CN103211866A - Soft capsule used for improving body immunity and heart and cerebral vessel function - Google Patents
Soft capsule used for improving body immunity and heart and cerebral vessel function Download PDFInfo
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- CN103211866A CN103211866A CN2013100973779A CN201310097377A CN103211866A CN 103211866 A CN103211866 A CN 103211866A CN 2013100973779 A CN2013100973779 A CN 2013100973779A CN 201310097377 A CN201310097377 A CN 201310097377A CN 103211866 A CN103211866 A CN 103211866A
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Abstract
A soft capsule used for improving body immunity and heart and cerebral vessel functions adopts propolis, a ginkgo biloba extract, beeswax, and linseed oil for a content, and adopts gelatin, glycerin, purified water and a cocoa shell pigment for a lorica. The mass ratio is as follows: 70-150 parts of propolis, 5-50 parts of the ginkgo biloba extract, 5-50 parts of beeswax, 150-350 parts of linseed oil, 290-310 parts of gelatin, 100-150 parts of glycerin, 300-350 parts of purified water, and 0.5-1 part of cocoa shell pigment. The raw materials are made into soft capsules by dosing, dissolving sol, pelleting, sizing, washing pills, drying, and sorting pills. Each pellet is of 0.4 g. The active ingredients contained in the formulation of the invention can enhance phagocytosis of white blood cells and macrophage, improve the body's non-specific and specific immunity, thus enhancing the body's immune function, and can effectively lower blood pressure, lower blood sugar, and prevent atherosclerosis sclerosis.
Description
Technical field
The present invention relates to a kind of combination formula, specifically a kind of soft capsule that is used for human body immunity improving power, improves cardio and vascular function.
Background technology
The normalization of immune existence and function is the stable basic assurance of body's immunity, any part damaged or all can cause the incomplete and disorderly of immunologic function unusually wherein, thus reduce or the forfeiture immunologic function.Older, factors such as operating pressure is big, rhythm of life is fast, bad life style can cause body immunity decline, easy catching a cold, cardiovascular and cerebrovascular disease increase, gastrointestinal dysfunction etc.Cardiovascular and cerebrovascular disease has " sickness rate height, disability rate height, mortality rate height, relapse rate height, complication is many " i.e. characteristics of " four is high by more than ", has become one of the highest disease of human mortality rate.Prevention cardiovascular and cerebrovascular disease and raising body autoimmunity are improved health conditions most important for the mankind.Thereby be necessary the preparation developing human body immunity improving power, improve cardio and vascular function.
Summary of the invention
Technical problem to be solved by this invention provides and a kind ofly is used for human body immunity improving power, improves the soft capsule of cardio and vascular function, and has advantages such as therapeutic effect is good, cheap, taking convenience.
The technical scheme that the present invention is adopted for its technical problem of solution is: a kind of soft capsule that is used for human body immunity improving power, improves cardio and vascular function, adopting propolis, Folium Ginkgo extract, Cera Flava, Semen Lini oil is content, gelatin, glycerol, purified water, Cacao pigment are softgel shell, and the quality proportioning is that each composition of 70～150 parts of propolis, 5～50 parts of Folium Ginkgo extract, 5～50 parts in Cera Flava, 150～350 parts of Semen Lini oil, 290～310 parts in gelatin, 100～150 parts of glycerol, 300～350 parts of purified water, 0.5～1 part of Cacao pigment is made soft capsule.
Its concrete preparation technology is: take by weighing propolis, Folium Ginkgo extract, Cera Flava, Semen Lini oil by formula proportion; Wherein propolis is put into freezer cold preservation, and temperature is controlled at-8 ℃～-3 ℃, and cold preservation time is 2h; Propolis after the cold preservation is broken into pieces, pulverized, cross 100 mesh sieves with Folium Ginkgo extract; Get Semen Lini oil and be heated to 70 ℃-80 ℃, the limit adds the Cera Flava limit stirs, and makes it fully dissolve mixing, gets oily wax mixed liquor, leave standstill when being cooled to 30 ℃ of left and right sides, add the powder after propolis and Folium Ginkgo extract are pulverized, mix, mixed liquor passes through colloid mill 2～3 times, ground and mixed is even, (0.06MPa) degassing 30min makes the content feed liquid to evacuation, and is standby.Colloidal sol: take by weighing gelatin, glycerol, purified water, Cacao pigment by formula proportion.The purified water that earlier gelatin is added formula ratio 1/2 is soaked 2h, treat that its back of fully expanding adds glycerol and residue purified water, after being heated to 70～80 ℃ of abundant dissolvings, add Cacao pigment again, mixing, cross 100 mesh sieves, (0.06MPa) after the degassing thoroughly, it is stand-by that glue is put in the heat-preserving container (60 ± 5 ℃) for evacuation.Again through pelleting, finalize the design, wash ball, drying, choose ball, make soft capsule, every 0.4 gram.
The preparation method of the Folium Ginkgo extract in the preparation of the present invention: get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, dry by the fire 8～12h, pulverized 60 mesh sieves with pulverizer then, utilized Enzymatic Extraction, with glucosidase or transglycosylase enzymolysis and extraction, through ethanol precipitation, concentrated forming behind petroleum ether and ethyl acetate extraction.
60 ℃～70 ℃ 60% ethanol that adds 7 times of amounts, lixiviate 2h, every 10min stirs once, filters, and adds 60% ethanol of 7 times of amounts in the residue, and 60 ℃～70 ℃ are continued lixiviate 2h, and every 10min stirs once, filters, and merges lixiviating solution.60 ℃～70 ℃ are concentrated into relative density is 1.1～1.2 (50 ℃), and vacuum (0.08MPa, 60 ℃) drying was pulverized 100 mesh sieves then.
Of the present invention part is mass parts, is mass units such as this area microgram commonly used, milligram, gram, kilogram.
A preparation of the present invention suggestion day clothes effective dose is every day 2 times, and each 2, warm water takes.
The invention has the beneficial effects as follows: propolis can improve the nonspecific immunity of body by promoting cytophagous phagocytic function in the preparation, by the generation raising specific immunity of enhancing antibody; Folium Ginkgo extract can improve the specific immunity of body by the increase that stimulates lymphocytic propagation and IgG antibody content.And the flavone compound in propolis and the Folium Ginkgo extract also has blood fat reducing, prevention of arterial is atherosis, the function of blood sugar lowering.Alpha-linolenic acid in the Semen Lini oil can change the platelet membrane flowability, thereby changes platelet to the reactivity of stimulation and the number of platelet surface receptor, the formation of effectively anti-tampon.In sum, the use in conjunction of preparation mentioned component of the present invention is in enhance immunity and improve and synergistic effect is arranged aspect the cardiovascular function.
Compound basis
Propolis is the natural gum of Apis herborization, and sneaks into its palate glandular secretion thing and Cera Flava and chew a kind of colloid substance, the propolis that modulation forms through Apis and contain pharmacological components such as abundant flavonoids, terpenoid, fragrant phenol.Propolis has effects such as immunological enhancement, blood fat reducing, blood sugar lowering, anti-inflammation, antioxidation, antitumor.Aspect immunostimulant, the generation of energy such as the pinocembrin in the propolis, galangin, kaempferide enhancing antibody, the phagocytic activity of enhancing leukocyte and macrophage, the specificity and the nonspecific immunity of raising body.Flavone compound has blood fat reducing function; pillars of a house professor finds that at first propolis has the blood fat reducing effect; studies show that in a large number that subsequently propolis has tangible regulating action to hyperlipidemia, hypercholesterolemia; the accumulation of the fibriilar increase regulating liver-QI of energy prevention of arterial blood vessel hose lining inner cholesterol; atherosclerosis there is preventive effect; and can effectively remove deposit in the blood vessel wall, antithrombotic forms, the protection cardiovascular and cerebrovascular vessel.Flavone compound also has effect of lowering blood sugar, and experiment shows that it can obviously suppress the activity of alpha-glucosidase in the mouse small intestine, thereby delays the digestion of carbohydrate, postpones the absorption of disaccharidase, oligosaccharide, polysaccharide, postpones and reduce the rising of post-prandial glycemia.
Folium Ginkgo is the dried leaves of Ginkgoaceae plant Ginkgo biloba, and gather when leaf is still green autumn, and is in time dry.Modern pharmacological research shows, multiple effective active compositions such as contained flavonoid, lactone, terpenoid in the Folium Ginkgo, and pharmacological action is comparatively extensive.Folium Ginkgo extract energy enhancing human body immunity power; Blood lipid regulation, vessel softening, blood pressure lowering; Anti-inflammation; Antitumor; Looks improving and the skin nourishing, slow down aging etc.Aspect enhancing immunity, Folium Ginkgo extract can obviously strengthen the release of mouse lymphocyte mitochondrial dehydrogenase and neutrophilic granulocyte MPO (myeloperoxidase (MPO)), has the effect that improves mice immune cell function.And can make mouse anti SRBC (sheep red blood cell (SRBC)) antibody-producting cell number and antibody thereof produce increase, and can strengthen the phagocytic function of macrophage.The all right blood fat reducing of Folium Ginkgo extract, Li Chuanxun etc. studies show that the rat with hyperlipidemia forage feed SD, and preparation hyperlipemia rat model gives Folium Ginkgo flavone then, and the level of serum total cholesterol of rat and triglyceride obviously reduces as a result.Discovery Folium Ginkgo extract such as Chen Linxi have and delay to raise the effect that hypercholesterolemia rabbit arterial atherosclerotic plaque forms and the effect of the external oxidative modification of opposing low density lipoprotein, LDL.Folium Ginkgo extract also can suppress thrombocyte adhesiveness, regulate antiotasis and elastic force simultaneously.
Semen Lini oil is the oils of being produced through squeezing by Semen Lini, contains unsaturated fatty acid alpha-linolenic acid, gamma-Linolenic acid and 18 seed amino acids in the Semen Lini.Alpha-linolenic acid has multiple physiological function, and the prevention cardiovascular and cerebrovascular disease: alpha-linolenic acid can change the platelet membrane flowability, thereby changes platelet to the reactivity of stimulation and the number of platelet surface receptor.Therefore, can effectively prevent the formation of tampon, anti-hemostatic tube stops up, and avoids heart coronary artery and cerebrovascular place formation thrombosis and causes myocardial infarction and cerebral infarction.Secondly, alpha-linolenic acid can blood fat reducing: the metabolite of alpha-linolenic acid has gentle regulating action to blood lipid metabolism, can promote the conversion of blood plasma low density lipoprotein, LDL (LDL) to high density lipoprotein (HDL), low density lipoprotein, LDL (LDL) is reduced, high density lipoprotein (HDL) raises, thereby reach blood fat reducing, prevent atherosclerotic purpose.Reduce borderline hypertension: being borderline hypertension between blood pressure 145/90mmHg～160/95mmHg, is initial stage property hypertension, if life-time service depressor easily causes many untoward reaction.The metabolite of alpha-linolenic acid can blood vessel dilating, strengthens blood vessel elasticity, thereby plays hypotensive effect.But the alpha-linolenic acid blood sugar lowering is main by promoting pancreatic excreting insulin and the Stabilization of protection insulin in blood, can also reduce the opposing of target cell to insulin.
The function of said preparation:
One, raise immunity
Contained effective ingredient can strengthen the phagocytic activity of leukocyte and macrophage in the preparation of the present invention, improves the non-special row and the specific immunity ability of body, thus enhancing body's immunological function.
Two, prevent and treat cardiovascular disease
Flavone compound in the preparation of the present invention has blood fat reducing function, and it can combine with cholesterol or its conversion product cholic acid, suppresses it and absorbs at enteral, promotes its degraded and drainage, and atherosclerosis is had preventive effect.Alpha-linolenic acid can change the platelet membrane flowability, can effectively prevent the formation of tampon, and its metabolite has gentle regulating action to blood lipid metabolism, and effectively blood fat reducing, blood sugar lowering, prevents atherosclerosis.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
The invention will be further described below in conjunction with embodiment:
Embodiment 1: a kind of soft capsule that is used for human body immunity improving power, improves cardio and vascular function.Adopt 100 parts of propolis, 30 parts of Folium Ginkgo extract, 20 parts in Cera Flava, 250 parts of Semen Lini oil, 0.8 part in 300 parts in gelatin, 125 parts of glycerol, 325 parts of purified water, Cacao pigment through batching, colloidal sol, pelleting, finalize the design, wash ball, drying, choose ball, make soft capsule, every 0.4 gram.Every day 2 times, each 2, warm water takes.
Embodiment 2: a kind of soft capsule that is used for human body immunity improving power, improves cardio and vascular function.Adopt 130 parts of propolis, 20 parts of Folium Ginkgo extract, 20 parts in Cera Flava, 230 parts of Semen Lini oil, 1.0 parts in 310 parts in gelatin, 115 parts of glycerol, 350 parts of purified water, Cacao pigment through batching, colloidal sol, pelleting, finalize the design, wash ball, drying, choose ball, make soft capsule, every 0.4 gram.Every day 2 times, each 2, warm water takes.
Embodiment 3: a kind of soft capsule that is used for human body immunity improving power, improves cardio and vascular function.Adopt 80 parts of propolis, 50 parts of Folium Ginkgo extract, 10 parts in Cera Flava, 260 parts of Semen Lini oil, 0.5 part in 290 parts in gelatin, 135 parts of glycerol, 315 parts of purified water, Cacao pigment through batching, colloidal sol, pelleting, finalize the design, wash ball, drying, choose ball, make soft capsule, every 0.4 gram.Every day 2 times, each 2, warm water takes.
Embodiment 4: human feeding trial 1.
Use the preparation of the present invention of preparation among the embodiment 1, the human body immunity improving power effect of this product is tested.
The study subject standard: the crowd of simple hypoimmunity, the age is between 45-65 year, experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 100 routine experimenters, requirement grouping according to randomized, double-blind, be divided into test-meal group and matched group, consider to influence result's principal element as far as possible, as the age, sex, diet etc., carry out harmonious verification, with the comparability between the assurance group, every group of experimenter's 50 examples, the test-meal group is taken preparation of the present invention 2 times for each person every day, one time 2, matched group is taken placebo, takes 60d continuously, the grouping situation sees Table 1, the preceding two groups of hematurias of test-meal are routine and hepatic and renal function just, Chest X-rays, electrocardiogram, B ultrasonic etc. were checked all in normal range, two groups of subject age sexes, the equal no significant difference of macrophage content (P＞0.05) in lymphocyte in the blood and the body has comparability.
Data relatively as table 1 test-meal was last
After the test-meal situation see Table 2, table 3.
Table 2 blood testing-lymphocyte
Table 3 blood testing-macrophage
By table 2, table 3 as seen, take back 60d, lymphocyte and macrophage content all obviously improve (P＜0.01) before and after the test-meal of test-meal group, and significantly better than matched group, two group differences are (P＜0.01) very significantly.
The result shows, behind the examination clothes preparation 60d of the present invention, self relatively reach before and after the test-meal of test-meal group after the test-meal between test-meal group and matched group group relatively, blood medium-sized lymphocyte and macrophage content be obviously improve (P＜0.01) all, so the effect that this invention preparation has enhancing human body immunity power.
Embodiment 5: human feeding trial 2.
Use the preparation of the present invention of preparation among the embodiment 1, the cardio and vascular function effect of improving of this product is tested.
The study subject standard: the simple patient with cardiovascular and cerebrovascular disease, the age is between 45～70 years old.
Experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 200 routine experimenters, divide into groups according to the requirement of randomized, double-blind, be divided into test-meal group and matched group, consider influence result's principal element such as age, sex, diet etc. as far as possible, carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 100 examples.The test-meal group is taken this invention 2 times for each person every day, and each 2, matched group is taken placebo, takes 60d continuously.
The grouping situation sees Table 1.The equal no significant difference (P＞0.05) of serum total cholesterol (TC), triglyceride (TG) and HDL-C (HDL-C) has comparability in the preceding two groups of subject age of test-meal, sex, the blood.
Data relatively as table 1 test-meal was last
Situation sees Table 2 after the test-meal.
The comparison of test-meal group and matched group after table 2 test-meal
By table 2 as seen, take back 60d, obviously reduction (P＜0.01) of serum total cholesterol (TC), triglyceride (TG) in the blood before and after the test-meal of test-meal group, HDL-C (HDL-C) is rising (P＜0.05) obviously, and significantly better than matched group, two group differences are (P＜0.01) very significantly.
The result shows, behind the examination clothes preparation 60d of the present invention, self relatively reach comparison between test-meal group and matched group group after the test-meal before and after the test-meal of test-meal group, serum total cholesterol in the blood (TC), triglyceride (TG) obviously reduce (P＜0.01), HDL-C (HDL-C) is rising (P＜0.05) obviously, so this invention has the effect of blood lipid regulation, can well improve cardio and vascular function.
Claims (2)
1. one kind is used for human body immunity improving power, improve the soft capsule of cardio and vascular function, it adopts 70～150 parts of propolis, 5～50 parts of Folium Ginkgo extract, 5～50 parts in Cera Flava, Semen Lini oil is a content for 150～350 parts, wherein propolis is put into freezer cold preservation, temperature is controlled at-8 ℃～-3 ℃, cold preservation time is 2h, propolis after the cold preservation is broken into pieces, pulverize with Folium Ginkgo extract, cross 100 mesh sieves, get Semen Lini oil and be heated to 70 ℃～80 ℃, the limit adds the Cera Flava limit and stirs, make it fully dissolve mixing, get oily wax mixed liquor, leave standstill when being cooled to 30 ℃ of left and right sides, add the powder after propolis and Folium Ginkgo extract are pulverized, mix, mixed liquor passes through colloid mill 2～3 times, and ground and mixed is even ,-0.06MPa vacuumize degassing 30min, make the content feed liquid, again through colloidal sol, pelleting, typing, wash ball, dry, choose ball, make soft capsule, every 0.4 gram.
2. a kind of soft capsule that is used for human body immunity improving power, improves cardio and vascular function according to claim 1, the preparation method of its described Folium Ginkgo extract is: get fresh Folium Ginkgo, clean, dry, in 70 ℃ of baking ovens, dry by the fire 8～12h, pulverized 60 mesh sieves with pulverizer then, utilize Enzymatic Extraction, with glucosidase or transglycosylase enzymolysis and extraction, concentrated forming behind ethanol precipitation, petroleum ether and ethyl acetate extraction.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106136243A (en) * | 2016-08-26 | 2016-11-23 | 李仁宝 | A kind of Sargassum extract health care soft capsule |
| CN106361790A (en) * | 2016-08-26 | 2017-02-01 | 湖北新阳蜂业有限公司 | Bee propolis capsule and preparation method thereof |
| CN106943372A (en) * | 2017-03-16 | 2017-07-14 | 于桐浩 | A kind of auxiliary hyperglycemic soft capsule and its production technology |
| CN107029016A (en) * | 2017-05-27 | 2017-08-11 | 桦南仙紫食品科技有限公司 | Propolis purple perilla soft capsule and processing method |
| CN109567188A (en) * | 2018-12-28 | 2019-04-05 | 江苏鸿祺生物科技有限公司 | A kind of health-care food composition and its preparation method and application of propolis-containing extract |
| CN109601936A (en) * | 2018-12-28 | 2019-04-12 | 江苏鸿祺生物科技有限公司 | A kind of propolis extract and its health-care food composition preventing senile dementia |
| CN113876831A (en) * | 2021-10-12 | 2022-01-04 | 四川逢春制药有限公司 | Composition for improving memory and reducing blood fat, preparation method and application thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106136243A (en) * | 2016-08-26 | 2016-11-23 | 李仁宝 | A kind of Sargassum extract health care soft capsule |
| CN106361790A (en) * | 2016-08-26 | 2017-02-01 | 湖北新阳蜂业有限公司 | Bee propolis capsule and preparation method thereof |
| CN106943372A (en) * | 2017-03-16 | 2017-07-14 | 于桐浩 | A kind of auxiliary hyperglycemic soft capsule and its production technology |
| CN107029016A (en) * | 2017-05-27 | 2017-08-11 | 桦南仙紫食品科技有限公司 | Propolis purple perilla soft capsule and processing method |
| CN109567188A (en) * | 2018-12-28 | 2019-04-05 | 江苏鸿祺生物科技有限公司 | A kind of health-care food composition and its preparation method and application of propolis-containing extract |
| CN109601936A (en) * | 2018-12-28 | 2019-04-12 | 江苏鸿祺生物科技有限公司 | A kind of propolis extract and its health-care food composition preventing senile dementia |
| CN113876831A (en) * | 2021-10-12 | 2022-01-04 | 四川逢春制药有限公司 | Composition for improving memory and reducing blood fat, preparation method and application thereof |
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Application publication date: 20130724 |