CN102784254A - Chinese medicine composition assisting in reducing blood fat and preparation method of Chinese medicine composition - Google Patents
Chinese medicine composition assisting in reducing blood fat and preparation method of Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition assisting in reducing blood fat and a preparation method of the Chinese medicine composition. The Chinese medicine composition is prepared from Chinese medicines including southern ginseng, cassia seed, lotus leaves, rhizoma alismatis, seaweed and hawthorn, and the prepared oral Chinese medicine preparation has the remarkable effect of assisting in reducing the blood fat, has fine treatment effects and no toxic and side effects, and widely applicable to people.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to Chinese medicine composition of a kind of auxiliary antilipemic and preparation method thereof.
Background technology
Obesity is meant that obvious overweight and fat deposit to a certain degree is blocked up, is body fat, and especially triglyceride gathers a kind of state that too much causes.Owing to food intake too much or the change of organism metabolism cause body fat to gather too much causing excess weight to increase and cause human pathology, physiological change or hide.
Obesity can increase the danger of cardiovascular disease, influences the function of digestive system, influences the function of hormonal system, increases the danger that cancer takes place, and has joint soft tissue injury, reproductive performance to descend and mental maladjustment in addition.For many years, countries in the world are used to lose weight the funds of medicine research and development up to multi-million dollar, and the fat-reducing medicine that occurs on the market also is multifarious, countless, diet products kind surplus reaching 300 of formally on China market, selling especially at present.In the face of these diet products that emerge in an endless stream, consumer is usually dazzled, does not know how to have a liking for, so " follow advertisement to walk " often.The frequent exaggeration of propaganda of weight-reducing product advertisement that has, misguide the consumer, in addition consumer also could not explain eaten some months its mechanism of action of weight-reducing product where.What deserves to be mentioned is that alleviating of body weight has several factors.What we needed is the consumption of fat, rather than muscle, the forfeiture of moisture.There are a lot of appetrol holding a campaign of advertising at present on the market, declare what can alleviate how much in the week, not superstitious these advertisements, some medicine possibly contain catharsis agent or diuretic, possibly alleviate your some body weight in a short time, but moisture that loses and electrolyte.You may feel dizzy, and xerostomia is weak.And these medicines " fat-reducing " effect is not lasting.The medicament selection of fat-reducing is very crucial to the effect and the safety of fat-reducing.Because external popular appetite suppressant such as fenfluramine etc. have very severe complications to heart before some, so disabled in the U.S. at present.Therefore, be necessary to develop that a kind of side effect is little, the Chinese medicine of good effect and taking convenience.
Herb Gynostemmae Pentaphylli: hardship, little sweet, cold.Return lung, spleen, kidney channel.Function with cure mainly: blood pressure regulation, blood fat reducing, blood sugar regulation.Be used for the too high or unusual person of blood fat and blood pressure blood glucose.Compendium of Material Medica, " national Chinese herbal medicine compilation " record: drink Herb Gynostemmae Pentaphylli, treat tracheitis, pharyngolaryngitis, migraine, blood pressure lowering, blood fat reducing, help sleep etc.Main component: gypenoside, Herb Gynostemmae Pentaphylli glucoside (polysaccharide), water-soluble amino acid, flavonoid, multivitamin, trace element, mineral etc.
Semen Cassiae: sweet, hardship, salty, be slightly cold.Return large intestine, Liver Channel.Function with cure mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, constipation.Main component: anthraquinone analog compound emodin, physcione, chrysophanol, aloe-emodin and obtusifolin, obtusin, yellow obtusin, aurantio-obtusin and their glycoside and chrysophanic acid etc. still contain the Semen Cassiae glycoside. mucous in addition, protein, sitosterol, aminoacid and fatty wet goods
Folium Nelumbinis: hardship, flat.Return spleen, stomach, Liver Channel.Function with cure mainly: clearing away summer-heat and eliminating dampness, sending up the lucid YANG, cooling blood for hemostasis.Be used for the summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood is told nosebleed, the metrorrhagia of having blood in stool.Main component: 1. alkaloid: be mainly nuciferine, nuciferine, O-demethyl nuciferine.2. flavonoid: mainly comprise Quercetin, isoquercitin, lotus glycosides.
Rhizoma Alismatis: sweet, light, cold.Gui Jing: return kidney, urinary bladder channel.Function with cure mainly: promoting diuresis to eliminate damp pathogen, expel the heat-evil, change turbid blood fat reducing.Be used for dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.Main component: mainly contain terpenoid, wherein tetracyclic triterpene keto-alcohol derivant such as Alisol A BC etc. and acetas thereof, other also has choline, elements such as sugar and potassium, calcium, magnesium.
Sargassum: hardship, become, cold.Return liver, stomach, kidney channel.Function with cure mainly: eliminating phlegm and softening indurated mass eliminating stagnation, inducing diuresis to remove edema.Be used for goiter, scrofula, painful and swollen testis, phlegm retention edema.Main component: 1. Sargassum fusiforme (Harv.) Setch contains alginic acid, mannitol, and iodine, potassium oxide, Hijiki polysaccharide A, Hijiki polysaccharide B, Hijiki polysaccharide C and laminaran are laminarin.2. Sargassum contains alginic acid, mannitol, and iodine, potassium, crude protein, ash, sargassan, also containing with the cephalin is main phospholipids compounds.
Fructus Crataegi: acid, sweet, tepor.Return spleen, stomach, Liver Channel.Function with cure mainly: promoting digestion and invigorating the stomach, the circulation of qi promoting dissipating blood stasis is changed turbid blood fat reducing.Be used for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, obstruction of qi in the chest and cardialgia, hernia pain, hyperlipemia.Main component: Fructus Crataegi contains materials such as saccharide, protein, fat, vitamin C, carotene, starch, malic acid, citric acid, calcium and ferrum, also has flavone compound.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of auxiliary antilipemic, process by Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Nelumbinis, Rhizoma Alismatis, Sargassum and Fructus Crataegi.
The Chinese medicine composition of a kind of auxiliary antilipemic of the present invention, its raw material weight ratio of processing drug effect is:
Herb Gynostemmae Pentaphylli 5-15 part, Semen Cassiae 5-15 part, Folium Nelumbinis 5-10 part, Rhizoma Alismatis 15-20 part, Sargassum 2-5 part, Fructus Crataegi 5-15 part.
The Chinese medicine composition of a kind of auxiliary antilipemic of the present invention is characterized in that, the raw material weight ratio of processing drug effect is preferably:
10 parts of Herb Gynostemmae Pentaphylli, 10 parts of Semen Cassiaes, 6 parts on Folium Nelumbinis, 16 parts of Rhizoma Alismatis, 4 parts of Sargassums, 10 parts of Fructus Crataegis.
Another object of the present invention is to provide the method for preparing of the Chinese medicine composition of auxiliary antilipemic as stated, it is characterized in that, process: Herb Gynostemmae Pentaphylli 5-15 part, Semen Cassiae 5-15 part by the pharmacodynamic raw materials of following weight portion; Folium Nelumbinis 5-10 part; Rhizoma Alismatis 15-20 part, Sargassum 2-5 part, Fructus Crataegi 5-15 part.
The method for preparing of Chinese medicine composition of the present invention is characterized in that, may further comprise the steps:
(1) Rhizoma Alismatis (60%-70%), the Semen Cassiae with above-mentioned weight portion drops in the extraction pot, adds the ethanol that 4-6 doubly measures 60%-80%, and heating refluxes, extract 2-3 time, and each 1-2 hour, filter and obtain alcohol extract, merge alcohol extract, stand for standby use;
(2) filtering residue that filtration is obtained adds Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Sargassum, the Fructus Crataegi of above-mentioned weight portion, and adds 8-12 times of water by volume, decoct 2-3 time, and each 2-3 hour, merge aqueous extract, aqueous extract is for use, and medicinal residues discard;
(3) alcohol extract after will merging at 75 ℃ of following decompression recycling ethanols to there not being the alcohol flavor, the alcohol extraction concentrated solution, alcohol extraction concentrated solution and aqueous extract are merged, continue concentrated mixed extraction concentrated solution;
(4) mixed extraction concentrated solution drying under reduced pressure is pulverized.
(5) pulverize the back and add Rhizoma Alismatis powder (40%-30%), add the product that adjuvant is processed different dosage form again.
The method for preparing of Chinese medicine composition of the present invention is characterized in that, comprises following preferred steps:
(1), the Rhizoma Alismatis (60%-70%) of above-mentioned weight portion, Semen Cassiae are dropped in the extraction pot, add 4-6 and doubly measure 70% ethanol, heating; Pick up counting after the backflow beginning; Extracted 2 hours, and crossed and filter alcohol extract 1, filtering residue extracts 1 time with method; Filtration obtains alcohol extract 2, and alcohol extract merges stand for standby use;
(2), Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Sargassum, the Fructus Crataegi of the above-mentioned weight portion of filtering residue that above-mentioned filtration is obtained, add 8-12 times of water by volume, decoct 2 times, each 2 hours, merge aqueous extract, aqueous extract is for use, medicinal residues discard;
(3), the alcohol extract after will merging at 75 ℃ of following decompression recycling ethanols to there not being the alcohol flavor, alcohol extract, with alcohol extraction concentrated solution and the merging of water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution;
(4), mixed extraction concentrated solution drying under reduced pressure under 50 ℃, the condition of vacuum 0.10MPa, to moisture below 5%, pulverize, cross 40 mesh sieves, fine powder is subsequent use.
(5) pulverize the back and add Rhizoma Alismatis powder (40%-30%), add the product that adjuvant is processed different dosage form again.
Another object of the present invention is to provide a kind of peroral dosage form such as tablet, capsule, granule of auxiliary antilipemic.
Chinese medicine composition of the present invention has following advantage:
1, Chinese medicine composition medical material major part of the present invention is the integration of edible and medicinal herbs kind, no hormone, have no side effect, and taking convenience, effect is remarkable.
2, the property of medicine of Chinese medicine composition of the present invention is for cold; Few part is cool; Be aided with warm nature, the side effect to avoid cold medicine to cause too suddenly also takes into account the protection and the coordination of the function of the heart, liver, lung, spleen, kidney simultaneously; Demonstrated fully Chinese medicine organic conception and advantage, made the more comprehensive and treating both the principal and secondary aspects of a disease of drug effect and function.
3, the peroral dosage forms of being processed by above Six-element medicine such as granule, the auxiliary antilipemic effect is remarkable.
The specific embodiment
Following embodiment is used to further specify the present invention, but does not limit the present invention.
Drug effect embodiment
(1) diagnostic criteria is:
TC serum total cholesterol TG triglyceride
LDL-C low-density lipoprotein cholesterol HDL-C HDL-C
| Unit (mmol/L) | TC | HDL-C | LDL-C | TG |
| OK range | ＜5.18 | ＜3.37 | ＜1.70 | |
| The edge raises | 5.18-6.21 | 3.37-4.14 | 1.70-2.25 | |
| Raise | ≥6.22 | ≥1.55 | ≥4.14 | ≥2.26 |
| Reduce | ＜1.04 |
Effectively: TC reduces＞10%; TG reduces＞15%; HDL-C rising＞0.104mmol/L.
Invalid: as not reach effective standard person.
Be divided into test-meal group and matched group at random by experimenter's blood lipid level, age-based, sex, diet etc. carry out harmony to check, with the comparability between the assurance group.Every group of experimenter is no less than 50 examples.The test-meal group is taken the granule of embodiment 3, and matched group can be taken placebo or adopt blank, 45 days test periods.
The experimental group result is following
| TC | TG | |
| Effective percentage | 28％ | 51％ |
| Total effective rate | 79％ |
Conclusion: it is 28% that the T-CHOL effective percentage falls in experimental group, and the triglyceride reducing effective percentage is 51%, experimenter's T-CHOL; Triglyceride obviously reduces; With before the test-meal and matched group relatively, difference has significance (P＜0.01), this product has tangible auxiliary antilipemic effect.
2) case is for example:
Poplar XX, the man, 60 years old, before the treatment, T-CHOL 6.30, triglyceride 2.14 were taken the granule of embodiment 3 after 30 days, and T-CHOL drops to 5.5, and triglyceride drops to 1.82, the high density lipoprotein 0.16mmol/L that risen.
Song XX, the woman, 65 years old, before the treatment, T-CHOL 5.80, triglyceride 1.95 were taken the granule of embodiment 3 after 35 days, and T-CHOL drops to 5.14, and triglyceride drops to 1.69, the high density lipoprotein 0.12mmol/L that risen.
Preparation embodiment
Embodiment 1
Herb Gynostemmae Pentaphylli 10g, Semen Cassiae 10g, Folium Nelumbinis 6g, Rhizoma Alismatis 16g, Sargassum 4g; Fructus Crataegi 10g, the good medical material Rhizoma Alismatis of weighing (60-70%), Semen Cassiae drop in the extraction pot, add 8-12 and doubly measure 70% ethanol, heating; Pick up counting after the backflow beginning, extract 2h, cross and filter alcohol extract 1, filtering residue extracts 1 time with method; Filtration obtains alcohol extract 2, and alcohol extract merges, stand for standby use.To filter the gained filtering residue and add Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Sargassum, Fructus Crataegi and add 8-12 times of water by volume, decoct 2 times, each 2 hours, the merging aqueous extract, for use, medicinal residues discard.With the 75 ℃ of decompression recycling ethanols of alcohol extract after merging to there not being the alcohol flavor, the alcohol extraction concentrated solution, merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution.Mixed extraction concentrated solution drying under reduced pressure (the drying under reduced pressure condition is 50 ℃, vacuum 0.10MPa) to moisture is pulverized below 5%, crosses 40 mesh sieves, and fine powder is subsequent use.Use the extract dry powder that mixes is added the Rhizoma Alismatis (40-30%) that crushes and 12.5% the dextrin equivalent method mix homogeneously that progressively increases, adds 70% an amount of ethanol system soft material, 12 mesh sieves are granulated, and 60 spend and dry, and tabletting gets final product then.
Embodiment 2
Herb Gynostemmae Pentaphylli 100g, Semen Cassiae 100g, Folium Nelumbinis 60g, Rhizoma Alismatis 160g, Sargassum 40g; Fructus Crataegi 100g, the good medical material Rhizoma Alismatis of weighing (60-70%), Semen Cassiae drop in the extraction pot, add 8-12 and doubly measure 70% ethanol, heating; Pick up counting after the backflow beginning, extract 2h, cross and filter alcohol extract 1, filtering residue extracts 1 time with method; Filtration obtains alcohol extract 2, and alcohol extract merges, stand for standby use.To filter the gained filtering residue and add Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Sargassum, Fructus Crataegi and add 8-12 times of water by volume, decoct 2 times, each 2 hours, the merging aqueous extract, for use, medicinal residues discard.With the 75 ℃ of decompression recycling ethanols of alcohol extract after merging to there not being the alcohol flavor, the alcohol extraction concentrated solution, merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution.Mixed extraction concentrated solution drying under reduced pressure (the drying under reduced pressure condition is 50 ℃, vacuum 0.10MPa) to moisture is pulverized below 5%, crosses 40 mesh sieves, and fine powder is subsequent use.Use the extract dry powder that mixes is added the Rhizoma Alismatis (40-30%) that crushes and 12.5% the dextrin equivalent method mix homogeneously that progressively increases, adds 70% an amount of ethanol system soft material, 12 mesh sieves are granulated, and 60 spend and dry.Incapsulate, get capsule.
Embodiment 3
Herb Gynostemmae Pentaphylli 2000g, Semen Cassiae 2000g, Folium Nelumbinis 1200g, Rhizoma Alismatis 3200g, Sargassum 800g; Fructus Crataegi 2000g, the good medical material Rhizoma Alismatis of weighing (60-70%), Semen Cassiae drop in the extraction pot, add 8-12 and doubly measure 70% ethanol, heating; Pick up counting after the backflow beginning, extract 2h, cross and filter alcohol extract 1, filtering residue extracts 1 time with method; Filtration obtains alcohol extract 2, and alcohol extract merges, stand for standby use.To filter the gained filtering residue and add Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Sargassum, Fructus Crataegi and add 8-12 times of water by volume, decoct 2 times, each 2 hours, the merging aqueous extract, for use, medicinal residues discard.With the 75 ℃ of decompression recycling ethanols of alcohol extract after merging to there not being the alcohol flavor, the alcohol extraction concentrated solution, merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution.Mixed extraction concentrated solution drying under reduced pressure (the drying under reduced pressure condition is 50 ℃, vacuum 0.10MPa) to moisture is pulverized below 5%, crosses 40 mesh sieves, and fine powder is subsequent use.Use the extract dry powder that mixes is added the Rhizoma Alismatis (40-30%) that crushes and 12.5% the dextrin equivalent method mix homogeneously that progressively increases, adds 70% an amount of ethanol system soft material, 12 mesh sieves are granulated, and 60 spend and dry., get granule.
Claims (5)
1. the Chinese medicine composition of an auxiliary antilipemic is characterized in that, is processed by Herb Gynostemmae Pentaphylli, Semen Cassiae, Folium Nelumbinis, Rhizoma Alismatis, Sargassum and Fructus Crataegi.
2. the Chinese medicine composition of auxiliary antilipemic as claimed in claim 1 is characterized in that, is processed by following parts by weight of Chinese traditional medicine: Herb Gynostemmae Pentaphylli 5-15 part, Semen Cassiae 5-15 part, Folium Nelumbinis 5-10 part, Rhizoma Alismatis 15-20 part, Sargassum 2-5 part, Fructus Crataegi 5-15 part.
3. like the Chinese medicine composition of the arbitrary described auxiliary antilipemic of claim 1-2, it is characterized in that, process: 10 parts of Herb Gynostemmae Pentaphylli, 10 parts of Semen Cassiaes, 6 parts on Folium Nelumbinis, 16 parts of Rhizoma Alismatis, 4 parts of Sargassums, 10 parts of Fructus Crataegis by following parts by weight of Chinese traditional medicine.
4. like the method for preparing of the arbitrary Chinese medicine composition of claim 1-3, it is characterized in that, may further comprise the steps:
(1) Rhizoma Alismatis (60%-70%), the Semen Cassiae with above-mentioned weight portion drops in the extraction pot, adds the ethanol that 4-6 doubly measures 60%-80%, and heating refluxes, extract 2-3 time, and each 1-2 hour, filter and obtain alcohol extract, merge alcohol extract, stand for standby use;
(2) filtering residue that filtration is obtained adds Herb Gynostemmae Pentaphylli, Folium Nelumbinis, Sargassum, the Fructus Crataegi of above-mentioned weight portion, and adds 8-12 times of water by volume, decoct 2-3 time, and each 2-3 hour, merge aqueous extract, aqueous extract is for use, and medicinal residues discard;
(3) alcohol extract after will merging at 75 ℃ of following decompression recycling ethanols to there not being the alcohol flavor, the alcohol extraction concentrated solution, alcohol extraction concentrated solution and aqueous extract are merged, continue concentrated mixed extraction concentrated solution;
(4) mixed extraction concentrated solution drying under reduced pressure is pulverized.
(5) pulverize the back and add Rhizoma Alismatis powder (40%-30%), add the product that adjuvant is processed different dosage form again.
5. like the Chinese medicine composition of the arbitrary described auxiliary antilipemic of claim 1-3, it is characterized in that: the dosage form of described Chinese medicine composition is tablet, capsule, granule.
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| CN103589571A (en) * | 2013-11-26 | 2014-02-19 | 青岛嘉瑞生物技术有限公司 | Fermented Chinese herbal medicine health-care wine with functions of reducing blood fat and preventing arteriosclerosis |
| CN103689590A (en) * | 2013-11-29 | 2014-04-02 | 华侨大学 | Health food for assisting reducing blood fat and preparation method thereof |
| CN105343471A (en) * | 2015-11-26 | 2016-02-24 | 重庆壹心堂贸易有限公司 | Preparation method of traditional Chinese medicine with hypolipidemic effect |
| CN105462797A (en) * | 2015-12-10 | 2016-04-06 | 戴启亮 | Microbial fermentation lipid-lowering vinegar |
| CN108124995A (en) * | 2018-02-10 | 2018-06-08 | 广东基因方子生物医药科技有限公司 | A kind of composition with weight-reducing and function of relaxing bowel and preparation method thereof |
| CN108813511A (en) * | 2018-05-23 | 2018-11-16 | 安徽省六尺春翠农业科技有限公司 | A kind of pueraria lobata blood fat reducing health products and its processing method |
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| CN107854580A (en) * | 2017-12-22 | 2018-03-30 | 裴虎雷 | A kind of Chinese medicine composition of lipid-loweringing and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103589571A (en) * | 2013-11-26 | 2014-02-19 | 青岛嘉瑞生物技术有限公司 | Fermented Chinese herbal medicine health-care wine with functions of reducing blood fat and preventing arteriosclerosis |
| CN103589571B (en) * | 2013-11-26 | 2015-03-25 | 青岛嘉瑞生物技术有限公司 | Fermented Chinese herbal medicine health-care wine with functions of reducing blood fat and preventing arteriosclerosis |
| CN103689590A (en) * | 2013-11-29 | 2014-04-02 | 华侨大学 | Health food for assisting reducing blood fat and preparation method thereof |
| CN103689590B (en) * | 2013-11-29 | 2016-04-13 | 华侨大学 | Health food of a kind of auxiliary antilipemic and preparation method thereof |
| CN105343471A (en) * | 2015-11-26 | 2016-02-24 | 重庆壹心堂贸易有限公司 | Preparation method of traditional Chinese medicine with hypolipidemic effect |
| CN105462797A (en) * | 2015-12-10 | 2016-04-06 | 戴启亮 | Microbial fermentation lipid-lowering vinegar |
| CN108124995A (en) * | 2018-02-10 | 2018-06-08 | 广东基因方子生物医药科技有限公司 | A kind of composition with weight-reducing and function of relaxing bowel and preparation method thereof |
| CN108813511A (en) * | 2018-05-23 | 2018-11-16 | 安徽省六尺春翠农业科技有限公司 | A kind of pueraria lobata blood fat reducing health products and its processing method |
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| Publication number | Publication date |
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| CN102784254B (en) | 2015-04-29 |
| CN102579712A (en) | 2012-07-18 |
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