CN101952284A - 新的四环化合物 - Google Patents

新的四环化合物 Download PDF

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Publication number
CN101952284A
CN101952284A CN2008801226525A CN200880122652A CN101952284A CN 101952284 A CN101952284 A CN 101952284A CN 2008801226525 A CN2008801226525 A CN 2008801226525A CN 200880122652 A CN200880122652 A CN 200880122652A CN 101952284 A CN101952284 A CN 101952284A
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methyl
alkyl
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Chinese (zh)
Inventor
D·T·亨
A·A·普罗特
R·P·贾殷
S·杜加尔
S·查克拉瓦蒂
S·O·巴楚林
A·K·乌斯季诺夫
B·K·贝兹诺斯科
E·F·舍夫佐娃
V·V·格里戈里耶夫
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Medivation Technologies LLC
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Medivation Technologies LLC
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Priority to CN201610525730.2A priority Critical patent/CN106188043A/zh
Publication of CN101952284A publication Critical patent/CN101952284A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008801226525A 2007-10-25 2008-10-27 新的四环化合物 Pending CN101952284A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610525730.2A CN106188043A (zh) 2007-10-25 2008-10-27 四环化合物

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US98267807P 2007-10-25 2007-10-25
US98267907P 2007-10-25 2007-10-25
US60/982,679 2007-10-25
US60/982,678 2007-10-25
RU2007139634 2007-10-25
RU2007139634/04A RU2007139634A (ru) 2007-10-25 2007-10-25 Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения
US6233208P 2008-01-25 2008-01-25
US6233108P 2008-01-25 2008-01-25
US61/062,332 2008-01-25
US61/062,331 2008-01-25
US3375408P 2008-03-04 2008-03-04
US3375708P 2008-03-04 2008-03-04
US61/033,757 2008-03-04
US61/033,754 2008-03-04
PCT/US2008/081390 WO2009055828A1 (en) 2007-10-25 2008-10-27 New tetracyclic compounds

Related Child Applications (1)

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CN201610525730.2A Division CN106188043A (zh) 2007-10-25 2008-10-27 四环化合物

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CN101952284A true CN101952284A (zh) 2011-01-19

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CN201610525730.2A Pending CN106188043A (zh) 2007-10-25 2008-10-27 四环化合物

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US (6) US8338408B2 (enExample)
EP (1) EP2217598A1 (enExample)
JP (1) JP5665543B2 (enExample)
CN (2) CN101952284A (enExample)
AU (1) AU2008316560B2 (enExample)
BR (1) BRPI0816582A2 (enExample)
CA (1) CA2704008A1 (enExample)
PE (1) PE20091346A1 (enExample)
RU (1) RU2007139634A (enExample)
UY (1) UY31436A1 (enExample)
WO (1) WO2009055828A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103476417A (zh) * 2011-02-18 2013-12-25 梅迪维新技术公司 治疗糖尿病的化合物和方法
CN104105698A (zh) * 2011-11-10 2014-10-15 俄罗斯科学院生理活性化合物研究所 作为用于减少非受控蛋白质聚集之试剂的含氟5-[2-(吡啶-3-基)-乙基]-2,3,4-四氢-1h-吡啶并[4,3-b]吲哚
CN117186089A (zh) * 2023-07-07 2023-12-08 浙江大学 一种四氢咔啉衍生物的制备方法

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2145887B1 (en) * 2007-04-05 2016-04-27 Alla Chem, LLC. Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for the production and use thereof
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CN117186089A (zh) * 2023-07-07 2023-12-08 浙江大学 一种四氢咔啉衍生物的制备方法

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