CN101914581B - 一种提高多烯不饱和脂肪酸发酵产量的方法 - Google Patents
一种提高多烯不饱和脂肪酸发酵产量的方法 Download PDFInfo
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- CN101914581B CN101914581B CN201010237946.1A CN201010237946A CN101914581B CN 101914581 B CN101914581 B CN 101914581B CN 201010237946 A CN201010237946 A CN 201010237946A CN 101914581 B CN101914581 B CN 101914581B
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- fatty acid
- fermentation
- trehalose
- fermention medium
- unsaturated fatty
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- 238000000855 fermentation Methods 0.000 title claims abstract description 28
- 230000004151 fermentation Effects 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 26
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title abstract 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000003595 Aurantiochytrium limacinum Species 0.000 claims abstract description 16
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 13
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 13
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 13
- 229960003237 betaine Drugs 0.000 claims abstract description 13
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 14
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 10
- -1 polyene unsaturated fatty acid Chemical class 0.000 claims description 6
- 239000000463 material Substances 0.000 abstract description 6
- 244000005700 microbiome Species 0.000 abstract description 6
- 239000001963 growth medium Substances 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 241000233671 Schizochytrium Species 0.000 abstract 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 22
- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
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- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 4
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
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- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
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- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000233652 Chytridiomycota Species 0.000 description 1
- 241000199914 Dinophyceae Species 0.000 description 1
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241000144833 Halomonas salina Species 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 206010047400 Vibrio infections Diseases 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
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- 235000019197 fats Nutrition 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
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- 238000013467 fragmentation Methods 0.000 description 1
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- 235000013922 glutamic acid Nutrition 0.000 description 1
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- 239000013067 intermediate product Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
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- 230000035699 permeability Effects 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010237946.1A CN101914581B (zh) | 2010-07-27 | 2010-07-27 | 一种提高多烯不饱和脂肪酸发酵产量的方法 |
US13/812,496 US20130217085A1 (en) | 2010-07-27 | 2011-01-13 | Methods for improving fermentation yield of polyunsaturated fatty acids |
PCT/CN2011/070240 WO2012013025A1 (zh) | 2010-07-27 | 2011-01-13 | 提高多烯不饱和脂肪酸发酵产量的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010237946.1A CN101914581B (zh) | 2010-07-27 | 2010-07-27 | 一种提高多烯不饱和脂肪酸发酵产量的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101914581A CN101914581A (zh) | 2010-12-15 |
CN101914581B true CN101914581B (zh) | 2012-05-23 |
Family
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CN201010237946.1A Active CN101914581B (zh) | 2010-07-27 | 2010-07-27 | 一种提高多烯不饱和脂肪酸发酵产量的方法 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20130217085A1 (zh) |
CN (1) | CN101914581B (zh) |
WO (1) | WO2012013025A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101914581B (zh) * | 2010-07-27 | 2012-05-23 | 南京工业大学 | 一种提高多烯不饱和脂肪酸发酵产量的方法 |
CN102839129A (zh) * | 2011-06-23 | 2012-12-26 | 法国罗凯特兄弟公司 | 一种裂殖壶菌诱变方法及其产生的变异株 |
CN103305574B (zh) * | 2013-07-16 | 2016-01-27 | 深圳康泰生物制品股份有限公司 | 表达HBsAg的重组酿酒酵母菌发酵培养基及其配制方法和发酵工艺 |
CN104357498A (zh) * | 2014-09-24 | 2015-02-18 | 江苏省农业科学院 | 一种2,4-二氯苯氧乙酸在提高裂壶藻dha产量及促进裂壶藻油脂积累中的应用 |
CN105132485B (zh) * | 2015-09-24 | 2019-06-18 | 山东祥维斯生物科技股份有限公司 | 一种裂殖壶菌发酵生产dha的方法 |
FR3045069B1 (fr) * | 2015-12-14 | 2019-01-25 | Metabolium | Procede d'enrichissement de protistes en lipides riches en acides gras polyinsatures, plus particulierement de classe omega 3, et sa mise en oeuvre pour la production de ces lipides |
CN114009625B (zh) * | 2021-10-18 | 2024-06-25 | 南京师范大学 | 水产养殖饲料及其制备方法 |
CN116479063B (zh) * | 2023-05-04 | 2024-02-20 | 厦门汇盛生物有限公司 | 一种ω-3多不饱和脂肪酸的生产方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1916156A (zh) * | 2006-07-10 | 2007-02-21 | 温州大学 | 裂殖壶菌(Schizochytrium)WZU4771及其在制备DHA粉末和油脂中的应用 |
CN101575584A (zh) * | 2009-06-18 | 2009-11-11 | 南京工业大学 | 一种裂殖弧菌及利用其生产dha油脂的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1549753B1 (en) * | 2002-10-11 | 2010-09-08 | Nippon Suisan Kaisha, Ltd. | Process for producing microbial fat or oil having lowered unsaponifiable matter content |
WO2007120198A2 (en) * | 2005-11-08 | 2007-10-25 | University Of Florida Research Foundation, Inc. | Materials and methods for improved microbial production of organic compounds |
WO2007074479A1 (en) * | 2005-12-29 | 2007-07-05 | Abl Biotechnologies Ltd | Novel strain of schizochytrium limacinum useful in the production of lipids and extracellular polysaccharides and process thereof |
EP2105506A1 (de) * | 2008-03-26 | 2009-09-30 | Lonza Ag | Verfahren zur Herstellung PUFAs enthaltender Öle unter Verwendung von Mikroorganismen der Ordnung Labyrinthulomycota |
CN101914581B (zh) * | 2010-07-27 | 2012-05-23 | 南京工业大学 | 一种提高多烯不饱和脂肪酸发酵产量的方法 |
-
2010
- 2010-07-27 CN CN201010237946.1A patent/CN101914581B/zh active Active
-
2011
- 2011-01-13 US US13/812,496 patent/US20130217085A1/en not_active Abandoned
- 2011-01-13 WO PCT/CN2011/070240 patent/WO2012013025A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1916156A (zh) * | 2006-07-10 | 2007-02-21 | 温州大学 | 裂殖壶菌(Schizochytrium)WZU4771及其在制备DHA粉末和油脂中的应用 |
CN101575584A (zh) * | 2009-06-18 | 2009-11-11 | 南京工业大学 | 一种裂殖弧菌及利用其生产dha油脂的方法 |
Non-Patent Citations (1)
Title |
---|
陈诚.裂殖壶菌(Schizochytrium limacinum SR21)发酵制备二十二碳六烯酸(DHA)过程的初步研究.《中国优秀硕士学位论文》.2007,全文. * |
Also Published As
Publication number | Publication date |
---|---|
US20130217085A1 (en) | 2013-08-22 |
CN101914581A (zh) | 2010-12-15 |
WO2012013025A1 (zh) | 2012-02-02 |
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Address after: Room 207 and 208, building D6, Jiangsu Life Science Park, No. 9, Weidi Road, Xianlin street, Qixia District, Nanjing, Jiangsu 210000 Patentee after: Zhihe Biotechnology (Changzhou) Co.,Ltd. Country or region after: China Address before: Room 207 and 208, building D6, Jiangsu Life Science Park, No. 9, Weidi Road, Xianlin street, Qixia District, Nanjing, Jiangsu 210000 Patentee before: Nanjing Zhihe Biotechnology Co.,Ltd. Country or region before: China |
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