CN101827864A - G-csf缀合物的液体制剂 - Google Patents

G-csf缀合物的液体制剂 Download PDF

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Publication number
CN101827864A
CN101827864A CN200880104971A CN200880104971A CN101827864A CN 101827864 A CN101827864 A CN 101827864A CN 200880104971 A CN200880104971 A CN 200880104971A CN 200880104971 A CN200880104971 A CN 200880104971A CN 101827864 A CN101827864 A CN 101827864A
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CN
China
Prior art keywords
formulation according
aqueous formulation
csf
polymer
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880104971A
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English (en)
Chinese (zh)
Inventor
W·因德雷尔
C·谢克曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ratiopharm GmbH
Original Assignee
Biogenerix GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenerix GmbH filed Critical Biogenerix GmbH
Priority to CN201510065114.9A priority Critical patent/CN104689333B/zh
Publication of CN101827864A publication Critical patent/CN101827864A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200880104971A 2007-08-27 2008-08-27 G-csf缀合物的液体制剂 Pending CN101827864A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510065114.9A CN104689333B (zh) 2007-08-27 2008-08-27 G-csf 缀合物的液体制剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07115047.8 2007-08-27
EP07115047 2007-08-27
PCT/EP2008/061232 WO2009027437A1 (en) 2007-08-27 2008-08-27 Liquid formulation of g-csf conjugate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510065114.9A Division CN104689333B (zh) 2007-08-27 2008-08-27 G-csf 缀合物的液体制剂

Publications (1)

Publication Number Publication Date
CN101827864A true CN101827864A (zh) 2010-09-08

Family

ID=39862881

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880104971A Pending CN101827864A (zh) 2007-08-27 2008-08-27 G-csf缀合物的液体制剂
CN201510065114.9A Expired - Fee Related CN104689333B (zh) 2007-08-27 2008-08-27 G-csf 缀合物的液体制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510065114.9A Expired - Fee Related CN104689333B (zh) 2007-08-27 2008-08-27 G-csf 缀合物的液体制剂

Country Status (24)

Country Link
US (1) US8546328B2 (https=)
EP (2) EP2578235A3 (https=)
JP (2) JP5570988B2 (https=)
KR (1) KR20100052501A (https=)
CN (2) CN101827864A (https=)
AU (1) AU2008292186B9 (https=)
BR (1) BRPI0815975B8 (https=)
CA (1) CA2696594C (https=)
CY (1) CY1115908T1 (https=)
DE (1) DE202008017456U1 (https=)
DK (1) DK2197919T3 (https=)
EA (1) EA020069B1 (https=)
ES (1) ES2476915T3 (https=)
HR (1) HRP20140590T1 (https=)
IL (1) IL204190A (https=)
MX (1) MX2010002448A (https=)
NZ (1) NZ583276A (https=)
PL (1) PL2197919T3 (https=)
PT (1) PT2197919E (https=)
RS (1) RS53404B (https=)
SI (1) SI2197919T1 (https=)
UA (1) UA98001C2 (https=)
WO (1) WO2009027437A1 (https=)
ZA (1) ZA201000798B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111093628A (zh) * 2017-09-28 2020-05-01 阿尔法西格玛有限公司 治疗胃食管反流的口服组合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412737A (zh) * 2010-01-19 2017-12-01 韩美科学株式会社 长效g‑csf缀合物的液体制剂
MX2012010661A (es) 2010-03-17 2013-03-25 Biogenerix Gmbh Metodo para obtener factor estimulante de colonias de granulocitos (g-csf) humano recombinante biologicamente activo.
EP2384759A1 (en) 2010-05-06 2011-11-09 Suomen Punainen Risti Veripalvelu Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
WO2017181920A1 (zh) * 2016-04-18 2017-10-26 江苏恒瑞医药股份有限公司 一种重组人粒细胞集落刺激因子的制备方法
WO2019212429A2 (en) * 2018-05-04 2019-11-07 İlkogen İlaç Sanayi̇ Ve Ti̇caret A.Ş. Stable hybrid fc fusion g-csf formulation
KR102375269B1 (ko) * 2021-01-27 2022-03-17 한미약품 주식회사 단백질 액상 제제 및 이의 제조방법
CN114224853B (zh) * 2022-01-04 2022-09-23 山东新时代药业有限公司 聚乙二醇化重组人粒细胞刺激因子注射用冻干制剂
CN119698274A (zh) * 2022-08-19 2025-03-25 亿一生物医药开发(上海)有限公司 包含g-csf的制剂及其用途

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111093628A (zh) * 2017-09-28 2020-05-01 阿尔法西格玛有限公司 治疗胃食管反流的口服组合物
CN111093628B (zh) * 2017-09-28 2023-11-17 阿尔法西格玛有限公司 治疗胃食管反流的口服组合物

Also Published As

Publication number Publication date
EP2197919B1 (en) 2014-04-09
DK2197919T3 (da) 2014-07-07
JP2014101362A (ja) 2014-06-05
BRPI0815975B8 (pt) 2021-05-25
EA020069B1 (ru) 2014-08-29
RS53404B (sr) 2014-10-31
ES2476915T3 (es) 2014-07-15
BRPI0815975B1 (pt) 2019-04-02
CN104689333B (zh) 2018-05-29
KR20100052501A (ko) 2010-05-19
PT2197919E (pt) 2014-07-17
PL2197919T3 (pl) 2014-09-30
HRP20140590T1 (hr) 2014-08-15
US20110053844A1 (en) 2011-03-03
NZ583276A (en) 2012-06-29
CN104689333A (zh) 2015-06-10
EP2578235A2 (en) 2013-04-10
DE202008017456U1 (de) 2009-08-27
EP2197919A1 (en) 2010-06-23
AU2008292186B9 (en) 2014-07-03
JP5570988B2 (ja) 2014-08-13
CA2696594A1 (en) 2009-03-05
ZA201000798B (en) 2010-10-27
JP5836351B2 (ja) 2015-12-24
MX2010002448A (es) 2010-10-04
IL204190A (en) 2015-01-29
EA201070315A1 (ru) 2010-08-30
SI2197919T1 (sl) 2014-09-30
JP2010536929A (ja) 2010-12-02
BRPI0815975A2 (pt) 2015-02-18
CY1115908T1 (el) 2017-01-25
UA98001C2 (uk) 2012-04-10
CA2696594C (en) 2019-03-19
US8546328B2 (en) 2013-10-01
AU2008292186A1 (en) 2009-03-05
AU2008292186B2 (en) 2014-02-27
WO2009027437A1 (en) 2009-03-05
EP2578235A3 (en) 2013-08-28

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