AR071548A1 - Amidas de acido 3-substituido-4-oxo-3, 4-dihidro-imidazo[5, 1-d]1, 2, 3, 5-tetracina-8-carboxilico, un metodo para su preparacion e intermediarios de su sintesis, una composicion farmaceutica que las comprende y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer - Google Patents
Amidas de acido 3-substituido-4-oxo-3, 4-dihidro-imidazo[5, 1-d]1, 2, 3, 5-tetracina-8-carboxilico, un metodo para su preparacion e intermediarios de su sintesis, una composicion farmaceutica que las comprende y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancerInfo
- Publication number
- AR071548A1 AR071548A1 ARP080105534A ARP080105534A AR071548A1 AR 071548 A1 AR071548 A1 AR 071548A1 AR P080105534 A ARP080105534 A AR P080105534A AR P080105534 A ARP080105534 A AR P080105534A AR 071548 A1 AR071548 A1 AR 071548A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- compounds
- substituted
- dihydro
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- 125000004429 atom Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000012453 solvate Substances 0.000 abstract 3
- -1 para-methoxy-benzyl Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1452007P | 2007-12-18 | 2007-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071548A1 true AR071548A1 (es) | 2010-06-30 |
Family
ID=40427129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105534A AR071548A1 (es) | 2007-12-18 | 2008-12-18 | Amidas de acido 3-substituido-4-oxo-3, 4-dihidro-imidazo[5, 1-d]1, 2, 3, 5-tetracina-8-carboxilico, un metodo para su preparacion e intermediarios de su sintesis, una composicion farmaceutica que las comprende y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8450479B2 (enExample) |
| EP (2) | EP2698370A3 (enExample) |
| JP (1) | JP2011506588A (enExample) |
| CN (1) | CN101945874A (enExample) |
| AR (1) | AR071548A1 (enExample) |
| AU (1) | AU2008337261A1 (enExample) |
| CA (1) | CA2709749A1 (enExample) |
| IL (1) | IL206453A0 (enExample) |
| PE (1) | PE20091101A1 (enExample) |
| TW (1) | TW200934782A (enExample) |
| WO (1) | WO2009077741A2 (enExample) |
| ZA (1) | ZA201004554B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20091101A1 (es) | 2007-12-18 | 2009-07-26 | Pharminox Ltd | AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO |
| CA2763766A1 (en) | 2009-06-23 | 2010-12-29 | Pharminox Limited | 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use |
| EP2542553A1 (en) * | 2010-03-01 | 2013-01-09 | Pharminox Ltd | Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines |
| WO2012085501A1 (en) | 2010-12-20 | 2012-06-28 | Pharminox Limited | 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug |
| RU2545458C2 (ru) * | 2013-08-01 | 2015-03-27 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | ПРОТИВОТУБЕРКУЛЕЗНОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО: КОМПОЗИЦИЯ ИМИДАЗО[1,2-b]ТЕТРАЗИНА С ПИРАЗИНАМИДОМ |
| CN108276415B (zh) * | 2018-02-08 | 2019-07-05 | 台州职业技术学院 | 一种烷氧化三唑并四嗪类化合物及其制备方法和应用 |
| CA3109191A1 (en) * | 2018-08-09 | 2020-02-13 | The Board Of Trustees Of The University Of Illinois | Imidazotetrazine compounds |
| US12414952B2 (en) | 2018-11-20 | 2025-09-16 | Merck Sharp & Dohme Llc | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| JP2022507734A (ja) | 2018-11-20 | 2022-01-18 | メルク・シャープ・アンド・ドーム・コーポレーション | 置換アミノトリアゾロピリミジン及びアミノトリアゾロピラジンアデノシン受容体アンタゴニスト、医薬組成物及びそれらの使用 |
| JP2022511778A (ja) | 2018-11-30 | 2022-02-01 | メルク・シャープ・アンド・ドーム・コーポレーション | アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用 |
| AR117164A1 (es) | 2018-11-30 | 2021-07-14 | Merck Sharp & Dohme | Derivados de amino-triazoloquinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso para el tratamiento de diversos tipos de cáncer |
| GB201907813D0 (en) | 2019-05-31 | 2019-07-17 | Univ Nottingham | Therapeutic compounds |
| KR102571751B1 (ko) | 2020-03-24 | 2023-08-25 | 삼성에스디아이 주식회사 | 리튬 이차 전지의 전해질용 첨가제, 리튬 이차 전지용 전해질 및 이를 포함하는 리튬 이차 전지 |
| US20240294478A1 (en) * | 2021-06-18 | 2024-09-05 | Yale University | Anti-cancer compounds and methods of use |
| US20240400572A1 (en) * | 2021-09-23 | 2024-12-05 | Yale University | Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status |
| US20250129083A1 (en) * | 2022-02-01 | 2025-04-24 | The Board Of Trustees Of The University Of Illinois | Imidazotetrazine compounds and treatment of tmz-resistant cancers |
| GEAP202616916A (en) * | 2023-08-04 | 2026-05-25 | Modifi Biosciences Inc | Fluoroalkoxyalkylene-dihydroimidazo[5,1-d]tetrazinone compounds and related compounds and their use in treating medical conditions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260291A (en) | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
| OA07174A (fr) * | 1981-08-24 | 1984-04-30 | May & Baker Ltd | Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent. |
| GB2125402B (en) | 1982-08-17 | 1985-11-13 | May & Baker Ltd | New tetrazine derivatives |
| US4504475A (en) | 1983-05-24 | 1985-03-12 | Warner Lambert Company | 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds |
| GB9504361D0 (en) | 1995-03-04 | 1995-04-26 | Glaxo Spa | Heterocyclic compounds |
| WO2002057269A1 (en) | 2001-01-18 | 2002-07-25 | Schering Corporation | Synthesis of temozolomide and analogs |
| CN1742723A (zh) | 2004-09-02 | 2006-03-08 | 天津倍方科技发展有限公司 | 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途 |
| PE20091101A1 (es) | 2007-12-18 | 2009-07-26 | Pharminox Ltd | AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO |
| GB0807103D0 (en) | 2008-04-18 | 2008-05-21 | Univ Bradford The | Compounds |
| CA2763766A1 (en) | 2009-06-23 | 2010-12-29 | Pharminox Limited | 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use |
-
2008
- 2008-12-12 PE PE2008002071A patent/PE20091101A1/es not_active Application Discontinuation
- 2008-12-16 WO PCT/GB2008/004140 patent/WO2009077741A2/en not_active Ceased
- 2008-12-16 EP EP20130175051 patent/EP2698370A3/en not_active Withdrawn
- 2008-12-16 CA CA2709749A patent/CA2709749A1/en not_active Abandoned
- 2008-12-16 JP JP2010538886A patent/JP2011506588A/ja active Pending
- 2008-12-16 CN CN2008801269450A patent/CN101945874A/zh active Pending
- 2008-12-16 AU AU2008337261A patent/AU2008337261A1/en not_active Abandoned
- 2008-12-16 US US12/808,604 patent/US8450479B2/en not_active Expired - Fee Related
- 2008-12-16 EP EP08861839A patent/EP2229393A2/en not_active Withdrawn
- 2008-12-18 AR ARP080105534A patent/AR071548A1/es unknown
- 2008-12-18 TW TW097149411A patent/TW200934782A/zh unknown
-
2010
- 2010-06-17 IL IL206453A patent/IL206453A0/en unknown
- 2010-06-28 ZA ZA2010/04554A patent/ZA201004554B/en unknown
-
2013
- 2013-05-24 US US13/901,680 patent/US20130338104A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20130338104A1 (en) | 2013-12-19 |
| US20100286088A1 (en) | 2010-11-11 |
| TW200934782A (en) | 2009-08-16 |
| IL206453A0 (en) | 2010-12-30 |
| EP2698370A3 (en) | 2014-07-16 |
| CN101945874A (zh) | 2011-01-12 |
| ZA201004554B (en) | 2011-09-28 |
| US8450479B2 (en) | 2013-05-28 |
| WO2009077741A3 (en) | 2009-12-03 |
| EP2698370A2 (en) | 2014-02-19 |
| EP2229393A2 (en) | 2010-09-22 |
| AU2008337261A1 (en) | 2009-06-25 |
| PE20091101A1 (es) | 2009-07-26 |
| CA2709749A1 (en) | 2009-06-25 |
| JP2011506588A (ja) | 2011-03-03 |
| WO2009077741A2 (en) | 2009-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |