ZA201004554B - 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d] [1,2,3,5]-tetrazine-8-carboxylic acid amides as anticancer agents - Google Patents

3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d] [1,2,3,5]-tetrazine-8-carboxylic acid amides as anticancer agents

Info

Publication number
ZA201004554B
ZA201004554B ZA2010/04554A ZA201004554A ZA201004554B ZA 201004554 B ZA201004554 B ZA 201004554B ZA 2010/04554 A ZA2010/04554 A ZA 2010/04554A ZA 201004554 A ZA201004554 A ZA 201004554A ZA 201004554 B ZA201004554 B ZA 201004554B
Authority
ZA
South Africa
Prior art keywords
tetrazine
imidazo
dihydro
oxo
substituted
Prior art date
Application number
ZA2010/04554A
Other languages
English (en)
Inventor
Malcolm Francis Graham Stevens
David Cousin
Sharon Jennings
John Gareth Williams
Marc Geoffrey Hummersone
Jihong Zhang
Andrew James Mccarroll
Original Assignee
Pharminox Limited%
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharminox Limited% filed Critical Pharminox Limited%
Publication of ZA201004554B publication Critical patent/ZA201004554B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA2010/04554A 2007-12-18 2010-06-28 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d] [1,2,3,5]-tetrazine-8-carboxylic acid amides as anticancer agents ZA201004554B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1452007P 2007-12-18 2007-12-18
PCT/GB2008/004140 WO2009077741A2 (en) 2007-12-18 2008-12-16 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use

Publications (1)

Publication Number Publication Date
ZA201004554B true ZA201004554B (en) 2011-09-28

Family

ID=40427129

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/04554A ZA201004554B (en) 2007-12-18 2010-06-28 3-substituted-4-oxo-3,4-dihydro-imidazo-[5,1-d] [1,2,3,5]-tetrazine-8-carboxylic acid amides as anticancer agents

Country Status (12)

Country Link
US (2) US8450479B2 (enExample)
EP (2) EP2698370A3 (enExample)
JP (1) JP2011506588A (enExample)
CN (1) CN101945874A (enExample)
AR (1) AR071548A1 (enExample)
AU (1) AU2008337261A1 (enExample)
CA (1) CA2709749A1 (enExample)
IL (1) IL206453A0 (enExample)
PE (1) PE20091101A1 (enExample)
TW (1) TW200934782A (enExample)
WO (1) WO2009077741A2 (enExample)
ZA (1) ZA201004554B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
CA2763766A1 (en) 2009-06-23 2010-12-29 Pharminox Limited 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use
EP2542553A1 (en) * 2010-03-01 2013-01-09 Pharminox Ltd Methods and intermediates for the synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
WO2012085501A1 (en) 2010-12-20 2012-06-28 Pharminox Limited 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug
RU2545458C2 (ru) * 2013-08-01 2015-03-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" ПРОТИВОТУБЕРКУЛЕЗНОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО: КОМПОЗИЦИЯ ИМИДАЗО[1,2-b]ТЕТРАЗИНА С ПИРАЗИНАМИДОМ
CN108276415B (zh) * 2018-02-08 2019-07-05 台州职业技术学院 一种烷氧化三唑并四嗪类化合物及其制备方法和应用
CA3109191A1 (en) * 2018-08-09 2020-02-13 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds
US12414952B2 (en) 2018-11-20 2025-09-16 Merck Sharp & Dohme Llc Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
JP2022507734A (ja) 2018-11-20 2022-01-18 メルク・シャープ・アンド・ドーム・コーポレーション 置換アミノトリアゾロピリミジン及びアミノトリアゾロピラジンアデノシン受容体アンタゴニスト、医薬組成物及びそれらの使用
JP2022511778A (ja) 2018-11-30 2022-02-01 メルク・シャープ・アンド・ドーム・コーポレーション アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用
AR117164A1 (es) 2018-11-30 2021-07-14 Merck Sharp & Dohme Derivados de amino-triazoloquinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso para el tratamiento de diversos tipos de cáncer
GB201907813D0 (en) 2019-05-31 2019-07-17 Univ Nottingham Therapeutic compounds
KR102571751B1 (ko) 2020-03-24 2023-08-25 삼성에스디아이 주식회사 리튬 이차 전지의 전해질용 첨가제, 리튬 이차 전지용 전해질 및 이를 포함하는 리튬 이차 전지
US20240294478A1 (en) * 2021-06-18 2024-09-05 Yale University Anti-cancer compounds and methods of use
US20240400572A1 (en) * 2021-09-23 2024-12-05 Yale University Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status
US20250129083A1 (en) * 2022-02-01 2025-04-24 The Board Of Trustees Of The University Of Illinois Imidazotetrazine compounds and treatment of tmz-resistant cancers
GEAP202616916A (en) * 2023-08-04 2026-05-25 Modifi Biosciences Inc Fluoroalkoxyalkylene-dihydroimidazo[5,1-d]tetrazinone compounds and related compounds and their use in treating medical conditions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
OA07174A (fr) * 1981-08-24 1984-04-30 May & Baker Ltd Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent.
GB2125402B (en) 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4504475A (en) 1983-05-24 1985-03-12 Warner Lambert Company 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds
GB9504361D0 (en) 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
WO2002057269A1 (en) 2001-01-18 2002-07-25 Schering Corporation Synthesis of temozolomide and analogs
CN1742723A (zh) 2004-09-02 2006-03-08 天津倍方科技发展有限公司 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
GB0807103D0 (en) 2008-04-18 2008-05-21 Univ Bradford The Compounds
CA2763766A1 (en) 2009-06-23 2010-12-29 Pharminox Limited 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use

Also Published As

Publication number Publication date
US20130338104A1 (en) 2013-12-19
US20100286088A1 (en) 2010-11-11
TW200934782A (en) 2009-08-16
IL206453A0 (en) 2010-12-30
EP2698370A3 (en) 2014-07-16
CN101945874A (zh) 2011-01-12
US8450479B2 (en) 2013-05-28
WO2009077741A3 (en) 2009-12-03
EP2698370A2 (en) 2014-02-19
EP2229393A2 (en) 2010-09-22
AU2008337261A1 (en) 2009-06-25
PE20091101A1 (es) 2009-07-26
CA2709749A1 (en) 2009-06-25
JP2011506588A (ja) 2011-03-03
WO2009077741A2 (en) 2009-06-25
AR071548A1 (es) 2010-06-30

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