CN101821612A - 用于液相色谱洗脱液的转向的系统和方法 - Google Patents

用于液相色谱洗脱液的转向的系统和方法 Download PDF

Info

Publication number
CN101821612A
CN101821612A CN200880104228A CN200880104228A CN101821612A CN 101821612 A CN101821612 A CN 101821612A CN 200880104228 A CN200880104228 A CN 200880104228A CN 200880104228 A CN200880104228 A CN 200880104228A CN 101821612 A CN101821612 A CN 101821612A
Authority
CN
China
Prior art keywords
flow
port
waste
mass spectrometer
injection valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880104228A
Other languages
English (en)
Chinese (zh)
Inventor
江同保
切瑞尔·佛罗
莫瑞斯·G·菲伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EMD Millipore Corp
Original Assignee
Millipore Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millipore Corp filed Critical Millipore Corp
Publication of CN101821612A publication Critical patent/CN101821612A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN200880104228A 2007-08-24 2008-08-22 用于液相色谱洗脱液的转向的系统和方法 Pending CN101821612A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96611607P 2007-08-24 2007-08-24
US60/966,116 2007-08-24
PCT/US2008/010027 WO2009029232A1 (en) 2007-08-24 2008-08-22 System and method for diversion of a liquid chromatography eluant

Publications (1)

Publication Number Publication Date
CN101821612A true CN101821612A (zh) 2010-09-01

Family

ID=40029004

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880104228A Pending CN101821612A (zh) 2007-08-24 2008-08-22 用于液相色谱洗脱液的转向的系统和方法

Country Status (7)

Country Link
US (1) US8436297B2 (https=)
EP (2) EP2508880B1 (https=)
JP (1) JP2010537197A (https=)
CN (1) CN101821612A (https=)
ES (1) ES2436744T3 (https=)
SG (1) SG183001A1 (https=)
WO (1) WO2009029232A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006121916A1 (en) 2005-05-05 2006-11-16 Boston Scientific Limited Preshaped localization catheter and system for graphically reconstructing pulmonary vein ostia
JP2010537196A (ja) 2007-08-24 2010-12-02 ミリポア・コーポレーション バイオ医薬生成物中の抽出性物質を検出する方法
WO2009029232A1 (en) * 2007-08-24 2009-03-05 Millipore Corporation System and method for diversion of a liquid chromatography eluant
CN103293253B (zh) * 2013-05-24 2015-04-01 中国科学院过程工程研究所 生物技术药物高效纯化分析系统及其药物分离检测方法
JP6918555B2 (ja) * 2016-04-13 2021-08-11 株式会社堀場エステック クロマトグラフ用サンプラ及びクロマトグラフ用サンプラの操作方法
RU2653570C1 (ru) * 2017-07-14 2018-05-11 Федеральное государственное бюджетное учреждение науки Федеральный исследовательский центр питания, биотехнологии и безопасности пищи Способ количественного определения органических кислот (уксусной, яблочной, молочной) и углеводов (мальтозы, глюкозы, фруктозы) в полупродуктах спиртового производства методом высокоэффективной жидкостной хроматографии
CN109270192B (zh) * 2018-12-02 2024-02-02 太湖流域水文水资源监测中心（太湖流域水环境监测中心） 用于水产品磺胺类抗生素检测的前处理装置、方法和用途
EP3922989B1 (en) * 2019-02-04 2024-11-20 Hitachi High-Tech Corporation Liquid chromatograph mass spectrometer
GB202219580D0 (en) * 2022-12-22 2023-02-08 Thermo Fisher Scient Bremen Gmbh System and method for delivery of an analyte and a reference

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703360A (en) * 1996-08-30 1997-12-30 Hewlett-Packard Company Automated calibrant system for use in a liquid separation/mass spectrometry apparatus
US20050194318A1 (en) * 2001-04-25 2005-09-08 Can Ozbal High throughput autosampler
US20070048187A1 (en) * 2002-10-30 2007-03-01 Sheehan Terry L Use of temperature and flow profiles in gradient elution based analytical process
CN1936572A (zh) * 2005-09-23 2007-03-28 中国科学院大连化学物理研究所 一种超临界流体萃取－高效液相色谱联用系统

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962042A (en) * 1988-05-25 1990-10-09 The Dow Chemical Company Method for on-column injection gas chromatography
US4891137A (en) * 1989-03-03 1990-01-02 Spectra-Physics, Inc. Method and apparatus for membrane extraction of hydrolysis contaminates
US5693620A (en) * 1991-07-31 1997-12-02 Oncomembrane, Inc. Plasmalopsychosines and plasmalocerebrosides
US5468643A (en) * 1991-08-28 1995-11-21 The United States Of America As Represented By The Department Of Health And Human Services Switching valve system for direct biological sample injection for LC analysis
US6213122B1 (en) 1997-10-01 2001-04-10 3M Innovative Properties Company Electret fibers and filter webs having a low level of extractable hydrocarbons
WO2000045929A1 (en) * 1999-02-08 2000-08-10 Admetric Biochem Inc. Chromatographic system with pre-detector eluent switching
EP1325322A2 (en) * 2000-10-03 2003-07-09 Dionex Corporation Method and system for peak parking in liquid chromatography-mass spectrometer (lc-ms) analysis
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US7220383B2 (en) * 2001-07-13 2007-05-22 Metara, Inc. Method and instrument for automated analysis of fluid-based processing systems
US7132080B2 (en) * 2003-08-15 2006-11-07 Metara, Inc. Module for automated matrix removal
JP4258318B2 (ja) * 2003-08-22 2009-04-30 株式会社島津製作所 液体クロマトグラフ質量分析装置
BRPI0606239A2 (pt) * 2005-01-25 2009-06-09 Bayer Cropscience Sa métodos de análise de um ou mais compostos pesticidas
EP1856501B1 (en) * 2005-01-31 2017-12-20 Waters Technologies Corporation Method and apparatus for sample injection in liquid chromatography
FR2896585B1 (fr) * 2006-01-20 2008-12-05 Commissariat Energie Atomique Introduction d'additifs pour une interface d'ionisation a pression atmospherique en entree d'un spectrometre
JP4913470B2 (ja) * 2006-04-26 2012-04-11 株式会社島津製作所 流路切換えバルブを用いた高速液体クロマトグラフ及び分析方法
US8642351B2 (en) * 2006-09-20 2014-02-04 Waters Technologies Corporation Apparatus and methods of fluid chromatography
US20100015652A1 (en) * 2006-12-21 2010-01-21 Brian Walter Granda Antibody quantitation
JP2010537196A (ja) * 2007-08-24 2010-12-02 ミリポア・コーポレーション バイオ医薬生成物中の抽出性物質を検出する方法
WO2009029232A1 (en) * 2007-08-24 2009-03-05 Millipore Corporation System and method for diversion of a liquid chromatography eluant
US8106351B2 (en) * 2008-08-08 2012-01-31 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
US7834313B2 (en) * 2008-08-08 2010-11-16 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703360A (en) * 1996-08-30 1997-12-30 Hewlett-Packard Company Automated calibrant system for use in a liquid separation/mass spectrometry apparatus
US20050194318A1 (en) * 2001-04-25 2005-09-08 Can Ozbal High throughput autosampler
US20070048187A1 (en) * 2002-10-30 2007-03-01 Sheehan Terry L Use of temperature and flow profiles in gradient elution based analytical process
CN1936572A (zh) * 2005-09-23 2007-03-28 中国科学院大连化学物理研究所 一种超临界流体萃取－高效液相色谱联用系统

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI SUN ET AL.: "The effect of β-cyclodextrin on liquid chromatography/electrospray-mass spectrometry analysis of hydrophobic drug molecules", 《JOURNAL OF CHROMATOGRAPHY A》 *

Also Published As

Publication number Publication date
ES2436744T3 (es) 2014-01-07
EP2181325A1 (en) 2010-05-05
JP2010537197A (ja) 2010-12-02
US20110114833A1 (en) 2011-05-19
SG183001A1 (en) 2012-08-30
WO2009029232A1 (en) 2009-03-05
US8436297B2 (en) 2013-05-07
EP2508880B1 (en) 2013-11-13
EP2508880A1 (en) 2012-10-10

Similar Documents

Publication Publication Date Title
US8212207B2 (en) Method of detecting filter extractables in biopharmaceutical products by liquid chromatography-mass spectrometry
CN101821612A (zh) 用于液相色谱洗脱液的转向的系统和方法
WO2018107975A1 (zh) 一种右丙亚胺的分析方法
CN104914185B (zh) 一种法匹拉韦中有关物质的hplc测定方法
Charehsaz et al. Simple, fast and reliable liquid chromatographic and spectrophotometric methods for the determination of theophylline in urine, saliva and plasma samples
LoBrutto et al. Method validation
Taleuzzaman et al. Particle size role, Importance and Strategy of HPLC Analysis-An update
Gill et al. Development and validation of an HPLC-MS-MS method for quantitating bis (2, 2, 6, 6-tetramethyl-4-piperidyl) sebacate (Tinuvin 770) and a related substance in aqueous extracts of plastic materials
CN105675754B (zh) 高效液相色谱法测定利格列汀对映异构体含量的方法
CN104764840B (zh) 盐酸帕洛诺司琼及杂质的分离与检测方法
CN103323541B (zh) 肝素钠封管注射液的质量检测方法
CN105353062A (zh) 一种测定米诺环素及其有关物质的hplc分析方法
AU2004265763A1 (en) A method for assaying tropolone comprising complexing this molecule with Cu (II)
CN112394112B (zh) 一种检测硫酸羟氯喹中羟氯喹氮氧化物杂质含量的方法
CN100480698C (zh) 一种降压药物的检测方法
CN114062520A (zh) 一种硫酸羟氯喹及其有关物质的hplc分析方法
Chandak et al. Development and Validation of RP-HPLC Method of Gabapentin in Pure and Pharmaceutical Formulations
El-Attug et al. Method development and validation for trifluoroacetic acid determination by capillary electrophoresis in combination with capacitively coupled contactless conductivity detection (CE-C4D)
CN114965840B (zh) 一种生物体液中草甘膦、草铵膦及代谢物的检测方法
Mohammed et al. Quantitative Determination of Levofloxacin in Ophthalmic Solution by High-Performance Liquid Chromatography
Kowalski et al. Validated method for l‐ornithine‐l‐aspartate analysis in human plasma by capillary electrophoresis
Zaky et al. Rapid HPLC Determination of Ciprofloxacin, Ofloxacin, and, Marbofloxacin Alone or in a Mixture
Ohtsu et al. Regulated bioanalysis of conformers–A case study with ASP2151 in dog plasma and urine
Dilip et al. A Comprehensive Study of RP-HPLC Method Development for Bedaquiline: Leveraging Quality by Design for Optimal Separation, Identification, and Quantification in AntiTuberculosis Drug Analysis.
CN108760937A (zh) 醋酸卡泊芬净中残留乙二胺的测定及其应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: Massachusetts, USA

Applicant after: Millipore Corp.

Address before: Massachusetts, USA

Applicant before: Millipore Corp.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: MILLIPORE CORPORATION TO: EMD MILLIPORE CORPORATION

AD01 Patent right deemed abandoned

Effective date of abandoning: 20100901

C20 Patent right or utility model deemed to be abandoned or is abandoned