CN101918380B - 用于治疗炎性、心血管和cns病症的取代苯并唑pde4抑制剂 - Google Patents

用于治疗炎性、心血管和cns病症的取代苯并唑pde4抑制剂 Download PDF

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CN101918380B
CN101918380B CN200880125182.8A CN200880125182A CN101918380B CN 101918380 B CN101918380 B CN 101918380B CN 200880125182 A CN200880125182 A CN 200880125182A CN 101918380 B CN101918380 B CN 101918380B
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nhc
mmol
compound
phenyl
stirred
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CN101918380A (zh
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J·辛格
M·格尼
A·布尔金
V·桑达纳亚卡
A·吉谢廖夫
M·拉奥
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Decode Genetics ehf
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D277/62—Benzothiazoles
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  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200880125182.8A 2007-11-21 2008-11-20 用于治疗炎性、心血管和cns病症的取代苯并唑pde4抑制剂 Expired - Fee Related CN101918380B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98955707P 2007-11-21 2007-11-21
US60/989,557 2007-11-21
PCT/US2008/084199 WO2009067604A1 (en) 2007-11-21 2008-11-20 Substituted benzoazole pde4 inhibitors for treating inflammatory, cardiovascular and cns disorders

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CN101918380A CN101918380A (zh) 2010-12-15
CN101918380B true CN101918380B (zh) 2014-09-24

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CN200880125182.8A Expired - Fee Related CN101918380B (zh) 2007-11-21 2008-11-20 用于治疗炎性、心血管和cns病症的取代苯并唑pde4抑制剂
CN2008801251917A Pending CN101918381A (zh) 2007-11-21 2008-11-20 用于治疗肺部和心血管病症的取代苯并唑pde4抑制剂

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US (4) US20090130076A1 (https=)
EP (2) EP2225215A1 (https=)
JP (2) JP5524853B2 (https=)
KR (2) KR20100097711A (https=)
CN (2) CN101918380B (https=)
AU (2) AU2008326399C1 (https=)
CA (2) CA2722591A1 (https=)
IL (3) IL205884A0 (https=)
WO (2) WO2009067618A1 (https=)

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JP2533136Y2 (ja) 1991-03-01 1997-04-23 株式会社アマダ パンチプレス
US20090130076A1 (en) * 2007-11-21 2009-05-21 Decode Genetics Ehf Substituted benzoazole pde4 inhibitors for treating pulmonary and cardiovascular disorders
JP2011504505A (ja) * 2007-11-21 2011-02-10 デコード ジェネティクス イーエイチエフ 肺および心血管障害を治療するためのビアリールｐｄｅ４抑制剤
US8865723B2 (en) * 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
JP6282721B2 (ja) 2013-03-14 2018-02-21 ダート・ニューロサイエンス・（ケイマン）・リミテッド Ｐｄｅ４阻害剤としての置換ピリジン及びピラジン化合物
AU2016287463B2 (en) * 2015-07-02 2020-07-02 F. Hoffmann-La Roche Ag Benzoxazepin oxazolidinone compounds and methods of use
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
US12317744B2 (en) 2016-07-07 2025-05-27 Hodogaya Chemical Co., Ltd. Compound having a fused-azole ring structure and organic electroluminescent element
CN109053623B (zh) * 2018-08-27 2020-08-04 济南悟通生物科技有限公司 一种4-甲基-5-噻唑甲醛的制备方法
EP3925958A1 (en) * 2019-02-13 2021-12-22 Hodogaya Chemical Co., Ltd. Compound having benzazole ring structure, and organic electroluminescent device
GB202102088D0 (en) * 2021-02-15 2021-03-31 Mironid Ltd Compounds and their use as pde4 activators
CN115215800B (zh) * 2021-04-21 2023-07-18 赣江中药创新中心 一种二苯并环基-环胺基醚衍生物或盐及其制备方法和应用
WO2025194063A1 (en) * 2024-03-15 2025-09-18 Board Of Trustees Of Northern Illinois University Benzothiazole derivatives for treating diseases

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WO2009067618A1 (en) 2009-05-28
AU2008326385B2 (en) 2013-12-05
CN101918380A (zh) 2010-12-15
KR20100090289A (ko) 2010-08-13
CA2722586A1 (en) 2009-05-28
AU2008326399A1 (en) 2009-05-28
AU2008326385A1 (en) 2009-05-28
US8883833B2 (en) 2014-11-11
KR20100097711A (ko) 2010-09-03
US20120207729A1 (en) 2012-08-16
IL205883A0 (en) 2010-11-30
IL261853A (en) 2018-10-31
IL205884A0 (en) 2010-11-30
US20090130076A1 (en) 2009-05-21
AU2008326399C1 (en) 2014-08-14
CA2722591A1 (en) 2009-05-28
EP2225216A1 (en) 2010-09-08
CN101918381A (zh) 2010-12-15
WO2009067604A1 (en) 2009-05-28
US20140275553A1 (en) 2014-09-18
EP2225215A1 (en) 2010-09-08
JP5524853B2 (ja) 2014-06-18
JP2011504504A (ja) 2011-02-10
JP2011504183A (ja) 2011-02-03
US20090130077A1 (en) 2009-05-21
AU2008326399B2 (en) 2014-01-16
JP5529746B2 (ja) 2014-06-25

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