CN101848734B - 用于成像的经标记的iigf结合肽 - Google Patents

用于成像的经标记的iigf结合肽 Download PDF

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Publication number
CN101848734B
CN101848734B CN2008800242291A CN200880024229A CN101848734B CN 101848734 B CN101848734 B CN 101848734B CN 2008800242291 A CN2008800242291 A CN 2008800242291A CN 200880024229 A CN200880024229 A CN 200880024229A CN 101848734 B CN101848734 B CN 101848734B
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CN
China
Prior art keywords
cmbp
group
gly
peptide
cys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800242291A
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English (en)
Chinese (zh)
Other versions
CN101848734A (zh
Inventor
E·W·约翰内森
A·卡思伯特森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0709441A external-priority patent/GB0709441D0/en
Priority claimed from GB0715682A external-priority patent/GB0715682D0/en
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN101848734A publication Critical patent/CN101848734A/zh
Application granted granted Critical
Publication of CN101848734B publication Critical patent/CN101848734B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Solid State Image Pick-Up Elements (AREA)
CN2008800242291A 2007-05-16 2008-05-16 用于成像的经标记的iigf结合肽 Expired - Fee Related CN101848734B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0709441A GB0709441D0 (en) 2007-05-16 2007-05-16 Peptide imaging agents
GB0709441.0 2007-05-16
GB0715682.1 2007-08-13
GB0715682A GB0715682D0 (en) 2007-08-13 2007-08-13 Peptide imaging agents
PCT/GB2008/001696 WO2008139207A2 (en) 2007-05-16 2008-05-16 Labelled hgf binding peptides for imaging

Publications (2)

Publication Number Publication Date
CN101848734A CN101848734A (zh) 2010-09-29
CN101848734B true CN101848734B (zh) 2013-08-28

Family

ID=39743846

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800242291A Expired - Fee Related CN101848734B (zh) 2007-05-16 2008-05-16 用于成像的经标记的iigf结合肽

Country Status (17)

Country Link
US (1) US8529874B2 (enExample)
EP (1) EP2146749B1 (enExample)
JP (1) JP2010526859A (enExample)
KR (2) KR20150017387A (enExample)
CN (1) CN101848734B (enExample)
AT (1) ATE551073T1 (enExample)
AU (1) AU2008249821B2 (enExample)
BR (1) BRPI0811210B1 (enExample)
CA (1) CA2685553C (enExample)
ES (1) ES2385066T3 (enExample)
IL (1) IL201778A0 (enExample)
MX (1) MX2009012386A (enExample)
NZ (1) NZ581160A (enExample)
PL (1) PL2146749T3 (enExample)
RU (2) RU2473361C9 (enExample)
WO (1) WO2008139207A2 (enExample)
ZA (1) ZA200908016B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2148702A2 (en) * 2007-05-16 2010-02-03 GE Healthcare AS Pentamethine cyanine dyes carrying at least three sulfonic acid groups
GB0718967D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Peptide imaging agents
GB0918321D0 (en) 2009-10-20 2009-12-02 Ge Healthcare As Cyclic peptide synthesis
EP2588541A1 (en) * 2010-06-29 2013-05-08 GE Healthcare AS Dye compositions and dye syntheses
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
GB201013808D0 (en) 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
US20120088262A1 (en) * 2010-10-06 2012-04-12 Millipore Corporation Cyanine compounds, conjugates and method of use
MX2013010012A (es) 2011-03-01 2014-04-14 Ge Healthcare Ltd Analogos de octreotato radiomarcado como trazadores de tomografia por emision de positrones.
GB201103696D0 (en) 2011-03-04 2011-04-20 Ge Healthcare Ltd Technetium labelled peptides
DE102011118029A1 (de) * 2011-06-20 2012-12-20 Universität Leipzig Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
GB201116862D0 (en) 2011-09-30 2011-11-09 Ge Healthcare As Infusion imaging method
GB201121914D0 (en) * 2011-12-20 2012-02-01 Ge Healthcare Ltd Method for patient selection
US10046068B2 (en) * 2013-03-15 2018-08-14 Arizona Board Of Regents On Behalf Of Arizona State University Saccharide conjugates
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
CN105111773B (zh) * 2015-08-19 2017-06-27 大连理工大学 一类氨基菁类荧光染料及其制备方法和应用
GB201804835D0 (en) * 2018-03-26 2018-05-09 Ge Healthcare As Formulation and method of preparation
CN112129736B (zh) * 2020-09-22 2022-08-02 四川大学华西医院 粘蛋白和循环肿瘤细胞的均相可视化/荧光poct检测方法
WO2022258455A1 (en) * 2021-06-07 2022-12-15 Surgvision Gmbh Stable liquid phantom for near-infrared fluorescence verification
TW202404643A (zh) 2022-04-20 2024-02-01 大陸商同宜醫藥（蘇州）有限公司 化合物及用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078778A2 (en) * 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
WO2006115633A2 (en) * 2005-04-22 2006-11-02 University Of Washington Cyanine-chlorotoxin conjugate and method for intra-operative fluorescent visualization of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615646B2 (en) * 2002-05-10 2009-11-10 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
GB0223249D0 (en) * 2002-10-08 2002-11-13 Amersham Plc Improved imaging agents
US7510699B2 (en) * 2003-02-19 2009-03-31 Sicel Technologies, Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
NO20034350D0 (no) * 2003-09-29 2003-09-29 Amersham Health As Optisk avbilding av kolorektal kreft
EP1678258B1 (en) * 2003-10-31 2011-08-31 GE Healthcare Limited Cyanine dye labelling reagents
US7785566B2 (en) 2003-11-06 2010-08-31 Ge Healthcare, Inc. Pharmaceutical compounds
NO20035682D0 (no) 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av ösofagkreft og Barretts ösofag
US8236283B2 (en) * 2005-01-06 2012-08-07 Ge Healthcare As Optical imaging
WO2006078914A1 (en) * 2005-01-21 2006-07-27 Washington University In St. Louis Compounds having rd targeting motifs
GB0502277D0 (en) 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
NO20053354D0 (no) 2005-07-11 2005-07-11 Amersham Health As Optical imaging contrast agent.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078778A2 (en) * 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
WO2006115633A2 (en) * 2005-04-22 2006-11-02 University Of Washington Cyanine-chlorotoxin conjugate and method for intra-operative fluorescent visualization of cancer

Also Published As

Publication number Publication date
IL201778A0 (en) 2010-06-16
RU2473361C9 (ru) 2013-06-20
CN101848734A (zh) 2010-09-29
PL2146749T3 (pl) 2012-09-28
RU2473361C2 (ru) 2013-01-27
BRPI0811210B1 (pt) 2021-11-09
US20100150843A1 (en) 2010-06-17
EP2146749B1 (en) 2012-03-28
RU2009140478A (ru) 2011-06-27
US8529874B2 (en) 2013-09-10
KR20100016543A (ko) 2010-02-12
MX2009012386A (es) 2009-12-03
RU2475266C2 (ru) 2013-02-20
NZ581160A (en) 2012-05-25
JP2010526859A (ja) 2010-08-05
ES2385066T3 (es) 2012-07-17
BRPI0811210A2 (pt) 2014-11-11
WO2008139207A3 (en) 2009-02-26
EP2146749A2 (en) 2010-01-27
AU2008249821A1 (en) 2008-11-20
CA2685553A1 (en) 2008-11-20
AU2008249821B2 (en) 2013-08-22
WO2008139207A2 (en) 2008-11-20
ZA200908016B (en) 2012-04-25
KR20150017387A (ko) 2015-02-16
RU2009140475A (ru) 2011-06-27
ATE551073T1 (de) 2012-04-15
CA2685553C (en) 2017-03-28
KR101578225B1 (ko) 2015-12-17

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