CA2685553C - Peptide imaging agents - Google Patents

Peptide imaging agents Download PDF

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Publication number
CA2685553C
CA2685553C CA2685553A CA2685553A CA2685553C CA 2685553 C CA2685553 C CA 2685553C CA 2685553 A CA2685553 A CA 2685553A CA 2685553 A CA2685553 A CA 2685553A CA 2685553 C CA2685553 C CA 2685553C
Authority
CA
Canada
Prior art keywords
gly
cmbp
imaging agent
cys
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2685553A
Other languages
English (en)
French (fr)
Other versions
CA2685553A1 (en
Inventor
Edvin Wilhelm Johannesen
Alan Cuthbertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0709441A external-priority patent/GB0709441D0/en
Priority claimed from GB0715682A external-priority patent/GB0715682D0/en
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CA2685553A1 publication Critical patent/CA2685553A1/en
Application granted granted Critical
Publication of CA2685553C publication Critical patent/CA2685553C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056Peptides, proteins, polyamino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4842Monitoring progression or stage of a disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CA2685553A 2007-05-16 2008-05-16 Peptide imaging agents Active CA2685553C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0709441A GB0709441D0 (en) 2007-05-16 2007-05-16 Peptide imaging agents
GB0709441.0 2007-05-16
GB0715682A GB0715682D0 (en) 2007-08-13 2007-08-13 Peptide imaging agents
GB0715682.1 2007-08-13
PCT/GB2008/001696 WO2008139207A2 (en) 2007-05-16 2008-05-16 Labelled hgf binding peptides for imaging

Publications (2)

Publication Number Publication Date
CA2685553A1 CA2685553A1 (en) 2008-11-20
CA2685553C true CA2685553C (en) 2017-03-28

Family

ID=39743846

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2685553A Active CA2685553C (en) 2007-05-16 2008-05-16 Peptide imaging agents

Country Status (17)

Country Link
US (1) US8529874B2 (enExample)
EP (1) EP2146749B1 (enExample)
JP (1) JP2010526859A (enExample)
KR (2) KR20150017387A (enExample)
CN (1) CN101848734B (enExample)
AT (1) ATE551073T1 (enExample)
AU (1) AU2008249821B2 (enExample)
BR (1) BRPI0811210B1 (enExample)
CA (1) CA2685553C (enExample)
ES (1) ES2385066T3 (enExample)
IL (1) IL201778A0 (enExample)
MX (1) MX2009012386A (enExample)
NZ (1) NZ581160A (enExample)
PL (1) PL2146749T3 (enExample)
RU (2) RU2473361C9 (enExample)
WO (1) WO2008139207A2 (enExample)
ZA (1) ZA200908016B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008139206A2 (en) * 2007-05-16 2008-11-20 Ge Healthcare As Optical imaging agents
GB0718967D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Peptide imaging agents
GB0918321D0 (en) 2009-10-20 2009-12-02 Ge Healthcare As Cyclic peptide synthesis
GB201010878D0 (en) 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
US20130095040A1 (en) * 2010-06-29 2013-04-18 Ge Healthcare As Dye compositions and dye syntheses
GB201013808D0 (en) * 2010-08-18 2010-09-29 Ge Healthcare Ltd Peptide radiotracer compositions
EP2625281A2 (en) * 2010-10-06 2013-08-14 EMD Millipore Corporation Cyanine compounds, conjugates and method of use
RU2013140291A (ru) 2011-03-01 2015-04-10 ДжиИ ХЕЛТКЕР ЛИМИТЕД Меченые радиоактивной меткой аналоги октреотата в качестве рет-индикаторов
GB201103696D0 (en) 2011-03-04 2011-04-20 Ge Healthcare Ltd Technetium labelled peptides
DE102011118029A1 (de) 2011-06-20 2012-12-20 Universität Leipzig Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
GB201116862D0 (en) 2011-09-30 2011-11-09 Ge Healthcare As Infusion imaging method
GB201121914D0 (en) 2011-12-20 2012-02-01 Ge Healthcare Ltd Method for patient selection
WO2014152718A1 (en) * 2013-03-15 2014-09-25 Arizona Board Of Regents, For And On Behalf Of Arizona State University Saccharide conjugates
GB201314936D0 (en) 2013-08-21 2013-10-02 Ge Healthcare Ltd Radiolabelling method
GB201322456D0 (en) 2013-12-18 2014-02-05 Ge Healthcare Ltd Radiotracer compositions and methods
CN105111773B (zh) * 2015-08-19 2017-06-27 大连理工大学 一类氨基菁类荧光染料及其制备方法和应用
GB201804835D0 (en) * 2018-03-26 2018-05-09 Ge Healthcare As Formulation and method of preparation
CN112129736B (zh) * 2020-09-22 2022-08-02 四川大学华西医院 粘蛋白和循环肿瘤细胞的均相可视化/荧光poct检测方法
WO2022258455A1 (en) * 2021-06-07 2022-12-15 Surgvision Gmbh Stable liquid phantom for near-infrared fluorescence verification
TW202404643A (zh) 2022-04-20 2024-02-01 大陸商同宜醫藥(蘇州)有限公司 化合物及用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615646B2 (en) * 2002-05-10 2009-11-10 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
GB0223249D0 (en) * 2002-10-08 2002-11-13 Amersham Plc Improved imaging agents
WO2004075032A2 (en) * 2003-02-19 2004-09-02 Sicel Technologies Inc. In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
SI2949658T1 (sl) * 2003-03-03 2018-10-30 Dyax Corp. Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe
NO20034350D0 (no) * 2003-09-29 2003-09-29 Amersham Health As Optisk avbilding av kolorektal kreft
ATE522580T1 (de) * 2003-10-31 2011-09-15 Ge Healthcare Ltd Cyaninfarbstoffe als markieragenzien
US7785566B2 (en) 2003-11-06 2010-08-31 Ge Healthcare, Inc. Pharmaceutical compounds
NO20035682D0 (no) 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av ösofagkreft og Barretts ösofag
EP1833512A1 (en) * 2005-01-06 2007-09-19 GE Healthcare AS Optical imaging
US8053415B2 (en) * 2005-01-21 2011-11-08 Washington University In St. Louis Compounds having RD targeting motifs
GB0502277D0 (en) 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
ATE502048T1 (de) 2005-04-22 2011-04-15 Univ Washington Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs
NO20053354D0 (no) 2005-07-11 2005-07-11 Amersham Health As Optical imaging contrast agent.

Also Published As

Publication number Publication date
ES2385066T3 (es) 2012-07-17
PL2146749T3 (pl) 2012-09-28
US20100150843A1 (en) 2010-06-17
AU2008249821A1 (en) 2008-11-20
BRPI0811210A2 (pt) 2014-11-11
EP2146749A2 (en) 2010-01-27
RU2009140478A (ru) 2011-06-27
NZ581160A (en) 2012-05-25
KR101578225B1 (ko) 2015-12-17
KR20100016543A (ko) 2010-02-12
CN101848734A (zh) 2010-09-29
WO2008139207A3 (en) 2009-02-26
RU2009140475A (ru) 2011-06-27
MX2009012386A (es) 2009-12-03
CA2685553A1 (en) 2008-11-20
AU2008249821B2 (en) 2013-08-22
ZA200908016B (en) 2012-04-25
IL201778A0 (en) 2010-06-16
RU2473361C9 (ru) 2013-06-20
WO2008139207A2 (en) 2008-11-20
ATE551073T1 (de) 2012-04-15
BRPI0811210B1 (pt) 2021-11-09
RU2475266C2 (ru) 2013-02-20
KR20150017387A (ko) 2015-02-16
US8529874B2 (en) 2013-09-10
RU2473361C2 (ru) 2013-01-27
EP2146749B1 (en) 2012-03-28
JP2010526859A (ja) 2010-08-05
CN101848734B (zh) 2013-08-28

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Effective date: 20130416