CN105596646A - Medicine, health-care product or food composition for controlling blood glucose and treating abnormal blood lipid metabolism - Google Patents
Medicine, health-care product or food composition for controlling blood glucose and treating abnormal blood lipid metabolism Download PDFInfo
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Abstract
The invention provides a medicine, health-care product or food composition composed of Chinese wolfberry, Chinese yam and a crude drug A, wherein the crude drug A is selected from one of prepared rehmannia root, rhizoma polygonati and radix polygonati officinalis. The composition can control blood glucose and/or treat abnormal blood lipid metabolism, has exact curative effect, is available to suit the remedy to the case, is convenient to prepare, and almost has no waste of the crude drug.
Description
Technical field
The invention belongs to traditional Chinese medicine, health products or field of food, particularly, the present invention relates to control blood sugar and treatment blood fatMedicine, health products or the food compositions of metabolic disorder and preparation and application.
Background technology
Hyperglycaemia, high fat of blood and obesity etc. are " rich man's diseases " causing under modern life custom, especially type ii diabetes peopleOften follow fat metabolic disorder, the means of also not effecting a radical cure at present, need Long-term taking medicine or take that health food is controlled andImprove.
Prior art also has many formulas based on Chinese medicine to control blood sugar, blood fat and liver function, but they oftenBe limited by raw material (crude drug) kind too much, formula is complicated, and the quality of production is difficult to control. For example, Chinese patent the 96116603rdA kind of hypoglycemic electuary and preparation method thereof number is disclosed, it comprise pumpkin powder, precision corn, wheat bran, the Radix Astragali, the root of kudzu vine, radix rehmanniae recen,Chinese yam rhizome, corn stigma, mulberry fruit, matrimony vine, calcium activated, xylitol, pearl powder, stevioside, Semen sesami nigrum etc.; Chinese patentDisclose a kind of Amti-sanility health-care food No. 200510020632, it comprises Chinese yam, Poria cocos, coix seed, hawthorn, cassia seed or whatThe tuber of multiflower knotweed or rheum officinale, almond or peach kernel, kelp, oyster, SEMEN COAT GLYCINES NIGRUM, sealwort, the fruit of Chinese wolfberry, raspberry; Chinese patentDisclose a kind of Chinese olive lipopenicillinaseization sugar particle and preparation technology thereof for No. 201210034191, its Raw is: Chinese olive, balsam pear, HuangStilbene, the red sage root, rhizome of chuanxiong, the membrane of a chicken's gizzard, Chinese yam, hawthorn, matrimony vine, sealwort, mulberry leaf. In addition, the curative effect of the formula of prior art is not conventionallyToo definite, and very general for illness, the patient's condition, be difficult to suit the remedy to the case for concrete patient.
The inventor is through long-term and arduous research, and some fortune in addition, have found unexpectedly based on matrimony vine, mountainThe formula of medicine, prepared rhizome of rehmannia, sealwort and/or radix polygonati officinalis, wherein crude drug kind only has 2 or 3 kind, and preparation technology is simple, is convenient to control produceProduct quality, and determined curative effect, can significantly control blood sugar and/or treatment Dyslipidemia etc., more beyond thought, noSame formula is very strong to the specific aim of illness, the patient's condition, therefore can adapt to concrete patient, suits the remedy to the case.
In addition, be subject to doctor trained in Western medicine reductionism thought and the traditional Chinese medical science and concoct the impact of putting into practice, prior art adopts carrying of crude drug conventionallyGet thing (as extractive with organic solvent etc.) and be used as medicine, not only crude drug utilization rate is limited, and during can produce a large amount of waste residues and/Or waste liquid, also can be with organic solvent residual in medicine, and the inventor is not subject to the confinement of such prior art completely,Develop new preparation method, taken full advantage of to greatest extent crude drug, can not introduce any harmful substance (as, You JirongAgent), keep the pure natural property of product, and in preparation process, produce hardly any waste residue and/or waste liquid, very suitable to existingIn the situation of modern pay attention to day by day environmental pollution, carry out large-scale production.
Summary of the invention
The object of the present invention is to provide new medicine, health products or food compositions, it can be used as staple food substituteLong-term edible, for controlling blood sugar and/or treatment Dyslipidemia etc. In addition, the present invention also provides the system of said compositionPreparation Method, goods and application etc.
Particularly, in first aspect, the invention provides medicine, health products or food compositions, it is by matrimony vine, Chinese yamWith crude drug A composition, wherein crude drug A is selected from the one in prepared rhizome of rehmannia, sealwort and radix polygonati officinalis, and wherein matrimony vine, Chinese yam and crude drug AWeight ratio is 55～65:160～200:0～18.
In this article, medicine, health products and food are all that various equivalent modifications is known, can reference food andThe definition of drug regulatory department and standard. For example, in the present invention, crude drug (raw material) and preparation just meet the drug standardsCan be considered as composite medicine, what only meet food standard is food compositions.
In this article, raw material or crude drug are that various equivalent modifications is known. For example, matrimony vine has another name called the fruit of Chinese wolfberry, ripeGlutinous rehmannia has another name called cultivated land etc., and these raw materials or crude drug all can pass through open market purchase.
Preferably in the composition of first aspect present invention, the weight ratio of matrimony vine, Chinese yam and crude drug A be 58～63:170～190:0～16, more preferably 60:180:0～15, in the specific embodiment of the invention, can be 60:180:0,60:180:5,60:180:10 or 60:180:15. In the composition of first aspect present invention, the amount of crude drug A can be 0, i.e. the present inventionComposition on the one hand can be made up of matrimony vine and Chinese yam, so preferably the composition of first aspect present invention is by matrimony vine and mountainMedicine composition, and wherein the weight ratio of matrimony vine and Chinese yam is 55～65:160～200, is preferably 58～63:170～190, more excellentElect 60:180 as, as be 60:180.
In addition, also preferably the composition of first aspect present invention is made up of matrimony vine, Chinese yam and prepared rhizome of rehmannia, and Chinese holly whereinThe weight ratio of Qi, Chinese yam and prepared rhizome of rehmannia is 55～65:160～200:3～6, is preferably 58～63:170～190:4～6, moreBe preferably 60:180:5. Also preferably the composition of first aspect present invention is made up of matrimony vine, Chinese yam and sealwort, and Chinese holly whereinThe weight ratio of Qi, Chinese yam and sealwort is 55～65:160～200:8～12; Also the composition of preferred first aspect present invention is by Chinese hollyQi, Chinese yam and radix polygonati officinalis composition, and wherein the weight ratio of matrimony vine, Chinese yam and radix polygonati officinalis is 55～65:160～200:13～18, excellentElect 58～63:170～190:15～16 as, more preferably 60:180:15.
The inventor studies discovery, directly matrimony vine, Chinese yam and crude drug A are mixed (as, be pulverized and mixed), mouthfeel is bad, treatsImitate and also seem to be subject to impact. For this reason, the preparation method of the composition of first aspect present invention that the inventor is well-designed, gramTake above-mentioned defect, and can utilize all crude drugs to peak efficiency, during preparation, introduced hardly other materials, can keepThe pure natural property of product of the present invention, also produces discarded object (comprising waste residue and/or waste liquid) hardly. Therefore, preferably the present invention theComposition on the one hand, it is prepared by the following method:
(1) by Chinese yam and crude drug A boiling, then cooling;
(2) solid and the liquid that step (1) are obtained mix with matrimony vine and carry out homogenate pulverizing; With,
(3) crushed material step (1) being obtained is dry, then optionally pulverizes again.
Further, preferably wherein, the weight of water is 2～3.5 times of gross weight of Chinese yam and crude drug A, is preferably 3 times.
Also further, preferably wherein, the time of decoction is 20～60 minutes, is preferably 30 minutes.
Also further, preferably wherein, the cooling temperature reaching is 20～30 DEG C, is preferably room temperature. In this article, as nothingContradiction or especially instruction, room temperature can be 25 DEG C.
In second aspect, the invention provides the preparation method of the composition of first aspect present invention, it comprises:
(1) by Chinese yam and crude drug A boiling, then cooling;
(2) solid and the liquid that step (1) are obtained mix with matrimony vine and carry out homogenate pulverizing; With,
(3) crushed material step (1) being obtained is dry, then optionally pulverizes again.
Preferably in the preparation method of second aspect present invention, the weight of water be Chinese yam and crude drug A gross weight 2～3.5 times, be preferably 3 times.
Also preferred in the preparation method of second aspect present invention, the time of decoction is 20～60 minutes, is preferably 30 pointsClock.
Also preferred in the preparation method of second aspect present invention, the cooling temperature reaching is 20～30 DEG C, is preferably chamberTemperature. In this article, as noncontradictory or instruction especially, room temperature can be 25 DEG C.
In the preparation method of second aspect present invention, homogenate is pulverized and can be carried out with equal pulp grinder, and being dried can be with coldLyophilizer carries out, and these are all the equipment that can buy on open market.
In the third aspect, the invention provides medicine, health products or food compositions, it comprises the group of first aspect present inventionAcceptable auxiliary material on compound and medicine, on health products or on food. In this article, on medicine, on health products or can on foodThe auxiliary material of accepting refer to respectively compatible with crude drug A with matrimony vine, Chinese yam and do not affect their performance effects nontoxic medicine,Health products or food auxiliary material, comprise carrier, excipient, diluent and flavor enhancement etc.
In fourth aspect, the invention provides the preparation method of the goods of third aspect present invention, it comprises the present inventionThe composition of first aspect and the step together with acceptable auxiliary material combination on medicine, on health products or on food.
The composition of first aspect present invention and assistant agent are combined, can be mixed with various preparations (, goods),Be preferably solid pharmaceutical preparation and liquid preparation, as tablet, pill, capsule (comprise sustained release or delay release releasing pattern), pulvis,Formulation and the various slow release formulations such as supensoid agent, granule, tincture, syrup, emulsion agent, suspension, injection, thus be applicable to eachKind of form of medication, such as oral, non-enteron aisle injection, mucous membrane, muscle, intravenous, subcutaneous, intraocular, intracutaneous or through skin etc.Form of medication is most preferably oral. Optional auxiliary material comprises dispersant, as nanometer dispersant, as nano-starch, nanometer are stuck with pasteEssence, nanometer SiO2, nanometer CaCO3, nano-TiO2, nano zine oxide, nanometer indium, Nano Silver, nano-aluminum hydroxide, nano oxidizedIron, nanometer iron chloride, nano-sized carbon, nanometer selenium, nano aluminium oxide, nano magnesia. Other suitable auxiliary materials comprise polyethylene glycolClass, PVP class water-solubility carrier, as PEG2000-20000 or PVPK15-K90 or PVA or PVP-PVA or CPD etc. At thisIn the detailed description of the invention of invention, auxiliary material can be water, can keep like this pure natural property of product of the present invention.
Aspect the 5th, the composition that the invention provides first aspect present invention reduces blood sugar (especially meal in preparationRear blood sugar) level, reduce serum total cholesterol level, reduce serum triglyceride level, reduce serum low-density LP waterApplication in flat, to reduce serum GPT levels and/or reduction liver index medicine, health products or food.
The inventor finds the formula determined curative effects of different fine settings in the composition of first aspect present invention, to illness, diseaseThe specific aim of condition is very strong, therefore can adapt to concrete patient, suits the remedy to the case. Therefore, preferably in the application of fifth aspect present inventionIn, described composition is made up of matrimony vine, Chinese yam and sealwort, and wherein the weight ratio of matrimony vine, Chinese yam and sealwort is 55～65:160～200:8～12, are preferably 58～63:170～190:9～11, more preferably 60:180:10; Wherein said medicine, guarantorStrong product or food reduce serum total cholesterol level, reduce serum triglyceride level and/or reduce serum low-density LPLevel. The composition that should be made up of matrimony vine, Chinese yam and sealwort has been specially adapted to reduce the above-mentioned patient's condition but do not have otherwiseThe patient of the patient's condition (as normal in, liver function, without reducing serum GPT levels), can avoid otherwise unfavorableImpact.
Also preferred in the application of fifth aspect present invention, described composition is made up of matrimony vine, Chinese yam and radix polygonati officinalis, Er QieqiThe weight ratio of middle matrimony vine, Chinese yam and radix polygonati officinalis is 55～65:160～200:13～18, be preferably 58～63:170～190:15～16, more preferably 60:180:15; Wherein said medicine, health products or food reduce serum low-density LP level, reduce bloodClear gpt level and/or reduction liver index. The composition that should be made up of matrimony vine, Chinese yam and radix polygonati officinalis is specially adapted toHave reduce the above-mentioned patient's condition but do not have the otherwise patient's condition (as, total cholesterol level is normal, triglyceride levels is normal) diseasePeople, can avoid otherwise adverse effect.
Also preferably in the application of fifth aspect present invention, described composition is made up of matrimony vine and Chinese yam, and Chinese holly whereinThe weight ratio of Qi and Chinese yam is 55～65:160～200, is preferably 58～63:170～190, more preferably 60:180; Wherein instituteState medicine, health products or food and reduce liver index. The composition that should be made up of matrimony vine and Chinese yam has been specially adapted in reductionState the patient's condition but do not have the otherwise patient's condition (as, total cholesterol level is normal, triglyceride levels is normal, serum low-density fatProtein level is normal) patient, can avoid otherwise adverse effect.
Preferred in the application of fifth aspect present invention in addition, reducing blood sugar (especially postprandial blood sugar) level is instant risingEffect. Therefore in corresponding application, food can be appetizer before the meal.
Beneficial effect of the present invention is, in formula, crude drug kind is few, and preparation technology is simple, is convenient to control product quality,And determined curative effect; Can significantly control blood sugar and/or treatment Dyslipidemia etc., especially different formulas is to illness, diseaseThe specific aim of condition is very strong, can adapt to concrete patient, suits the remedy to the case; Preparation process takes full advantage of crude drug to greatest extent, canNot introduce any harmful substance, keep the pure natural property of product, and in preparation process, produce hardly any waste residue and/orWaste liquid, very environmental protection.
The present invention has quoted existing open source literature, and these documents are in order more clearly to describe the present invention, their full textContent is all included in herein, just looks like that repeated description is excessively the same in this article for their full text. For the ease of understanding, withUnder will by specific embodiment, present invention is described. It needs to be noted, these descriptions are only exemplaryDescribe, do not form limitation of the scope of the invention. Utilize the method described in the embodiment of the present invention, also can obtain the present inventionOther technical scheme. According to the discussion of this description, many variations of the present invention, change are concerning one of ordinary skill in the artAll obviously.
Detailed description of the invention
Crude drug and equipment etc. in following specific embodiment be from open market channel buy.
Embodiment 1 formula for a product of the present invention and preparation thereof
1, HH003 preparation technology
(1) Chinese yam is cleaned, taken Chinese yam 180g, add 540ml (3 times of amounts) water, decoct 30min, put to room temperature, put into iceCase refrigeration, for subsequent use.
(2) take matrimony vine 60.0g, put into refiner, above-mentioned Chinese yam for subsequent use and decoction liquor are put into refiner, low speedPulverize 1min, then pulverize 1min at a high speed, repeat 4 times.
(3) pour in freeze-drying dish, freeze drying, pulverizes, and obtains the dry powder of HH003.
(4) take HH003 dry powder, taking water as wetting agent, wetting agent consumption is 15%, No. 1 sieve series grain, dries 2h, 1 for 50 DEG CNumber whole grain of sieve.
2, HH003S preparation technology
(1) Chinese yam is cleaned, taken Chinese yam 180g, prepared rhizome of rehmannia 5g, add 555ml (3 times of amounts) water, decoct 30min, put to chamberTemperature, puts into refrigerator cold-storage, for subsequent use.
(2) take matrimony vine 60.0g, put into refiner, above-mentioned Chinese yam for subsequent use, prepared rhizome of rehmannia and decoction liquor are put into refinerIn, low speed is pulverized 1min, then pulverizes 1min at a high speed, repeats 4 times.
(3) pour in freeze-drying dish, freeze drying, pulverizes, and obtains the dry powder of HH003S.
(4) take HH003S dry powder, taking water as wetting agent, wetting agent consumption is 15%, No. 1 sieve series grain, dries 2h for 50 DEG C,No. 1 whole grain of sieve.
3, HH003H preparation technology
(1) Chinese yam is cleaned, taken Chinese yam 180g, sealwort 10g, add 570ml (3 times of amounts) water, decoct 30min, put to chamberTemperature, puts into refrigerator cold-storage, for subsequent use.
(2) take matrimony vine 60.0g, put into refiner, above-mentioned Chinese yam for subsequent use, sealwort and decoction liquor are put into refinerIn, low speed is pulverized 1min, then pulverizes 1min at a high speed, repeats 4 times.
(3) pour in freeze-drying dish, freeze drying, pulverizes, and obtains the dry powder of HH003H.
(4) take HH003H dry powder, taking water as wetting agent, wetting agent consumption is 15%, No. 1 sieve series grain, dries 2h for 50 DEG C,No. 1 whole grain of sieve.
4, HH003Y preparation technology
(1) Chinese yam is cleaned, taken Chinese yam 180g, radix polygonati officinalis 15g, add 585ml (3 times of amounts) water, decoct 30min, put to chamberTemperature, puts into refrigerator cold-storage, for subsequent use.
(2) take matrimony vine 60.0g, put into refiner, above-mentioned Chinese yam for subsequent use, radix polygonati officinalis and decoction liquor are put into refinerIn, low speed is pulverized 1min, then pulverizes 1min at a high speed, repeats 4 times.
(3) pour in freeze-drying dish, freeze drying, pulverizes, and obtains the dry powder of HH003Y.
(4) take HH003Y dry powder, taking water as wetting agent, wetting agent consumption is 15%, No. 1 sieve series grain, dries 2h for 50 DEG C,No. 1 whole grain of sieve.
The short-term drug effect clinical observation of embodiment 2 product of the present invention to hyperglycemia patient Postprandial glucose control
The type ii diabetes people's of insulin insensitivity postprandial blood sugar is the important indicator of abnormal carbohydrate metabolism, therefore this realityExecute example by the detection of this type of patient's postprandial blood sugar being investigated to the blood sugar decreasing effect of medicine. According to state food drug administrationClinical testing standard carry out, (age is in 45-56 year, three one group of people, its fasting blood-glucose 7.5mM/L for patient to random packetAbove, after the meal more than 10mM/L) HH003 that respectively prepared by oral administration embodiment 1, HH003Y, HH003H, dosage is with above-mentioned powderOr particle meter, be 30g. 30min after taking medicine upper ante prandium, patient's 30g poach corn of taking food, chemically examines blood sugar after 2h, result asShown in following table 1.
Result shows, HH003, HH003Y and HH003H to hyperglycemia patient postprandial blood sugar by significant control action,Long-term use do not report side effect and bad reaction (as, easily sweat and lose hair), and their onsets immediately, testIn process, all the mouthfeel to these products represents well, to be therefore particularly suitable as appetizer etc.
Blood sugar comparison before and after table 1 medication/nonuser dining
Note: F: women M: male sex's hypoglycemic ratio: "-" is blood sugar rising
Embodiment 3 product of the present invention merges the pharmacodynamics test of rats with nonalcoholic fatty liver disease to diabetes B
Get HH003 prepared by embodiment 1, HH003Y, HH003H, HH003S, taking 0.5%CMC-Na be mixed with concentration asThe solution for standby of 50mg/ml.
Get 60 Wistar rats (male, body weight 180-200g, feeding environment: SPF level Animal House, freely ingest, 12hIllumination/12h dark), adaptability is raised 1 week. In the 2nd week, be divided at random Normal group (10) and modeling according to body weightGroup (60), Normal group is fed and is raised basal feed, and modeling group is fed and is raised high-sugar-fat-diet. After modeling 4 weeks, modeling group abdominal cavity notePenetrate streptozotocin (Streptozocin, STZ) 25mg/kg and continue high fat diet, the intraperitoneal injection of Normal group equal-volumeCitric acid-sodium citrate buffer also continues normal diet, and at the 9th weekend, rat overnight fasting, measures fasting blood-glucose (FBG) and containAmount and insulin content (Fins) also calculate insulin index (ISI), with fasting blood-glucose > 11.1rnmol/L and ISI reduce and thinkModel is successfully established. Measure simultaneously the blood lipid level (TC, TG, LDL-C, HDL-C, FFA) of each group of rat and liver function (ALT,AST, TB). Successful modeling rat is divided into model group, HH003 group, HH003Y group, HH003H group, HH003S group at random, everyOrganize 10, single cage is raised. Each administration group gavage gives relative medicine (dosage is in dry powder, 500mg/kg), gives continuouslyMedicine 4 weeks. Feed and raise basal feed except Normal group during this period, all the other each groups are still fed and are raised high-sugar-fat-diet. Measure weeklyRat body weight, after last administration, water is can't help in fasting, and after 12h, rat is weighed, and femoral artery is got blood, and separation of serum is measured in serum totalCholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) level, and measure serum glutamic pyruvic transminase (ALT) waterFlat, get in addition liver organization, weigh, calculate liver index.
Product of the present invention is as shown in table 2 to the result of the test of blood fat. Compared with Normal group, in model group rat serumTC, TG, LDL-C significantly raise (p < 0.05), the disorder of hints model HypercholesterolemicRats Rats. Compared with model group, HH003HGroup Serum TC, TG, LDL-C level significantly reduce (p < 0.05); HH003Y group rat blood serum LDL-C level significantly reduces (p<0.05)。
The impact of table 2. product of the present invention on blood fat (n＝10).
#P < 0.05, with Normal group comparison; * p < 0.05, with model group comparison
Product of the present invention is as shown in table 3 to the result of the test of liver. Compared with Normal group, the liver of model group ratIndex, serum ALT activities significantly raise (p < 0.05), and hints model Liver Function occurs abnormal. Compared with model group,HH003 group rat liver index significantly reduces (p < 0.05); HH003Y group rat liver index and serum ALT activities all have significantlyReduce (p < 0.05).
The impact of table 3. product of the present invention on liver index of correlation (n＝10).
#P < 0.05, with Normal group comparison; * p < 0.05, with model group comparison.
Claims (10)
1. medicine, health products or food compositions, it is made up of matrimony vine, Chinese yam and crude drug A, and wherein crude drug A is selected from prepared rhizome of rehmannia, HuangOne in essence and radix polygonati officinalis, and wherein the weight ratio of matrimony vine, Chinese yam and crude drug A is 55～65:160～200:0～18, preferablyBe 58～63:170～190:0～16, more preferably 60:180:0～15, as be 60:180:0,60:180:5,60:180:10Or 60:180:15.
2. composition claimed in claim 1, it is prepared by the following method:
(1) by Chinese yam and crude drug A boiling, then cooling;
(2) solid and the liquid that step (1) are obtained mix with matrimony vine and carry out homogenate pulverizing; With,
(3) crushed material step (1) being obtained is dry, then optionally pulverizes again.
3. composition claimed in claim 2, wherein,
The weight of water is 2～3.5 times of gross weight of Chinese yam and crude drug A, is preferably 3 times;
The time decocting is 20～60 minutes, is preferably 30 minutes; And/or,
The cooling temperature reaching is 20～30 DEG C, is preferably room temperature.
4. the preparation method of arbitrary composition of claim 1～3, it comprises:
(1) by Chinese yam and crude drug A boiling, then cooling;
(2) solid and the liquid that step (1) are obtained mix with matrimony vine and carry out homogenate pulverizing; With,
(3) crushed material step (1) being obtained is dry, then optionally pulverizes again.
5. medicine, health products or food compositions, it comprises on arbitrary composition and medicine of claim 1～3, on health productsOr acceptable auxiliary material on food.
6. arbitrary composition of claim 1～3 reduces blood sugar (especially postprandial blood sugar) level in preparation, reduction serum is totalCholesterol levels, reduction serum triglyceride level, reduction serum low-density LP level, reduction serum glutamic pyruvic transminase waterFlat and/or reduce the application in medicine, health products or the food of liver index.
7. application claimed in claim 6, wherein said composition is made up of matrimony vine, Chinese yam and sealwort, and wherein matrimony vine, mountainThe weight ratio of medicine and sealwort is 55～65:160～200:8～12, is preferably 58～63:170～190:9～11, more preferably60:180:10; Wherein said medicine, health products or food reduces serum total cholesterol level, reduces serum triglyceride level,And/or reduction serum low-density LP level.
8. application claimed in claim 6, wherein said composition is made up of matrimony vine, Chinese yam and radix polygonati officinalis, and wherein matrimony vine, mountainThe weight ratio of medicine and radix polygonati officinalis is 55～65:160～200:13～18, is preferably 58～63:170～190:15～16, more preferablyFor 60:180:15; Wherein said medicine, health products or food reduce serum low-density LP level, reduction serum paddy third turnsAmmonia enzyme level and/or reduction liver index.
9. application claimed in claim 6, wherein said composition is made up of matrimony vine and Chinese yam, and wherein matrimony vine and Chinese yamWeight ratio is 55～65:160～200, is preferably 58～63:170～190, more preferably 60:180; Wherein said medicine, guarantorStrong product or food reduce liver index.
10. application claimed in claim 6, wherein reducing blood sugar (especially postprandial blood sugar) level is instant onset.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511968A (en) * | 2016-11-23 | 2017-03-22 | 武汉百思凯瑞纳米科技有限公司 | Selenium-rich oral solution with effects of reducing blood sugar, reducing blood fat and boosting immunity and preparation method thereof |
| CN107041558A (en) * | 2017-06-20 | 2017-08-15 | 慧谷生命科技湖北有限公司 | A kind of Poria cocos radix polygonati officinalis meal replacement powder suitable for diabetes |
| CN109200183A (en) * | 2017-07-03 | 2019-01-15 | 无限极（中国）有限公司 | A kind of herbal composite and preparation method thereof and product |
| CN110300594A (en) * | 2017-09-08 | 2019-10-01 | 北京慧宝源生物技术股份有限公司 | Control the pharmaceutical composition of blood glucose |
| CN110731508A (en) * | 2019-11-14 | 2020-01-31 | 南充观音山农业科技有限公司 | Preparation method of traditional Chinese medicine food for enhancing human immunity and product |
| CN114766628A (en) * | 2022-05-21 | 2022-07-22 | 温州岁安健康食品有限公司 | Meal replacement powder for diabetics to eat and preparation method thereof |
| CN116531459A (en) * | 2023-05-30 | 2023-08-04 | 中国医学科学院药用植物研究所 | Preparation method and application of rhizoma polygonati and Chinese wolfberry pills |
| CN118286349A (en) * | 2024-04-10 | 2024-07-05 | 山西献果园生物科技股份有限公司 | Traditional Chinese medicine composition with blood sugar regulating function and preparation method and application thereof |
-
2015
- 2015-11-20 CN CN201510813258.8A patent/CN105596646B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 张玲允: "山药枸杞粥治疗脾虚消化不良", 《山东中医杂志》 * |
| 高学敏: "《中药学》", 28 February 2003 * |
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