CN101890094A - Health care product for assisting in reducing blood fat and preparation method thereof - Google Patents
Health care product for assisting in reducing blood fat and preparation method thereof Download PDFInfo
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- CN101890094A CN101890094A CN2010101480811A CN201010148081A CN101890094A CN 101890094 A CN101890094 A CN 101890094A CN 2010101480811 A CN2010101480811 A CN 2010101480811A CN 201010148081 A CN201010148081 A CN 201010148081A CN 101890094 A CN101890094 A CN 101890094A
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Abstract
The invention provides a health care product for assisting in reducing blood fat and a preparation method thereof. The health care product is prepared from the following raw materials in part by weight: 15 to 25 parts of black currant seed powder, 12 to 20 parts of seabuckthorn fruit powder, 2.2 to 2.9 parts of hawthorn extract powder, 2.0 to 2.7 parts of dextrin, 0.6 to 0.12 part of starch and 0.3 to 0.9 part of microcrystalline cellulose. The preparation method comprises the following steps of: putting the raw materials into a double cone mixer for mixing uniformly and a granulator for pelletizing by using a proper amount of 9 percent starch slurry sequentially; after the raw materials are pelletized, drying the particles, wherein the drying temperature is between 45 and 55 DEG C; and the drying time is 5 to 7 hours; putting the dried particles into a rotary hard capsule machine for filling, polishing, quality checking and packaging to obtain the product; wherein the method also comprises the following steps of preparing the black currant seed powder, the seabuckthorn fruit powder and the hawthorn extract powder; and then preparing and processing the combined fine powder, and screening the fine powder with a 60 to 80-mesh screen. The vacuum degree of drying and processing is controlled to be below -0.09MPa; the vacuum degree of concentration is controlled to be -0.08MPa; the volume ratio of the material to liquid nitrogen is 1:4 when the material is frozen and ground at a low temperature; the using specification of the health care product is 300mg/particle; and 6 particles are taken per day, 3 times per day, and 2 particles each time.
Description
Technical field
The present invention relates to blood fat reducing health products, be particularly useful for the production method of auxiliary antilipemic health product.
Background technology
Blood fat is the neutral fat (triglyceride and cholesterol) in the blood plasma and the general name of lipoid (phospholipid, glycolipid, sterin, steroid), extensively is present in the human body, and they are necessary materials of life cells basal metabolism.Main component in the blood fat is triglyceride and cholesterol, and they all are lyophobic dusts, must specific proteins and polarity lipoid in blood form a hydrophilic lipoprotein, could betransported in blood, and enter histiocyte.Hyperlipemia is not only a kind of commonly encountered diseases, and is the main hazard factor that causes atherosclerosis, hypertension, coronary heart disease, diabetes, cholelithiasis chronic diseases, is seriously threatening human health.
The mechanism of action that is used for the Chinese medicine blood fat reducing at present mainly is minimizing or suppresses the absorption of cholesterol at intestinal, suppresses the synthetic of cholesterol and triglyceride, influences distribution, transfer and the removing of blood fat, increases the discharge of bile acid, promotes the drainage of cholesterol.With respect to Western medicine, the applicating history of Chinese medicine aspect blood fat reducing is long, aboundresources, and prescription is flexible, and curative effect is sure, and toxic and side effects is little, the normal foodization of medicine, prolonged application better tolerance, and low price have a lot of advantageous advantages.
Literature search discloses: a kind of treatment hyperlipidemia medicine and preparation method thereof (number of patent application 200810303845) has been invented by No.1 Hospital Attached to Xinjiang Medical Univ. and Xinjiang bass open-birth thing Technology Dev Company Ltd.; Prescription comprises: black currant 240-360 part, Fructus Crataegi 500-750 part, Radix Glycyrrhizae 100-150 part, adjuvant 0-144 part.What the invention provides has an auxiliary antilipemic efficiency health-care product, has differently greatly with the above-mentioned raw materials apolegamy, takes distinctive preparation method, keep its functional component to greatest extent, take safety, have the health-care effect of auxiliary antilipemic, meet the requirement of health food GMP production standard.
Summary of the invention
Order of the present invention is: the health promoting product of the auxiliary antilipemic effect that provides, optimize selection, and the effect of tool health-care, its preparation method safe and reasonable meets the requirement of health food GMP production standard.
The object of the present invention is achieved like this: health product of a kind of auxiliary antilipemic and preparation method thereof, raw material is prepared with parts by weight, is made up of seed of black currant powder 15-25 part, seabuckthorn fruit powder 12-20 part, hawthorn extract powder 2.2-2.9 part, dextrin 2.0-2.7 part, starch 0.6-0.12 part, microcrystalline Cellulose 0.3-0.9 part; The best is formulated as 19 parts in seed of black currant powder, 16 parts of seabuckthorn fruit powders, 2.6 parts in hawthorn extract powder, 2.3 parts in dextrin, 0.9 part of starch, 0.6 part of microcrystalline Cellulose; During preparation raw material is placed the double-cone mixer mix homogeneously successively, place granulator again, the starch slurry with an amount of 9% is granulated, the back oven dry of granulating, bake out temperature 45-55 ℃, time 5-7 hour; To dry granule again places rotary hard capsule machine to advance filling, polishing, quality inspection, packing to get product.
Described health product and preparation method thereof, the oven dry of 6-10 purpose requirement seed of black currant is selected in the preparation of seed of black currant powder for use, and temperature must not surpass 55 ℃, and drying is powdery after the freezing pulverizer is pulverized; Repeat above-mentioned freezing and pulverizing process once, merge fine powder, promptly get the seed of black currant powder after sieving.
Described health product and preparation method thereof, the fresh fruit or the freezing Fructus Hippophae of requirement are got in the preparation of seabuckthorn fruit powder, carry out freezing and pulverize, and ground product is the thick-pasty mastic; Its cream is placed the vacuum drying oven inner drying, and temperature is no more than 45-55 ℃, about 10-16 of time hour; Repeat above-mentioned deep freeze refrigerator crushing process after the drying once, merge fine powder, promptly get seabuckthorn fruit powder after sieving.
Described health product and preparation method thereof, the preparation of hawthorn extract powder is got the Fructus Crataegi medical material of requirement and is pulverized through pulverizer, and the 38-45 order that sieves adds 70% ethanol that 10-15 doubly measures, and reflux, extract, 1-2 hour, filters one time lixiviating solution; Add 70% ethanol that 6-12 doubly measures in medicinal residues again, reflux, extract, 1-2 hour, the lixiviating solution of secondary filter also mixed with once lixiviating solution; Mixing immersion needs vacuum concentration, and temperature 60-65 ℃, reclaim ethanol, obtain hawthorn extract; Its cream is placed the vacuum drying oven drying, and temperature 65-70 ℃, dried hawthorn extract places pulverizer to pulverize, and is powdery; Repeat above-mentioned crushing process once, merge fine powder, promptly get the hawthorn extract powder after sieving.
Described health product and preparation method thereof, dry vacuum degree control-below the 0.09Mpa, the concentration vacuum degree control is at-0.08Mpa.
Described health product and preparation method thereof, material and liquid nitrogen volume ratio when freezing is pulverized are 1: 4.
Described health product and preparation method thereof, the fine powder after formulated merges adopts 60-80 order net to sieve and gets final product.
Described health product and preparation method thereof, the specification of using during the product health care is the 300mg/ grain, 6 of day clothes, every day 3 times, each 2.
Described health product and preparation method thereof, selecting for use of raw material and medicament is the commercially available prod.
The black currant that this product is selected for use (black currant) has another name called black currant, black bean fruit, is the fruit that Saxifragaceae (saxifrage) tea foot of a hill or mountain belongs to (Ribes) plant, belongs to perennial undershrub.Fruit black, subsphaeroidal, sweet and sour, delicate fragrance, nutritious.The black currant that the Emin County, Xinjiang produces contains mineral such as the calcium, magnesium, sodium, potassium, ferrum, phosphorus, zinc of abundant vitamin A, B, C, D and higher proportion after measured in the fruit, contains the aminoacid of needed by human body; 1000g black currant fresh fruit contains vitamin C 2.34g, and anthocyanidin and flavonoid content are abundant.
The Fructus Hippophae that this product is selected for use has another name called vinegar willow, acid thorn, is general designation, machaka or the dungarunga of Elaeangnaceae plant Hippophae (Hippophaerhamnoides.L).Fruit is oval, orange yellow.Its chemical analysis mainly contains flavonoid, vitamins, terpenoid, steroidal class, protein and amino acids, oil ﹠ fat acids, volatile oil, organic acid, sugar and trace element etc., is a kind of nutritious, the plant that medical value is high.Its multifarious active component has killing and suppresses tumor cell, radioprotective, anticoagulation, blood fat reducing, blood pressure lowering, prevents biologic activity such as blood vessel embolism, antioxidation, resisting fatigue, enhancing body vigor and immunity.
The Fructus Crataegi that this product is selected for use is a rosaceous plant, and fruit contains Crataegolic acid, oleanolic acid, malic acid, citric acid, chlorogenic acid, caffeic acid, vitamin C, hyperin, Quercetin, epicatechin etc.Slightly warm in nature, sour in the mouth, sweet.Help digestion dissipating blood stasis.Be used for accumulation of food in the stomach and intes tine due to indigestion, dyspepsia, infantile malnutrition, the blood stasis amenorrhea also is used for bacillary dysentery, enteritis, hypertension etc.
This product select for use the adjuvant used when being preparation of dextrin, starch and microcrystalline Cellulose, do not have any pharmacologically active, the pharmacologically active of main functional component is not had influence yet, be to improve the moulding process of preparation and the effect that improves stability.
The present invention selects materials scientific and reasonable, more notes keeping the constant of original quality on processing method, and product drug effect and health all have both at the same time, and show technological progress.
The specific embodiment
Embodiment
The preparation method of health product:
1. raw material is prepared with parts by weight: get 25 parts in seed of black currant powder, 20 parts of seabuckthorn fruit powders, 2.2 parts in hawthorn extract powder, 2.3 parts in dextrin, 0.8 part of starch, 0.6 part of microcrystalline Cellulose; The best is formulated as 19 parts in seed of black currant powder, 16 parts of seabuckthorn fruit powders, 2.6 parts in hawthorn extract powder, 2.3 parts in dextrin, 0.9 part of starch, 0.6 part of microcrystalline Cellulose;
2. raw material is prepared with weight ratio: get 19 kilograms in seed of black currant powder, 16 kilograms of seabuckthorn fruit powders, 2.6 kilograms in hawthorn extract powder, 2.3 kilograms in dextrin, 0.9 kilogram of starch, 0.6 kilogram of microcrystalline Cellulose;
1., the preparation method of 2. preparing: seed of black currant powder, seabuckthorn fruit powder, hawthorn extract powder, dextrin, starch, microcrystalline Cellulose are placed the double-cone mixer mix homogeneously successively, place granulator to granulate again, adopts the starch slurry granulation of 0.2 kilogram or 0.9 kilogram or 1.5 kilogram 9%; Granulation is placed on drying baker, and temperature is 50 ℃, about 6 hours of time; Dried granule places rotary hard capsule machine to advance filling, polishing, and quality inspection, packing get product.
The serum blood fat experiment of animal:
Get 60 of Wistar rats, body weight 160.0 ± 11.9g, male and female half and half are divided into 6 groups at random according to body weight, sex, and 10 every group, the antihyperlipidemic product Capsules group of branch physiology saline control group, model group, positive control drug XUEZHIKANG JIAONANG group and three various dose;
Adopt reagent: cholesterol, sodium deoxycholate, propylthiouracil sheet, Adeps Sus domestica, propylene glycol reagent and serum total cholesterol, triglyceride, HDL-C, low-density lipoprotein cholesterol are measured test kit;
The preparation of modeling feedstuff lipomul: 10% cholesterol, 25% Adeps Sus domestica, 3% sodium cholate, 10% tween 80,20% propylene glycol, adding distil water are to 100ml, and use stirs.
Experimental result:
The normal saline matched group: rat is fed with normal diet, and uses normal saline ig, once a day, and continuous 2 weeks;
Model group: rat is used the modeling forage feed, and uses normal saline ig, once a day, and continuous 2 weeks;
Positive control drug XUEZHIKANG JIAONANG group: rat is used the modeling forage feed, and with XUEZHIKANG JIAONANG 0.125g/kg ig, once a day, continuous 2 weeks;
This product divides three various dose groups to feed rats, is respectively 0.60,0.30,0.15g/kg ig, once a day, and continuous 2 weeks;
After the administration of rat last, fasting be can't help water 10 hours, got jugular vein blood and prepared serum, verified its result with kit measurement.See Table.
The table product is to the influence of experimental hyperlipidemia rat blood serum blood fat
Annotate: compare * P＜0.05 with the blank group; Compare+P＜0.05 with model group.
Last table result shows: this product low dose group and middle dosage group can obviously reduce the content of triglyceride in the experimental hyperlipidemia rat blood serum (TG), T-CHOL (TC) and low-density lipoprotein cholesterol (LDL-C), can obviously the raise content of experimental hyperlipidemia rat blood serum middle-high density lipoprotein cholesterol (HDL-C), difference has significance (P＜0.05).High dose group can obviously reduce the content of triglyceride in the experimental hyperlipidemia rat blood serum (TG), T-CHOL (TC) and low-density lipoprotein cholesterol (LDL-C), difference has significance (P＜0.05), but little to the content influence of experimental hyperlipidemia rat blood serum middle-high density lipoprotein cholesterol (HDL-C).This product has good effect to blood fat reducing, but is not proportionate between the dose-effect.And positive control set product (being XUEZHIKANG JIAONANG) only has good behaviour in this binomial index of content of triglyceride (TG), T-CHOL (TC) in reducing the experimental hyperlipidemia rat blood serum.
Claims (9)
1. health product of an auxiliary antilipemic and preparation method thereof, it is characterized in that: raw material is prepared with parts by weight, is made up of seed of black currant powder 15-25 part, seabuckthorn fruit powder 12-20 part, hawthorn extract powder 2.2-2.9 part, dextrin 2.0-2.7 part, starch 0.6-0.12 part, microcrystalline Cellulose 0.3-0.9 part; The best is formulated as 19 parts in seed of black currant powder, 16 parts of seabuckthorn fruit powders, 2.6 parts in hawthorn extract powder, 2.3 parts in dextrin, 0.9 part of starch, 0.6 part of microcrystalline Cellulose; During preparation raw material is placed the double-cone mixer mix homogeneously successively, place granulator again, the starch slurry with an amount of 9% is granulated, the back oven dry of granulating, bake out temperature 45-55 ℃, time 5-7 hour; To dry granule again places rotary hard capsule machine to advance filling, polishing, quality inspection, packing to get product.
2. according to described health product of claim 1 and preparation method thereof, it is characterized in that: the preparation of seed of black currant powder, select the oven dry of 6-10 purpose requirement seed of black currant for use, temperature must not surpass 55 ℃, and drying is powdery after the freezing pulverizer is pulverized; Repeat above-mentioned freezing and pulverizing process once, merge fine powder, promptly get the seed of black currant powder after sieving.
3. according to described health product of claim 1 and preparation method thereof, it is characterized in that: the preparation of seabuckthorn fruit powder, get the fresh fruit or the freezing Fructus Hippophae of requirement, carry out freezing and pulverize, ground product is the thick-pasty mastic; Its cream is placed the vacuum drying oven inner drying, and temperature is no more than 45-55 ℃, about 10-16 of time hour; Repeat above-mentioned deep freeze refrigerator crushing process after the drying once, merge fine powder, promptly get seabuckthorn fruit powder after sieving.
4. according to described health product of claim 1 and preparation method thereof, it is characterized in that: the preparation of hawthorn extract powder, get the Fructus Crataegi medical material of requirement and pulverize through pulverizer, the 38-45 order sieves, add 70% ethanol that 10-15 doubly measures, reflux, extract, 1-2 hour, filter one time lixiviating solution; Add 70% ethanol that 6-12 doubly measures in medicinal residues again, reflux, extract, 1-2 hour, the lixiviating solution of secondary filter also mixed with once lixiviating solution; Mixing immersion needs vacuum concentration, and temperature 60-65 ℃, reclaim ethanol, obtain hawthorn extract; Its cream is placed the vacuum drying oven drying, and temperature 65-70 ℃, dried hawthorn extract places pulverizer to pulverize, and is powdery; Repeat above-mentioned crushing process once, merge fine powder, promptly get the hawthorn extract powder after sieving.
5. according to described health product of claim 1 and preparation method thereof, it is characterized in that: dry vacuum degree control-below the 0.09Mpa, the concentration vacuum degree control is at-0.08Mpa.
6. according to described health product of claim 1 and preparation method thereof, it is characterized in that: material and liquid nitrogen volume ratio when freezing is pulverized are 1: 4.
7. according to described health product of claim 1 and preparation method thereof, it is characterized in that: the fine powder after formulated merges, adopt 60-80 order net to sieve and get final product.
8. according to described health product of claim 1 and preparation method thereof, it is characterized in that: the specification of using during the product health care is the 300mg/ grain, 6 of day clothes, every day 3 times, each 2.
9. according to described health product of claim 1 and preparation method thereof, it is characterized in that: selecting for use of raw material and medicament is the commercially available prod.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103689590A (en) * | 2013-11-29 | 2014-04-02 | 华侨大学 | Health food for assisting reducing blood fat and preparation method thereof |
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2010
- 2010-04-16 CN CN2010101480811A patent/CN101890094A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 《亚太传统医药》 20091231 谢蓉蓉等 天然药物有效成分调脂治疗的研究进展 149-152 1-9 第5卷, 第12期 2 * |
| 《江西中医学院学报》 20021231 康旭亮等 单味中药提取物降血脂的研究进展 10-12 1-9 第14卷, 第3期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103689590A (en) * | 2013-11-29 | 2014-04-02 | 华侨大学 | Health food for assisting reducing blood fat and preparation method thereof |
| CN103689590B (en) * | 2013-11-29 | 2016-04-13 | 华侨大学 | Health food of a kind of auxiliary antilipemic and preparation method thereof |
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