CN101883786A - 人源化的notch融合蛋白组合物及治疗方法 - Google Patents

人源化的notch融合蛋白组合物及治疗方法 Download PDF

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Publication number
CN101883786A
CN101883786A CN2008801120573A CN200880112057A CN101883786A CN 101883786 A CN101883786 A CN 101883786A CN 2008801120573 A CN2008801120573 A CN 2008801120573A CN 200880112057 A CN200880112057 A CN 200880112057A CN 101883786 A CN101883786 A CN 101883786A
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简·奇塔杰瓦斯基
嘉莉·夏伯尔
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Medicinal Chemistry (AREA)
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CN2008801120573A 2007-08-23 2008-08-22 人源化的notch融合蛋白组合物及治疗方法 Pending CN101883786A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96605207P 2007-08-23 2007-08-23
US60/966,052 2007-08-23
PCT/US2008/010045 WO2009025867A2 (en) 2007-08-23 2008-08-22 Compositions of humanized notch fusion proteins and methods of treatment

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CN101883786A true CN101883786A (zh) 2010-11-10

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US (2) US9127085B2 (enExample)
EP (1) EP2193143B1 (enExample)
JP (2) JP2010536855A (enExample)
KR (1) KR20100076947A (enExample)
CN (1) CN101883786A (enExample)
AU (1) AU2008289462B2 (enExample)
BR (1) BRPI0815291A2 (enExample)
CA (1) CA2697262A1 (enExample)
IL (2) IL204111A (enExample)
MX (1) MX2010002053A (enExample)
NZ (3) NZ600171A (enExample)
RU (1) RU2532830C2 (enExample)
SG (1) SG183763A1 (enExample)
WO (1) WO2009025867A2 (enExample)
ZA (1) ZA201001427B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103917247A (zh) * 2011-10-04 2014-07-09 纽约哥伦比亚大学理事会 人类notch1引诱物
CN104870476A (zh) * 2012-11-21 2015-08-26 药物抗体公司 靶向vegfr-2和dll4的双靶向抗体及包含它的药物组合物
CN108707628A (zh) * 2018-05-28 2018-10-26 上海海洋大学 斑马鱼notch2基因突变体的制备方法
CN108753833A (zh) * 2018-05-28 2018-11-06 上海海洋大学 斑马鱼notch3基因突变体的制备方法
CN109467598A (zh) * 2018-11-28 2019-03-15 生命谷（海南）生物科技股份有限公司 肿瘤相关基因notch1突变短肽及其应用
CN110753552A (zh) * 2017-06-19 2020-02-04 细胞设计实验室股份有限公司 用于降低嵌合Notch受体的免疫原性的方法和组合物
CN115584341A (zh) * 2022-11-07 2023-01-10 浙江大学 一种鱼成肌细胞分化培养基及人造鱼肉组织方法
CN116790603A (zh) * 2023-08-18 2023-09-22 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途

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US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2005111072A2 (en) * 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Notch-based fusion proteins and uses thereof
US9567396B2 (en) 2006-03-07 2017-02-14 Evonik Degussa Gmbh Notch inhibition in the prevention of vein graft failure
WO2007103114A2 (en) 2006-03-07 2007-09-13 The Brigham & Women's Hospital, Inc. Notch inhibition in the treatment or prevention of atherosclerosis
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
WO2009103637A1 (en) * 2008-02-22 2009-08-27 Vrije Universiteit Brussel Method for generating islet beta cells from dedifferentiated exocrine pancreatic cells
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
KR20110074846A (ko) * 2008-08-22 2011-07-04 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 노치３ 신호전달의 디코이 억제제로서의 인간 노치３ 기반 융합 단백질
EP2493497A4 (en) * 2009-11-01 2013-07-24 Brigham & Womens Hospital NOTCH INHIBITION IN THE TREATMENT AND PROPHYLAXIS OF ADIPOSITAS AND METABOLISM SYNDROME
MX2012008085A (es) 2010-01-13 2012-09-12 Oncomed Pharm Inc Agentes de union notch1 y metodos de uso de los mismos.
EP2970468B1 (en) 2013-03-13 2021-07-07 Novartis AG Notch2 binding molecules for treating respiratory diseases
WO2014151950A1 (en) * 2013-03-15 2014-09-25 The Trustees Of Columbia University In The City Of New York Notch1 decoy antagonists protect from obesity-induced insulin resistance and fatty liver
US20160030513A1 (en) * 2013-03-15 2016-02-04 The Trustees Of Columbia University In The City Of New York Notch1 Decoy Antagonists Protect From Obesity-Induced Insulin Resistance and Fatty Liver
WO2016167306A1 (ja) * 2015-04-16 2016-10-20 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗ヒトＮｏｔｃｈ４抗体
US11026996B2 (en) 2016-05-25 2021-06-08 The Trustees Of Columbia University In The City Of New York Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling
US12065479B2 (en) 2017-11-16 2024-08-20 The Regents Of The University Of California Force sensor cleavage domain containing chimeric polypeptides and methods of use thereof
US20230174633A1 (en) * 2020-03-30 2023-06-08 Memorial Sloan Kettering Cancer Center Methods and compositions for modulating lipid storage in adipose tissue
CN112961250B (zh) * 2021-03-01 2023-06-06 长春金赛药业有限责任公司 抗体融合蛋白及其应用
CN114062682A (zh) * 2021-11-10 2022-02-18 厦门大学附属心血管病医院 Notch3作为检测靶标的应用

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US20030082651A1 (en) * 2000-09-22 2003-05-01 Genentech, Inc. Notch receptor agonists and uses
WO2003087159A2 (en) * 2002-04-05 2003-10-23 Lorantis Limited Modulators of the notch signalling pathway and uses thereof in medical treatment
WO2004024764A1 (en) * 2002-09-10 2004-03-25 Lorantis Limited Pharmaceutical composition and medical treatments comprising notch ligand proteins
US20060002924A1 (en) * 2002-08-03 2006-01-05 Bodmer Mark W Conjugate of notch signalling pathway modulators and their use in medical treatment
US20060030694A1 (en) * 2004-04-29 2006-02-09 Jan Kitajewski Notch-based fusion proteins and uses thereof
US20060134121A1 (en) * 2004-10-29 2006-06-22 Gavin Thurston DII4 antagonists, assays, and therapeutic methods thereof
US20070104746A1 (en) * 2005-07-29 2007-05-10 Seishiro Fujii Methods and compositions for reducing skin damage

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JP2005526701A (ja) 2001-11-14 2005-09-08 ロランティス リミテッド 内科療法
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JP5478254B2 (ja) 2006-10-19 2014-04-23 ジェネンテック， インコーポレイテッド 抗ノッチ３アゴニスト抗体とノッチ３関連疾患の治療におけるその使用
KR20110074846A (ko) 2008-08-22 2011-07-04 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 노치３ 신호전달의 디코이 억제제로서의 인간 노치３ 기반 융합 단백질
AR088048A1 (es) * 2011-10-04 2014-05-07 Univ Columbia Señuelos notch1 humanos

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US20030082651A1 (en) * 2000-09-22 2003-05-01 Genentech, Inc. Notch receptor agonists and uses
WO2003087159A2 (en) * 2002-04-05 2003-10-23 Lorantis Limited Modulators of the notch signalling pathway and uses thereof in medical treatment
US20060002924A1 (en) * 2002-08-03 2006-01-05 Bodmer Mark W Conjugate of notch signalling pathway modulators and their use in medical treatment
WO2004024764A1 (en) * 2002-09-10 2004-03-25 Lorantis Limited Pharmaceutical composition and medical treatments comprising notch ligand proteins
US20050261477A1 (en) * 2002-09-10 2005-11-24 Champion Brian R Pharmaceutical compositions and medical treatments comprising notch ligand proteins
US20060030694A1 (en) * 2004-04-29 2006-02-09 Jan Kitajewski Notch-based fusion proteins and uses thereof
US20060134121A1 (en) * 2004-10-29 2006-06-22 Gavin Thurston DII4 antagonists, assays, and therapeutic methods thereof
US20070104746A1 (en) * 2005-07-29 2007-05-10 Seishiro Fujii Methods and compositions for reducing skin damage

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103917247A (zh) * 2011-10-04 2014-07-09 纽约哥伦比亚大学理事会 人类notch1引诱物
CN104870476A (zh) * 2012-11-21 2015-08-26 药物抗体公司 靶向vegfr-2和dll4的双靶向抗体及包含它的药物组合物
CN104870476B (zh) * 2012-11-21 2018-04-13 药物抗体公司 靶向vegfr‑2和dll4的双靶向抗体及包含它的药物组合物
CN110753552B (zh) * 2017-06-19 2024-03-19 细胞设计实验室股份有限公司 用于降低嵌合Notch受体的免疫原性的方法和组合物
US12617825B2 (en) 2017-06-19 2026-05-05 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
US12297243B2 (en) 2017-06-19 2025-05-13 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
CN110753552A (zh) * 2017-06-19 2020-02-04 细胞设计实验室股份有限公司 用于降低嵌合Notch受体的免疫原性的方法和组合物
CN108707628A (zh) * 2018-05-28 2018-10-26 上海海洋大学 斑马鱼notch2基因突变体的制备方法
CN108707628B (zh) * 2018-05-28 2021-11-23 上海海洋大学 斑马鱼notch2基因突变体的制备方法
CN108753833A (zh) * 2018-05-28 2018-11-06 上海海洋大学 斑马鱼notch3基因突变体的制备方法
CN109467598B (zh) * 2018-11-28 2021-11-09 生命谷（海南）生物科技股份有限公司 肿瘤相关基因notch1突变短肽及其应用
CN109467598A (zh) * 2018-11-28 2019-03-15 生命谷（海南）生物科技股份有限公司 肿瘤相关基因notch1突变短肽及其应用
CN115584341A (zh) * 2022-11-07 2023-01-10 浙江大学 一种鱼成肌细胞分化培养基及人造鱼肉组织方法
CN116790603A (zh) * 2023-08-18 2023-09-22 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途
CN116790603B (zh) * 2023-08-18 2023-10-31 成都中科奥格生物科技有限公司 一种sgRNA、CRISPR/Cas9载体及其构建方法和用途

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JP2010536855A (ja) 2010-12-02
RU2010110812A (ru) 2011-09-27
MX2010002053A (es) 2010-07-28
KR20100076947A (ko) 2010-07-06
EP2193143B1 (en) 2016-06-08
EP2193143A2 (en) 2010-06-09
US20110008342A1 (en) 2011-01-13
NZ583649A (en) 2012-06-29
CA2697262A1 (en) 2009-02-26
US9127085B2 (en) 2015-09-08
AU2008289462B2 (en) 2014-01-23
RU2532830C2 (ru) 2014-11-10
EP2193143A4 (en) 2012-01-25
BRPI0815291A2 (pt) 2015-02-03
NZ600171A (en) 2014-01-31
JP2016040245A (ja) 2016-03-24
SG183763A1 (en) 2012-09-27
WO2009025867A3 (en) 2009-12-30
US20160115217A1 (en) 2016-04-28
NZ618129A (en) 2015-05-29
WO2009025867A2 (en) 2009-02-26
IL220723A0 (en) 2012-08-30
AU2008289462A1 (en) 2009-02-26
IL204111A (en) 2015-08-31
ZA201001427B (en) 2011-05-25

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Application publication date: 20101110