ES2548380T3 - 7-Hidroxicumarinas sustituidas con heterociclo reactivas y sus conjugados - Google Patents

7-Hidroxicumarinas sustituidas con heterociclo reactivas y sus conjugados Download PDF

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Publication number
ES2548380T3
ES2548380T3 ES10158457.1T ES10158457T ES2548380T3 ES 2548380 T3 ES2548380 T3 ES 2548380T3 ES 10158457 T ES10158457 T ES 10158457T ES 2548380 T3 ES2548380 T3 ES 2548380T3
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ES
Spain
Prior art keywords
compound
alkyl
alkoxy
amino
dye
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Active
Application number
ES10158457.1T
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English (en)
Spanish (es)
Inventor
Zhenjun Diwu
Timothy Dubrovsky
Barnaby Abrams
Jinfang Liao
Qinglin Meng
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Becton Dickinson and Co
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Becton Dickinson and Co
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Publication of ES2548380T3 publication Critical patent/ES2548380T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
ES10158457.1T 2009-04-01 2010-03-30 7-Hidroxicumarinas sustituidas con heterociclo reactivas y sus conjugados Active ES2548380T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US165862P 1999-11-16
US16586209P 2009-04-01 2009-04-01

Publications (1)

Publication Number Publication Date
ES2548380T3 true ES2548380T3 (es) 2015-10-16

Family

ID=42224506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10158457.1T Active ES2548380T3 (es) 2009-04-01 2010-03-30 7-Hidroxicumarinas sustituidas con heterociclo reactivas y sus conjugados

Country Status (6)

Country Link
US (1) US8431416B2 (enExample)
EP (1) EP2236508B1 (enExample)
JP (1) JP5697886B2 (enExample)
CN (1) CN101914093B (enExample)
ES (1) ES2548380T3 (enExample)
SG (1) SG165300A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
EP2691383B1 (en) * 2011-03-30 2015-01-21 3M Innovative Properties Company Fluorogenic or fluorophoric compounds and uses thereof
KR102022483B1 (ko) * 2012-03-29 2019-09-18 스미또모 가가꾸 가부시키가이샤 염료용 화합물
ES2628529T3 (es) 2012-10-24 2017-08-03 Tintes de cianina-azaindolina sustituidos con hidroxamato, y bioconjugados de los mismos
RU2733740C2 (ru) * 2015-06-29 2020-10-06 Иммуноджен, Инк. Конъюгаты сконструированных антител с цистеиновыми заменами
ITUA20161706A1 (it) * 2016-03-15 2017-09-15 Cyanagen S R L Nuovi coloranti cumarinici e relativi coniugati
KR102836360B1 (ko) 2016-04-15 2025-07-23 베크만 컬터, 인코포레이티드 광활성 거대분자 및 그의 용도
JP6821490B2 (ja) * 2017-04-03 2021-01-27 日本化薬株式会社 クマリン化合物又はそれらの塩、並びにこれを含んだ顔料組成物
GB201716931D0 (en) * 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
AU2019425175A1 (en) * 2019-01-21 2021-08-19 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Advanced methods for automated high-performance identification of carbohydrates and carbohydrate mixture composition patterns and systems therefore as well as methods for calibration of multi wavelength fluorescence detection systems therefore, based on new fluorescent dyes
CN109721592B (zh) * 2019-03-04 2022-09-30 河南理工大学 一种含香豆素的氨基吡嗪酰腙衍生物的荧光探针及其制备方法和应用
EP3747957A1 (en) 2019-06-07 2020-12-09 Universidade de Évora Fluorescent vinyl tiophene and bitiophene coumarins dyes and method of synthesis thereof
WO2021154933A1 (en) * 2020-01-30 2021-08-05 Aat Bioquest, Inc. Uv excitable polyfluorene based conjugates and their use in methods of analyte detection
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
CN112679569B (zh) * 2020-10-22 2022-05-27 山西大学 一种荧光探针及其制备方法和应用
CN117015711A (zh) 2021-02-05 2023-11-07 贝克曼库尔特有限公司 用于阻止聚合物染料-抗体缀合物之间的非特异性相互作用的组合物和方法
CN113121513B (zh) * 2021-04-26 2023-05-16 安徽大学 一种咔唑-香豆素基腙类化合物及其制备方法和用途
JP2024517437A (ja) 2021-05-04 2024-04-22 ベックマン コールター， インコーポレイテッド Ｕｖ吸収性ポリマー、組成物およびその使用
CN120936679A (zh) 2023-03-17 2025-11-11 贝克曼库尔特有限公司 苯并噻吩并吡咯花菁染料

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3556959A (en) 1968-03-29 1971-01-19 Frank Passal Nickel plating
IT1088554B (it) 1977-11-17 1985-06-10 F I D I A Spa Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina
US4235781A (en) 1979-09-20 1980-11-25 Thomas C. Elder, Inc. 6 Or 8 Haloallyl substituted 7-hydroxycoumarins
US4259233A (en) 1979-10-23 1981-03-31 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
DE3044128A1 (de) 1980-11-24 1982-07-15 Bayer Ag, 5090 Leverkusen Cumarine, verfahren zu ihrer herstellung und ihre verwendung
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
SE8505716D0 (sv) 1985-12-03 1985-12-03 Biocarb Ab Novel compounds and conjugates thereof
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5049673A (en) 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
US5405975A (en) 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
US5648270A (en) 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5453517A (en) 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
US5516629A (en) 1990-04-16 1996-05-14 Cryopharm Corporation Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins
NL9001639A (nl) 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
YU187991A (sh) 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5516911A (en) 1993-12-30 1996-05-14 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent intracellular calcium indicators
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
US5741657A (en) 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
US6342379B1 (en) 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5684142A (en) 1995-06-07 1997-11-04 Oncor, Inc. Modified nucleotides for nucleic acid labeling
US5668268A (en) 1995-11-27 1997-09-16 Hybridon, Inc. Passivated polymer supports for nucleic acid synthesis
US5955604A (en) 1996-10-15 1999-09-21 The Regents Of The University Of California Substrates for β-lactamase and uses thereof
US5696157A (en) * 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US5830912A (en) * 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
US6207404B1 (en) 1999-09-30 2001-03-27 Gentest Corporation Coumarin-based CYP3A fluorescent assay reagents
US7304168B2 (en) 2003-08-14 2007-12-04 Board Of Regents, University Of Texas System Photo-caged fluorescent molecules
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
US20100029017A1 (en) 2008-07-29 2010-02-04 Becton, Dickinson And Company Mono-chlorinated hydroxycoumarin conjugates

Also Published As

Publication number Publication date
CN101914093A (zh) 2010-12-15
CN101914093B (zh) 2015-08-26
JP2010254993A (ja) 2010-11-11
EP2236508A1 (en) 2010-10-06
SG165300A1 (en) 2010-10-28
EP2236508B1 (en) 2015-08-26
JP5697886B2 (ja) 2015-04-08
US20100255504A1 (en) 2010-10-07
US8431416B2 (en) 2013-04-30

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