CN101855227A - 杂环衍生物 - Google Patents
杂环衍生物 Download PDFInfo
- Publication number
- CN101855227A CN101855227A CN200880115686A CN200880115686A CN101855227A CN 101855227 A CN101855227 A CN 101855227A CN 200880115686 A CN200880115686 A CN 200880115686A CN 200880115686 A CN200880115686 A CN 200880115686A CN 101855227 A CN101855227 A CN 101855227A
- Authority
- CN
- China
- Prior art keywords
- methyl
- alkyl
- hete rocyclic
- rocyclic derivatives
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07120603 | 2007-11-13 | ||
EP07120603.1 | 2007-11-13 | ||
PCT/EP2008/065306 WO2009062930A1 (en) | 2007-11-13 | 2008-11-11 | Heterocyclic derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101855227A true CN101855227A (zh) | 2010-10-06 |
CN101855227B CN101855227B (zh) | 2013-01-23 |
Family
ID=39472607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801156861A Active CN101855227B (zh) | 2007-11-13 | 2008-11-11 | 杂环衍生物 |
Country Status (18)
Country | Link |
---|---|
US (1) | US8129397B2 (zh) |
EP (1) | EP2209791B1 (zh) |
JP (1) | JP5455130B2 (zh) |
KR (1) | KR20100106370A (zh) |
CN (1) | CN101855227B (zh) |
AR (1) | AR069286A1 (zh) |
AU (1) | AU2008322986B2 (zh) |
BR (1) | BRPI0819202A2 (zh) |
CA (1) | CA2703901C (zh) |
CL (1) | CL2008003362A1 (zh) |
CO (1) | CO6270365A2 (zh) |
EC (1) | ECSP10010247A (zh) |
MX (1) | MX2010004686A (zh) |
PE (1) | PE20091167A1 (zh) |
RU (1) | RU2010123895A (zh) |
TW (1) | TW200934497A (zh) |
WO (1) | WO2009062930A1 (zh) |
ZA (1) | ZA201002580B (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200934497A (en) | 2007-11-13 | 2009-08-16 | Organon Nv | Heterocyclic derivatives |
WO2016081649A1 (en) * | 2014-11-18 | 2016-05-26 | Emory University | Thieno[2,3-d]pyrimidin-4-one derivatives as nmdar modulators and uses related thereto |
DK3386591T3 (da) | 2015-12-09 | 2020-09-28 | Cadent Therapeutics Inc | Heteroaromatic nmda receptor modulators and uses thereof |
ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
US11274107B2 (en) | 2016-12-22 | 2022-03-15 | Cadent Therapeutics, Inc. | NMDA receptor modulators and uses thereof |
GB201702221D0 (en) * | 2017-02-10 | 2017-03-29 | Univ Of Sussex | Compounds |
GB201803340D0 (en) | 2018-03-01 | 2018-04-18 | Univ Of Sussex | Compounds |
EP3830092B1 (en) | 2018-08-03 | 2023-05-03 | Novartis AG | Heteroaromatic nmda receptor modulators and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005040110A1 (en) * | 2003-10-08 | 2005-05-06 | Eli Lilly And Company | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors |
ES2383115T3 (es) * | 2004-01-09 | 2012-06-18 | Eli Lilly And Company | Compuestos de tiofeno y furano |
RU2401258C2 (ru) * | 2005-03-16 | 2010-10-10 | Авентис Фармасьютикалз Инк. | Дипиразолы в качестве средств для центральной нервной системы |
GB0507298D0 (en) * | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
KR101288144B1 (ko) * | 2005-06-14 | 2013-07-18 | 아스카 세이야쿠 가부시키가이샤 | 티에노피리미딘 유도체 |
TW200934497A (en) | 2007-11-13 | 2009-08-16 | Organon Nv | Heterocyclic derivatives |
-
2008
- 2008-10-28 TW TW097141383A patent/TW200934497A/zh unknown
- 2008-11-11 EP EP08849917.3A patent/EP2209791B1/en active Active
- 2008-11-11 KR KR1020107012728A patent/KR20100106370A/ko not_active Application Discontinuation
- 2008-11-11 WO PCT/EP2008/065306 patent/WO2009062930A1/en active Application Filing
- 2008-11-11 CA CA2703901A patent/CA2703901C/en active Active
- 2008-11-11 RU RU2010123895/04A patent/RU2010123895A/ru unknown
- 2008-11-11 BR BRPI0819202 patent/BRPI0819202A2/pt not_active IP Right Cessation
- 2008-11-11 JP JP2010533556A patent/JP5455130B2/ja active Active
- 2008-11-11 CN CN2008801156861A patent/CN101855227B/zh active Active
- 2008-11-11 MX MX2010004686A patent/MX2010004686A/es not_active Application Discontinuation
- 2008-11-11 AU AU2008322986A patent/AU2008322986B2/en active Active
- 2008-11-12 AR ARP080104926A patent/AR069286A1/es unknown
- 2008-11-12 PE PE2008001915A patent/PE20091167A1/es not_active Application Discontinuation
- 2008-11-12 US US12/269,306 patent/US8129397B2/en active Active
- 2008-11-12 CL CL2008003362A patent/CL2008003362A1/es unknown
-
2010
- 2010-04-13 ZA ZA2010/02580A patent/ZA201002580B/en unknown
- 2010-05-13 CO CO10057470A patent/CO6270365A2/es not_active Application Discontinuation
- 2010-06-11 EC EC2010010247A patent/ECSP10010247A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP2209791A1 (en) | 2010-07-28 |
AR069286A1 (es) | 2010-01-13 |
ECSP10010247A (es) | 2010-07-30 |
TW200934497A (en) | 2009-08-16 |
JP5455130B2 (ja) | 2014-03-26 |
MX2010004686A (es) | 2010-05-19 |
WO2009062930A1 (en) | 2009-05-22 |
JP2011503139A (ja) | 2011-01-27 |
CL2008003362A1 (es) | 2009-06-26 |
US20090131455A1 (en) | 2009-05-21 |
BRPI0819202A2 (pt) | 2015-05-05 |
CA2703901A1 (en) | 2009-05-22 |
CA2703901C (en) | 2016-05-10 |
US8129397B2 (en) | 2012-03-06 |
ZA201002580B (en) | 2010-12-29 |
RU2010123895A (ru) | 2011-12-20 |
EP2209791B1 (en) | 2014-01-22 |
KR20100106370A (ko) | 2010-10-01 |
CO6270365A2 (es) | 2011-04-20 |
PE20091167A1 (es) | 2009-08-03 |
AU2008322986B2 (en) | 2013-08-01 |
CN101855227B (zh) | 2013-01-23 |
AU2008322986A1 (en) | 2009-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Holland Applicant after: N.V. Organon Address before: Holland Applicant before: N.V. ORGANON |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: ORGANON NV TO: MSD OUSI CO., LTD. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: ORGANON BIOLOGICAL NETHERLANDS CO., LTD. Free format text: FORMER OWNER: MSD OUSI CO., LTD. Effective date: 20131010 Owner name: MERCK SHARP + DOHME CORP. Free format text: FORMER OWNER: ORGANON BIOLOGICAL NETHERLANDS CO., LTD. Effective date: 20131010 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20131010 Address after: Haarlem Patentee after: MERCK SHARP & DOHME B.V. Address before: Haarlem Patentee before: Organon biological science Holland Co.,Ltd. Effective date of registration: 20131010 Address after: Haarlem Patentee after: Organon biological science Holland Co.,Ltd. Address before: Holland Patentee before: N.V. Organon |