CN111617063B - Washing-free disinfectant - Google Patents
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Abstract
The invention provides a no-clean disinfectant and a preparation method and application thereof, wherein the disinfectant comprises the following components and contents of 20-130g/L of film-forming agent, 1-10g/L of perfluorinated organic compound, 800ml/L of ethanol 600-. The no-clean disinfectant can form a layer of protective film on the surface of an object, can disinfect and inhibit bacteria for a long time, and has good bactericidal effect by utilizing the synergistic effect of the film-forming agent, the ethanol and the perfluorinated organic compound.
Description
Technical Field
The invention relates to a no-clean disinfectant, a preparation method and application thereof.
Background
The disinfectant is used for killing pathogenic microorganisms on the transmission medium, so that the pathogenic microorganisms are killed outside a human body, and the transmission of the pathogenic microorganisms is controlled.
The disinfectant can be divided into three categories of high efficiency, medium efficiency and low efficiency according to the sterilization capability of the chemical disinfectant on microorganisms. The high-efficiency disinfectant is a disinfectant capable of killing all microorganisms including bacteria, fungi, bacterial spores and viruses. Such as chlorine dioxide, glutaraldehyde, hydrogen peroxide, etc., and such disinfectants are also known as sterilants. By a moderate disinfectant is meant a disinfectant that does not kill bacterial spores, but does kill bacterial propagules, fungi and most viruses. Such as ethanol, chlorine preparations, coal phenol soap solutions, and the like. The low-efficiency disinfectant is a disinfectant which can kill most of bacterial propagules, partial fungi and viruses but can not kill bacterial spores, tubercle bacillus and certain fungi and viruses, such as chlorhexidine, benzalkonium bromide, triclosan and the like.
The novel coronavirus belongs to the beta genus coronavirus, no direct data of the disinfection effect of the novel coronavirus exists at present, and based on the previous knowledge of the coronavirus, the coronavirus is an RNA virus with an envelope, and if the envelope is damaged by a disinfectant, RNA in the envelope can be degraded, so that the virus is inactivated. Based on the nature of coronavirus envelope, the envelope is mainly composed of 75% alcohol, ether, chloroform, formaldehyde, chlorine-containing disinfectant, peracetic acid and ultraviolet rays, which can inactivate coronavirus.
A disinfectant guideline is published in the national health commission office in 2020, 2 and 19, and ethanol content in alcohol disinfectant is regulated to be 70-80%, and ethanol content in the alcohol disinfectant is more than 60%, but the ethanol disinfection effect is short, and long-acting disinfection and bacteriostasis cannot be realized.
Because of the irritability of ethanol, the skin is easily chapped by long-term use of ethanol, which causes microbial invasion and microbial proliferation, and therefore, there is a need for a disinfectant containing ethanol, which has a long-lasting disinfecting and bacteriostatic action and reduces the irritability of ethanol.
Disclosure of Invention
The invention aims to provide a no-clean disinfectant which has long-acting disinfection and bacteriostasis, does not cause sticky feeling on a protective film and is friendly to skin, and a preparation method and application thereof. The washing-free disinfectant can form a protective film on the surface of an object and has long-acting disinfection and bacteriostasis effects. The perfluorinated organic compound is added into the disinfectant, so that the formed protective film can be disinfected and bacteriostatic for a long time, the hand sticking feeling is avoided after spraying, and the sprayed part is prevented from becoming red and allergic due to the fact that the environment is sealed after the film is formed.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention provides a no-clean disinfectant, which is characterized by comprising the following components in percentage by weight:
20-130g/L of film forming agent
1-10g/L of perfluorinated organic compound
Chlorhexidine gluconate 0.3-5g/L
Ethanol 600-
The balance being water.
As a preferable technical scheme of the invention, the no-clean disinfectant is characterized in that the disinfectant comprises the following components in percentage by weight:
50-100g/L of film-forming agent
2-6g/L of perfluorinated organic compound
Chlorhexidine gluconate 2.5-3.8g/L
780ml/L of ethanol 650-
The balance being water.
Preferably, the disinfectant comprises the following components in percentage by weight:
film forming agent 78g/L
Perfluoroorganic Compound 3.2g/L
Chlorhexidine gluconate 3.5g/L
Ethanol 750ml/L
The balance being water.
As a preferable technical solution of the present invention, the no-clean disinfectant is characterized in that the perfluorinated organic compound is one or more selected from perfluorohexane, perfluorinated perhydrophenanthrene, perfluorodecalin, and perfluorodimethylcyclohexane, and preferably, the perfluorinated organic compound comprises perfluorohexane: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethyl cyclohexane is as follows: (12-20): (21-33): (35-43): (5-9), preferably, the ratio of perfluorohexane: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethyl cyclohexane is as follows: 15:29:37:7.
As a preferable technical scheme, the no-clean disinfectant is characterized in that the film forming agent is prepared by the following method: mixing chitosan solution with the concentration of 6-15g/L, polyvinyl alcohol solution with the concentration of 200-300 g/L and tamarind gum solution with the concentration of 2-8g/L according to the volume ratio: (3-5): (4-6): (1-3) mixing, preferably, the film forming agent is prepared by the following method: mixing 7g/L chitosan solution, 257g/L polyvinyl alcohol solution and 4g/L tamarind gum solution according to the volume ratio: 4: 6: 2 and mixing.
As a preferable technical scheme, the no-clean disinfectant is characterized in that the chitosan solution is prepared by the following method:
adding 6-15g of chitosan into 1L of acetic acid solution with the weight percentage concentration of 2-5%, and stirring for 2-4h to form a chitosan solution.
As a preferable technical scheme of the invention, the no-clean disinfectant is characterized in that the disinfectant comprises the following components in percentage by weight:
film forming agent 78g/L
Perfluoroorganic Compound 3.2g/L
Chlorhexidine gluconate 3.5g/L
Ethanol 750ml/L
The balance of water;
wherein: among the perfluoroorganic compounds, perfluorohexane: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethyl cyclohexane is as follows: 15:29:37: 7;
the film forming agent is prepared by the following method: mixing 7g/L chitosan solution, 257g/L polyvinyl alcohol solution and 4g/L tamarind gum solution according to the volume ratio: 4: 6: 2 and mixing.
The invention also provides a preparation method of the no-clean disinfectant, which is characterized in that the disinfectant is prepared by the following method: adding the film forming agent, the perfluorinated organic compound, the ethanol and the water into a container, and stirring for 3-5 hours at normal temperature to prepare the disinfectant.
The invention also provides the use of the no-clean disinfectant, which is characterized in that the no-clean disinfectant is sprayed on the surface of an object to form a protective film.
The invention also provides application of the no-clean disinfectant, which is characterized in that the no-clean disinfectant is applied to preparing a skin external disinfectant for killing bacteria or viruses, preferably, the bacteria are escherichia coli, staphylococcus aureus and pseudomonas aeruginosa, and preferably, the viruses are influenza viruses.
The invention also provides a disinfecting product characterized in that it is prepared by combining the disinfecting solution of any one of claims 1 to 6 with a disinfecting solution carrier, preferably the disinfecting solution carrier is selected from the group consisting of cotton balls and gauze.
Compared with the prior art, the invention has the following beneficial effects:
(1) the no-clean disinfectant can form a layer of protective film on the surface of an object, can disinfect and inhibit bacteria for a long time, and has good bactericidal effect by utilizing the synergistic effect of the film-forming agent, the ethanol and the perfluorinated organic compound.
(2) The protective film formed after the no-clean disinfectant is sprayed is good in use experience, a subject can normally move after the protective film is formed, the formed protective film does not have a sticky feeling, the protective film is easy to remove, and the skin of the subject cannot be damaged due to overlarge tension.
(3) The perfluorinated organic matter added into the no-clean disinfectant increases the oxygen content of the protective film, so that a subject does not become red locally or cause allergy due to sealing after spraying.
(4) The no-clean disinfectant disclosed by the invention can be used in a plurality of scenes, and is suitable for disinfecting the surfaces of objects in hospitals, vehicles, dense population environments and epidemic areas.
Detailed Description
The present invention is not limited by the following examples, and specific embodiments may be determined according to the technical solutions and practical situations of the present invention.
Example 1
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 20g of film forming agent, 1g of perfluorinated organic compound, 0.3g of chlorhexidine gluconate, 600ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 2
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 50g of film forming agent, 2g of perfluorinated organic compound, 2.5g of chlorhexidine gluconate, 650ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 3
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 78g of film forming agent, 3.2g of perfluorinated organic compound, 3.5g of chlorhexidine gluconate, 750ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 4 an example of a disinfecting solution of the invention includes the following components: 100g of film forming agent, 6g of perfluorinated organic compound, 3.8g of chlorhexidine gluconate, 780ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 5
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 130g of film forming agent, 10g of perfluorinated organic compound, 5g of chlorhexidine gluconate, 800ml of ethanol and the balance of water, wherein the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 6
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 78g of film forming agent, 3.2g of perfluorinated organic compound, 3.5g of chlorhexidine gluconate, 750ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 6g/L, a polyvinyl alcohol solution with the concentration of 200g/L and a tamarind gum solution with the concentration of 2g/L according to the volume ratio of 3: 4: 1 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 7
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 78g of film forming agent, 3.2g of perfluorinated organic compound, 3.5g of chlorhexidine gluconate, 750ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 15g/L, a polyvinyl alcohol solution with the concentration of 300g/L and a tamarind gum solution with the concentration of 8g/L according to the volume ratio of 5: 6: 3, mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 8
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 78g of film forming agent, 3.2g of perfluorinated organic compound, 3.5g of chlorhexidine gluconate, 750ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethyl cyclohexane to the perfluorodimethyl cyclohexane is 12:21:35: 5.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Example 9
In one embodiment of the disinfecting solution of the present invention, the disinfecting solution comprises the following components: 78g of film forming agent, 3.2g of perfluorinated organic compound, 3.5g of chlorhexidine gluconate, 750ml of ethanol and the balance of water, and the total volume is 1 l.
Wherein the content of perfluorohexane in the perfluoroorganic compound is as follows: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethyl cyclohexane is 20:33:43: 9.
The film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
The chitosan solution is prepared by the following method: 8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
Comparative example 1
This comparative example provides a no-clean disinfectant having the same composition as example 3 except that it does not contain a perfluoro organic compound.
Comparative example 2
This comparative example provides a no-clean disinfectant, in which the perfluoro organic compound is perfluorohexane, and the other composition contents are the same as those in example 3.
Comparative example 3
The comparative example provides a no-clean disinfectant, wherein no tamarind gum solution is added in the preparation process of the film forming agent, and the other composition contents are the same as those in example 3.
Comparative example 4
The comparative example provides a no-clean disinfectant, wherein the chitosan solution is not added in the preparation process of the film forming agent, and the other composition contents are the same as those in the example 3.
Comparative example 5
A no-clean disinfectant comprises the following components:
ethanol 750ml/L
Chlorhexidine gluconate 3.5g/L
The balance of water
The leave-on disinfectant solutions of examples 1 to 9 and comparative examples 1 to 4 were subjected to skin irritation test, sterilization effect test, stability test, and hand contamination test, and the test results are shown below.
Experimental example I, skin irritation test
Selecting 12 adult healthy SD rats, and shearing the back hairs on two sides of the spine of the experimental animal, wherein the hair removing range is 1.5cm multiplied by 1.5 cm; 0.3mL of the disinfectant prepared in examples 1 to 9 and comparative examples 1 to 3 was applied directly to the skin, and then covered and fixed with two layers of gauze (2 cm. times.2 cm) and one layer of non-irritating oilpaper, and the other side was used as a control. After 2h of stimulation, removing residual test substances by using deionized water; the application is carried out for 7 days 1 time per day, and the result is observed 12h after each application.
| Group of | Effect of irritation test |
| Example 1 | No erythema and redness |
| Example 2 | No erythema and redness |
| Example 3 | No erythema and redness |
| Example 4 | No erythema and redness |
| Example 5 | No erythema and redness |
| Example 6 | No erythema and redness |
| Example 7 | No erythema and redness |
| Example 8 | No erythema and redness |
| Example 9 | No erythema and redness |
| Comparative example 1 | Moderate red and swollen |
| Comparative example 2 | Slight red and swollen |
| Comparative example 3 | Slight red and swollen |
| Comparative example 4 | No erythema and redness |
The results show that after 7 days of continuous smearing, the SD rats in examples 1-9 have no erythema and redness, the SD rat has moderate redness and redness, the perfluoro organic compound in comparative example 1 is perfluorohexane, and the SD rat has slight redness and redness, which shows that the disinfection solution of the application has a certain amount of oxygen in the protective film after spraying the disinfection solution by adding several different perfluoro organic compounds and mutual synergy between the organic compounds, so that the redness and swelling caused by a closed environment are avoided, the SD rat has slight redness and swelling without adding the tamarind gum solution in the preparation process of the protective film in comparative example 3, and researches show that the skin allergic reaction can be caused by chitosan, and the allergic reaction of the chitosan can be eliminated by adding the tamarind gum solution.
Experimental example II, monitoring of Sterilization Effect
The examples and the comparative examples are tested for the bactericidal effect according to the carrier soaking quantitative bactericidal test in the disinfectant technical specification 2002 edition, the average values of the killing time and the killing rate of three bacteria including staphylococcus aureus, escherichia coli and pseudomonas aeruginosa are calculated, and the bacteriostasis time with the bacterial proliferation rate lower than 10% is tested, and the results are shown in the table 2;
| group of | Killing time min | The killing rate% | Time of bacteriostasis h |
| Example 1 | 0.7 | 99.9% | 23.5 |
| Example 2 | 0.5 | 99.9% | 25.2 |
| Example 3 | 0.4 | 99.9% | 29.2 |
| Example 4 | 0.6 | 99.9% | 26.4 |
| Example 5 | 0.7 | 99.9% | 23.8 |
| Example 6 | 0.5 | 99.9% | 21.3 |
| Example 7 | 0.5 | 99.9% | 19.6 |
| Example 8 | 0.7 | 99.9% | 21.6 |
| Example 9 | 0.6 | 99.9% | 22.5 |
| Comparative example 1 | 0.7 | 99.9% | 13.5 |
| Comparative example 2 | 0.7 | 99.9% | 16.5 |
| Comparative example 3 | 0.6 | 99.9% | 16.9 |
| Comparative example 4 | 0.7 | 99.9% | 14.6 |
| Comparative example 5 | 0.6 | 99.9% | 0.5 |
As can be seen from Table 2, the disinfectant prepared in examples 1-9 has short bacteria killing time, high killing rate, long bacteriostasis time of 29.2h, and the comparative example 1 lacks of perfluoro organic compounds, which obviously shortens the bacteriostasis time, the comparative example 2 lacks of perfluoro hexane, which shortens the bacteriostasis time as well, while the comparative example 3 lacks of tamarind gum solution, which also reduces the bacteriostasis time, the comparative example 5 only contains ethanol and chlorhexidine gluconate, which greatly shortens the bacteriostasis time, which indicates that the formed protective film can prolong the bacteriostasis time and improve the killing rate of bacteria, and the bacteriostasis time can be further prolonged by the preparation of film forming agent and perfluoro organic compounds in the disinfectant.
Experimental example III stability test
1. Test subjects: wash-free disinfectant prepared in examples 1-9 and comparative examples 1 and 3
2. The test method comprises the following steps:
heat resistance stability: the no-clean disinfectant prepared in examples 1 to 9 and comparative examples 1 and 3 was stored in a plastic bottle, allowed to stand at 42 ± 2 ℃ for 3 months, taken out and returned to normal temperature, and the appearance of the sample was observed. The test results are shown in Table 1
TABLE 3 appearance
| Group of | 0 month | 1 month | 2 month | 3 month |
| Example 1 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 2 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 3 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 4 | ||||
| Example 5 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 6 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 7 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 8 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Example 9 | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity | No demixing, no peculiar smell, no turbidity |
| Comparative example 1 | No demixing, no peculiar smell, no turbidity | No demixing, slight turbidity of the product, no peculiar smell | No demixing, turbidity and peculiar smell | |
| Comparative example 3 | No demixing, no peculiar smell, no turbidity | Demixing without off-taste | ---- | ---- |
High and low temperature stability: storing the bottled non-washing disinfectant at-20 deg.C for 24h, taking out, standing at room temperature for 24h, standing at 42 + -2 deg.C for 24h, repeating the operation for 2 times, and observing the appearance of the non-washing disinfectant
TABLE 4 appearance
| Group of | Appearance of the product |
| Example 1 | No delamination and no odor, and the product is transparent |
| Example 2 | No delamination and no odor, and the product is transparent |
| Example 3 | No delamination and no odor, and the product is transparent |
| Example 4 | No delamination and no odor, and the product is transparent |
| Example 5 | No delamination and no odor, and the product is transparent |
| Example 6 | No delamination and no odor, and the product is transparent |
| Example 7 | No delamination and no odor, and the product is transparent |
| Example 8 | No delamination and no odor, and the product is transparent |
| Example 9 | No delamination and no odor, and the product is transparent |
| Comparative example 1 | Delamination and production ofTurbid product |
| Comparative example 3 | Demixing, product cloudiness |
As is clear from the results in tables 3 and 4, the addition of the perfluoro organic compound and tamarind gum in examples 1-9 can improve the quality of the no-clean disinfectant
Experimental example four, hand contamination test
And 2 subjects are divided into 13 groups, all the subjects are sprayed with the no-clean disinfectant of the comparative example 5 on the first day, the subjects are sprayed with the no-clean disinfectant of the examples 1-9 and the comparative examples 1-4 on the 3 rd day respectively and then carry out normal activities, after 4 hours, the forms of the protective films are observed, the subjects slightly press LB agar plates with two hands, the LB agar plates are incubated overnight at 37 ℃, the colony count is counted, and the bacteriostasis rate is calculated.
The first day inhibition rate = (number of colonies before treatment-number of colonies of spray comparative example 5), the test results are as follows:
TABLE 5 bacteriostasis rate of comparative example 5
| Group of | Comparative example 5 bacteriostatic ratio (%) |
| Subject 1 | 12.3 |
| Subject 2 | 13.4 |
| Subject 3 | 14.5 |
| Subject 4 | 12.6 |
| Subject 5 | 18.2 |
| Subject 6 | 13.7 |
| Subject 7 | 12.6 |
| Subject 8 | 12.7 |
| Subject 9 | 13.2 |
| Subject 10 | 14.2 |
| Subject 11 | 16.7 |
| Subject 12 | 12.7 |
| Subject 13 | 12.7 |
As is clear from the results in Table 5, the leave-on disinfectant of comparative example 5, which contains only 75% alcohol and chlorhexidine gluconate, rapidly volatilizes after alcohol spraying, has a short antibacterial effect, and subjects need to frequently sterilize, and the skin is easily dried and chapped due to the irritation of alcohol.
The bacteriostasis rate on the third day = (the number of colonies before treatment-the number of colonies sprayed with disinfectant), and the test results are as follows:
TABLE 6
| Group of | Antibacterial ratio (%) of no-clean disinfectant | Form of the protective film |
| Subject 1 (example 1) | 81.7 | The protective film is complete and is not sticky |
| Subject 2 (example 2) | 83.5 | The protective film is complete and is not sticky |
| Subject 3 (example 3) | 91.6 | The protective film is complete and is not sticky |
| Subject 4 (example 4) | 85.7 | The protective film is complete and is not sticky |
| Subject 5 (example 5) | 82.3 | The protective film is complete and is not sticky |
| Subject 6 (example 6) | 83.6 | The protective film is complete and is not sticky |
| Subject 7 (example 7) | 81.4 | The protective film is complete and is not sticky |
| Subject 8 (example 8) | 83.2 | The protective film is complete and is not sticky |
| Subject 9 (example 9) | 82.4 | The protective film is complete and is not sticky |
| Subject 10 (comparative example 1) | 54.2 | The protective film partially falls off and agglomerates |
| Subject 11 (comparative example 2) | 69.5 | The protective film partially falls off and agglomerates |
| Subject 12 (comparative example 3) | 61.6 | The protective film partially falls off and agglomerates |
| Subject 13 (comparative example 4) | 63.1 | The protective film partially falls off and agglomerates |
From the experimental results, it can be seen that the subjects 1-9 were sprayed with the leave-on disinfectant of examples 1-9, respectively, to form films on the surfaces of both hands, thereby inhibiting the growth of bacteria and prolonging the disinfection effect. And the perfluorinated organic compound, the film-forming agent, the ethanol and the chlorhexidine gluconate are matched with each other, so that the antibacterial rate can be improved, and the formula of the perfluorinated organic compound, the film-forming agent, the ethanol and the chlorhexidine gluconate can ensure that the protective film of the no-clean disinfectant after film formation is complete and is not sticky.
The applicant states that the present invention is illustrated in detail by the above examples, but the present invention is not limited to the above detailed methods, i.e. it is not meant that the present invention must rely on the above detailed methods for its implementation. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (14)
1. The no-clean disinfectant is characterized by comprising the following components in percentage by weight:
20-130g/L of film forming agent
1-10g/L of perfluorinated organic compound
Ethanol 600-
Chlorhexidine gluconate 0.3-5g/L
The balance of water;
among the perfluoroorganic compounds, perfluorohexane: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is (12-20): (21-33): (35-43): (5-9);
the film forming agent is prepared by the following method: mixing chitosan solution with concentration of 6-15g/L, polyvinyl alcohol solution with concentration of 200-300 g/L, and tamarind gum solution with concentration of 2-8g/L according to volume ratio (3-5): (4-6): (1-3) mixing.
2. The no-clean disinfectant as claimed in claim 1, wherein the disinfectant comprises the following components by weight:
50-100g/L of film-forming agent
2-6g/L of perfluorinated organic compound
780ml/L of ethanol 650-
Chlorhexidine gluconate 2.5-3.8g/L
The balance being water.
3. The no-clean disinfectant as claimed in claim 1, wherein the disinfectant comprises the following components by weight:
film forming agent 78g/L
Perfluoroorganic Compound 3.2g/L
Chlorhexidine gluconate 3.5g/L
Ethanol 750ml/L
The balance being water.
4. The leave-in disinfectant of claim 1 wherein the ratio of perfluorohexane: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethylcyclohexane is 15:29:37: 7.
5. The leave-in disinfectant of claim 1 wherein said film former is prepared by the process of: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
6. The leave-in disinfectant of claim 1 wherein said chitosan solution is prepared by the following process:
adding 6-15g of chitosan into 1L of acetic acid solution with the weight percentage concentration of 2-5%, and stirring for 2-4h to form a chitosan solution.
7. The leave-in disinfectant of claim 1 wherein said chitosan solution is prepared by the following process:
8g of chitosan is added into 1L of acetic acid solution with the weight percentage concentration of 2.5 percent, and the chitosan solution is formed after stirring for 3 hours.
8. The no-clean disinfectant as claimed in claim 1, wherein the components and contents of the disinfectant are as follows:
film forming agent 78g/L
Perfluoroorganic Compound 3.2g/L
Chlorhexidine gluconate 3.5g/L
Ethanol 750ml/L
The balance of water;
wherein: among the perfluoroorganic compounds, perfluorohexane: perfluoro perhydrophenanthrene: perfluorodecalin: the mass ratio of the perfluorodimethyl cyclohexane to the perfluorodimethyl cyclohexane is 15:29:37: 7;
the film forming agent is prepared by the following method: mixing a chitosan solution with the concentration of 7g/L, a polyvinyl alcohol solution with the concentration of 257g/L and a tamarind gum solution with the concentration of 4g/L according to the volume ratio of 4: 6: 2 and mixing.
9. Use of the no-clean disinfectant according to any one of claims 1 to 6, wherein the no-clean disinfectant is used for preparing a skin external disinfectant for killing bacteria or viruses.
10. The use of the no-clean disinfectant as claimed in claim 9, wherein the no-clean disinfectant is sprayed on the surface of an object to form a protective film.
11. The use of the leave-in disinfectant of claim 9 wherein the bacteria are escherichia coli, staphylococcus aureus, pseudomonas aeruginosa.
12. The use of the leave-in disinfectant of claim 9 wherein the virus is an influenza virus.
13. A disinfecting product prepared by combining the disinfecting solution of any one of claims 1 to 6 and a disinfecting solution carrier.
14. A disinfecting product as recited in claim 13, wherein said disinfecting liquid carrier is selected from the group consisting of cotton balls and gauze.
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