CN103125510A - Compound phthalic dicarboxaldehyde polyquaternium cationic surface active agent disinfectant and preparation and application thereof - Google Patents
Compound phthalic dicarboxaldehyde polyquaternium cationic surface active agent disinfectant and preparation and application thereof Download PDFInfo
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- CN103125510A CN103125510A CN2013100955215A CN201310095521A CN103125510A CN 103125510 A CN103125510 A CN 103125510A CN 2013100955215 A CN2013100955215 A CN 2013100955215A CN 201310095521 A CN201310095521 A CN 201310095521A CN 103125510 A CN103125510 A CN 103125510A
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Abstract
The invention discloses a compound phthalic dicarboxaldehyde polyquaternium cationic surface active agent disinfectant and preparation and application thereof. The disinfectant comprises the following components by mass percent: 0.1-1% of phthalic dicarboxaldehyde, 0.001-0.2% of a polyquaternium cationic surface active agent, 0.001-0.1% of edetic acid, 1-30% of alcohol and the balance of purified water. The compound phthalic dicarboxaldehyde polyquaternium cationic surface active agent disinfectant is obtained by dissolving the phthalic dicarboxaldehyde in the alcohol, adding the purified water, the polyquaternium cationic surface active agent and the edetic acid, stirring for dissolving, and regulating the pH value to 7.5-8.5 by using a pH modifier. The disinfectant is suitable for high-level disinfection of thermolabile medical appliances, has no pungent smell, and is safe and low toxically, stable in nature and convenient to use.
Description
Technical field
The present invention relates to chemosterilant, particularly a kind of compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant and preparation and application thereof.
Background technology
At present disinfection product main component has aldehydes, Operand, compound phenol, chlorinated product, quaternary ammonium salt etc., and wherein aldehyde product is mainly glutaraldehyde and formaldehyde goods, and the product take o-phthalaldehyde(OPA) and polyquaternium as major constituent is not yet arranged.o-phthalaldehyde(OPA) (O-phthalaldehyde, OPA) finished product is a kind of flaxen acicular crystal, can be water-soluble, also be dissolvable in water the organic solvents such as pure and mild ether, it is a kind of wide spectrum, efficiently, the new disinfectant of low-corrosiveness, see the earliest (the Alfa MJ such as Alfa in 1994, Sitter DL.In hospital evalution of orthophthalaldehyde as a high level disinfectant for flexible endoscopes[J] .J Hosp Infect, 1994, (26): report 15.), used by drugs approved by FDA in 1999.The research o-phthalaldehyde(OPA) is to intend replacing glutaraldehyde as the original intention of disinfectant, because the bactericidal effect of o-phthalaldehyde(OPA) is better than glutaraldehyde (Rutala WA, Weber DJ.New disinfction and sterilization methods[J] .Emerging infectious diseases, 2001,7 (2): 348.).research is found, the pH value of antiseptic solution has very significantly impact to Germicidal Efficacy of Orthophthalaldehyde, stronger (the Walsh SE of the bactericidal effect of o-phthalaldehyde(OPA) under alkali condition, Maillard JY, Russell AD.Ortho-phthalaldehyde:a possible alternative to glutaradehyde for high level disinfection[J] .Applied Microbiology, 1999, 86 (6): 1039), but the researchs such as Xu Nengfeng find that also its bactericidal effect descends on the contrary when pH surpasses 9.0, optimum pH value is that 7.5~8.5(is permitted the energy cutting edge of a knife or a sword, stand in great numbers prosperous, Xu Wenti, Deng. o-phthalaldehyde(OPA) is killed the extremely research of influence factor of bacillus subtilis black variety gemma effect. Chinese Disinfection magazine, 2005, 22 (2): 125.).Single o-phthalaldehyde(OPA) kill bacteria gemma needs the time long, need to improve its dissipation ability and speed by formula.And the concentration meeting decrease to some degree when reusing of single o-phthalaldehyde(OPA), this has also affected disinfection effect.Once had the composite report of o-phthalaldehyde(OPA) and little molecule quaternary ammonium salt (woods grand plan etc., the development of quaternary ammonium salt complex phthalic aldehyde disinfectant, Chemical Industry in Guangzhou, 2008,36(4): 40-41; Zuo Zhiwen etc., the research of o-phthalaldehyde(OPA) and the effect of Domiphen bromide Synergistic biocidal, Shandong medicine thing, 2008,27(4): 245-249), but little molecule quaternary ammonium salt toxicity is stronger and unstable.The quaternary ammonium salt of aggretion type is as polymer composite, and the functional group that has kept quaternary ammonium salt is active and reduced its toxicity, the also corresponding raising of its degree of stability in the aqueous solution.And single polyquaternium only is the low elimination agent of killing activity, adopt the polyquaternium cationic surfactant to add to allocate the o-phthalaldehyde(OPA) antiseptic solution as compound synergic reagent, make it still keep very fast dissipation speed when the O-phthalic aldehyde concentration descends, yet there are no any report.
Summary of the invention
The shortcoming that primary and foremost purpose of the present invention is to overcome prior art provides a kind of compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant with not enough.
Another object of the present invention is to provide the preparation method of above-mentioned compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
A further object of the present invention is to provide the application of above-mentioned compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Purpose of the present invention is achieved through the following technical solutions:
A kind of compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant, comprise following component by mass percentage: o-phthalaldehyde(OPA) 0.1~1%, polyquaternium cationic surfactant 0.001~0.2%, ethylenediamine tetra-acetic acid 0.001~0.1%, alcohol 1~30%, surplus is purified water, transfers pH to 7.5~8.5 with pH adjusting agent; In such scheme, each component sum is 100%.
Preferably, described compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant comprises following component by mass percentage: o-phthalaldehyde(OPA) 0.4~0.58%, polyquaternium cationic surfactant 0.01~0.2%, ethylenediamine tetra-acetic acid 0.01~0.1%, alcohol 5~30%, surplus is purified water, transfers pH to 8 with pH adjusting agent.
Described polyquaternium cationic surfactant comprises: polyquaternium-6, polyquaternium-37, Merquat 280, polyquaternium-1227, PEI-BZ(benzyl polymine), MOME(dichloroether and N, N dimethylamino the third two urea condensation compounds, Wuhan Fengfan Chemical Co., Ltd. produces) and IME(expoxy propane and imidazolium compounds, company's productions such as anti-special commerce and trade Co., Ltd of Wuhan Fengfan Chemical Co., Ltd., Wuhan hundred) in one or more compounds.
Described pH adjusting agent is preferably sodium bicarbonate.
The preparation method of above-mentioned compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant comprises the steps: by described content and component, o-phthalaldehyde(OPA) is dissolved in alcohol, add purified water, polyquaternium cationic surfactant and ethylenediamine tetra-acetic acid, stirring and dissolving transfers pH to 7.5~8.5 namely to obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant with pH adjusting agent.
The application of above-mentioned compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant in thermo-labile medical apparatus sterilizing.
The present invention has following advantage and effect with respect to prior art:
(1) disinfectant of the present invention can improve o-phthalaldehyde(OPA) to the killing effect of bacterial spore, improves the Disinfection Effect under o-phthalaldehyde(OPA) organic matter protective condition.
(2) disinfectant of the present invention has no irritating odor, safety and low toxicity, and stable in properties, easy to use.
Embodiment
The present invention is described in further detail below in conjunction with embodiment, but embodiments of the present invention are not limited to this.
Embodiment 1
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 100kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 2kg polyquaternium-6,0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 2
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 200kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 2kg polyquaternium-37,0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 3
Weigh o-phthalaldehyde(OPA) 4kg, add alcohol (95%, V/V) 100kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 2kg Merquat 280,1kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 4
Weigh o-phthalaldehyde(OPA) 0.58kg, add alcohol (95%, V/V) 200kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 2kg PEI-BZ, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 5
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 100kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 0.1kg PEI-BZ, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 6
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 300kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 0.5kg PEI-BZ, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 7
Weigh o-phthalaldehyde(OPA) 4kg, add alcohol (95%, V/V) 200kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 1kg PEI-BZ, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 8
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 100kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 1.5kg MOME, 0.1kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 9
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 300kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 2kg polyquaternium-1227,0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 10
Weigh o-phthalaldehyde(OPA) 4kg, add alcohol (95%, V/V) 100kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 1kg PEI-BZ, 0.5kg polyquaternium 22,0.5kg IME, 0.1kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, approximately need sodium bicarbonate 1.5kg, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 11
Weigh o-phthalaldehyde(OPA) 4kg, add alcohol (95%, V/V) 300kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 0.5kg polyquaternium-1227,1.5kg IME, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Embodiment 12
Weigh o-phthalaldehyde(OPA) 4kg, add alcohol (95%, V/V) 50kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 1kg MOME, 1kg IME, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Comparative Examples 1
Weigh o-phthalaldehyde(OPA) 5.8kg, add alcohol (95%, V/V) 300kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
Comparative Examples 2
Weigh o-phthalaldehyde(OPA) 4kg, add alcohol (95%, V/V) 200kg mix and blend 15 minutes in agitator tank, add 500kg purified water, 0.2kg ethylenediamine tetra-acetic acid, stirred 10 minutes, add purified water to 1000kg, mix and blend 30 minutes, regulate pH with sodium bicarbonate, measure while stirring pH to approximately stopping adding at 8 o'clock, namely obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant.
With the above-mentioned compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant for preparing to bacillus subtilis black variety gemma (ATCC9372, available from Military Medical Science Institute) and staphylococcus aureus (ATCC6538, available from Military Medical Science Institute) carry out killing effect detection (detecting by 2002 editions " disinfection technology standard "), result is as shown in Table 1 and Table 2.
The killing effect of table 1 pair bacillus subtilis black variety gemma
Learn from table 1, when O-phthalic aldehyde concentration lower (4%), adopt lower polyquaternium concentration (0.1%), the killing rate to bacillus subtilis black variety gemma was from the 86.4%(Comparative Examples 2 without polyquaternium in 60 minutes) be elevated to 92%(embodiment 7).And the polyquaternium concentration to 0.2% that raises this moment, killing rate significantly was increased to (embodiment 10,11,12) more than 98% in 60 minutes.And when the O-phthalic aldehyde concentration is elevated to 0.58%, 60 minutes killing rate 98.8%(Comparative Examples 1 during without polyquaternium), and when polyquaternium concentration was 0.01%, killing rate had reached 99.5%(embodiment 5).
The killing effect of table 2 pair Staphylococcus aureus
Learn from table 2, when the O-phthalic aldehyde concentration is 0.4%, without polyquaternium, must the killing rate of Staphylococcus aureus could be reached 99.9%(Comparative Examples 2 in 5 minutes); And rising polyquaternium concentration, there is shortening (embodiment 7,10,11 and 12) in various degree the time of killing.When the O-phthalic aldehyde concentration is 0.58%, must killing rate be submitted to high to 99.9%(Comparative Examples 1 in 3 minutes); And rising polyquaternium concentration can shorten the time of killing (embodiment 1,2,4,5,6 etc.) to staphylococcus aureus greatly.
From table 1,2 as can be known, all mentioned polyquaterniums of the present invention all have synergy preferably with o-phthalaldehyde(OPA), can improve it to bacillus subtilis black variety gemma and Staphylococcus aureus killing action.
Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under Spirit Essence of the present invention and principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (6)
1. compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant, it is characterized in that comprising following component by mass percentage: o-phthalaldehyde(OPA) 0.1~1%, polyquaternium cationic surfactant 0.001~0.2%, ethylenediamine tetra-acetic acid 0.001~0.1%, alcohol 1~30%, surplus is purified water, transfers pH to 7.5~8.5 with pH adjusting agent.
2. compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant according to claim 1, it is characterized in that comprising following component by mass percentage: o-phthalaldehyde(OPA) 0.4~0.58%, polyquaternium cationic surfactant 0.01~0.2%, ethylenediamine tetra-acetic acid 0.01~0.1%, alcohol 5~30%, surplus is purified water, transfers pH to 8 with pH adjusting agent.
3. compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant according to claim 1, it is characterized in that: described polyquaternium cationic surfactant comprises: one or more compounds in polyquaternium-6, polyquaternium-37, Merquat 280, polyquaternium-1227, PEI-BZ, MOME and IME.
4. compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant according to claim 1, it is characterized in that: described pH adjusting agent is sodium bicarbonate.
5. the preparation method of the described compound ortho-phthalaldehyde polyquaternium of claim 1~4 any one cationic surfactant disinfectant, it is characterized in that comprising the steps: o-phthalaldehyde(OPA) is dissolved in alcohol, add purified water, polyquaternium cationic surfactant and ethylenediamine tetra-acetic acid, stirring and dissolving transfers pH to 7.5~8.5 namely to obtain compound ortho-phthalaldehyde polyquaternium cationic surfactant disinfectant with pH adjusting agent.
6. the application of the described compound ortho-phthalaldehyde polyquaternium of claim 1~4 any one cationic surfactant disinfectant in thermo-labile medical apparatus sterilizing.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103960236A (en) * | 2013-11-19 | 2014-08-06 | 中国人民解放军疾病预防控制所 | OPA (ortho-phthalaldehyde)-containing compound disinfectant as well as preparation method and application thereof |
CN105548166A (en) * | 2015-12-30 | 2016-05-04 | 广州市医德生物科技有限责任公司 | OPA (o-phthalaldehyde) disinfector concentration range detection test paper |
CN111662208A (en) * | 2019-03-06 | 2020-09-15 | 中国科学院化学研究所 | Trimeric quaternary ammonium salt surfactant constructed by dynamic imine bonds, and preparation method and application thereof |
CN114916545A (en) * | 2022-06-02 | 2022-08-19 | 合肥天帆医药科技有限公司 | Low-grey-dyeing o-phthalaldehyde disinfectant and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101161070A (en) * | 2006-10-13 | 2008-04-16 | 广东海洋大学 | Double chain quaternary ammonium salt complex phthalic two methylene oxide disinfectant |
CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
CN102077828A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Compound disinfectant containing quaternary ammonium salt |
-
2013
- 2013-03-22 CN CN2013100955215A patent/CN103125510A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101161070A (en) * | 2006-10-13 | 2008-04-16 | 广东海洋大学 | Double chain quaternary ammonium salt complex phthalic two methylene oxide disinfectant |
CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
CN102077828A (en) * | 2009-11-27 | 2011-06-01 | 天津瑞普生物技术股份有限公司 | Compound disinfectant containing quaternary ammonium salt |
Non-Patent Citations (6)
Title |
---|
佟会等: "季铵盐类抗菌剂及其应用研究进展", 《贵州化工》 * |
左志文等: "邻苯二甲醛与度米芬协同杀菌作用的研究", 《齐鲁药事》 * |
张葵花等: "有机抗菌剂研究现状及发展趋势", 《涂料工业》 * |
林宏图等: "季铵盐复合邻苯二甲醛消毒剂的研制", 《广州化工》 * |
江山等: "新型有机高分子抗菌剂", 《高分子通报》 * |
王瑛等: "低相对分子质量水溶性聚季铵盐的合成及其性能研究", 《化学世界》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103960236A (en) * | 2013-11-19 | 2014-08-06 | 中国人民解放军疾病预防控制所 | OPA (ortho-phthalaldehyde)-containing compound disinfectant as well as preparation method and application thereof |
CN105548166A (en) * | 2015-12-30 | 2016-05-04 | 广州市医德生物科技有限责任公司 | OPA (o-phthalaldehyde) disinfector concentration range detection test paper |
CN111662208A (en) * | 2019-03-06 | 2020-09-15 | 中国科学院化学研究所 | Trimeric quaternary ammonium salt surfactant constructed by dynamic imine bonds, and preparation method and application thereof |
CN114916545A (en) * | 2022-06-02 | 2022-08-19 | 合肥天帆医药科技有限公司 | Low-grey-dyeing o-phthalaldehyde disinfectant and preparation method and application thereof |
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