SG165300A1 - Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates - Google Patents

Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates

Info

Publication number
SG165300A1
SG165300A1 SG201002257-2A SG2010022572A SG165300A1 SG 165300 A1 SG165300 A1 SG 165300A1 SG 2010022572 A SG2010022572 A SG 2010022572A SG 165300 A1 SG165300 A1 SG 165300A1
Authority
SG
Singapore
Prior art keywords
substituted
heterocycle
hydroxycoumarin
dyes
conjugates
Prior art date
Application number
SG201002257-2A
Other languages
English (en)
Inventor
Zhenjun Diwu
Timothy Dubrovsky
Barnaby Abrams
Jinfang Liao
Qinglin Meng
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Publication of SG165300A1 publication Critical patent/SG165300A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG201002257-2A 2009-04-01 2010-03-31 Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates SG165300A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16586209P 2009-04-01 2009-04-01
US12/726,267 US8431416B2 (en) 2009-04-01 2010-03-17 Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates

Publications (1)

Publication Number Publication Date
SG165300A1 true SG165300A1 (en) 2010-10-28

Family

ID=42224506

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201002257-2A SG165300A1 (en) 2009-04-01 2010-03-31 Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates

Country Status (6)

Country Link
US (1) US8431416B2 (enExample)
EP (1) EP2236508B1 (enExample)
JP (1) JP5697886B2 (enExample)
CN (1) CN101914093B (enExample)
ES (1) ES2548380T3 (enExample)
SG (1) SG165300A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
JP6425538B2 (ja) * 2011-03-30 2018-11-21 スリーエム イノベイティブ プロパティズ カンパニー 蛍光性化合物又は発蛍光団化合物、並びにこれらの使用法
KR102022483B1 (ko) * 2012-03-29 2019-09-18 스미또모 가가꾸 가부시키가이샤 염료용 화합물
EP2912464B1 (en) 2012-10-24 2017-04-26 Becton Dickinson and Company Hydroxamate substituted azaindoline-cyanine dyes and bioconjugates of the same
HUE052616T2 (hu) * 2015-06-29 2021-05-28 Immunogen Inc Ciszteinmódosított antitestek konjugátumai
ITUA20161706A1 (it) 2016-03-15 2017-09-15 Cyanagen S R L Nuovi coloranti cumarinici e relativi coniugati
WO2017180998A2 (en) 2016-04-15 2017-10-19 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
JP6821490B2 (ja) * 2017-04-03 2021-01-27 日本化薬株式会社 クマリン化合物又はそれらの塩、並びにこれを含んだ顔料組成物
GB201716931D0 (en) * 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
JP7464609B2 (ja) * 2019-01-21 2024-04-09 マックス－プランク－ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 炭水化物および炭水化物混合組成物パターンの自動化高性能同定のための先進的方法、ならびにそのためのシステム、ならびに新しい蛍光色素に基づく、そのための多波長蛍光検出システムの較正のための方法
CN109721592B (zh) * 2019-03-04 2022-09-30 河南理工大学 一种含香豆素的氨基吡嗪酰腙衍生物的荧光探针及其制备方法和应用
EP3747957A1 (en) 2019-06-07 2020-12-09 Universidade de Évora Fluorescent vinyl tiophene and bitiophene coumarins dyes and method of synthesis thereof
CN115280147A (zh) * 2020-01-30 2022-11-01 阿特生物探索公司 可紫外激发的基于聚芴的缀合物及其在分析物检测方法中的用途
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
CN112679569B (zh) * 2020-10-22 2022-05-27 山西大学 一种荧光探针及其制备方法和应用
US20240125773A1 (en) 2021-02-05 2024-04-18 Beckman Coulter, Inc. Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates
CN113121513B (zh) * 2021-04-26 2023-05-16 安徽大学 一种咔唑-香豆素基腙类化合物及其制备方法和用途
AU2022269592A1 (en) 2021-05-04 2023-10-05 Beckman Coulter, Inc. Uv-absorbing polymers, compositions and uses thereof
WO2024196805A1 (en) 2023-03-17 2024-09-26 Beckman Coulter, Inc. Benzothienopyrrole cyanine dyes

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3556959A (en) 1968-03-29 1971-01-19 Frank Passal Nickel plating
IT1088554B (it) 1977-11-17 1985-06-10 F I D I A Spa Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina
US4235781A (en) 1979-09-20 1980-11-25 Thomas C. Elder, Inc. 6 Or 8 Haloallyl substituted 7-hydroxycoumarins
US4259233A (en) 1979-10-23 1981-03-31 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
DE3044128A1 (de) 1980-11-24 1982-07-15 Bayer Ag, 5090 Leverkusen Cumarine, verfahren zu ihrer herstellung und ihre verwendung
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
SE8505716D0 (sv) 1985-12-03 1985-12-03 Biocarb Ab Novel compounds and conjugates thereof
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5049673A (en) 1987-10-30 1991-09-17 The Regents Of The University Of California Fluorescent indicator dyes for calcium working at long wavelengths
US5648270A (en) 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5516629A (en) 1990-04-16 1996-05-14 Cryopharm Corporation Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins
US5453517A (en) 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
US5405975A (en) 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
NL9001639A (nl) 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5208148A (en) 1990-12-07 1993-05-04 Molecular Probes, Inc. Lipophilic fluorescent glycosidase substrates
YU187991A (sh) 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5516911A (en) 1993-12-30 1996-05-14 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent intracellular calcium indicators
US6150510A (en) 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
US5741657A (en) 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
US5684142A (en) 1995-06-07 1997-11-04 Oncor, Inc. Modified nucleotides for nucleic acid labeling
US6342379B1 (en) 1995-06-07 2002-01-29 The Regents Of The University Of California Detection of transmembrane potentials by optical methods
US5668268A (en) 1995-11-27 1997-09-16 Hybridon, Inc. Passivated polymer supports for nucleic acid synthesis
US5955604A (en) 1996-10-15 1999-09-21 The Regents Of The University Of California Substrates for β-lactamase and uses thereof
US5696157A (en) * 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US5830912A (en) * 1996-11-15 1998-11-03 Molecular Probes, Inc. Derivatives of 6,8-difluoro-7-hydroxycoumarin
US6221612B1 (en) 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
US6207404B1 (en) 1999-09-30 2001-03-27 Gentest Corporation Coumarin-based CYP3A fluorescent assay reagents
US7304168B2 (en) 2003-08-14 2007-12-04 Board Of Regents, University Of Texas System Photo-caged fluorescent molecules
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
US20100029017A1 (en) 2008-07-29 2010-02-04 Becton, Dickinson And Company Mono-chlorinated hydroxycoumarin conjugates

Also Published As

Publication number Publication date
EP2236508A1 (en) 2010-10-06
ES2548380T3 (es) 2015-10-16
JP5697886B2 (ja) 2015-04-08
US20100255504A1 (en) 2010-10-07
CN101914093A (zh) 2010-12-15
EP2236508B1 (en) 2015-08-26
US8431416B2 (en) 2013-04-30
CN101914093B (zh) 2015-08-26
JP2010254993A (ja) 2010-11-11

Similar Documents

Publication Publication Date Title
SG165300A1 (en) Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates
Verma et al. FRET based biosensor: principle applications recent advances and challenges
Agrawal et al. Counting single native biomolecules and intact viruses with color-coded nanoparticles
Wang et al. Quantum dots: a promising fluorescent label for probing virus trafficking
Clapp et al. Two‐photon excitation of quantum‐dot‐based fluorescence resonance energy transfer and its applications
Waggoner Fluorescent labels for proteomics and genomics
Massey et al. Mind your P's and Q's: the coming of age of semiconducting polymer dots and semiconductor quantum dots in biological applications
Behnke et al. Encapsulation of hydrophobic dyes in polystyrene micro-and nanoparticles via swelling procedures
Geissler et al. Lanthanides and quantum dots as Forster resonance energy transfer agents for diagnostics and cellular imaging
Bell et al. Epicocconone, A Novel Fluorescent Compound from the Fungus Epicoccum n igrum
Yang et al. Highly selective red-and green-emitting two-photon fluorescent probes for cysteine detection and their bio-imaging in living cells
Hötzer et al. Fluorescence in nanobiotechnology: sophisticated fluorophores for novel applications
Zhang et al. Single molecule photobleaching (SMPB) technology for counting of RNA, DNA, protein and other molecules in nanoparticles and biological complexes by TIRF instrumentation
Karpenko et al. Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging
Liu et al. High-efficiency dual labeling of influenza virus for single-virus imaging
Kong et al. High-bright fluorescent carbon dots and their application in selective nucleoli staining
Chang et al. Research progress of near-infrared fluorescence immunoassay
WO2008015415A3 (en) Asymmetric fluoro-substituted polymethine dyes
WO2008054600A3 (en) Compositions and methods for biodetection by nucleic acid-templated chemistry
Menéndez et al. NIR fluorescent biotinylated cyanine dye: optical properties and combination with quantum dots as a potential sensing device
Kovtun et al. Quantum dot approaches for target-based drug screening and multiplexed active biosensing
Powe et al. Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry
WO2008108074A1 (ja) 蛍光プローブ
Song et al. Development of a novel fluorophore for real-time biomonitoring system
EP2251380A3 (en) Dye conjugates and methods of use