CN101869221B - Feed additive for improving reproductive capacity of sow and preparation method thereof - Google Patents

Feed additive for improving reproductive capacity of sow and preparation method thereof Download PDF

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Publication number
CN101869221B
CN101869221B CN2010101955026A CN201010195502A CN101869221B CN 101869221 B CN101869221 B CN 101869221B CN 2010101955026 A CN2010101955026 A CN 2010101955026A CN 201010195502 A CN201010195502 A CN 201010195502A CN 101869221 B CN101869221 B CN 101869221B
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sow
vitamin
percent
feed additive
rate
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CN101869221A (en
Inventor
王友明
姚中磊
楼永波
姚国佳
靳明亮
汪以真
金海丽
林继和
周金伟
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Zhejiang University ZJU
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Abstract

The invention discloses a feed additive for improving the reproductive capacity of a sow. The feed additive comprises the following raw materials in percentage by weight: 45 to 50 percent of epimedium, 10 to 15 percent of leonurus, 5 to 10 percent of semen cuscutae, 5 to 10 percent of angelica sinensis, 3 to 5 percent of safflower, 0.3 to 0.5 percent of vitamin A, 1 to 2 percent of vitamin E, 0.5 to 0.8 percent of folic acid and the balance of zeolite powder. The invention also discloses a preparation method for the feed additive. The method comprises the following steps of: mixing the epimedium, the leonurus, the semen cuscutae, the angelica sinensis and the safflower; smashing a mixture to a particle size of between 25 and 40 microns; adding the vitamin A, the vitamin E, the folic acid and the zeolite powder; and mixing uniformly. The feed additive prepared by the method has the characteristics of less additive amount and quick response when in use, and can remarkably improve the oestrus rate and the conception rate of the sow, and has no toxic or side effect.

Description

A kind of feed addictive that improves reproductive capacity of sow and preparation method thereof
Technical field
The present invention relates to a kind of feed addictive, particularly relate to a kind of feed addictive that improves reproductive capacity of sow and preparation method thereof.
Background technology
The Along with people's growth in the living standard; People constantly increase for pork consumption demand amount, must increase the supply of live pig through increasing sow quantity, infer according to present sow variety breeding performance of raising and sow livestock on hand quantity; The live pig supply should be greater than demand now; Yet true really not so, the not enough present situation of cut of pork often appearred in recent years, and pork holds at high price; Here except eqpidemic disease reason (death rate is high) and nutrition reason (production performance fails to bring into play fully), lowly closely related with sow production capacity.
Sow production capacity is low, and it is low mainly to show as the rate of oestrusing, and the breeding success rate is low, and litter size is few, causes the breed decrease in efficiency.According to investigations, purebred ratio with hybridization virgin sow out of heat is about about 30% and 20% more than 9 monthly ages, and it is out of heat even up to more than 50% more than 9 monthly ages that the virgin sow is hybridized on the pig farm that has; Postpartum is purebred to be respectively about 25% and 20% with the crossbreeding sow back ratio out of heat more than 10 days that weans, and is respectively about 10% and 5% above ratio out of heat more than 30 days.The pig farm that has reach postpartum 40~50 days time still some sow can not normally oestrus, increased nonproductive fate greatly, the nonproductive fate on the pig farm that has even reach more than 100 days has reduced the sow economic use value; The conception rate of sow of breeding simultaneously is about 70%, if these present situations can not get effective improvement, will bring about great losses for aquaculture.Want to improve farrow in sow year nest number and nest litter size; We will start with from sow with functions of promoting sexual maturity; By means of suitable technique and product, of the right age breeding virgin sow or the long-term wean sow that does not oestrus are oestrused as early as possible, impel its symptom of estrus obvious; And improve sow number of eggs ovulated and conception rate, increase sow year litter size.
Most researchers thinks that the main cause of the weary feelings of sow is relevant with the sex hormone secretion deficiency, and most manual works lures the feelings method to achieve the goal through the injection hormone.Hormone commonly used has pregnant mare serum gonadotrop(h)in (PMSG) (PMSG), estrogen and tristeronum compositum, but PMSG makes ovary produce anovular large follicle easily, because the PMSG long half time, can cause sow out of heat for a long time after luring the feelings failure, forfeiture reproductive capacity; Estrogen regular meeting influences the normality cycle of sow, uses estrogen to lure the sow great majority of feelings failure in considerable time, can't recover normally to oestrus; Tristeronum compositum can make the oestrus of sow rate reach more than 80%, but the breeding conception rate has only (weary feelings sow manual work lures the research and the commentary of feelings method, Wang Zukun, Heilungkiang animal reproduction, the 4th phase, 2000) about 20%.It is thus clear that injection hormone method effect is unstable, can not correctly regulate the endocrine of sow, does not have the effect that lures feelings.
For this reason, part scholar changes the research thinking, sets about utilizing Chinese herbal medicine to impel oestrus of sow, has obtained certain effect.Chinese herb feed additive have promote growth, prevent disease, the function such as prevent miscarriage of promoting the sexual maturity, use the back to the animals and animal product noresidue, have no side effect, be difficult for developing immunity to drugs.From the modern nutriology theory analysis, contained alkaloid, polysaccharide, glucoside, volatile fatty acid, organic acid etc. all are bioactivators in the Chinese herbal feed additive, with being impregnated good action are arranged to promoting oestrus of sow.The scholar is arranged, and (hormone and Chinese herbal and crude drugs preparations are to the effect and the contrast test of sow atypical estrus, and Huang is ignorant, Chinese animal and veterinary; The 7th phase; 2006) utilize the Chinese herbal treatment sow to lack feelings,, exist that addition height, drug effect are slow, waste is serious and problems such as palatability difference though obtained certain effect; Thereby cause pig to produce few food or food refusal behavior, do not reach desirable effect.
Summary of the invention
The invention provides the Chinese herbal medicine composite feed additive that a kind of addition is few, drug effect also can obviously improve oestrus of sow rate and conception rate soon.
A kind of feed addictive that improves reproductive capacity of sow, its raw material weight percentage consists of:
Barrenwort 45~50%
Motherwort 10~15%
The seed of Chinese dodder 5~10%
Radix Angelicae Sinensis 5~10%
Safflower 3~5%
Vitamin A 0.3~0.5%
Vitamin E 1~2%
Folic acid 0.5~0.8%
All the other are zeolite powder.
Preferably, its raw material weight percentage consists of:
Barrenwort 45~50%
Motherwort 10~15%
The seed of Chinese dodder 10%
Radix Angelicae Sinensis 10%
Safflower 5%
Vitamin A 0.5%
Vitamin E 2%
Folic acid 0.8%
All the other are zeolite powder.
Barrenwort: warm in nature, flavor is hot, sweet, returns liver, kidney channel, has kidney-replenishing, strengthing aitch bone, and the wet effect of dispeling the wind is used to treat impotence and seminal emission, coils diseases such as the atrophic debility of bones is soft, arthralgia due to wind-dampness, numbness contracture.
Motherwort: cool in nature, bitter is returned liver, pericardium channel, has the effect of invigorate blood circulation, dispel silt, menstruation regulating, the water that disappears, and can treat irregular menstruation, threatened abortion difficult labour, and placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, diseases such as the swollen sore of carbuncle at hematuria.
The seed of Chinese dodder: warm in nature, it is sweet to distinguish the flavor of, and returns liver, kidney channel, have nourishing liver and kidney, the controlling nocturnal emission with astringent drugs urine that contracts, antiabortive, make eye bright, the effect of antidiarrheal cures mainly impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen and suffers from a deficiency of the kidney and rush down.
Radix Angelicae Sinensis: warm in nature, it is sweet, hot to distinguish the flavor of, and returns liver, the heart, the spleen channel; Having enriches blood invigorates blood circulation; Menstruction regulating and pain relieving, the effect that relaxes bowel cures mainly sallow, the dizzy palpitaition of the deficiency of blood, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores.
Safflower: warm in nature, flavor is hot, and the thoughts of returning home, Liver Channel have the effect of the latus rectum of invigorating blood circulation, blood stasis removing analgesic, cure mainly through close, dysmenorrhoea, lochia are not all right, abdominal mass lump in the abdomen, traumatic injury.
Above-mentioned Chinese medicine all can be selected from the commercially available prod.
Vitamin A can be selected the vitamin A micro-capsule of 500,000 IU/ gram for use.
Vitamin E can be selected 50% vitamin E powder for use.
It is 99% folic acid that folic acid can be selected purity for use.
The fineness of zeolite powder is 80~120 orders, uses as carrier.
Said vitamin and zeolite powder all can be selected from the commercially available prod.
Vitamin A, E, folic acid etc. all are the important nutrient that ovum forms.When sow is deficient in vitamin A, conception rate can occurs and descend, show as undesired, the difficult labour of oestrusing, miscarriage, stillborn foetus, weak tire, monster and retention of afterbirth; Sow pig then shows as the delay of oestrusing, influences the development of ovary, and rate of embryonic death is high.Suitably improve the addition of diet vitamin A, can improve sow nest litter size and number pigs weaned.Vitamin E and reproductive capability are closely related, can promote the generation of thyroid-stimulating hormone and corticotropin and promoting sexual gland hormone, strengthen the ovary function; Make ovarian follicle increase lutein cell, replenishing vitamins E in the sow daily ration can not only improve conception rate; Reduce foetal death, increase the nest litter size, and can strengthen the anti-stress ability of piglet; Piglet is dead before reducing wean, shortens sow and weans to inter oestrual period.Research shows, the sow nest litter size of the high-level vitamin E of feeding, to produce the young number of living all higher, and mammitis-hysteritis-agalactia syndrome (MMA) incidence of disease is lower.The ovary function descends when sow is deficient in vitamin E, and sexual cycle is unusual, can not be fertilized the unusual or appearance of embryonic development.Folic acid has important effect to the reproductive performance of keeping sow with promotion fetus early development.Its major function is the coenzyme in various different enzyme systems, participates in the synthetic of purine, so quite important to synthesizing of DNA, RNA.Keeping aspect the Steady breed function of broad sow, can improve the nest litter size; Keep good lactation power, prevent that lactation is disorderly.The sow daily ration adds folic acid can improve embryo survival, the stable nest litter size that improves.When lacking folic acid, stillborn foetus can appear.
More than all medicine coordination linkages, sow is oestrused as early as possible, promote ovulation to be impregnated simultaneously.Use the back and improve the sow sexual desire, impel the characteristic of oestrusing obvious, can safeguard the health of sow body, promote reproductive organs tissue development and reparation, promote reproduction and immunity function, improve ovum quality and number of eggs ovulated, improve conception rate, reduce the feelings rate of returning.
Feed addictive of the present invention in use, it adds according to ratio of percentage by weight 0.08~0.12% in feed.
The preparation method of above-mentioned feed addictive; Comprise: with percentage by weight is that 45~50% barrenwort, 10~15% motherwort, 5~10% the seed of Chinese dodder, 5~10% Radix Angelicae Sinensis and 3~5% safflower mix; Being crushed to particle diameter is 25~40 microns; Adding percentage by weight is 0.3~0.5% vitamin A, 1~2% vitamin E, 0.5~0.8% folic acid and zeolite powder, mixes.
Broken being meant with the biological cell broken wall of cell grade micro mist is the comminution process of purpose, and it is not purpose with the smashing fineness, but pursues the sporoderm-broken rate of cell.Broken through the cell grade micro mist, can the fineness of former green material be brought up to more than 300 orders from 40~80 orders of traditional handicraft, for general medicinal material, the breaking-wall cell rate under this fineness condition is greater than 95%.Cell intracellular active ingredient behind broken wall fully comes out, the rate of release and the burst size of medicine can significantly improve.The medicinal material particle is after the cell grade micro mist is broken, and microscopically is observed only has the minute quantity intact cell to exist.The cell grade micro mist is broken to mainly contain following advantage aborning: (1) increases the drug absorption rate, improves the Chinese traditional medicine biology utilization rate: after Chinese medicine cell grade micro mist is broken, the main pharmacodynamics composition of medicine be distributed in usually in the cell with cytoplasm in, and being main in the cell.Active ingredient comes out in its cell behind the breaking-wall cell, so drug effect increases substantially, and onset speed is fast; (2) help the retains biological activity composition; Improve drug effect: in the broken process of cell grade micro mist; Do not produce superheating phenomenon through control, even can under low-temperature condition, carry out, and pulverizing speed is fast; Help keeping the bioactive ingredients and the various nutritional labeling of non-refractory like this, thereby improve drug effect; (3) conservation, be convenient to use: Chinese medicine can use the dosage littler than former prescription medicine under the situation that obtains same curative effect after the cell grade micro mist is broken.General medicine can no longer pass through processing such as lixiviate, decoction after the cell grade micro mist is broken, reduced loss of active ingredients in the production link, has maximally utilised raw material, so this technology is suitable for the pulverizing of rare Chinese medicine, and owing to the increase of fineness.Can improve mouthfeel, be convenient to take.On the other hand, be in totally-enclosed dustless system, to carry out because of the cell grade micro mist is broken, can effectively avoid outside contamination, make the content of microorganisms of product and dust content be able to control.
Beneficial effect of the present invention is embodied in:
(1) Chinese herbal medicine composite feed additive of the present invention can obviously improve oestrus of sow rate and conception rate;
(2) Chinese herbal medicine composite feed additive of the present invention, addition is few in use, and effective.Problems such as have in the traditional Chinese medicine interpolation process that adding proportion is high, cost is high, drug effect is slow, waste is serious and process technology is improper; And adopt the broken technology of cell grade micro mist that effective ingredient is directly come out; Improve the absorption and the bioavilability of medicine greatly, shortened the drug effect time.Not only reduce addition but also reduce cost definite effect simultaneously.
(3) Chinese herbal medicine composite feed additive of the present invention, has no side effect at noresidue.Used additive mostly contains the antibiotic, hormone of chemical synthesis etc. in the conventional feed, and secondary residual harm humans is healthy thereby these compositions very easily cause poison, pollution of ecological environment.And in feed, add feed addictive of the present invention; All adopt non-harmful natural Chinese medicinal herb and vitamin; Do not add any chemical synthesis antiseptic and poisonous and harmful substance, do not produce the cross-resistance of people and animals' concomitant medication, thoroughly avoided the secondary residual drawback of conventional feed poisoning.
The specific embodiment
Feed addictive herbal raw material of the present invention is purchased in Anhui Province Bozhou City letter Li De pharmaceutcal corporation, Ltd.
Embodiment 1
Respectively barrenwort, motherwort, the seed of Chinese dodder, Radix Angelicae Sinensis and safflower are dried, weighing barrenwort 450 grams, motherwort 100 grams, the seed of Chinese dodder 100 restrain respectively then, Radix Angelicae Sinensis 100 restrains, safflower 50 grams, section arrangement then; Mix, mixed mixture is at first carried out 60 order coarse crushings, it is broken to adopt QYF type fluidized bed air flow crusher to carry out the cell grade micro mist then; It is 25~40 microns (approximately fineness is 350~500 orders) that mixture is crushed to average grain diameter; And the vitamin A micro-capsule 5 that adds 500,000 IU/ gram again restrains 50% vitamin E powder, 20 grams, 99% folic acid 8 grams; Add carrier zeolite powder (fineness is 100 orders) again; Total amount reaches 1000 grams, mixes once more, promptly obtains feed addictive of the present invention.
Embodiment 2
Identical with embodiment 1 method; The weight of the raw material that adds is respectively: vitamin A micro-capsule 5 grams of barrenwort 500 grams, motherwort 150 grams, the seed of Chinese dodder 100 grams, Radix Angelicae Sinensis 100 grams, safflower 50 grams, 500,000 IU/ gram; 50% vitamin E powder, 20 grams; 99% folic acid 8 grams are according to preparing the Chinese herbal medicine composite feed additive with embodiment 1 identical preparation method.
Embodiment 3
Identical with embodiment 1 method; The weight of the raw material that adds is respectively: vitamin A micro-capsule 5 grams of barrenwort 450 grams, motherwort 150 grams, the seed of Chinese dodder 100 grams, Radix Angelicae Sinensis 100 grams, safflower 50 grams, 500,000 IU/ gram; 50% vitamin E powder, 20 grams; 99% folic acid 8 grams are according to preparing the Chinese herbal medicine composite feed additive with embodiment 1 identical preparation method.
Application examples 1
Test place: the just flat plant in Xiaoshan, Hangzhou.
Test period: the test since on July 20th, 2008, September 2 in 2008 end of day, 44 days experimental periods,, wherein 22 days is feed period.
The selection of test pig and grouping: select physique healthy and strong, more than the body weight 120kg, passed through 48 of the replacement gilts of growing up of not oestrusing as yet of the age in days of oestrusing, be divided into 2 processed group at random, each processed group is established 3 repetitions, and each repeats 8.
Basal diet prescription and nutrient content: as shown in table 1.
The test daily ration: the additive that utilizes embodiment 1 to prepare is that 0.1% consumption substitutes 0.1% zeolite powder in the basal ration prescription as the test daily ration according to percentage by weight.
Table 1
Figure BSA00000150333200071
Annotate: contain in every kilogram of feed: the rope A 12000IU that supports one's family, vitamin D 1500IU; 45 milligrams of vitamin Es, vitamin K 32 milligrams, Cobastab 12 milligrams, Cobastab 26 milligrams, Cobastab 120.025 milligram, 0.2 milligram of biotin, 4 milligrams in folic acid, 25 milligrams in pantothenic acid, 50 milligrams in nicotinic acid; 5 milligrams of Cu, 75 milligrams of Zn, 80 milligrams of Fe, 10 milligrams of Mn, 0.25 milligram of Se, 0.3 milligram of I, 500 milligrams in choline, 300 milligrams in 15% aureomycin; Wherein DE, Lys, Met+Cys and Thr are calculated value, and all the other are measured value; Wherein, the additive that compound premix is made up of trace element and amino acid etc. can adopt commercially available product.
Test pig breeding method: adopt conventional artificial insemination method to breed.
Process of the test is handled and data acquisition: perform estrus induction, semen deposition, write down a number of oestrusing.The test feed that sow after the semen deposition is stopped using and promotes the sexual maturity changes the gestation material of feeding special into.Conception rate is added up in the judgement (do not return feelings as confining spectrum in 18-24 days with the back of breeding usually in the production, this test was not returned feelings as confining spectrum in back 24 days to breed) of being impregnated, and the record data such as effect of being impregnated.
Data: adopt SPSS (16.0) that data are handled, and carry out one-way analysis of variance and least significant difference method (LSD) check.Data are represented with average.
Test result:
(1) add feed addictive of the present invention to oestrus of sow to influence the result as shown in table 2:
Table 2
Figure BSA00000150333200081
Visible by table 2, test group oestrus of sow rate has improved 87.52% (p<0.01) than control group.
(2) add feed addictive of the present invention to sow be impregnated to influence the result as shown in table 3:
Table 3
Figure BSA00000150333200082
Can know that by table 3 test group sow conception rate has improved 28% (p<0.05) than control group.
Can be known that by above-mentioned test data in the sow daily ration, behind the interpolation feed addictive of the present invention, compare with control group, test group oestrus of sow rate has improved 87.52% (p<0.01), conception rate has improved 28% (p<0.05).Show that adding feed addictive of the present invention has obvious effects to improving reproductive capacity of sow.
Application examples 2
Test period: the test since on August 15th, 2009, September 28 in 2009 end of day, feed period 44 days, wherein 22 days is feed period.
Test place: with application examples 1.
The selection of test pig and grouping: select physique healthy and strong; Often occur postpartum out of heat or that the post-partum estrus unclear symptoms shows, or feelings often appear returning and or inter oestrual period surpass 10 days; Grow up 60 of multiparity sows are divided into 2 processed group at random, and each processed group is established 3 repetitions; Each repeats 10, the two kinds of feeds of feeding respectively.The feed preparation is the same with processing.
The test daily ration: the additive that utilizes embodiment 2 to prepare is that 0.1% consumption substitutes 0.1% zeolite powder in the basal ration prescription as the test daily ration according to percentage by weight.
Basal diet, test pig breeding method, process of the test processing and data acquisition and data processing method are with application examples 1.
Test result:
(1) add feed addictive of the present invention to oestrus of sow to influence test result as shown in table 4:
Table 4
Figure BSA00000150333200091
Visible by table 4, test group oestrus of sow rate has improved 47.04% (p<0.01) than control group.
(2) add feed addictive of the present invention to sow be impregnated to influence test result as shown in table 5:
Table 5
Figure BSA00000150333200092
Can know that by table 5 test group sow conception rate has improved 11.72% (p<0.05) than control group.
Can be known that by above-mentioned test data in the sow daily ration, behind the interpolation feed addictive of the present invention, compare with control group, test group oestrus of sow rate has improved 47.04% (p<0.01), conception rate has improved 11.72% (p<0.05).Show that adding feed addictive of the present invention has obvious effects to the reproductive capacity of sow that improves through postpartum.

Claims (3)

1. feed addictive that improves reproductive capacity of sow, its raw material weight percentage consists of:
Figure FDA0000143358860000011
2. feed addictive according to claim 1 is characterized in that, described raw material weight percentage consists of:
Figure FDA0000143358860000012
3. the preparation method of feed addictive as claimed in claim 1; Comprise: with percentage by weight is that 45~50% barrenwort, 10~15% motherwort, 5~10% the seed of Chinese dodder, 5~10% Radix Angelicae Sinensis and 3~5% safflower mix; Being crushed to particle diameter is 25~40 microns; Adding percentage by weight is 0.3~0.5% vitamin A, 1~2% vitamin E, 0.5~0.8% folic acid and zeolite powder, mixes.
CN2010101955026A 2010-06-08 2010-06-08 Feed additive for improving reproductive capacity of sow and preparation method thereof Expired - Fee Related CN101869221B (en)

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CN102239973A (en) * 2011-08-15 2011-11-16 赣州八维生物科技有限公司 Additive used for nursing sows, preparation process and using method thereof
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CN105124266A (en) * 2015-09-06 2015-12-09 泗洪县东盛家畜养殖有限公司 Chinese herbal medicine additive capable of increasing ovulation rate of sows
CN105379979A (en) * 2015-11-22 2016-03-09 衡阳市富矿饲料添加剂有限公司 Chinese herbal medicine additive capable of prolonging productive life of breeding sow and preparation method thereof
CN106070018A (en) * 2016-06-17 2016-11-09 安徽省农业科学院畜牧兽医研究所 Small-fat-tail sheep ewe and the hybridization of Australia Baigong sheep produce Australia and tremble with fear the method for three generations ram
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