CN101848909A - 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶 - Google Patents

可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶 Download PDF

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Publication number
CN101848909A
CN101848909A CN200780012623A CN200780012623A CN101848909A CN 101848909 A CN101848909 A CN 101848909A CN 200780012623 A CN200780012623 A CN 200780012623A CN 200780012623 A CN200780012623 A CN 200780012623A CN 101848909 A CN101848909 A CN 101848909A
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aliphatic group
compound
disease
group
independently
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J-M·吉米内斯
P·克里尔
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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CN200780012623A 2006-02-14 2007-02-12 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶 Pending CN101848909A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77314306P 2006-02-14 2006-02-14
US60/773,143 2006-02-14
PCT/US2007/003767 WO2007095223A2 (en) 2006-02-14 2007-02-12 Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
CN101848909A true CN101848909A (zh) 2010-09-29

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Application Number Title Priority Date Filing Date
CN200780012623A Pending CN101848909A (zh) 2006-02-14 2007-02-12 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶

Country Status (7)

Country Link
US (1) US7659283B2 (https=)
EP (1) EP2004645A2 (https=)
JP (1) JP2009528991A (https=)
CN (1) CN101848909A (https=)
AU (1) AU2007215161A1 (https=)
CA (1) CA2641254A1 (https=)
WO (1) WO2007095223A2 (https=)

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CN109071455A (zh) * 2016-03-11 2018-12-21 科尔沃斯制药股份有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法

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US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
CN102532133A (zh) 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
WO2007114926A2 (en) 2006-04-04 2007-10-11 The Regents Of The University Of California Kinase antagonists
AU2007338754A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
JP5788316B2 (ja) 2008-07-08 2015-09-30 インテリカイン, エルエルシー キナーゼインヒビターおよび使用方法
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
KR101173678B1 (ko) 2010-10-20 2012-08-13 한국과학기술연구원 피롤로[3,2-c]피리딘 유도체 및 그의 제조 방법
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
MX2015003874A (es) 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
WO2015008844A1 (ja) 2013-07-18 2015-01-22 大鵬薬品工業株式会社 Fgfr阻害剤耐性癌の治療薬
TR201907147T4 (tr) 2013-07-18 2019-06-21 Taiho Pharmaceutical Co Ltd Fgfr inhibitörünün aralıklı uygulanmasına yönelik anti-tümör ilaç.
RS59144B1 (sr) 2013-11-13 2019-09-30 Vertex Pharma Inhibitori replikacije virusa influence
HRP20181272T1 (hr) 2013-11-13 2018-10-05 Vertex Pharmaceuticals Incorporated Postupci priprave inhibitora replikacije virusa influence
CN107001356B (zh) * 2014-07-31 2019-09-03 默克专利有限公司 用于神经退化性疾病的中氮茚衍生物
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤を調製する方法

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CN1279682A (zh) * 1997-10-20 2001-01-10 霍夫曼-拉罗奇有限公司 双环激酶抑制剂
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CN109071455A (zh) * 2016-03-11 2018-12-21 科尔沃斯制药股份有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法
CN109071455B (zh) * 2016-03-11 2022-08-02 嘉兴和剂药业有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法

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WO2007095223A2 (en) 2007-08-23
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