CN101914093B - 反应性的杂环取代的7-羟基香豆素类以及它们的结合物 - Google Patents

反应性的杂环取代的7-羟基香豆素类以及它们的结合物 Download PDF

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CN101914093B
CN101914093B CN201010228953.5A CN201010228953A CN101914093B CN 101914093 B CN101914093 B CN 101914093B CN 201010228953 A CN201010228953 A CN 201010228953A CN 101914093 B CN101914093 B CN 101914093B
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CN101914093A (zh
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第五振君
T·杜布洛韦斯基
B·阿布拉姆斯
廖劲芳
孟庆林
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Becton Dickinson and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201010228953.5A 2009-04-01 2010-04-01 反应性的杂环取代的7-羟基香豆素类以及它们的结合物 Active CN101914093B (zh)

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US16586209P 2009-04-01 2009-04-01
US61/165,862 2009-04-01

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US (1) US8431416B2 (enExample)
EP (1) EP2236508B1 (enExample)
JP (1) JP5697886B2 (enExample)
CN (1) CN101914093B (enExample)
ES (1) ES2548380T3 (enExample)
SG (1) SG165300A1 (enExample)

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US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
EP2691383B1 (en) * 2011-03-30 2015-01-21 3M Innovative Properties Company Fluorogenic or fluorophoric compounds and uses thereof
KR102022483B1 (ko) * 2012-03-29 2019-09-18 스미또모 가가꾸 가부시키가이샤 염료용 화합물
ES2628529T3 (es) 2012-10-24 2017-08-03 Tintes de cianina-azaindolina sustituidos con hidroxamato, y bioconjugados de los mismos
RU2733740C2 (ru) * 2015-06-29 2020-10-06 Иммуноджен, Инк. Конъюгаты сконструированных антител с цистеиновыми заменами
ITUA20161706A1 (it) * 2016-03-15 2017-09-15 Cyanagen S R L Nuovi coloranti cumarinici e relativi coniugati
KR102836360B1 (ko) 2016-04-15 2025-07-23 베크만 컬터, 인코포레이티드 광활성 거대분자 및 그의 용도
JP6821490B2 (ja) * 2017-04-03 2021-01-27 日本化薬株式会社 クマリン化合物又はそれらの塩、並びにこれを含んだ顔料組成物
GB201716931D0 (en) * 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
AU2019425175A1 (en) * 2019-01-21 2021-08-19 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Advanced methods for automated high-performance identification of carbohydrates and carbohydrate mixture composition patterns and systems therefore as well as methods for calibration of multi wavelength fluorescence detection systems therefore, based on new fluorescent dyes
CN109721592B (zh) * 2019-03-04 2022-09-30 河南理工大学 一种含香豆素的氨基吡嗪酰腙衍生物的荧光探针及其制备方法和应用
EP3747957A1 (en) 2019-06-07 2020-12-09 Universidade de Évora Fluorescent vinyl tiophene and bitiophene coumarins dyes and method of synthesis thereof
WO2021154933A1 (en) * 2020-01-30 2021-08-05 Aat Bioquest, Inc. Uv excitable polyfluorene based conjugates and their use in methods of analyte detection
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
CN112679569B (zh) * 2020-10-22 2022-05-27 山西大学 一种荧光探针及其制备方法和应用
CN117015711A (zh) 2021-02-05 2023-11-07 贝克曼库尔特有限公司 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法
CN113121513B (zh) * 2021-04-26 2023-05-16 安徽大学 一种咔唑-香豆素基腙类化合物及其制备方法和用途
JP2024517437A (ja) 2021-05-04 2024-04-22 ベックマン コールター， インコーポレイテッド Ｕｖ吸収性ポリマー、組成物およびその使用
CN120936679A (zh) 2023-03-17 2025-11-11 贝克曼库尔特有限公司 苯并噻吩并吡咯花菁染料

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ES2548380T3 (es) 2015-10-16
CN101914093A (zh) 2010-12-15
JP2010254993A (ja) 2010-11-11
EP2236508A1 (en) 2010-10-06
SG165300A1 (en) 2010-10-28
EP2236508B1 (en) 2015-08-26
JP5697886B2 (ja) 2015-04-08
US20100255504A1 (en) 2010-10-07
US8431416B2 (en) 2013-04-30

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