CN102197811A - Compound orthophthalaldehyde disinfectant - Google Patents
Compound orthophthalaldehyde disinfectant Download PDFInfo
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- CN102197811A CN102197811A CN2011100906065A CN201110090606A CN102197811A CN 102197811 A CN102197811 A CN 102197811A CN 2011100906065 A CN2011100906065 A CN 2011100906065A CN 201110090606 A CN201110090606 A CN 201110090606A CN 102197811 A CN102197811 A CN 102197811A
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- phthalaldehyde
- orthophthalaldehyde
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- disinfectant
- opa
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Abstract
The invention relates to compound orthophthalaldehyde disinfectant, and a preparation method and application thereof. The compound orthophthalaldehyde disinfectant is prepared from orthophthalaldehyde (1), quaternary phosphor salt (2), organic acid (3), a penetrating agent (4), ampholyticsurfactant (5) and deionized water (6). The compound orthophthalaldehyde disinfectant is characterized by comprising 0.1 to 10.0 percent of the orthophthalaldehyde and 0.1 to 10.0 percent of quaternary phosphor salt. The compound orthophthalaldehyde disinfectant can kill enteropathogenic bacteria, pyogenic cocci, hepatitis virus, avian influenza virus, various epidemic diseases, bacterial spore and the like, and is applicable to performing sterilization on articles in farms, environments, air, ground, water, epidemic focus, health and epidemic prevention and the like.
Description
Technical field
The present invention relates to a kind of broad-spectrum high efficacy type disinfection solution.Relate to a kind of specifically by the formulated compound ortho-phthalaldehyde thimerosal of o-phthalaldehyde(OPA), quaternary alkylphosphonium salt, bleeding agent, organic acid, amphoteric surfactant and deionized water.The present invention with tetra methylol sulfuric acid phosphorus as quaternary alkylphosphonium salt, with the inositol phosphate as organic acid.
Background technology
O-phthalaldehyde(OPA) chemistry formula:
C
8H
6O
2
Tetra methylol sulfuric acid phosphorus chemistry formula:
[(CH
2OH)
4P]
2SO
4
Inositol phosphate chemistry formula:
C
6H
18O
24P
6
This compound ortho-phthalaldehyde thimerosal has comprised o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, inositol phosphate, bleeding agent, amphoteric surfactant and deionized water.Because o-phthalaldehyde(OPA) has fat-soluble, can react with the lipoprotein on the gemma outermost layer, and the PH scope of tetra methylol sulfuric acid phosphorus is bigger, electronegative group on the stronger easier absorption microbial cell of polarization under alkali condition, generate electrovalent bond and infiltrate cell membrane, change the permeability of cell membrane.Both act synergistically down, and the osmotic pressure of cell membrane changes, and permeability strengthens, protein denaturation, and cross-linking reaction takes place and makes its curing, sex change, inactivation in the easier core space that enters cytosis and cell of o-phthalaldehyde(OPA) that have the aromatic hydrocarbon characteristic this moment.The adding of inositol phosphate has strengthened the antioxidation of o-phthalaldehyde(OPA), has also avoided GOLD FROM PLATING SOLUTION to belong to the influence of ion simultaneously.And amphoteric surfactant, the compatibility that it is good, wetability, detergency, solubilising, dispersiveness etc. help the agent directly cell wall or the membrane structure of destroy microorganisms, strengthen its permeability, accelerate the reaction rate of o-phthalaldehyde(OPA) and microprotein and improve bactericidal effect.
Summary of the invention
Novel technical problem to be solved of the present invention is a kind of compound ortho-phthalaldehyde thimerosal, and it is 1 because the folk prescription o-phthalaldehyde(OPA) is faint for killing the gemma effect, long action time, and it 2 is removed for residual being difficult for of disinfectant.For solving this technical problem, it is by o-phthalaldehyde(OPA) that the novel technical scheme of taking is provided, tetra methylol sulfuric acid phosphorus, and the inositol phosphate, bleeding agent and deionized water are formulated.The test recipe that this programme is formed is to contain o-phthalaldehyde(OPA) 1.0-102.4g among every 1000ml, tetra methylol sulfuric acid phosphorus 1.3-133.3g, inositol phosphate 2.0-100.0g, bleeding agent 1.0-200.0g, amphoteric surfactant 3.3-333.3g.
Embodiment
Implement 1. these compound ortho-phthalaldehyde thimerosals and mainly comprise o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, inositol phosphate, poly alkyl alcohol oxyalkyl ether, dodecyl dimethyl amine-oxides and deionized water.The described compound ortho-phthalaldehyde thimerosal of wherein every 1000ml contains o-phthalaldehyde(OPA) 1.02g, tetra methylol sulfuric acid phosphorus 6.67g, and inositol phosphate 10g, poly alkyl alcohol oxyalkyl ether 15.1g, dodecyl dimethyl amine-oxides 6.6g, surplus is a deionized water.
Implement 2. these compound ortho-phthalaldehyde thimerosals and mainly comprise o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, inositol phosphate, poly alkyl alcohol oxyalkyl ether, dodecyl dimethyl amine-oxides and deionized water.The described compound ortho-phthalaldehyde thimerosal of wherein every 1000ml contains o-phthalaldehyde(OPA) 5.7g, tetra methylol sulfuric acid phosphorus 13.3g, and inositol phosphate 20g, poly alkyl alcohol oxyalkyl ether 20.2g, dodecyl dimethyl amine-oxides 3.3g, surplus is a deionized water.
Implement 3. these compound ortho-phthalaldehyde thimerosals and mainly comprise o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, in the described compound ortho-phthalaldehyde thimerosal of every 1000ml contain o-phthalaldehyde(OPA) 10.2g, tetra methylol sulfuric acid phosphorus 26.7g, inositol phosphate 30g, poly alkyl alcohol oxyalkyl ether 30.3g, dodecyl dimethyl amine-oxides 33.3g, surplus is a deionized water.
Implement 4. these compound ortho-phthalaldehyde thimerosals and mainly comprise o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, inositol phosphate, poly alkyl alcohol oxyalkyl ether, dodecyl dimethyl amine-oxides and deionized water.The described compound ortho-phthalaldehyde thimerosal of wherein every 1000ml contains o-phthalaldehyde(OPA) 51.02g, tetra methylol sulfuric acid phosphorus 40.0g, and inositol phosphate 10.0g, poly alkyl alcohol oxyalkyl ether 10.0g, dodecyl dimethyl amine-oxides 33.3g, surplus is a deionized water.
Implement 5. these compound ortho-phthalaldehyde thimerosals and mainly comprise o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, inositol phosphate, poly alkyl alcohol oxyalkyl ether, dodecyl dimethyl amine-oxides and deionized water.The described compound ortho-phthalaldehyde thimerosal of wherein every 1000ml contains o-phthalaldehyde(OPA) 30.6g, tetra methylol sulfuric acid phosphorus 66.6g, and inositol phosphate 100g, poly alkyl alcohol oxyalkyl ether 140.0g, dodecyl dimethyl amine-oxides 200g, surplus is a deionized water.
Implement 6. these compound ortho-phthalaldehyde thimerosals and mainly comprise o-phthalaldehyde(OPA), tetra methylol sulfuric acid phosphorus, inositol phosphate, poly alkyl alcohol oxyalkyl ether, dodecyl dimethyl amine-oxides and deionized water.The described compound ortho-phthalaldehyde of wherein every 1000ml 121.2 liquid of sterilizing contain o-phthalaldehyde(OPA) 15.31g, tetra methylol sulfuric acid phosphorus 40.0g, inositol phosphate 70g, poly alkyl alcohol oxyalkyl ether 151.5g, dodecyl dimethyl amine-oxides 83.3g, surplus is a deionized water.
This compound ortho-phthalaldehyde thimerosal is killed the bacillus subtilis black variety gemma conclusion and is seen the following form:
(1) compound ortho-phthalaldehyde solution is to the killing effect of experimental bacteria
Annotate: negative control is asepsis growth.
Conclusion: sample stoste effect 45min kills logarithm value all＜3.00 to what dye on stainless steel substrates bacillus subtilis black variety gemma; 90min, 135min kill logarithm value all＞3.00 to what dye on stainless steel substrates bacillus subtilis black variety gemma, and therefore, the suggestion disinfective action time is made as 90-135min.
Claims (2)
1. a compound ortho-phthalaldehyde thimerosal is characterized in that the formulated thimerosal of (1) o-phthalaldehyde(OPA) (2) quaternary alkylphosphonium salt (3) organic acid (4) bleeding agent (5) amphoteric surfactant (6) deionized water, contain o-phthalaldehyde(OPA) in every liter: 1.0-102.4g quaternary alkylphosphonium salt: 1.3-133.3g, organic acid: 2.0-100.0g, bleeding agent 1.0-200.0g, amphoteric surfactant 3.3-333.3g.
2. according to claim 1, it is characterized in that in the compound ortho-phthalaldehyde thimerosal, the content of o-phthalaldehyde(OPA) is: the 0.1-10.0% quaternary alkylphosphonium salt: 0.1-10.0% organic acid: 0.1-10% bleeding agent: 0.1-20% amphoteric surfactant: 0.1-10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110090606.5A CN102197811B (en) | 2011-04-12 | 2011-04-12 | Compound orthophthalaldehyde disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110090606.5A CN102197811B (en) | 2011-04-12 | 2011-04-12 | Compound orthophthalaldehyde disinfectant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102197811A true CN102197811A (en) | 2011-09-28 |
| CN102197811B CN102197811B (en) | 2014-03-12 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110090606.5A Expired - Fee Related CN102197811B (en) | 2011-04-12 | 2011-04-12 | Compound orthophthalaldehyde disinfectant |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN105962002A (en) * | 2016-05-05 | 2016-09-28 | 中国农业科学院农产品加工研究所 | Method for killing bacterial spores in gentle manner |
| CN107960427A (en) * | 2017-11-28 | 2018-04-27 | 山西大学 | A kind of indoor sterilization disinfectant and preparation method thereof |
| CN113632788A (en) * | 2021-09-07 | 2021-11-12 | 南京巨鲨显示科技有限公司 | Disinfectant and preparation method thereof |
Citations (4)
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| CN1439261A (en) * | 2003-03-14 | 2003-09-03 | 杨书堂 | Composition of phthalyl diformaldehyde disinfectant |
| CN1613308A (en) * | 2004-09-24 | 2005-05-11 | 北京长江脉医药科技有限责任公司 | Antiseptics and preparation thereof |
| CN101785460A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
-
2011
- 2011-04-12 CN CN201110090606.5A patent/CN102197811B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1439261A (en) * | 2003-03-14 | 2003-09-03 | 杨书堂 | Composition of phthalyl diformaldehyde disinfectant |
| CN1613308A (en) * | 2004-09-24 | 2005-05-11 | 北京长江脉医药科技有限责任公司 | Antiseptics and preparation thereof |
| CN101785460A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN101926362A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound orthophaladetyde phenyl ammonium chloride disinfectant and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 林立旺等: "复方邻苯二甲醛的研制及消毒性能观察", 《中国消毒学杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636601A (en) * | 2013-12-10 | 2014-03-19 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN103636601B (en) * | 2013-12-10 | 2015-08-05 | 山东新华医疗器械股份有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN105962002A (en) * | 2016-05-05 | 2016-09-28 | 中国农业科学院农产品加工研究所 | Method for killing bacterial spores in gentle manner |
| CN105962002B (en) * | 2016-05-05 | 2019-07-09 | 中国农业科学院农产品加工研究所 | The method that mild formula kills bacterial spore |
| CN107960427A (en) * | 2017-11-28 | 2018-04-27 | 山西大学 | A kind of indoor sterilization disinfectant and preparation method thereof |
| CN113632788A (en) * | 2021-09-07 | 2021-11-12 | 南京巨鲨显示科技有限公司 | Disinfectant and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102197811B (en) | 2014-03-12 |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Jiangsu Tian Yijian disinfectant company limited Assignor: Chen Yiping|Pan Yunping|Wang Peipei Contract record no.: 2012320000826 Denomination of invention: Compound orthophthalaldehyde disinfectant License type: Exclusive License Open date: 20110928 Record date: 20120626 |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20140312 Termination date: 20160412 |