CN101863871A - 蔷薇红景天总苷及其医药用途和制备方法 - Google Patents
蔷薇红景天总苷及其医药用途和制备方法 Download PDFInfo
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- CN101863871A CN101863871A CN201010177549A CN201010177549A CN101863871A CN 101863871 A CN101863871 A CN 101863871A CN 201010177549 A CN201010177549 A CN 201010177549A CN 201010177549 A CN201010177549 A CN 201010177549A CN 101863871 A CN101863871 A CN 101863871A
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- rhodiola
- ethanol
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Abstract
Description
组别 | 剂量mg/Kg体重 | 动物数 | 游泳时间min |
模型组 | 10 | 13.8±3.1 | |
RRB低剂量组 | 30 | 10 | 35.9±2.6** |
RRB中剂量组 | 100 | 10 | 37.2±2.7** |
RRB高剂量组 | 300 | 10 | 35.9±3.2** |
式1化合物 | 10 | 10 | 39.2±4.1** |
阳性药 | 250 | 10 | 34.9±2.5** |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 英文俗名 | 文献对照 |
2-(4-hydroxyphenyl)ethyl,β-D-Glucopyranoside2-(4-羟基苯基)乙醇,β-D-葡萄糖苷 | C14H20O7 | 323.1107 | SalidrosideRhodosinRhodioloside | Rhodiolarosea[8] |
2-[4-[(3,4,5-trihydroxybenzoyl)oxy]phenyl]ethyl,β-D-Glucopyranoside2-[4-[(3,4,5-三羟基苯甲酰基)氧基]苯基]乙醇,β-D-葡萄糖苷 | C21H24O1 1 | 475.1216 | Pharienside | Rhodiolaphariensis[9] |
2-(4-methoxyphenyl)ethyl,β-D-Glucopyranoside2-(4-甲氧基苯基)乙醇,β-D-葡萄糖苷 | C15H22O7 | 337.1263 | Viridoside | Rhodiolaviridula[10] |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 英文俗名 | 文献对照 |
(2E)-3-phenyl-2-propen-1-yl-β-D-Glucopyranoside | C15H20O6 | 319.1158 | Rosin | Rhodiolarosea[11] |
(2E)-3-苯基-2-丙烯-1-醇,β-D-葡萄糖苷 | ||||
(2E)-3-phenyl-2-propen-1-yl6-O-β-L-arabinofuranosyl-β-D-Glucopyranoside(2E)-3-苯基-2-丙烯-1-醇,6-O-β-L-呋喃阿拉伯糖基-β-D-葡萄糖苷 | C20H28O10 | 451.158 | Rosarin | Rhodiolarosea[11] |
(2E)-3-(4-methoxyphenyl)-2-propen-1-yl-β-D-Glucopyranoside(2E)-3-(4-甲氧基苯基)-2-丙烯-1-醇,β-D-葡萄糖苷 | C16H22O7 | 349.1263 | Rhodiolarosea[12] |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 英文俗名 | 文献对照 |
(2E)-3-(4-methoxyphenyl)-2-propen-1-yl6-O-β-L-arabinopyranosyl-β-D-Glucopyranoside(2E)-3-(4-甲氧基苯基)-2-丙烯-1-醇,6-O-β-L-吡喃阿拉伯糖基-β-D-葡萄糖苷 | C21H30O11 | 481.1686 | Rhodiolarosea[13] |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 英文俗名 | 文献对照 |
3,4,5-trihydroxy-,1,1′-[(2R,2′R,3R,3′R,4R)-3,3′,4,4′-tetrahydro-5,5′,7,7′-tetrahydroxy-2,2′-bis(3,4,5-trihydroxyphenyl)[4,8′-bi-2H-1-benzopyran]-3,3′-diyl]ester,Benzoic acid3,4,5-三羟基-,1,1′-[(2R,2′R,3R,3′R,4R)-3,3′,4,4′-四氢-5,5′,7,7′-四羟基-2,2′-bis(3,4,5-三羟基苯基)[4,8′-bi-2H-1-苯并呋喃]-3,3′-二醇],苯甲酸酯 | C44H34O2 2 | 913.1464 | Rhodisin | Rhodiolasemenovii[14] |
3,3′,4′,5,7,8-Hexahydroxyflavone3,3′,4′,5,7,8-六羟基黄酮 | C15H10O8 | 317.0298 | ArticulatidinEquisporol | Rhodiola rosea[15] |
3,3′,4′,5,7,8-Hexahydroxyflavone,7-O-α-L-Rhamnopyranoside3,3′,4′,5,7,8-六羟基黄酮,7-O-α-L-鼠李糖苷 | C21H20O1 2 | 463.0876 | Rhodiolgin | Rhodiola rosea[16] |
3,4′,5,7,8-Pentahydroxyflavone,4′-O-β-D-Glucopyranoside3,4′,5,7,8-五羟基黄酮,4′-O-β-D-葡萄糖苷 | C21H20O1 2 | 463.0876 | Gelidolin | Rhodiola gelida[17] |
3,3′,4′,5,7,8-Hexahydroxyflavone,7-O-[β-D-Glucopyranosyl-(1→3)-α-L-rhamnopyranoside] | C27H30O1 7 | 625.1405 | Rhodioflavonoside | Rhodiolaquadrifida[18] |
3,3′,4′,5,7,8-Hexahydroxyflavone,7-O-α-L-Rhamnopyranoside,8-O-β-D-glucopyranoside3,3′,4′,5,7,8-六羟基黄酮,7-O-α-L-鼠李糖基,8-O-β-D-葡萄糖苷 | C27H30O1 7 | 625.1405 | Rhodiolgidin | Rhodiola rosea[16] |
3,4′,5,7,8-Pentahydroxyflavone3,4′,5,7,8-五羟基黄酮 | C15H10O7 | 301.0348 | Herbacetin | Rhodiola algida[19] |
3,4′,5,7,8-Pentahydroxyflavone,3-O-β-D-Glucopyranoside,8-β-D-xylopyranoside3,4′,5,7,8-五羟基黄酮,3-O-β-D-葡萄糖苷,8-β-D-木糖苷 | C26H28O1 6 | 595.1299 | Rhodalidin | Rhodiola rosea[16] |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 英文俗名 | 文献对照 |
3,4′,5,7,8-Pentahydroxyflavone,4′,8-Di-O-β-D-xylopyranoside3,4′,5,7,8-五羟基黄酮,4′,8-双O-β-D-木糖基 | C25H26O1 5 | 565.1193 | Herbacetin4′,8-dixyloside | Rhodiolakrylovii[20] |
3,4′,5,7,8-Pentahydroxyflavone,4′-O-β-D-Xylopyranoside,8-O-α-L-arabinopyranoside3,4′,5,7,8-五羟基黄酮,4′-O-β-D-木糖基,8-O-α-L-吡喃阿拉伯糖苷 | C25H26O1 5 | 565.1193 | Rhodalide | Rhodiola algida[21] |
3,4′,5,7,8-Pentahydroxyflavone,4′-O-α-L-Rhamnopyranoside3,4′,5,7,8-五羟基黄酮,4′-O-α-L-鼠李糖苷 | C21H20O1 1 | 447.0927 | Rhodiolatuntoside | Constit.ofRhodiolaatuntsuensis[22] |
3,4′,5,7,8-Pentahydroxyflavone,7-O-α-L-Rhamnopyranoside3,4′,5,7,8-五羟基黄酮,7-O-α-L-鼠李糖苷 | C21H20O1 1 | 447.0927 | Rhodionin | Rhodiola rosea[16] |
3,4′,5,7,8-Pentahydroxyflavone,8-O-α-L-Rhamnopyranoside3,4′,5,7,8-五羟基黄酮,8-O-α-L-鼠李糖苷 | C21H20O1 1 | 447.0927 | Litvinolin | Rhodiolakrylovii[20] |
3,4′,5,7-tetrahydroxyflavone,3-O-β-D-glucopyranoside3,4′,5,7-四羟基黄酮,3-O-β-D-葡萄糖苷 | C21H20O1 1 | 447.0927 | Isoastragalin | Gossypiumhirsutumflowers[29] |
3,4′,5,7,8-Pentahydroxyflavone,4′-O-β-D-Glucuronopyranoside3,4′,5,7,8-五羟基黄酮,4′-O-β-D-葡萄糖苷 | C21H18O1 3 | 477.0669 | Alginin | Rhodiola algida[23] |
3,4′,5,7,8-Pentahydroxyflavone, | C27H30O1 | 609.1456 | Rhodiosin | Rhodiola rosea[24] |
7-O-[β-D-Glucopyranosyl-(1→3)-α-L-rhamnopyranoside]3,4′,5,7,8-五羟基黄酮,7-O-[β-D-葡萄糖基-(1→3)-α-L-鼠李糖苷] | 6 |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 英文俗名 | 文献对照 |
3,4′,5,7,8-Pentahydroxyflavone,7-O-α-L-Rhamnopyranoside,8-O-β-D-glucopyranoside3,4′,5,7,8-五羟基黄酮,7-O-α-L-鼠李糖基,8-O-β-D-葡萄糖苷 | C27H30O1 6 | 609.1456 | Rhodionidin | Rhodiola rosea[16] |
3,4′,5,7,8-Pentahydroxyflavone,8-O-α-D-xylopyranoside3,4′,5,7,8-五羟基黄酮,8-O-α-D-木糖苷 | C20H18O1 1 | 433.0771 | Herbacetin8-xylopyranoside | Rhodiolafastigiata[25] |
3,4′,5,7,8-Pentahydroxyflavone,8-O-α-L-Arabinopyranoside3,4′,5,7,8-五羟基黄酮8-O-α-L-吡喃阿拉伯糖苷 | C20H18O1 1 | 433.0771 | Rhodalgin | Rhodiola algida[23] |
3,4′,5,7,8-Pentahydroxyflavone,8-O-β-D-Arabinofuranoside3,4′,5,7,8-五羟基黄酮,8-O-β-D-呋喃阿拉伯糖苷 | C20H18O1 1 | 433.0771 | Rhodiolafastigiata[26] | |
3,4′,5,7,8-Pentahydroxyflavone,8-O-β-D-Xylopyranoside3,4′,5,7,8-五羟基黄酮,8-O-β-D-吡喃木糖苷 | C20H18O1 1 | 433.0771 | Rhodalin | Rhodiola algida[27]and Rhodiolarosea[24] |
3,4′,5,7,8-Pentahydroxyflavone,7-O-β-L-Arabinopyranoside3,4′,5,7,8-五羟基黄酮,7-O-β-L-吡喃阿拉伯糖苷 | C20H18O1 1 | 433.0771 | Gelolin | Rhodiola gelida[21] |
3,4′,5,7-tetrahydroxyflavone,7-O-α-L-Rhamnopyranoside3,4′,5,7-四羟基黄酮,7-O-α-L-鼠李糖苷 | C15H10O6 | 285.0399 | Kaempferol | Rhodiola coccineaand Rhodiolaquadrifida[28] |
3,4,5-trihydroxy-Benzoic acid3,4,5-三羟基-苯甲酸 | C7H6O5 | 169.0137 | Gallica acid | Rhodiola coccineaand Rhodiolaquadrifida[28] |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 俗名 | 文献对照 |
3,7-Dimethyl-2,6-octadiene-1,4-diol,(2E,4R)-型,1-O-β-D-Glucopyranoside3,7-二甲基-2,6-辛二烯-1,4-二醇,(2E,4R)-型,1-O-β-D-葡萄 | C16H28O7 | 355.1733 | Rosiridin | Rhodiola rosea[24] |
糖苷 | ||||
3,7-Dimethyl-2,6-octadiene-1,4-diol,(2E,4R)-型,4-O-(3,4,5-Trihydroxybenzoyl),8-O-β-D-glucopyranoside3,7-二甲基-2,6-辛二烯-1,4-二醇,(2E,4R)-型,4-O-(3,4,5-三羟基苯基),8-O-β-D-葡萄糖苷 | C23H32O11 | 507.1842 | SachalinosideA | Rhodiolasachalinensis[31] |
(2Z)-3,7-dimethyl-2,6-octadien-1-yl,6-O-α-L-arabinopyranosyl-β-D-Glucopyranoside(2Z)-3,7-二甲基-2,6-辛二烯-1-醇,6-O-α-L-吡喃阿拉伯糖基-β-D-葡萄糖苷 | C21H36O10 | 471.2206 | Sacranoside B | Rhodiola sacraand Rhodiolaeradix[32] |
3,7-Dimethyl-2-octene-1,4,7-triol,(2E,4R)-型3,7-二甲基-2-辛烯-1,4,7-三醇,(2E,4R)-型 | C10H20O3 | 211.1310 | Sachalinol A | Rhodiolasachalinensis[31] |
3-(4-Hydroxy-5,5-dimethyl-2-furanyl)-2-buten-1-ol,(2E,4R,6R)-型3-(4-羟基-5,5-二甲基-2-呋喃基)-2-丁烯-1-醇,(2E,4R,6R)-型 | C10H18O3 | 209.1154395.2410 | Sachalinol C | Rhodiolasachalinensis[31] |
3-(4-Hydroxy-5,5-dimethyl-2-furanyl)-2-buten-1-ol,(2E,4R,6S)-型3-(4-羟基-5,5-二甲基-2-呋喃基)-2-丁烯-1-醇,(2E,4R,6S)-型 | C10H18O3 | 209.1154395.2410 | Sachalinol B | Rhodiolasachalinensis[31] |
2-Methyl-3-buten-2-ol,O-β-D-Glucopyranoside2-甲级-3-丁烯-2-醇,O-β-D-葡萄糖苷 | C11H20O6 | 271.1158 | Crenulatin | Rhodiolacrenulata[34] |
化合物英文名称 | 分子式 | 检测离子[M+Na]+ | 俗名 | 文献对照 |
2-Hydroxymethyl-2-butenoicacid,(Z)-型,Nitrile,O-β-D-glucopyranoside2-羟基甲基-2-丁烯氰,(Z)-型,O-β-D-葡萄糖苷 | C11H17NO6 | 282.0954 | Rhodiocyanoside D | Rhodiola sacra[32] |
4-Hydroxy-2-methyl-2-butenoic acid,(Z)-型,Nitrile,4-O-β-D-glucopyranoside4-羟基-2-甲基-2-丁烯氰,(Z)-型,4-O-β-D-葡萄糖苷 | C11H17NO6 | 282.0954 | MultifidinRhodiocyanoside A | Rhodiolaquadrifida[33] |
3,7-Dimethyl-2,6-octadiene-1,4,7-triol,(2E,4R)-型, | C16H28O8 | 371.1682 | RhodiolosideA | Rhodiola rosea[35] |
1-O-β-D-Glucopyranoside3,7-二甲基-2,6-辛二烯-1,4,7-三醇,(2E,4R)-型,1-O-β-D-葡萄糖苷 | ||||
3,7-Dimethyl-2,6-octadiene-1,4-diol,(2E,4R)-型,1-[α-D-Glucopyranosyl-(1-6)-O-β-D-Glucopyranoside3,7-二甲基-2,6-辛二烯-1,4-二醇,(2E,4R)-型,1-[α-D-葡萄糖基-(1-6)-O-β-D-葡萄糖苷 | C22H38O12 | 517.2261 | RhodiolosideB | Rhodiola rosea[35] |
3,7-Dimethyl-2,6-octadiene-1,4-diol,(2E,4R)-型,1-O-[β-D-Glucopyranosyl-(1-3)-O-β-D-Glucopyranoside3,7-二甲基-2,6-辛二烯-1,4-二醇,(2E,4R)-型,1-O-[β-D-葡萄糖基-(1-3)-O-β-D-葡萄糖苷 | C22H38O12 | 517.2261 | RhodiolosideC | Rhodiola rosea[35] |
3,7-Dimethyl-2-octene-1,4,7-triol,(2E,4R)-型,1-O-β-D-Glucopyranoside3,7-二甲基-2-辛烯-1,4,7-三醇,(2E,4R)-型,1-O-β-D-葡萄糖苷 | C16H30O8 | 373.1838 | RhodiolosideD | Rhodiola rosea[35] |
3,7-Dimethyl-2-octene-1,4,7-triol,(2E,4R)-型,1-O-[α-L-Arabinopyranosyl-(1-6)-β-D-Glucopyranoside3,7-二甲基-2-辛烯-1,4,7-三醇,(2E,4R)-型,1-O-[α-L-吡喃阿拉伯糖基-(1-6)-β-D-葡萄糖苷 | C21H38O11 | 489.2312 | RhodiolosideE | Rhodiola rosea[35] |
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