CN101926362A - Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof - Google Patents
Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof Download PDFInfo
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- CN101926362A CN101926362A CN200910053622XA CN200910053622A CN101926362A CN 101926362 A CN101926362 A CN 101926362A CN 200910053622X A CN200910053622X A CN 200910053622XA CN 200910053622 A CN200910053622 A CN 200910053622A CN 101926362 A CN101926362 A CN 101926362A
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Abstract
The invention relates to a compound orthophaladetyde phenyl ammonium chloride disinfectant and a preparation method thereof. The compound orthophaladetyde phenyl ammonium chloride disinfectant comprises the following components by weight: 0.2-1 wt% of orthophaladetyde, 0.05-0.5 wt% of phenyl ammonium chloride, 0.1-1 wt% of dipotassium phosphate, 0.1-1 wt% of monopotassium phosphate, 0.1-0.3 wt% of sodium polyacrylate, 0.05-0.2 wt% of antioxidant, 0.01-0.1 wt% of disodium ethylene diamine tetraacetic acid and the balance of water. The preparation method of the compound orthophaladetyde phenyl ammonium chloride disinfectant comprises the following steps of: adding the orthophaladetyde into water according to the content and components, and stirring for dissolving; adding the dipotassium phosphate, the monopotassium phosphate, the sodium polyacrylate, the antioxidant and the disodium ethylene diamine tetraacetic acid in sequence, and stirring for dissolving; and adding the phenyl ammonium chloride, and stirring for dissolving to obtain the compound orthophaladetyde phenyl ammonium chloride disinfectant. The disinfectant is applicable to the high-level disinfection of thermolabile medical apparatus and instruments. The disinfectant has no pungent smell, safety, low toxicity, stable properties and convenient use.
Description
Technical field
The present invention relates to disinfectant, relate in particular to a kind of compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof.
Background technology
O-phthalaldehyde(OPA) is a kind of novel aldehydes chemosterilant, has the advantages that corrosivity is low, not volatile, excitant is little, need not activate directly to use, and begins to use it for sterilizing endoscope in 1994 abroad, finds that it has good disinfection efficacy.O-phthalaldehyde(OPA) in 1999 have obtained the authentication of U.S. FDA, as a kind of high level disinfection agent, can be used for repeated treatments temperature-sensitive Medical Devices, can bring into play quick high level disinfection effect 20 ℃ of room temperatures.But o-phthalaldehyde(OPA) also exists significant disadvantages, mainly shows not ideal enough to the killing action of bacterium and gemma, and the character instability, easy oxidized destruction.
Phenyl chloride is a kind of novel quaternary ammonium salt antimicrobial compound, in various products, can be killed a large amount of gram-positive bacterias and Gram-negative bacteria by U.S. food and drug administration's approved applications fast.Especially can cooperate with various bactericidal components, play synergistic function.
Summary of the invention
The object of the invention provides a kind of compound orthophaladetyde phenyl ammonium chloride disinfectant, by scientific formula combination, strengthens the kill efficiency to bacterium and gemma of o-phthalaldehyde(OPA), and improves the stability of disinfectant.
A kind of compound orthophaladetyde phenyl ammonium chloride disinfectant, it comprises each component of following each percetage by weight:
O-phthalaldehyde(OPA), 0.2-1;
Phenyl chloride, 0.05-0.5;
Dipotassium hydrogen phosphate, 0.1-1;
Potassium dihydrogen phosphate, 0.1-1;
Sodium Polyacrylate, 0.1-0.3;
Antioxidant, 0.05-0.2;
Disodium ethylene diamine tetraacetate, 0.01-0.1;
Water, surplus.
Described disinfectant, described antioxidant are that sodium ascorbate or sodium isoascorbate or both share.
The preparation method of described disinfectant is: by described content and component, o-phthalaldehyde(OPA) is added to the water stirring and dissolving; Add dipotassium hydrogen phosphate, potassium dihydrogen phosphate, Sodium Polyacrylate, antioxidant, disodium ethylene diamine tetraacetate successively, stirring and dissolving; Add Phenyl chloride again, stirring and dissolving promptly gets described compound orthophaladetyde phenyl ammonium chloride disinfectant.
Characteristics of the present invention are to be main sterilization component with o-phthalaldehyde(OPA) and Phenyl chloride, cooperate the soda acid buffering to, corrosion inhibiter, antioxidant, chelating agent again, by the scientific matching of each component, obtain the high level disinfection performance.Phenyl chloride has the cationic surface active agent effect simultaneously as a kind of novel quaternary ammonium salt antimicrobial compound, can improve the permeability of bacteria cell wall, helps lend some impetus to o-phthalaldehyde(OPA) and penetrates into bacterial body.Dipotassium hydrogen phosphate and potassium dihydrogen phosphate are formed buffer system, keep the pH value of solution, improve the stability of disinfectant.Sodium Polyacrylate can further reduce the compound orthophaladetyde phenyl ammonium chloride disinfectant to corrosion of metal as corrosion inhibiter, and reaching does not all have corrosion substantially to stainless steel, carbon steel, copper, aluminium.Sodium ascorbate or sodium isoascorbate have good antioxidation, suppress the oxidizing process of o-phthalaldehyde(OPA).Disodium ethylene diamine tetraacetate is a kind of chelating agent, and the antioxygen synergistic effect is arranged, and can improve the stability of this disinfectant.
Embodiment
Below, in conjunction with specific embodiments, further specify the present invention:
A kind of compound orthophaladetyde phenyl ammonium chloride disinfectant, it comprises each component of following each percetage by weight:
O-phthalaldehyde(OPA), 0.2-1;
Phenyl chloride, 0.05-0.5;
Dipotassium hydrogen phosphate, 0.1-1;
Potassium dihydrogen phosphate, 0.1-1;
Sodium Polyacrylate, 0.1-0.3;
Antioxidant, 0.05-0.2;
Disodium ethylene diamine tetraacetate, 0.01-0.1;
Water, surplus.
Described disinfectant, described antioxidant are that sodium ascorbate or sodium isoascorbate or both share.
The preparation method of described disinfectant is: by described content and component, o-phthalaldehyde(OPA) is added to the water stirring and dissolving; Add dipotassium hydrogen phosphate, potassium dihydrogen phosphate, Sodium Polyacrylate, antioxidant, disodium ethylene diamine tetraacetate successively, stirring and dissolving; Add Phenyl chloride again, stirring and dissolving promptly gets described compound orthophaladetyde phenyl ammonium chloride disinfectant.
Embodiment 1
O-phthalaldehyde(OPA) 3 grams are joined in the 985 gram water stirring and dissolving; Add dipotassium hydrogen phosphate 5 grams, potassium dihydrogen phosphate 4 grams, Sodium Polyacrylate 1 gram, sodium isoascorbate 0.5 gram, disodium ethylene diamine tetraacetate 0.5 gram successively, stirring and dissolving; Add Phenyl chloride 1 gram again, stirring and dissolving promptly gets described compound orthophaladetyde phenyl ammonium chloride disinfectant.
Embodiment 2
O-phthalaldehyde(OPA) 5 grams are joined in the 985.8 gram water stirring and dissolving; Add dipotassium hydrogen phosphate 2 grams, potassium dihydrogen phosphate 2 grams, Sodium Polyacrylate 2 grams, sodium isoascorbate 0.5 gram, sodium ascorbate 0.5 gram, disodium ethylene diamine tetraacetate 0.2 gram successively, stirring and dissolving; Add Phenyl chloride 2 grams again, stirring and dissolving promptly gets described compound orthophaladetyde phenyl ammonium chloride disinfectant.
Embodiment 3
O-phthalaldehyde(OPA) 10 grams are joined in the 971 gram water stirring and dissolving; Add dipotassium hydrogen phosphate 8 grams, potassium dihydrogen phosphate 6 grams, Sodium Polyacrylate 3 grams, sodium ascorbate 0.5 gram, disodium ethylene diamine tetraacetate 1 gram successively, stirring and dissolving; Add Phenyl chloride 0.5 gram again, stirring and dissolving promptly gets described compound orthophaladetyde phenyl ammonium chloride disinfectant.
The various embodiments described above disinfectant there is no corrosion phenomenon to stainless steel substrates, carbon steel coupon, copper sheet, aluminium flake continuous dipping 14 days.
Adopt the suspension quantitative disinfecting test, under 19-21 ℃ of condition, effect 2min is 100% to the killing rate of staphylococcus aureus, Escherichia coli, Candida albicans; Effect 60min is 100% to the bacillus subtilis black variety gemma killing rate.
The accelerated stability test result shows that 54 ℃ of constant temperature were deposited 14 days, and O-phthalic aldehyde rate of descent is less than 2%, and Phenyl chloride content rate of descent is less than 5%; 37 ℃ of constant temperature were deposited 90 days, and O-phthalic aldehyde rate of descent is less than 4%, and Phenyl chloride content rate of descent is less than 8%.
As the compound orthophaladetyde phenyl ammonium chloride disinfectant that above-mentioned embodiment makes, product has no irritating odor, safety and low toxicity, and stable in properties, easy to use.This disinfectant can be used for the sterilization of medicine equipment, is specially adapted to the high level disinfection of thermo-labile medicine equipment, is particularly useful for scope automatically washing and sterilizing machine scope is carried out the high level disinfection processing.
Claims (3)
1. compound orthophaladetyde phenyl ammonium chloride disinfectant, it comprises each component of following each percetage by weight:
O-phthalaldehyde(OPA), 0.2-1;
Phenyl chloride, 0.05-0.5;
Dipotassium hydrogen phosphate, 0.1-1;
Potassium dihydrogen phosphate, 0.1-1;
Sodium Polyacrylate, 0.1-0.3;
Antioxidant, 0.05-0.2;
Disodium ethylene diamine tetraacetate, 0.01-0.1;
Water, surplus.
2. disinfectant according to claim 1 is characterized in that, described antioxidant is that sodium ascorbate or sodium isoascorbate or both share.
3. the preparation method of disinfectant according to claim 1 and 2 is: by described content and component, o-phthalaldehyde(OPA) is added to the water stirring and dissolving; Add dipotassium hydrogen phosphate, potassium dihydrogen phosphate, Sodium Polyacrylate, antioxidant, disodium ethylene diamine tetraacetate successively, stirring and dissolving; Add Phenyl chloride again, stirring and dissolving promptly gets described compound orthophaladetyde phenyl ammonium chloride disinfectant.
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| CN 200910053622 CN101926362B (en) | 2009-06-23 | 2009-06-23 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
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| CN 200910053622 CN101926362B (en) | 2009-06-23 | 2009-06-23 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
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| CN101926362A true CN101926362A (en) | 2010-12-29 |
| CN101926362B CN101926362B (en) | 2013-08-21 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102197811A (en) * | 2011-04-12 | 2011-09-28 | 陈义平 | Compound orthophthalaldehyde disinfectant |
| CN103125510A (en) * | 2013-03-22 | 2013-06-05 | 广州市医德生物科技有限责任公司 | Compound phthalic dicarboxaldehyde polyquaternium cationic surface active agent disinfectant and preparation and application thereof |
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103749445A (en) * | 2013-12-31 | 2014-04-30 | 中国船舶重工集团公司第七一八研究所 | Compound o-phthalaldehyde disinfection concentrated liquid |
| CN103960236A (en) * | 2013-11-19 | 2014-08-06 | 中国人民解放军疾病预防控制所 | OPA (ortho-phthalaldehyde)-containing compound disinfectant as well as preparation method and application thereof |
| CN104106566A (en) * | 2014-06-18 | 2014-10-22 | 武汉品瑞医学科技有限公司 | O-phthalic aldehyde disinfectant and preparation method thereof |
| CN104621104A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Disinfectant with low corrosiveness |
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| US20050171121A1 (en) * | 2004-01-30 | 2005-08-04 | Zhu Peter C. | Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization |
| CN1650706A (en) * | 2004-02-05 | 2005-08-10 | 刘家鹤 | Phthalyl formaldehyde disinfectant |
| CN1836508A (en) * | 2005-03-25 | 2006-09-27 | 黄雅钦 | Novel compound o-Phthalaldehyde microemusion sterilization composition |
| CN101238816A (en) * | 2007-02-06 | 2008-08-13 | 上海利康消毒高科技有限公司 | Single-component activation pentanedial disinfecting agent and preparation thereof |
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| US20050171121A1 (en) * | 2004-01-30 | 2005-08-04 | Zhu Peter C. | Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization |
| CN1650706A (en) * | 2004-02-05 | 2005-08-10 | 刘家鹤 | Phthalyl formaldehyde disinfectant |
| CN1613308A (en) * | 2004-09-24 | 2005-05-11 | 北京长江脉医药科技有限责任公司 | Antiseptics and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102197811A (en) * | 2011-04-12 | 2011-09-28 | 陈义平 | Compound orthophthalaldehyde disinfectant |
| CN102197811B (en) * | 2011-04-12 | 2014-03-12 | 陈义平 | Compound orthophthalaldehyde disinfectant |
| CN103125510A (en) * | 2013-03-22 | 2013-06-05 | 广州市医德生物科技有限责任公司 | Compound phthalic dicarboxaldehyde polyquaternium cationic surface active agent disinfectant and preparation and application thereof |
| CN103960236A (en) * | 2013-11-19 | 2014-08-06 | 中国人民解放军疾病预防控制所 | OPA (ortho-phthalaldehyde)-containing compound disinfectant as well as preparation method and application thereof |
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103636601B (en) * | 2013-12-10 | 2015-08-05 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103749445A (en) * | 2013-12-31 | 2014-04-30 | 中国船舶重工集团公司第七一八研究所 | Compound o-phthalaldehyde disinfection concentrated liquid |
| CN104106566A (en) * | 2014-06-18 | 2014-10-22 | 武汉品瑞医学科技有限公司 | O-phthalic aldehyde disinfectant and preparation method thereof |
| CN104106566B (en) * | 2014-06-18 | 2016-08-24 | 朗力生物医药(武汉)有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
| CN104621104A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Disinfectant with low corrosiveness |
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| CN101926362B (en) | 2013-08-21 |
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