CN101946001A - 多肽-核酸结合物及其应用 - Google Patents

多肽-核酸结合物及其应用 Download PDF

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Publication number
CN101946001A
CN101946001A CN2008801270674A CN200880127067A CN101946001A CN 101946001 A CN101946001 A CN 101946001A CN 2008801270674 A CN2008801270674 A CN 2008801270674A CN 200880127067 A CN200880127067 A CN 200880127067A CN 101946001 A CN101946001 A CN 101946001A
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compound
polypeptide
disease
sequence
seq
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Chinese (zh)
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理查德·贝利沃
米歇尔·德默勒
克里斯蒂安·切
安东尼·雷吉纳
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Angiochem Inc
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Angiochem Inc
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
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CN2008801270674A 2007-12-20 2008-12-19 多肽-核酸结合物及其应用 Pending CN101946001A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US882507P 2007-12-20 2007-12-20
US61/008,825 2007-12-20
PCT/CA2008/002269 WO2009079790A1 (en) 2007-12-20 2008-12-19 Polypeptide-nucleic acid conjugates and uses thereof

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CN101946001A true CN101946001A (zh) 2011-01-12

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US (1) US20110039785A1 (https=)
EP (1) EP2235175A4 (https=)
JP (1) JP2011505846A (https=)
CN (1) CN101946001A (https=)
AU (1) AU2008340943A1 (https=)
BR (1) BRPI0821310A2 (https=)
CA (1) CA2709635A1 (https=)
MX (1) MX2010006925A (https=)
RU (1) RU2010129761A (https=)
WO (1) WO2009079790A1 (https=)
ZA (1) ZA201004609B (https=)

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CN106103716A (zh) * 2013-07-12 2016-11-09 乔治亚洲立大学研究基金会 Rna干扰dna聚合酶并抑制dna合成的方法及其复合物组分
CN106282118A (zh) * 2015-06-24 2017-01-04 武汉荣实医药科技有限公司 阿尔兹海默症关键致病因子app的基因工程细胞株和药物筛选模型
WO2019037133A1 (zh) * 2017-08-25 2019-02-28 深圳市博奥康生物科技有限公司 靶向沉默APP的shRNA
CN111208284A (zh) * 2018-11-22 2020-05-29 北京大学 糖代谢标记探针、包含其的试剂盒及其应用
CN114787355A (zh) * 2019-10-16 2022-07-22 海阳制药 具有血脑屏障穿透能力的肽-核酸复合物及包含该肽-核酸复合物的组合物

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US7557182B2 (en) 2005-02-18 2009-07-07 Angiochem Inc. Molecules for transporting a compound across the blood-brain barrier
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
JP5436856B2 (ja) 2005-07-15 2014-03-05 アンジオケム インコーポレーティッド 薬学的複合体における担体としてのアプロチニンポリペプチドの使用
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US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
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CA2745524C (en) 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
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WO2010121379A1 (en) 2009-04-20 2010-10-28 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
AU2010268726A1 (en) 2009-07-02 2012-01-19 Angiochem Inc. Multimeric peptide conjugates and uses thereof
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US8691580B2 (en) * 2010-04-09 2014-04-08 Merck Sharp & Dohme Corp. Single chemical entities and methods for delivery of oligonucleotides
RU2664452C2 (ru) * 2010-04-19 2018-08-17 Нлифе Терапеутикс, С.Л. Конъюгат, медицинское средство и способы лечения и/или профилактики депрессии и болезни, связанной с отложением телец Леви
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
WO2012150960A1 (en) * 2011-05-05 2012-11-08 Avi Biopharma, Inc. Peptide oligonucleotide conjugates
US9161948B2 (en) 2011-05-05 2015-10-20 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
US20140259192A1 (en) 2011-07-12 2014-09-11 Sanofi Transgenic animal comprising a deletion or functional deletion of the 3'utr of an endogenous gene
US9150858B2 (en) 2011-08-04 2015-10-06 Yeda Research And Development Co. Ltd. Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions
WO2013078562A2 (en) * 2011-12-01 2013-06-06 Angiochem Inc. Targeted enzyme compounds and uses thereof
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JP6195848B2 (ja) * 2012-01-27 2017-09-13 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 糖ポリマーを用いた生体分子の安定化
AU2013273894A1 (en) * 2012-06-15 2015-02-05 Angiochem Inc. Targeted iduronidase compounds
EP2885318A4 (en) 2012-08-14 2016-03-30 Angiochem Inc PEPTIDE DENDRIMER CONJUGATES AND ITS USES
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