486449B1 (cg-RX-API-DMAC7.html)
CN (1) CN101959934B (cg-RX-API-DMAC7.html)
DK (1) DK3042922T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009089542A2 (cg-RX-API-DMAC7.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101706B2 (en) 2008-01-11 2012-01-24 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
US8110651B2 (en) * 2008-01-11 2012-02-07 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
EP2310440A4 (en) * 2008-07-10 2013-06-05 Serina Therapeutics Inc POLYOXAZOLINES WITH INTERNAL END GROUPS, POLYOXAZOLINES MANUFACTURED FROM PROTECTED INITIAL GROUPS AND CORRESPONDING COMPOUNDS
BR112013017140B1 (pt) 2011-01-04 2019-12-17 Bender Analytical Holding Bv polímeros reticulados e implantes provenientes de polioxazolina eletrofilicamente ativada
CN102731791B (zh) * 2011-04-13 2016-04-13 北京大学 温度敏感型嵌段共聚物及其水凝胶和其用途
US20140271527A1 (en) * 2011-11-01 2014-09-18 Serina Therapeutics, Inc. Subcutaneous delivery of polymer conjugates of therapeutic agents
US8383093B1 (en) * 2011-11-01 2013-02-26 Serina Therapeutics, Inc. Subcutaneous delivery of poly(oxazoline) conjugates
BR112014016338B1 (pt) * 2012-01-02 2021-01-26 Universiteit Gent polímeros de polioxazolina e processos para a sua preparação, conjugados destes polímeros e usos médicos dos mesmos
US9416228B2 (en) 2012-03-16 2016-08-16 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline
US10035822B2 (en) 2012-11-15 2018-07-31 Apellis Pharmaceuticals, Inc. Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
US10071168B2 (en) 2014-07-31 2018-09-11 Serina Therapeutics, Inc. Polyoxazoline antibody drug conjugates
EP3197940B1 (en) 2014-09-26 2023-02-15 Alcon Inc. Polymerizable polysiloxanes with hydrophilic substituents
JP6683398B2 (ja) 2014-10-06 2020-04-22 ガット テクノロジーズ ビー．ブイ．Ｇａｔｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． 組織接着性多孔質止血製品
KR20180090785A (ko) 2015-10-07 2018-08-13 아펠리스 파마슈티컬스 인코포레이티드 투여 요법
CN105418911A (zh) * 2015-12-29 2016-03-23 南京工业大学 一种聚(2-r-2-噁唑啉)嵌段聚(肌氨酸)双亲性嵌段共聚物的制备方法
BR112019020955A2 (pt) 2017-04-07 2020-05-05 Apellis Pharmaceuticals, Inc. regimes de dosagem e composições e métodos relacionados
DE102018000650A1 (de) * 2018-01-27 2019-08-01 Friedrich-Schiller-Universität Jena Verfahren zur Bestimmung von Verunreinigungen in Polyalkylenethern oder Polyalkylenaminen und dessen Verwendung
CN120154736A (zh) * 2018-07-27 2025-06-17 塞瑞纳治疗阿拉巴马公司 儿茶酚化合物和水溶性聚合物的可裂解缀合物以及使用它们的治疗方法
US12485181B2 (en) * 2019-06-28 2025-12-02 Serina Therapeutics (Al), Inc. Polyoxazoline-drug conjugates with novel pharmacokinetic properties
CN113354811B (zh) * 2020-02-19 2024-05-07 华东理工大学 一种侧链含有氨基和/或羟基的噁唑啉聚合物，其制备方法及应用
CN112661961B (zh) * 2020-12-28 2022-05-06 中国科学院长春应用化学研究所 两亲性聚噁唑啉共聚物、其制备方法及应用
WO2022173667A1 (en) 2021-02-09 2022-08-18 Serina Therapeutics, Inc. Polyoxazoline-lipid conjugates and lipid nanoparticles and pharmaceutical compositions including same
IL309502A (en) 2021-09-03 2024-02-01 CureVac SE Lipid nanoparticles for nucleic acid delivery involving phosphatidylserine
EP4763287A2 (en) 2021-09-03 2026-06-24 CureVac SE Novel lipid nanoparticles for delivery of nucleic acids
KR20230044782A (ko) 2021-09-27 2023-04-04 삼성전자주식회사 패치 안테나를 포함하는 안테나 구조 및 이를 포함하는 전자 장치
EP4422698A1 (en) 2021-10-29 2024-09-04 CureVac SE Improved circular rna for expressing therapeutic proteins
EP4469091A1 (en) 2022-01-28 2024-12-04 CureVac SE Nucleic acid encoded transcription factor inhibitors
KR20250153298A (ko) 2023-03-08 2025-10-24 큐어백 에스이 핵산 전달을 위한 신규의 지질 나노입자 제형
WO2024230934A1 (en) 2023-05-11 2024-11-14 CureVac SE Therapeutic nucleic acid for the treatment of ophthalmic diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635571A (en) * 1995-06-30 1997-06-03 Cornell Research Foundation, Inc. Polymerizable macromonomers and polymers prepared therefrom

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4709039A (en) * 1986-03-21 1987-11-24 The Dow Chemical Company Vinyloxazoline monomer and preparation thereof
WO1990002144A1 (en) 1988-08-22 1990-03-08 Fused Kontacts Of Chicago, Inc. Compositions for making improved gas permeable contact lenses
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5130126A (en) 1990-07-09 1992-07-14 Nippon Oil & Fats Co., Ltd. Polymer-drug conjugate and a method of producing it
US5416071A (en) 1991-03-12 1995-05-16 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release containing epo and hyaluronic acid
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
ATE375363T1 (de) 1997-07-14 2007-10-15 Bolder Biotechnology Inc Derivate des wachstumshormons und verwandte proteine
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
PE20010288A1 (es) 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
DE19936014C2 (de) 1999-08-04 2003-04-03 Zf Lemfoerder Metallwaren Ag Gummilager mit axialer Dämpfung
WO2001076639A2 (en) 2000-04-06 2001-10-18 Pharmacia Corporation Chemically-modified myelopoietin conjugates
US20030191291A1 (en) 2000-09-08 2003-10-09 Kochendoerfer Gerd G. Synthetic erythropoiesis stimulating proteins
AU2001290312A1 (en) 2000-10-16 2002-04-29 Chugai Seiyaku Kabushiki Kaisha Peg-modified erythropoietin
US6759496B2 (en) * 2000-12-18 2004-07-06 Bausch & Lomb Incorporated Poly(2-oxazoline) biomedical devices
AU3323002A (en) 2000-12-20 2002-07-01 Hoffmann La Roche Erythropoietin conjugates
KR100401296B1 (ko) 2000-12-27 2003-10-11 드림바이오젠 주식회사 수식물질에 의해 수식된 단백질 변이체 및 이것의 제조방법
US7077939B1 (en) 2001-06-18 2006-07-18 The Texas A&M University System Method and apparatus for nanoparticle transport and detection
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
US7125843B2 (en) 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
JP3984541B2 (ja) * 2001-12-26 2007-10-03 財団法人川村理化学研究所 星型ポリオキサゾリンからなる粒子およびその製造方法
WO2003066069A1 (en) 2002-02-01 2003-08-14 Intradigm Corporation Polymers for delivering peptides and small molecules in vivo
EP1344810A1 (en) 2002-03-13 2003-09-17 Infineum International Limited Fuel additive compositions for diesel engine equipped with a particulate trap
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
WO2004108667A2 (en) 2003-05-30 2004-12-16 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
PT1512736T (pt) 2003-09-05 2018-05-29 Infineum Int Ltd Composições estabilizadas de aditivos para gasóleo
US8057821B2 (en) * 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
NZ555308A (en) 2004-12-22 2010-10-29 Ambrx Inc Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
WO2007010552A2 (en) 2005-03-17 2007-01-25 Serum Institute Of India Limited N- terminal peg conjugate of erythropoietin
CN106046370A (zh) 2007-02-28 2016-10-26 塞瑞纳治疗公司 聚噁唑啉poz化合物、合成其的方法、以及靶分子‑poz偶联物
US8110651B2 (en) * 2008-01-11 2012-02-07 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
US8101706B2 (en) * 2008-01-11 2012-01-24 Serina Therapeutics, Inc. Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635571A (en) * 1995-06-30 1997-06-03 Cornell Research Foundation, Inc. Polymerizable macromonomers and polymers prepared therefrom

Also Published As

Publication number Publication date
US20110009594A1 (en) 2011-01-13
EP3042922B1 (en) 2017-07-19
WO2009089542A2 (en) 2009-07-16
US8110651B2 (en) 2012-02-07
US9169354B2 (en) 2015-10-27
KR20110007084A (ko) 2011-01-21
JP5514736B2 (ja) 2014-06-04
EP2235090A2 (en) 2010-10-06
CN101959934A (zh) 2011-01-26
JP2011510120A (ja) 2011-03-31
US20120136123A1 (en) 2012-05-31
DK3042922T3 (en) 2017-10-23
WO2009089542A3 (en) 2009-10-01
EP2669313A1 (en) 2013-12-04
EP3042922A1 (en) 2016-07-13
EP2669313B1 (en) 2016-03-23
EP2235090A4 (en) 2011-10-05
KR101486449B1 (ko) 2015-01-26
EP2235090B1 (en) 2013-09-04

Similar Documents

Publication Publication Date Title
CN101959934A (zh) 聚噁唑啉共聚物的多官能形式和包含它的药物组合物
US8088884B2 (en) Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
JP5615558B2 (ja) 活性ポリオキサゾリンおよびそれを含む組成物
KR101647334B1 (ko) 불활성 말단기를 가진 폴리옥사졸린, 보호된 개시기로부터 제조된 폴리옥사졸린 및 그와 관련된 화합물
US11925689B2 (en) Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: alabama

Patentee after: Serena Treatment (Alabama) Co.

Country or region after: U.S.A.

Address before: alabama

Patentee before: Serina Therapeutics, Inc.

Country or region before: U.S.A.