CN101883567B - 二氨基吩噻嗪的治疗用途 - Google Patents

二氨基吩噻嗪的治疗用途 Download PDF

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Publication number
CN101883567B
CN101883567B CN2008801190788A CN200880119078A CN101883567B CN 101883567 B CN101883567 B CN 101883567B CN 2008801190788 A CN2008801190788 A CN 2008801190788A CN 200880119078 A CN200880119078 A CN 200880119078A CN 101883567 B CN101883567 B CN 101883567B
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daptz
compound
mtc
dose
alkyl
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CN101883567A (zh
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克劳德·M·维奇克
戴蒙·J·维奇克
约翰·M·D·斯托里
查尔斯·R·哈林顿
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Wista Laboratories Ltd
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Wista Laboratories Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2008801190788A 2007-10-03 2008-10-01 二氨基吩噻嗪的治疗用途 Active CN101883567B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96054407P 2007-10-03 2007-10-03
US60/960,544 2007-10-03
PCT/GB2008/003315 WO2009044127A1 (en) 2007-10-03 2008-10-01 Therapeutic use of diaminophenothiazines

Publications (2)

Publication Number Publication Date
CN101883567A CN101883567A (zh) 2010-11-10
CN101883567B true CN101883567B (zh) 2012-12-26

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CN2008801190788A Active CN101883567B (zh) 2007-10-03 2008-10-01 二氨基吩噻嗪的治疗用途

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US (3) US9149481B2 (https=)
EP (2) EP2205245B1 (https=)
JP (1) JP5592261B2 (https=)
CN (1) CN101883567B (https=)
AU (1) AU2008306688B2 (https=)
BR (1) BRPI0818182B1 (https=)
CA (2) CA3027974C (https=)
DK (2) DK2954932T3 (https=)
ES (2) ES2701089T3 (https=)
HR (1) HRP20151006T1 (https=)
HU (1) HUE025199T2 (https=)
MY (1) MY161656A (https=)
PL (2) PL2954932T3 (https=)
PT (2) PT2954932T (https=)
SI (2) SI2205245T1 (https=)
WO (1) WO2009044127A1 (https=)

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EP2013191B3 (en) 2006-03-29 2019-02-27 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
CA3027974C (en) * 2007-10-03 2022-03-15 Wista Laboratories Ltd. Therapeutic use of diaminophenothiazines
CN102958525B (zh) 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
US8828986B2 (en) 2011-04-20 2014-09-09 Prosetta Antiviral Inc. Antiviral compounds
US9192611B2 (en) 2010-11-30 2015-11-24 Wista Laboratories Ltd. Formulations comprising methylthioninium chloride
US8703137B2 (en) 2011-01-31 2014-04-22 Intellect Neurosciences Inc. Treatment of tauopathies
EA025033B1 (ru) * 2011-02-11 2016-11-30 Уиста Лэборэтэриз Лтд. Диаминиевые соли фенотиазина и их применение
CN102690244A (zh) * 2011-03-22 2012-09-26 中国科学院上海生命科学研究院 调节α-突触核蛋白积聚的物质及其制药用途
US20130315825A1 (en) * 2012-05-03 2013-11-28 Washington University Tricyclic heteroaromatic compounds as alpha-synuclein ligands
CN103864717B (zh) * 2014-04-04 2015-11-11 山东理工大学 一种针状亚甲基白晶体的制备方法
CN103923036B (zh) * 2014-04-24 2015-09-16 山东理工大学 一种棒状亚甲基蓝晶体的制备方法
CN105541756B (zh) * 2015-12-17 2018-02-09 陕西方舟制药有限公司 一种制备1‑(3，7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法
KR102592614B1 (ko) 2016-07-25 2023-10-24 위스타 레보레이토리스 리미티드 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage)
GB201614834D0 (en) * 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
DK3826639T3 (da) 2018-07-26 2024-09-23 Wista Lab Ltd Optimeret dosering af diaminophenothiaziner i populationer
WO2020201828A1 (en) 2019-04-05 2020-10-08 Tauc3 Biologics Limited Anti-tauc3 antibodies and uses thereof
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909493D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
CN111956245A (zh) * 2020-08-27 2020-11-20 复旦大学附属肿瘤医院 术后认知功能障碍预防评估方法，系统和装置
WO2023232764A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
AU2023346900A1 (en) 2022-09-21 2025-04-10 TauRx Therapeutics Management Ltd Novel formulations and vehicles
WO2024163665A1 (en) * 2023-01-31 2024-08-08 Unlearn.AI, Inc. Systems and methods for prognostic covariate adjustment in logistic regression for randomized controlled trial design

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WO2006091728A2 (en) * 2005-02-24 2006-08-31 The Trustees Of The University Of Pennsylvania Microtubule stabilizing compounds and methods of their use
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PL2004155T3 (pl) * 2006-03-29 2018-08-31 Wista Laboratories Ltd. Inhibitory agregacji białek
EP2013191B3 (en) * 2006-03-29 2019-02-27 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
DK3121169T3 (da) * 2006-07-11 2022-02-28 Wista Lab Ltd Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser
CN101820884B (zh) * 2007-06-19 2013-08-28 维斯塔实验室有限公司 用于治疗轻度认知缺损的吩噻嗪化合物
CA3027974C (en) * 2007-10-03 2022-03-15 Wista Laboratories Ltd. Therapeutic use of diaminophenothiazines

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Also Published As

Publication number Publication date
EP2954932B1 (en) 2018-09-19
EP2954932A1 (en) 2015-12-16
CA2701075C (en) 2019-02-12
BRPI0818182A2 (pt) 2020-06-23
US20100290986A1 (en) 2010-11-18
AU2008306688A1 (en) 2009-04-09
SI2205245T1 (sl) 2015-10-30
BRPI0818182B1 (pt) 2021-10-19
CA3027974A1 (en) 2009-04-09
ES2546819T3 (es) 2015-09-28
HUE025199T2 (en) 2016-01-28
PT2205245E (pt) 2015-10-13
PL2205245T3 (pl) 2015-12-31
HRP20151006T1 (hr) 2015-10-23
EP2205245A1 (en) 2010-07-14
WO2009044127A1 (en) 2009-04-09
JP2010540606A (ja) 2010-12-24
US20190151329A1 (en) 2019-05-23
CN101883567A (zh) 2010-11-10
MY161656A (en) 2017-04-28
PT2954932T (pt) 2018-12-12
US20160030444A1 (en) 2016-02-04
CA2701075A1 (en) 2009-04-09
HK1211889A1 (en) 2016-06-03
PL2954932T3 (pl) 2019-04-30
US10188658B2 (en) 2019-01-29
HK1140675A1 (en) 2010-10-22
ES2701089T3 (es) 2019-02-20
AU2008306688B2 (en) 2014-05-22
SI2954932T1 (sl) 2019-01-31
CA3027974C (en) 2022-03-15
DK2954932T3 (en) 2018-12-17
EP2205245B1 (en) 2015-06-24
JP5592261B2 (ja) 2014-09-17
US9149481B2 (en) 2015-10-06
DK2205245T3 (en) 2015-09-28

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