CN104106566A - O-phthalic aldehyde disinfectant and preparation method thereof - Google Patents
O-phthalic aldehyde disinfectant and preparation method thereof Download PDFInfo
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- CN104106566A CN104106566A CN201410270702.1A CN201410270702A CN104106566A CN 104106566 A CN104106566 A CN 104106566A CN 201410270702 A CN201410270702 A CN 201410270702A CN 104106566 A CN104106566 A CN 104106566A
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- phthalaldehyde
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Abstract
The invention relates to an o-phthalic aldehyde disinfectant and a preparation method thereof. The disinfectant adopts D-isoascorbyl aldehyde acetal as the antioxidant, and comprises the following components in percentage by weight: 0.3 to 1.0% of o-phthalic aldehyde, 0.02 to 0.2% of D-isoascorbyl aldehyde acetal, 0.1 to 2.0% of buffering agent, 0.2 to 2.0% of chelating agent, 0.05 to 5.0% of corrosion inhibitor, and the balance being water. The preparation method comprises the following steps: according to the components and contents mentioned above, adding o-phthalic aldehyde into water, stirring to dissolve the o-phthalic aldehyde, orderly adding D-isoascorbyl aldehyde acetal, buffering agent, chelating agent, and corrosion inhibitor, and stirring to dissolve so as to obtain the o-phthalic aldehyde disinfectant. The added D-isoascorbyl aldehyde acetal has a high-effective antioxidant effect, moreover has stable properties and low toxicity, and is capable of prominently improving the stability and safety of o-phthalic aldehyde.
Description
Technical field
The present invention relates to a kind of O-phthalaldehyde disinfectant, relate in particular to the different Vc acetal of a kind of new and effective, safe antioxidant used (ketone) in O-phthalaldehyde disinfectant.
Background technology
O-phthalaldehyde(OPA) (ortho-phthalaldehyde, OPA), is the new disinfectant of a kind of wide spectrum, efficient, low-corrosiveness, starts to use it for endoscopy disinfection abroad in 1994, finds that it has good Disinfection Effect.O-phthalaldehyde(OPA) in 1999 have obtained the authentication of U.S. FDA, as a kind of high level disinfection agent, can be used for repeatedly processing temperature-sensitive Medical Devices.But o-phthalaldehyde(OPA) also exists obvious shortcoming, its character is unstable, easy oxidized destruction.
Different Vc acetal (ketone) is that straight chain saturated aliphatic aldehyde, cyclohexanone, benzaldehyde or cinnamic acid acetalation or the ketal of different Vc and C6-C12 forms.Carbonyl in aldehyde ketone molecule reacts with the adjacent glycol of C5, C6 in different Vc molecular structure the different Vc acetal (ketone) generating, retained the adjacent dienol structure in different Vc molecular structure, not only retained its non-oxidizability, also strengthened its non-oxidizability simultaneously, made different Vc acetal (ketone) antioxidant be better than different Vc.
Summary of the invention
The object of the invention is to provide a kind of O-phthalaldehyde disinfectant, adopts different Vc acetal (ketone) as antioxidant, and has added buffer, chelating agent and corrosion inhibiter, has improved the stability of O-phthalaldehyde disinfectant.
In described disinfectant, containing o-phthalaldehyde(OPA), preferred concentration is 0.3-1.0%(W/W);
In described disinfectant, different Vc acetal (ketone) is one or more in the different Vc acetal of lauryl aldehyde, the different Vc ketal of cyclohexanone, the different Vc acetal of benzaldehyde, the different Vc acetal of cinnamic acid, and preferred concentration is 0.02-0.2%(W/W);
In described disinfectant, buffer is one or more in dipotassium hydrogen phosphate, sodium hydrogen phosphate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, and preferred concentration is 0.1-2.0%(W/W);
In described disinfectant, chelating agent is one or more in sodium nitrilo triacetate, sodium ethylene diamine tetracetate, diethylene triamine pentaacetic acid sodium, and preferred concentration is 0.2-2.0%(W/W);
In described disinfectant, corrosion inhibiter is one or both in sodium phosphate trimer, calgon.Preferred concentration is 0.05-5.0%(W/W);
In described disinfectant, other components are purified water.
The preparation method of described disinfectant is: by described component and content, o-phthalaldehyde(OPA) is added in purified water, be stirred to dissolve; Add successively different Vc acetal (ketone), buffer, chelating agent and corrosion inhibiter, be stirred to dissolve, obtain described O-phthalaldehyde disinfectant.
Feature of the present invention is to take o-phthalaldehyde(OPA) as main sterilization component, and the different Vc acetal (ketone) of take is antioxidant, by the scientific matching of each component, makes o-phthalaldehyde(OPA) more stable, can bring into play more superior high level disinfection performance.It is antioxidant that the present invention adopts different Vc acetal (ketone), can significantly improve the antioxidant levels of disinfectant, improves the stability of disinfectant.Buffer mainly maintains disinfectant pH value at 6.5-8.5, improves stability and the antibiotic and sterilizing ability of disinfectant.Chelating agent, as the chelating composition to metal ion in system, is conducive to the stable of disinfectant system.Corrosion inhibiter can reduce disinfectant to corrosion of metal, promotes the compatibility of disinfectant to material, expands the scope of application of disinfectant.
Embodiment
Following examples are only further detailed the present invention, should not be construed as the present invention is further limited.
embodiment 1a kind of formula of composition of phthalyl diformaldehyde disinfectant is as table 1:
The formula of table 1 embodiment 1
O-phthalaldehyde(OPA) 3g is added in 990.3g water, be stirred to dissolve; Add successively the different Vc acetal of lauryl aldehyde 0.2g, dipotassium hydrogen phosphate 2g, potassium dihydrogen phosphate 2g, sodium ethylene diamine tetracetate 2g, sodium phosphate trimer 0.5g, stirring and dissolving, obtains described O-phthalaldehyde disinfectant.
embodiment 2a kind of formula of composition of phthalyl diformaldehyde disinfectant is as table 2:
The formula of table 2 embodiment 2
| O-phthalaldehyde(OPA) | 10g |
| The different Vc ketal of cyclohexanone | 1g |
| Sodium hydrogen phosphate | 8g |
| Sodium dihydrogen phosphate | 6g |
| Sodium nitrilo triacetate | 10g |
| Sodium phosphate trimer | 20g |
| Water | 945g |
O-phthalaldehyde(OPA) 10g is added in 945g water, be stirred to dissolve; Add successively the different Vc ketal of cyclohexanone 1g, sodium hydrogen phosphate 8g, sodium dihydrogen phosphate 6g, sodium nitrilo triacetate 10g, sodium phosphate trimer 20g, be stirred to dissolve, obtain described O-phthalaldehyde disinfectant.
The formula of 3 one kinds of composition of phthalyl diformaldehyde disinfectants of embodiment is as table 3:
The formula of table 3 embodiment 3
| O-phthalaldehyde(OPA) | 10g |
| The different Vc acetal of cinnamic acid | 1g |
| The different Vc ketal of cyclohexanone | 1g |
| Sodium hydrogen phosphate | 10g |
| Sodium dihydrogen phosphate | 10g |
| Diethylene triamine pentaacetic acid sodium | 20g |
| Calgon | 50g |
| Water | 898g |
O-phthalaldehyde(OPA) 10g is added in 898g water, be stirred to dissolve; Add successively the different Vc acetal of cinnamic acid 1g, the different Vc ketal of cyclohexanone 1g, sodium hydrogen phosphate 10g, sodium dihydrogen phosphate 10g, diethylene triamine pentaacetic acid sodium 20g, calgon 50g, be stirred to dissolve, obtain described O-phthalaldehyde disinfectant.
embodiment 4a kind of formula of composition of phthalyl diformaldehyde disinfectant is as table 4:
The formula of table 4 embodiment 4
| O-phthalaldehyde(OPA) | 5g |
| The different Vc ketal of cyclohexanone | 1g |
| Dipotassium hydrogen phosphate | 8g |
| Potassium dihydrogen phosphate | 6g |
| Diethylene triamine pentaacetic acid sodium | 15g |
| Calgon | 20g |
| Sodium phosphate trimer | 20g |
| Water | 925g |
O-phthalaldehyde(OPA) 5g is added in 925g water, be stirred to dissolve; Add successively the different Vc ketal of cyclohexanone 1g, dipotassium hydrogen phosphate 8g, potassium dihydrogen phosphate 6g, diethylene triamine pentaacetic acid sodium 15g, calgon 20g, sodium phosphate trimer 20g, be stirred to dissolve, obtain described O-phthalaldehyde disinfectant.
embodiment 5o-phthalaldehyde disinfectant accelerated stability test result is as table 5:
Table 5 O-phthalaldehyde disinfectant accelerated stability test result
| Embodiment | O-phthalic aldehyde (%) | 25 ℃ of constant temperature are deposited 90 days content rates of descent (%) | 40 ℃ of constant temperature are deposited 90 days content rates of descent (%) | 60 ℃ of constant temperature are deposited 90 days content rates of descent (%) |
| * | 0.5 | 3.5 | 6.2 | 10.3 |
| 1 | 0.3 | 0.4 | 0.9 | 1.5 |
| 2 | 1.0 | 0.3 | 0.8 | 1.2 |
| 3 | 1.0 | 0.3 | 0.8 | 1.0 |
| 4 | 0.5 | 0.2 | 0.7 | 1.0 |
Note: * is not containing different Vc ketal, and other are consistent with embodiment 4.
embodiment 6o-phthalaldehyde disinfectant to the killing effect of bacterium as table 6:
The killing effect of table 6 O-phthalaldehyde disinfectant to bacterium
As the O-phthalaldehyde disinfectant that above-described embodiment adopts different Vc acetal to make as antioxidant, stable in properties, long shelf-life, sterilization effect is good, is applicable to the sterilization of medicine equipment.
Claims (6)
1. an O-phthalaldehyde disinfectant, is characterized in that: adopt different Vc acetal as antioxidant, it comprises each component of following mass percent:
O-phthalaldehyde(OPA): 0.3-1.0%;
Different Vc acetal (ketone): 0.02-0.2%;
Buffer: 0.1-2.0%;
Chelating agent: 0.2-2.0%;
Corrosion inhibiter: 0.05-5.0%;
Water: surplus.
2. o-phthalaldehyde(OPA) thimerosal according to claim 1, it is characterized in that, adopt different Vc acetal (ketone) to make antioxidant, its quality percentage composition is 0.02%-0.2%, and different Vc acetal (ketone) used forms for straight chain saturated aliphatic aldehyde, cyclohexanone, benzaldehyde and the cinnamic acid of C6-C12 and different Vc acetalation or ketal.
3. o-phthalaldehyde(OPA) thimerosal according to claim 1, it is characterized in that, contain buffer, its quality percentage composition is 0.1%-2.0%, keep the pH of disinfectant at 6.5-8.5, buffer used is one or more in dipotassium hydrogen phosphate, sodium hydrogen phosphate, potassium dihydrogen phosphate, sodium dihydrogen phosphate.
4. o-phthalaldehyde(OPA) thimerosal according to claim 1, it is characterized in that, contain chelating agent, its quality percentage composition is 0.2%-2.0%, and chelating agent used is one or more in sodium nitrilo triacetate, sodium ethylene diamine tetracetate, diethylene triamine pentaacetic acid sodium.
5. O-phthalaldehyde disinfectant according to claim 1, is characterized in that containing corrosion inhibiter, and its quality percentage composition is 0.05%-5.0%, and corrosion inhibiter used is one or more in sodium phosphate trimer, calgon.
6. O-phthalaldehyde disinfectant according to claim 1, oxidation resistance is strong, stable in properties, long shelf-life, sterilization effect is good, is applicable to the sterilization of medicine equipment.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104957134A (en) * | 2015-07-08 | 2015-10-07 | 北京中海诚达科贸有限公司 | Composite method of phthalic dicarboxaldehyde sterilizing agent for thermosensitive medical instrument |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
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| US20050171216A1 (en) * | 2004-01-30 | 2005-08-04 | Zhu Peter C. | Germicidal compositions containing phthalaldehyde mixtures and methods of using such compositions for disinfection or sterilization |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
| CN101940207A (en) * | 2009-07-09 | 2011-01-12 | 上海利康消毒高科技有限公司 | Foam-shaped disinfectant used for washing machine and preparation method thereof |
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| US20050171216A1 (en) * | 2004-01-30 | 2005-08-04 | Zhu Peter C. | Germicidal compositions containing phthalaldehyde mixtures and methods of using such compositions for disinfection or sterilization |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
| CN101940207A (en) * | 2009-07-09 | 2011-01-12 | 上海利康消毒高科技有限公司 | Foam-shaped disinfectant used for washing machine and preparation method thereof |
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| 余衍文: "《VC缩醛（酮）和异VC缩醛（酮）的合成及其抗氧化性能研究》", 《南昌大学硕士学位论文》, 31 December 2008 (2008-12-31) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104957134A (en) * | 2015-07-08 | 2015-10-07 | 北京中海诚达科贸有限公司 | Composite method of phthalic dicarboxaldehyde sterilizing agent for thermosensitive medical instrument |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
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