CN101842707B - 用于对选自bnp和bnp原的不稳定抗原定量的免疫测定法 - Google Patents

用于对选自bnp和bnp原的不稳定抗原定量的免疫测定法 Download PDF

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Publication number
CN101842707B
CN101842707B CN200880011741.2A CN200880011741A CN101842707B CN 101842707 B CN101842707 B CN 101842707B CN 200880011741 A CN200880011741 A CN 200880011741A CN 101842707 B CN101842707 B CN 101842707B
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Prior art keywords
bnp
antibody
immune complex
probnp
antigen
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English (en)
Chinese (zh)
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CN101842707A (zh
Inventor
娜塔利亚·N·塔姆
亚历克西·G·卡特鲁卡
弗拉迪米尔·L·菲拉托夫
奥尔加·V·科洛索瓦
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Hytest Ltd
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Hytest Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00—Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04—Sandwich assay format
    • G01N2470/06—Second binding partner specifically binding complex of analyte with first binding partner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200880011741.2A 2007-04-13 2008-04-14 用于对选自bnp和bnp原的不稳定抗原定量的免疫测定法 Active CN101842707B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US91160307P 2007-04-13 2007-04-13
US60/911,603 2007-04-13
FI20075251A FI20075251A0 (fi) 2007-04-13 2007-04-13 Immunomääritys epästabiilien antigeenien määrittämiseksi
FI20075251 2007-04-13
PCT/FI2008/050184 WO2008125733A1 (en) 2007-04-13 2008-04-14 Immunoassay for quantification of an unstable antigen selected from bnp and probnp

Publications (2)

Publication Number Publication Date
CN101842707A CN101842707A (zh) 2010-09-22
CN101842707B true CN101842707B (zh) 2016-11-09

Family

ID=38009904

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CN200880011741.2A Active CN101842707B (zh) 2007-04-13 2008-04-14 用于对选自bnp和bnp原的不稳定抗原定量的免疫测定法

Country Status (9)

Country Link
US (3) US9034591B2 (https=)
EP (1) EP2135087B1 (https=)
JP (1) JP5686593B2 (https=)
CN (1) CN101842707B (https=)
CA (1) CA2683911C (https=)
DK (1) DK2135087T3 (https=)
ES (1) ES2599635T3 (https=)
FI (1) FI20075251A0 (https=)
WO (1) WO2008125733A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2919611B1 (fr) 2007-08-03 2009-10-23 Bio Rad Pasteur Sa Nouvel epitope du bnp (1-32) et anticorps diriges contre cet epitope
US8778699B2 (en) 2010-08-04 2014-07-15 Idexx Laboratories, Inc. Detection of degradation products of canine NT-proBNP
JP2012140331A (ja) * 2010-12-28 2012-07-26 Tosoh Corp タグペプチド
EP2712423A4 (en) 2011-02-25 2015-06-10 Wellstat Diagnostics Llc Assays for detecting enzymatic activity
AU2012262154B2 (en) 2011-05-31 2016-08-04 Idexx Laboratories, Inc. Detection of degradation products of feline NT-proBNP
EP2759551B1 (en) * 2011-09-21 2019-05-22 Fujirebio Inc. Antibodies binding to an affinity complex comprising 25oh vitamin d2 or d3 and an antibody thereto
CN102608335A (zh) * 2012-04-19 2012-07-25 协和生物制药（天津）有限公司 NT-proBNP时间分辨荧光免疫分析试剂盒的制备方法
JP7664226B2 (ja) 2019-08-13 2025-04-17 ゲンティアン アクティーゼルスカブ Ｎｔ－プロｂｎｐの定量のための高感度粒子増感アッセイ
CN113956355B (zh) * 2021-07-26 2023-06-23 无锡傲锐东源生物科技有限公司 抗人脑利钠肽(bnp)兔单克隆抗体及其应用
IL311792A (en) 2021-10-01 2024-05-01 Gentian As A new method for determining the concentration of N-terminal prohormone BNP (NT-PROBNP) in a sample

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583003A (en) * 1989-09-25 1996-12-10 Agen Limited Agglutination assay
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
CN1161609C (zh) * 1997-09-11 2004-08-11 盐野义制药株式会社 哺乳类γ－BNP衍生物特异的免疫测定方法及其试剂盒
US20030219734A1 (en) 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
CA2430889A1 (en) * 2002-06-19 2003-12-19 Bayer Corporation Stabilization of brain natriuretic peptide (bnp) in blood samples, methods and compositions related thereto
FI20022048A0 (fi) * 2002-11-18 2002-11-18 Valtion Teknillinen Ei-kompetetiivinen immunomääritys pienille analyyteille
KR100771999B1 (ko) * 2004-05-20 2007-10-31 김상돈 그레이팅
US7731965B2 (en) * 2005-02-17 2010-06-08 Abbott Lab Human ring specific BNP antibodies
CA2629438C (en) 2005-11-09 2014-02-25 Abbott Laboratories Human bnp immunospecific antibodies
WO2007138163A2 (en) * 2006-05-26 2007-12-06 Hytest Ltd. Antibodies and standard for nt-probnp and probnp immunoassays
US20080064045A1 (en) 2006-09-07 2008-03-13 Huaiqin Wu Biomarker fragments for the detection of human BNP

Also Published As

Publication number Publication date
FI20075251A0 (fi) 2007-04-13
EP2135087A4 (en) 2011-06-22
US20130071949A1 (en) 2013-03-21
US9034592B2 (en) 2015-05-19
US9034591B2 (en) 2015-05-19
EP2135087A1 (en) 2009-12-23
CA2683911A1 (en) 2008-10-23
DK2135087T3 (en) 2016-11-14
US20150219675A1 (en) 2015-08-06
WO2008125733A1 (en) 2008-10-23
ES2599635T3 (es) 2017-02-02
EP2135087B1 (en) 2016-09-14
JP5686593B2 (ja) 2015-03-18
CN101842707A (zh) 2010-09-22
US9145459B2 (en) 2015-09-29
WO2008125733A8 (en) 2009-07-30
JP2010523994A (ja) 2010-07-15
CA2683911C (en) 2017-01-10
US20100203560A1 (en) 2010-08-12

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