CN101896811B - 制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法 - Google Patents

制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法 Download PDF

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Publication number
CN101896811B
CN101896811B CN200880120033.2A CN200880120033A CN101896811B CN 101896811 B CN101896811 B CN 101896811B CN 200880120033 A CN200880120033 A CN 200880120033A CN 101896811 B CN101896811 B CN 101896811B
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China
Prior art keywords
reactant
phenylimino
phenothiazine
solvent
mediator
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Expired - Fee Related
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CN200880120033.2A
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English (en)
Chinese (zh)
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CN101896811A (zh
Inventor
卡伦·L·马尔福瑞特
亨利·C·阿恩特
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Bayer Healthcare LLC
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Bayer Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Emergency Medicine (AREA)
CN200880120033.2A 2007-12-10 2008-12-08 制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法 Expired - Fee Related CN101896811B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US717807P 2007-12-10 2007-12-10
US61/007,178 2007-12-10
PCT/US2008/085810 WO2009076268A1 (en) 2007-12-10 2008-12-08 Process of making 3-phenylimino-3h-phenothiazine or 3-phenylimino-3h-phenoxazine mediator

Publications (2)

Publication Number Publication Date
CN101896811A CN101896811A (zh) 2010-11-24
CN101896811B true CN101896811B (zh) 2014-04-16

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Family Applications (1)

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CN200880120033.2A Expired - Fee Related CN101896811B (zh) 2007-12-10 2008-12-08 制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法

Country Status (9)

Country Link
US (4) US8022204B2 (cg-RX-API-DMAC7.html)
EP (1) EP2229590B1 (cg-RX-API-DMAC7.html)
JP (1) JP5705546B2 (cg-RX-API-DMAC7.html)
CN (1) CN101896811B (cg-RX-API-DMAC7.html)
BR (1) BRPI0820585A2 (cg-RX-API-DMAC7.html)
CA (1) CA2707902C (cg-RX-API-DMAC7.html)
MX (1) MX2010006389A (cg-RX-API-DMAC7.html)
RU (1) RU2524660C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009076268A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5705546B2 (ja) * 2007-12-10 2015-04-22 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ ３−フェニルイミノ−３ｈ−フェノチアジン又は３−フェニルイミノ−３ｈ−フェノキサジンメディエーターを調製する方法
US8668819B2 (en) * 2009-11-10 2014-03-11 Bayer Healthcare Llc Underfill recognition system for a biosensor
GB201223166D0 (en) * 2012-12-21 2013-02-06 Alere Switzerland Gmbh Test strip
CN107290400B (zh) * 2016-03-31 2020-02-18 艾康生物技术(杭州)有限公司 测定全血样本中特定成分的组合物和电化学测试条
CN107290415B (zh) * 2016-03-31 2022-01-28 艾康生物技术(杭州)有限公司 电化学传感器及其试剂组合物和应用
CN112194641A (zh) * 2020-09-02 2021-01-08 商丘师范学院 一种同时检测次氯酸和抗坏血酸的柔性电极及其制备方法和应用
CN112511569B (zh) * 2021-02-07 2021-05-11 杭州筋斗腾云科技有限公司 网络资源访问请求的处理方法、系统及计算机设备
CN118772197A (zh) * 2024-06-07 2024-10-15 江苏鱼跃凯立特生物科技有限公司 一种苯胺2，4二磷酸及制备方法和制备二磷酸苯胺吩噻嗪的方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2141437A (en) * 1983-06-13 1984-12-19 Oreal New indoaniline and indophenol compounds for use in hair-dyeing
EP0775699A1 (en) * 1995-11-22 1997-05-28 Bayer Corporation Method for the preparation of substituted 3-(phenylimino)-3H-phenothiazines and phenoxazines

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631166C2 (de) * 1976-07-10 1983-05-26 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Oxazinfarbstoffen
FR2480767A1 (fr) * 1980-04-18 1981-10-23 Ugine Kuhlmann Procede de preparation de colorants oxaziniques basiques
DE3278334D1 (en) * 1981-10-23 1988-05-19 Genetics Int Inc Sensor for components of a liquid mixture
PH20433A (en) 1982-12-02 1987-01-05 Wellcome Found Phenothiazine compounds
GB2132194A (en) 1982-12-02 1984-07-04 Wellcome Found Phenothiazines
ZA838959B (en) * 1982-12-02 1985-07-31 Wellcome Found Aromatic compounds
CA1219040A (en) * 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
GB8424709D0 (en) 1984-10-01 1984-11-07 Minnesota Mining & Mfg Azine redox dyes and leuco azine dyes
DE68924026T3 (de) * 1988-03-31 2008-01-10 Matsushita Electric Industrial Co., Ltd., Kadoma Biosensor und dessen herstellung.
US4941308A (en) * 1988-07-25 1990-07-17 Abbott Laboratories Method of packaging for a sterilizable calibratable medical device
US4863016A (en) * 1988-07-25 1989-09-05 Abbott Laboratories Packaging for a sterilizable calibratable medical device
DE3826922A1 (de) * 1988-08-09 1990-02-22 Boehringer Mannheim Gmbh Verfahren zur kolorimetrischen bestimmung eines analyten mittels enzymatischer oxidation
US5236567A (en) * 1989-05-31 1993-08-17 Nakano Vinegar Co., Ltd. Enzyme sensor
US5212092A (en) * 1992-05-22 1993-05-18 Puritan-Bennett Corporation Storage and calibration solution for multiparameter intravascular blood gas sensor device
US5298144A (en) * 1992-09-15 1994-03-29 The Yellow Springs Instrument Company, Inc. Chemically wired fructose dehydrogenase electrodes
ZA938555B (en) * 1992-11-23 1994-08-02 Lilly Co Eli Technique to improve the performance of electrochemical sensors
US5393615A (en) * 1994-02-03 1995-02-28 Miles Inc. Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof
US5498542A (en) * 1994-09-29 1996-03-12 Bayer Corporation Electrode mediators for regeneration of NADH and NADPH
US5520786A (en) * 1995-06-06 1996-05-28 Bayer Corporation Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof
EP0775669B1 (en) 1995-11-16 2001-05-02 Texas Instruments Incorporated Low volatility solvent-based precursors for nanoporous aerogels
US5801057A (en) * 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
DE19639169A1 (de) * 1996-09-24 1998-04-02 Boehringer Mannheim Gmbh Redoxaktive Verbindungen und deren Anwendung
US6221586B1 (en) 1997-04-09 2001-04-24 California Institute Of Technology Electrochemical sensor using intercalative, redox-active moieties
US5798031A (en) * 1997-05-12 1998-08-25 Bayer Corporation Electrochemical biosensor
ATE308924T1 (de) * 1998-02-17 2005-11-15 Abbott Lab Gerät zum entnehmen und analysieren von interstitieller flüssigkeit
JP3694424B2 (ja) * 1998-09-29 2005-09-14 松下電器産業株式会社 グルコースセンサ
US6338790B1 (en) * 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US7163616B2 (en) * 2001-09-14 2007-01-16 Bayer Corporation Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes
CA2455669A1 (en) * 2003-02-04 2004-08-04 Bayer Healthcare, Llc Method and test strip for determining glucose in blood
US8007656B2 (en) * 2003-10-24 2011-08-30 Bayer Healthcare Llc Enzymatic electrochemical biosensor
JP5705546B2 (ja) * 2007-12-10 2015-04-22 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ ３−フェニルイミノ−３ｈ−フェノチアジン又は３−フェニルイミノ−３ｈ−フェノキサジンメディエーターを調製する方法
CA2708156C (en) 2007-12-10 2018-01-23 Bayer Healthcare Llc Reagents and methods for detecting analytes
KR101984796B1 (ko) 2012-05-03 2019-06-03 에스케이하이닉스 주식회사 반도체 메모리 장치, 그것을 포함하는 메모리 시스템 및 그것의 동작 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2141437A (en) * 1983-06-13 1984-12-19 Oreal New indoaniline and indophenol compounds for use in hair-dyeing
EP0775699A1 (en) * 1995-11-22 1997-05-28 Bayer Corporation Method for the preparation of substituted 3-(phenylimino)-3H-phenothiazines and phenoxazines

Also Published As

Publication number Publication date
CA2707902C (en) 2016-10-25
JP2011507809A (ja) 2011-03-10
US9039878B2 (en) 2015-05-26
US8357797B2 (en) 2013-01-22
WO2009076268A1 (en) 2009-06-18
CN101896811A (zh) 2010-11-24
US20150225356A1 (en) 2015-08-13
US20090171081A1 (en) 2009-07-02
BRPI0820585A2 (pt) 2015-06-16
US20130126350A1 (en) 2013-05-23
JP5705546B2 (ja) 2015-04-22
US8022204B2 (en) 2011-09-20
RU2010128610A (ru) 2012-01-20
MX2010006389A (es) 2010-06-25
EP2229590B1 (en) 2018-11-21
CA2707902A1 (en) 2009-06-18
RU2524660C2 (ru) 2014-07-27
US20110313155A1 (en) 2011-12-22
EP2229590A1 (en) 2010-09-22
US9656976B2 (en) 2017-05-23
HK1147554A1 (en) 2011-08-12

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