CN103689590B - Health food of a kind of auxiliary antilipemic and preparation method thereof - Google Patents

Health food of a kind of auxiliary antilipemic and preparation method thereof Download PDF

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CN103689590B
CN103689590B CN201310631349.0A CN201310631349A CN103689590B CN 103689590 B CN103689590 B CN 103689590B CN 201310631349 A CN201310631349 A CN 201310631349A CN 103689590 B CN103689590 B CN 103689590B
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extract
agar
algin
health food
herb gynostemmae
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CN103689590A (en
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肖美添
熊霜
叶静
黄雅燕
张学勤
赵鹏
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Huaqiao University
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/256Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Dispersion Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of health food for auxiliary antilipemic and preparation method thereof, form primarily of following composition of raw materials: agar-agar, algin, hawthorn, gynostemma pentaphylla, rhizoma alismatis, cassia seed.The present invention is by limiting composition and the proportioning of this health food, and the preparation method of each Chinese medical extract, make it can suppress the absorption of cholesterol, promote the excretion of cholesterol and triglycerides, reduce small intestine to the absorption of lipid, thus from the multi-faceted effect reaching reducing blood lipid.In addition, all raw materials of the present invention are natural plant raw material, have that raw material sources are wide, cost is low, to advantages such as body have no side effect, effectively can reduce the blood lipid level of hyperlipemic patients, containment atherosclerotic.

Description

Health food of a kind of auxiliary antilipemic and preparation method thereof
Technical field
The present invention relates to technical field of health care food, be specifically related to a kind of based on agar-agar, algin, take Chinese medicine as the health food of auxiliary auxiliary antilipemic, the invention still further relates to the preparation method of this health food.
Background technology
ESC 2013 (ESC2013) reports the result of dyslipidemia international research (DYSIS) China research in mid-term, although show to receive fat-reducing medicament (LLD) treatment, but still having the patient of larger proportion, there is continuation dyslipidemia in the patient that especially cardiovascular risk is higher.Result of study is pointed out, still in the urgent need to optimizing lipid-lowering therapy scheme.
Fat metabolism or running make lipids contents in blood plasma be called hyperlipemia higher than during normal range (NR) extremely.High fat of blood is the hazards that the cardiovascular disease such as coronary heart disease, myocardial infarction is the most serious.The blood fat increased can be described as " rubbish " in blood vessel, and especially LDL-C and triglycerides increase and can cause serious destruction to blood vessel, is cause coronary heart disease, the heart to obstruct " arch-criminal ".At present, lipid-regulation medicine clinically has: (1) trihydroxy trimethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor (Statins); (2) fibrate (the special class of shellfish); (3) cholic acid chelating agent; (4) nicotinic acid class; (5) selective cholesterol absorption inhibitor (clothing Ezetimibe).Though Western medicine is clinically effective soon, effect is obvious, long-term taking, drug toxicity is large, easily causes the symptoms such as stomach reaction, flush, headache, insomnia, weakness of limbs, has certain damage to liver, kidney.Traditional Chinese medicine for treating hyperlipidemia curative effect is slow, and the medication cycle is long.
Dietary fiber (dietaryfiber is called for short DF) refers to not easily digested, the general name of the macromolecular substances based on polysaccharide, the condensate be made up of materials such as cellulose, pectic substance, hemicellulose and glycoprotein.It is current a kind of functional food of generally acknowledging in the world, is called as the 7th nutrient except water, protein, carbohydrate, lipid, vitamin, the large nutrient of mineral matter six.Research shows, common atherosclerotic, hypertension, coronary heart disease, hyperlipemia are all relevant with dietary fiber intake deficiency.
The strong water absorbing capacity of dietary fiber can make the volume of ight soil in enteron aisle increase, and accelerates its transport speed, reduces the time of wherein harmful substance contact intestines wall; Lignin wherein can absorb bile acid, and pectin in conjunction with cholesterol, thus can reach minimizing intestines wall to the absorption of cholesterol, the effect of increased excretions of cholesterol metabolism, while making body inner cholesterol content decline, promotes that bile acid is discharged from ight soil.
Agar-agar and algin all belong to soluble dietary fiber, have strong absorptive, can absorb the moisture in enteron aisle, and intestinal contents is expanded, and increase stool amount; At stimulation intestines wall, while relief of constipation, be combined with cholesterol, promote cholesterol catabolism.Hawthorn, containing the composition such as vitamin C, flavones, has food digesting stomach fortifying, the stasis of blood is fallen apart in promoting the circulation of qi, changes effect of turbid lipopenicillinase; Gynostemma pentaphylla, containing the composition such as gypenoside, ginsenoside, has effect of eliminating inflammation and expelling toxin, cough-relieving apophlegmatic; Rhizoma alismatis, containing compositions such as Alisol B monoacetate, 24-acetylalisol A, has clearing damp and promoting diuresis, expels the heat-evil, changes effect of turbid lipopenicillinase; Cassia seed, containing the composition such as Chrysophanol, aurantio-obtusin, the effect there is removing heat to brighten vision, relaxing bowel.
Hawthorn, gynostemma pentaphylla, rhizoma alismatis, cassia seed, all have blood fat reducing function, extensively approved by the world of medicine.But have no dietary fiber and Chinese Medicine and Clavicular, utilize its synergy to reach the relevant report of reducing blood lipid object.Therefore, inventor is by different from Chinese medicine for dietary fiber compatibility, and the health food of exploitation auxiliary antilipemic has realistic meaning.
Summary of the invention
The medicine that the object of the invention is to utilize China traditional is theoretical, provide a kind of can the health food of auxiliary antilipemic, this health food cost is low, source is wide, have no side effect to body, has the effect reducing hyperlipemic patients blood lipid level.
The present invention is achieved through the following technical solutions:
A health food for auxiliary antilipemic, its raw material comprises agar-agar 0 ~ 70wt%, algin 0 ~ 70wt%; Also comprise Chinese medicine additive, this Chinese medicine additive adopts the Alisma extract of 0 ~ 50wt%; Wherein, the consumption lower limit of Chinese medicine additive is non-vanishing, and the consumption lower limit of agar-agar and algin is all non-vanishing.
Described agar-agar derives from fragrant plant mentioned in ancient texts, agar, Yi Guzao or laver, and described algin derives from sea-tangle, undaria pinnitafida, bulk kelp, sargassum fusifome or sargassum.
Above-mentioned Chinese medicine additive adopts the Alisma extract of 0 ~ 50wt% and the Herb Gynostemmae Pentaphylli extract of 0 ~ 50wt%; Wherein, be zero when Alisma extract is different with the consumption lower limit of Herb Gynostemmae Pentaphylli extract.
Above-mentioned Chinese medicine additive adopts the cassia seed extract of the haw thorn extract of 0 ~ 50wt%, the Herb Gynostemmae Pentaphylli extract of 0 ~ 50wt% and 0 ~ 50wt%; Wherein, haw thorn extract, Herb Gynostemmae Pentaphylli extract are zero time different with the consumption lower limit of cassia seed extract.
A preparation method for the health food of auxiliary antilipemic, mixes each raw material according to weight proportion, grinds to form smalls, incapsulate, every 0.3-0.6 gram.
The preparation method of described haw thorn extract or Alisma extract or Herb Gynostemmae Pentaphylli extract or cassia seed extract is as follows: be the ethanol water refluxing extraction 2 ~ 4 times of 0 ~ 70% by hawthorn or rhizoma alismatis or gynostemma pentaphylla or cassia seed concentration of volume percent, solid-to-liquid ratio 1:5 ~ 1:10, each 1 ~ 4h, filter and merge extract, reduced pressure concentration obtains concentrate,-80 DEG C of freeze overnight, freeze drying or spraying dry.
The present invention, compared with existing like product, has good lipid-lowering effect.Its feature is, by soluble dietary fiber and Chinese Medicine and Clavicular, effectively can play the synergy of the two.The seaweed diet fiber such as agar-agar, algin has gel characteristic, in enteron aisle, form gel, separates and detention cholesterol, affects the contact of cholesterol and digestive ferment, bile acid micelle and intestinal mucosa, thus is beneficial to the decomposition excretion of metabolism of lipid and cholesterol.Simultaneously, seaweed diet fiber directly can adsorb cholesterol (TC), triglycerides (TG) and the FBA (FBA) in enteron aisle and excrete with ight soil, the enteron aisle decreasing TC, TG and FBA absorbs again, accelerate the catabolism of cholesterol, block enterohepatic circulation of bile acid, thus serum TC, TG level are reduced.Flavones in Chinese medicine hawthorn by suppressing the activity of trihydroxy trimethyl glutaryl coenzyme A (HMG-CoA) reductase, can suppress the synthesis of endogenous cholesterol.Rhizoma alismatis can affect the decomposition of fat, reduces the synthesis of acetyl coenzyme A, thus affects the synthesis of cholesterol, and has prevention lipoids be detained in blood or penetrate into the ability of intestines inwall, promotes transport and the removing of Blood Cholesterol.Gypenoside in gynostemma pentaphylla, ginsenoside etc. can increase metabolism and the excretion of cholesterol, thus reduce blood cholesterol level.Archen in cassia seed can promote the metabolism of cholesterol.
Feature of the present invention is also, serum total cholesterol (TC), triglycerides (TG) and LDL-C (LDL-C) level can be reduced simultaneously, and increasing high density lipoprotein cholesterol (HDL-C) level, reduce arteriosclerotic risk.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Following examples are only limitted to be described further curative effect of the present invention.
Embodiment one
A health food for auxiliary antilipemic, its each weight percentages of components is: agar-agar 50wt%, algin 30wt%, Alisma extract 20wt%.
Embodiment two
A health food for auxiliary antilipemic, its each weight percentages of components is: agar-agar 50wt%, algin 30wt%, Alisma extract 8wt%, Herb Gynostemmae Pentaphylli extract 12wt%.Embodiment three
A health food for auxiliary antilipemic, its each weight percentages of components is: agar-agar 27wt%, algin 27wt%, haw thorn extract 18wt%, Herb Gynostemmae Pentaphylli extract 15wt%, cassia seed extract 13wt%.
Embodiment four
A health food for auxiliary antilipemic, its each weight percentages of components is: agar-agar 55%, algin 10%, haw thorn extract 15%, Herb Gynostemmae Pentaphylli extract 10%, cassia seed extract 10%.
In the present invention, agar-agar derives from fragrant plant mentioned in ancient texts, agar, Yi Guzao or laver, and algin derives from sea-tangle, undaria pinnitafida, bulk kelp, sargassum fusifome or sargassum.
The preparation method of the health food of a kind of auxiliary antilipemic of the present invention, mixes each raw material according to weight proportion, grinds to form smalls, incapsulate, every 0.3-0.6 gram.
Wherein, the preparation method of described haw thorn extract or Alisma extract or Herb Gynostemmae Pentaphylli extract or cassia seed extract is as follows: be the ethanol water refluxing extraction 2 ~ 4 times of 0 ~ 70% by hawthorn or rhizoma alismatis or gynostemma pentaphylla or cassia seed concentration of volume percent, solid-to-liquid ratio 1:5 ~ 1:10, each 1 ~ 4h, filter and merge extract, reduced pressure concentration obtains concentrate ,-80 DEG C of freeze overnight, freeze drying, is ground into powder.Or after merging extract, filtrate is condensed into the concentrate of relative density between 1.05 ~ 1.20, then uses pneumatic spray drying powdered, the inlet temperature of spray dryer 150 ~ 200 DEG C, outlet temperature 60 ~ 80 DEG C.
Pharmacodynamic observation
1. the present invention is to the reducing effect of hyperlipemia lipid of mice level.
1.1 animal subject
Kunming kind SD mouse, male, 60, body weight 20 ± 2g, is provided (credit number: SCXK (Fujian) 2005 ~ 0003) by Fuzhou Neptunus Fuyao Pharmaceuticals Co., Ltd..
The foundation of 1.2 mouse hyperlipidemia models and administration
Mouse hyperlipidemia model adopts high lipid food to cause hyperlipemia method, and high lipid food formula is as follows: 78.8% normal diet; 10.0% lard; 10.0% yolk powder; 0.2% sodium taurocholate; 1.0% cholesterol.Blank group gives normal diet, and all the other each group all gives high lipid food.
After mouse adaptability raises one week, separate 12 at random and give normal diet as blank group, all the other 48 give high lipid food, free diet drinking-water.After 10d, orbital venous plexus gets blood, measures serum total cholesterol (TC), total triglycerides (TG), HDL-C cholesterol (HDL-C), LDL-C (LDL-C) level.According to serum TC level, mouse is divided into model group, Simvastatin group, embodiment one group, embodiment two groups at random.
Mouse gavage every day 1 time, while gastric infusion, every day, free diet was drunk water, and dosage is 10mLkg -1, successive administration 4 weeks.Each group gives following test medicine respectively:
Embodiment one group: gavage gives the compound of the health food in the embodiment of the present invention one;
Embodiment two groups: gavage gives the compound of the health food in the embodiment of the present invention two;
Simvastatin group: gavage gives the Simvastatin of Isodose;
Blank group, model group: gavage gives Isodose physiological saline;
1.3 Testing index
Detect T-CHOL (TC), triglycerides (TG), HDL-C (HDL-C) and LDL-C (LDL-C) level in serum.
1.4 experimental result
After 4 weeks, get blood, measure index of correlation, result is as table 1.
Table 1 health food of the present invention is on the impact of high fat lipid of mice
Note: contrast with model group, * P<0.05; Contrast with model group, * * P<0.01.
Table 1 shows, and embodiment one, embodiment two and Simvastatin group all can reduction high fat mouse TC, TG, LDL-C levels in various degree, raise HDL-C level.Contrast with model group, embodiment one and embodiment two all pole conspicuousness can reduce high fat mouse TC, TG, LDL-C level (P<0.01); Embodiment two extremely significantly can raise high fat mouse HDL-C level (P<0.01), and embodiment one significantly can raise high fat mouse HDL-C level (P<0.05).
As mentioned above, embodiment one and embodiment two all effectively can reduce high fat lipid of mice level, have the effect of auxiliary antilipemic.
2. the present invention is to the reducing effect of hyperlipemia Serum Lipids in Experimental HypercholesterolemicRats.
2.1 animal subject
SPF level SD rat, male, 50, body weight 200 ± 20g, is provided (credit number: SCXK (Fujian) 2005 ~ 0003) by Fuzhou Neptunus Fuyao Pharmaceuticals Co., Ltd..
The foundation of 2.2 rat hyperlipidemia models and administration
Rat adopts high lipid food to cause hyperlipemia method, and high lipid food is filled a prescription same mouse.
After adaptability raises one week, separate 10 at random and give normal diet as blank group, all the other give high lipid food, and after 1 ~ 2 week, eyeground vein clump is taken a blood sample, separation of serum, detects indices in serum.And according to TC grouping, often organize 10, totally 4 groups, be respectively: dosage group and embodiment three low dose group in model group, embodiment three high dose group, embodiment three.Rat presses 10mLkg every day -1gavage 1 time, gives high lipid food while gavage, successive administration 4 weeks, and each group dosage is as follows:
Table 2 embodiment three high, medium and low dosage group dosage (mLkg -1)
Blank group and model group give the physiological saline of Isodose, and high, medium and low group of embodiment three is according to table 2 gastric infusion.
2.3 Testing index
Detect T-CHOL (TC), triglycerides (TG), HDL-C (HDL-C) and LDL-C (LDL-C) level in serum.
2.4 experimental result
Table 3 embodiment three is on the impact of High fat diet rats blood fat
Note: contrast with model group, * P<0.05; Contrast with model group, * * P<0.01.
Experimental result shows, and embodiment three high dose, middle dosage group can extremely significantly reduce High fat diet rats blood lipid level.
3. conclusion
Comprehensive Experiment result, high fat of blood animal is given continuously to the present invention 30 days of various dose, each dosage group and model group contrast, and all can reduce serum total cholesterol, triglycerides and low-density lipoprotein cholesterol level, increasing high density lipoprotein cholesterol levels.
Criterion according to Ministry of Public Health's " health food inspection and assessment technical specification (2003 editions) " judges, the present invention has the effect of auxiliary antilipemic.

Claims (5)

1. a health food for auxiliary antilipemic, is characterized in that, its raw material comprises agar-agar, algin and Alisma extract, and the percentage by weight of agar-agar, algin and Alisma extract is as follows: agar-agar 50wt%, algin 30wt%, Alisma extract 20wt%;
The preparation method of the health food of described auxiliary antilipemic is: mixed according to weight proportion by each raw material, grind to form smalls, incapsulate, every 0.3-0.6 gram;
Wherein, the preparation method of described Alisma extract is as follows: be the ethanol water refluxing extraction 2 ~ 4 times of 0 ~ 70% by rhizoma alismatis concentration of volume percent, solid-to-liquid ratio 1:5 ~ 1:10, each 1 ~ 4h, filter and merge extract, reduced pressure concentration obtains concentrate ,-80 DEG C of freeze overnight, freeze drying, is ground into powder; Or after merging extract, filtrate is condensed into the concentrate of relative density between 1.05 ~ 1.20, then uses pneumatic spray drying powdered, the inlet temperature of spray dryer 150 ~ 200 DEG C, outlet temperature 60 ~ 80 DEG C.
2. the health food of a kind of auxiliary antilipemic according to claim 1, is characterized in that, described agar-agar derives from fragrant plant mentioned in ancient texts, agar, Yi Guzao or laver, and described algin derives from sea-tangle, undaria pinnitafida, bulk kelp, sargassum fusifome or sargassum.
3. the health food of an auxiliary antilipemic, it is characterized in that, its raw material comprises agar-agar, algin, Alisma extract and Herb Gynostemmae Pentaphylli extract, the percentage by weight of agar-agar, algin, Alisma extract and Herb Gynostemmae Pentaphylli extract is as follows: agar-agar 50wt%, algin 30wt%, Alisma extract 8wt%, Herb Gynostemmae Pentaphylli extract 12wt%;
The preparation method of the health food of described auxiliary antilipemic is: mixed according to weight proportion by each raw material, grind to form smalls, incapsulate, every 0.3-0.6 gram;
Wherein, the preparation method of described Alisma extract or Herb Gynostemmae Pentaphylli extract is as follows: be the ethanol water refluxing extraction 2 ~ 4 times of 0 ~ 70% by rhizoma alismatis or gynostemma pentaphylla concentration of volume percent, solid-to-liquid ratio 1:5 ~ 1:10, each 1 ~ 4h, filter and merge extract, reduced pressure concentration obtains concentrate ,-80 DEG C of freeze overnight, freeze drying, is ground into powder; Or after merging extract, filtrate is condensed into the concentrate of relative density between 1.05 ~ 1.20, then uses pneumatic spray drying powdered, the inlet temperature of spray dryer 150 ~ 200 DEG C, outlet temperature 60 ~ 80 DEG C.
4. the health food of an auxiliary antilipemic, it is characterized in that, its raw material comprises agar-agar, algin, haw thorn extract, Herb Gynostemmae Pentaphylli extract and cassia seed extract, the percentage by weight of agar-agar, algin, haw thorn extract, Herb Gynostemmae Pentaphylli extract and cassia seed extract is as follows: agar-agar 27wt%, algin 27wt%, haw thorn extract 18wt%, Herb Gynostemmae Pentaphylli extract 15wt%, cassia seed extract 13wt%;
The preparation method of the health food of described auxiliary antilipemic is: mixed according to weight proportion by each raw material, grind to form smalls, incapsulate, every 0.3-0.6 gram;
Wherein, the preparation method of described haw thorn extract or Herb Gynostemmae Pentaphylli extract or cassia seed extract is as follows: be the ethanol water refluxing extraction 2 ~ 4 times of 0 ~ 70% by hawthorn or gynostemma pentaphylla or cassia seed concentration of volume percent, solid-to-liquid ratio 1:5 ~ 1:10, each 1 ~ 4h, filter and merge extract, reduced pressure concentration obtains concentrate ,-80 DEG C of freeze overnight, freeze drying, is ground into powder; Or after merging extract, filtrate is condensed into the concentrate of relative density between 1.05 ~ 1.20, then uses pneumatic spray drying powdered, the inlet temperature of spray dryer 150 ~ 200 DEG C, outlet temperature 60 ~ 80 DEG C.
5. the health food of an auxiliary antilipemic, it is characterized in that, its raw material comprises agar-agar, algin, haw thorn extract, Herb Gynostemmae Pentaphylli extract and cassia seed extract, the percentage by weight of agar-agar, algin, haw thorn extract, Herb Gynostemmae Pentaphylli extract and cassia seed extract is as follows: agar-agar 55%, algin 10%, haw thorn extract 15%, Herb Gynostemmae Pentaphylli extract 10%, cassia seed extract 10%;
The preparation method of the health food of described auxiliary antilipemic is: mixed according to weight proportion by each raw material, grind to form smalls, incapsulate, every 0.3-0.6 gram;
Wherein, the preparation method of described haw thorn extract or Herb Gynostemmae Pentaphylli extract or cassia seed extract is as follows: be the ethanol water refluxing extraction 2 ~ 4 times of 0 ~ 70% by hawthorn or gynostemma pentaphylla or cassia seed concentration of volume percent, solid-to-liquid ratio 1:5 ~ 1:10, each 1 ~ 4h, filter and merge extract, reduced pressure concentration obtains concentrate ,-80 DEG C of freeze overnight, freeze drying, is ground into powder; Or after merging extract, filtrate is condensed into the concentrate of relative density between 1.05 ~ 1.20, then uses pneumatic spray drying powdered, the inlet temperature of spray dryer 150 ~ 200 DEG C, outlet temperature 60 ~ 80 DEG C.
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CN102246920A (en) * 2011-08-18 2011-11-23 高益槐 Health-care food capable of assisting in reduction of blood fat and preparation method thereof
CN102784254A (en) * 2012-03-20 2012-11-21 河南九势制药股份有限公司 Chinese medicine composition assisting in reducing blood fat and preparation method of Chinese medicine composition

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