CN101945874A - 作为抗癌剂的3-取代的-4-氧代-3,4-二氢-咪唑并[5,1-d][1,2,3,5]-四嗪-8-甲酰胺类 - Google Patents

作为抗癌剂的3-取代的-4-氧代-3,4-二氢-咪唑并[5,1-d][1,2,3,5]-四嗪-8-甲酰胺类 Download PDF

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Publication number
CN101945874A
CN101945874A CN2008801269450A CN200880126945A CN101945874A CN 101945874 A CN101945874 A CN 101945874A CN 2008801269450 A CN2008801269450 A CN 2008801269450A CN 200880126945 A CN200880126945 A CN 200880126945A CN 101945874 A CN101945874 A CN 101945874A
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China
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independently
compound according
saturated aliphatic
compound
alkylene
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CN2008801269450A
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English (en)
Chinese (zh)
Inventor
M·F·G·史蒂文斯
D·卡森
S·詹宁斯
A·J·麦卡罗尔
J·G·威廉姆斯
M·G·休默索恩
J·张
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Pharminox Ltd
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Pharminox Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2008801269450A 2007-12-18 2008-12-16 作为抗癌剂的3-取代的-4-氧代-3,4-二氢-咪唑并[5,1-d][1,2,3,5]-四嗪-8-甲酰胺类 Pending CN101945874A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1452007P 2007-12-18 2007-12-18
US61/014,520 2007-12-18
PCT/GB2008/004140 WO2009077741A2 (en) 2007-12-18 2008-12-16 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use

Publications (1)

Publication Number Publication Date
CN101945874A true CN101945874A (zh) 2011-01-12

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CN2008801269450A Pending CN101945874A (zh) 2007-12-18 2008-12-16 作为抗癌剂的3-取代的-4-氧代-3,4-二氢-咪唑并[5,1-d][1,2,3,5]-四嗪-8-甲酰胺类

Country Status (12)

Country Link
US (2) US8450479B2 (enExample)
EP (2) EP2698370A3 (enExample)
JP (1) JP2011506588A (enExample)
CN (1) CN101945874A (enExample)
AR (1) AR071548A1 (enExample)
AU (1) AU2008337261A1 (enExample)
CA (1) CA2709749A1 (enExample)
IL (1) IL206453A0 (enExample)
PE (1) PE20091101A1 (enExample)
TW (1) TW200934782A (enExample)
WO (1) WO2009077741A2 (enExample)
ZA (1) ZA201004554B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108276415A (zh) * 2018-02-08 2018-07-13 台州职业技术学院 一种烷氧化三唑并四嗪类化合物及其制备方法和应用
CN113271939A (zh) * 2018-08-09 2021-08-17 伊利诺伊大学董事会 咪唑四嗪化合物

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PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
US9024018B2 (en) * 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use
WO2011107726A1 (en) 2010-03-01 2011-09-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
WO2012085501A1 (en) 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
RU2545458C2 (ru) * 2013-08-01 2015-03-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" ПРОТИВОТУБЕРКУЛЕЗНОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО: КОМПОЗИЦИЯ ИМИДАЗО[1,2-b]ТЕТРАЗИНА С ПИРАЗИНАМИДОМ
WO2020106558A1 (en) 2018-11-20 2020-05-28 Merck Sharp & Dohme Corp. Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
WO2020106560A1 (en) 2018-11-20 2020-05-28 Merck Sharp & Dohme Corp. Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
PE20211768A1 (es) 2018-11-30 2021-09-07 Merck Sharp & Dohme Derivados de amino triazolo quinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmaceuticas y su uso
JP2022511778A (ja) 2018-11-30 2022-02-01 メルク・シャープ・アンド・ドーム・コーポレーション アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用
GB201907813D0 (en) 2019-05-31 2019-07-17 Univ Nottingham Therapeutic compounds
KR102571751B1 (ko) 2020-03-24 2023-08-25 삼성에스디아이 주식회사 리튬 이차 전지의 전해질용 첨가제, 리튬 이차 전지용 전해질 및 이를 포함하는 리튬 이차 전지
WO2022266468A1 (en) * 2021-06-18 2022-12-22 Yale University Anti-cancer compounds and methods of use
US20240400572A1 (en) * 2021-09-23 2024-12-05 Yale University Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status
US20250129083A1 (en) * 2022-02-01 2025-04-24 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds and treatment of tmz-resistant cancers
TW202515538A (zh) * 2023-08-04 2025-04-16 美商莫迪菲生物科學有限公司 氟烷氧基伸烷基－二氫咪唑并〔５，１－ｄ〕四嗪酮化合物及相關化合物以及其在治療醫學疾患中之用途

Citations (2)

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US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
CN1742723A (zh) * 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途

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OA07174A (fr) 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
GB2125402B (en) 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4504475A (en) 1983-05-24 1985-03-12 Warner Lambert Company 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds
GB9504361D0 (en) 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
AR035419A1 (es) 2001-01-18 2004-05-26 Schering Corp Un proceso para preparar compuestos imidazo-tetrazin-4-ona, compuestos intermediarios, sales de adicion de acidos, un proceso para preparar la temozolomida, un proceso para preparar intermediarios
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
GB0807103D0 (en) 2008-04-18 2008-05-21 Univ Bradford The Compounds
US9024018B2 (en) 2009-06-23 2015-05-05 Pharminox Limited 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
CN1742723A (zh) * 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108276415A (zh) * 2018-02-08 2018-07-13 台州职业技术学院 一种烷氧化三唑并四嗪类化合物及其制备方法和应用
CN108276415B (zh) * 2018-02-08 2019-07-05 台州职业技术学院 一种烷氧化三唑并四嗪类化合物及其制备方法和应用
CN113271939A (zh) * 2018-08-09 2021-08-17 伊利诺伊大学董事会 咪唑四嗪化合物
US12234240B2 (en) 2018-08-09 2025-02-25 The Board Of Trustees Of The University Of Illinois Substituted imidazo[5,1-d][1,2,3,5]tetrazines for the treatment of cancer
CN113271939B (zh) * 2018-08-09 2025-03-07 伊利诺伊大学董事会 咪唑四嗪化合物

Also Published As

Publication number Publication date
JP2011506588A (ja) 2011-03-03
PE20091101A1 (es) 2009-07-26
WO2009077741A3 (en) 2009-12-03
EP2698370A2 (en) 2014-02-19
EP2698370A3 (en) 2014-07-16
AR071548A1 (es) 2010-06-30
EP2229393A2 (en) 2010-09-22
US8450479B2 (en) 2013-05-28
US20100286088A1 (en) 2010-11-11
IL206453A0 (en) 2010-12-30
CA2709749A1 (en) 2009-06-25
AU2008337261A1 (en) 2009-06-25
ZA201004554B (en) 2011-09-28
WO2009077741A2 (en) 2009-06-25
TW200934782A (en) 2009-08-16
US20130338104A1 (en) 2013-12-19

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