CN101809034B - C3b抗体及用于预防和治疗补体相关病症的方法 - Google Patents
C3b抗体及用于预防和治疗补体相关病症的方法 Download PDFInfo
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- CN101809034B CN101809034B CN200880102282.9A CN200880102282A CN101809034B CN 101809034 B CN101809034 B CN 101809034B CN 200880102282 A CN200880102282 A CN 200880102282A CN 101809034 B CN101809034 B CN 101809034B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93372107P | 2007-06-07 | 2007-06-07 | |
| US60/933,721 | 2007-06-07 | ||
| US5506808P | 2008-05-21 | 2008-05-21 | |
| US60/055,068 | 2008-05-21 | ||
| PCT/US2008/065771 WO2008154251A2 (en) | 2007-06-07 | 2008-06-04 | C3b antibodies and methods for the prevention and treatment of complement- associated disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101809034A CN101809034A (zh) | 2010-08-18 |
| CN101809034B true CN101809034B (zh) | 2015-07-08 |
Family
ID=39712089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880102282.9A Expired - Fee Related CN101809034B (zh) | 2007-06-07 | 2008-06-04 | C3b抗体及用于预防和治疗补体相关病症的方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8012473B2 (OSRAM) |
| EP (1) | EP2162470A2 (OSRAM) |
| JP (3) | JP5683265B2 (OSRAM) |
| KR (3) | KR20150029002A (OSRAM) |
| CN (1) | CN101809034B (OSRAM) |
| AR (1) | AR066916A1 (OSRAM) |
| AU (1) | AU2008262048B2 (OSRAM) |
| BR (1) | BRPI0812767A2 (OSRAM) |
| CA (1) | CA2690124A1 (OSRAM) |
| CL (1) | CL2008001656A1 (OSRAM) |
| IL (1) | IL201820A0 (OSRAM) |
| MX (1) | MX2009013082A (OSRAM) |
| PE (1) | PE20090416A1 (OSRAM) |
| RU (1) | RU2473563C2 (OSRAM) |
| SG (2) | SG10201608952QA (OSRAM) |
| TW (2) | TWI441832B (OSRAM) |
| WO (1) | WO2008154251A2 (OSRAM) |
| ZA (1) | ZA200907575B (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2826788B1 (en) | 2006-06-21 | 2017-12-13 | MUSC Foundation for Research Development | Targeting complement factor h for treatment of diseases by the use of cr2-fh molecules |
| PE20091388A1 (es) * | 2007-11-02 | 2009-09-24 | Novartis Ag | Moleculas y metodos para modular el componente de complemento |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| US10239937B2 (en) | 2009-11-05 | 2019-03-26 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| WO2011084496A1 (en) * | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
| WO2011123044A1 (en) * | 2010-03-31 | 2011-10-06 | Anamar Ab | Method to detect tissue degradation leading to inflammation |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| MX2012014975A (es) | 2010-06-22 | 2013-03-12 | Univ Colorado Regents | Anticuerpos al fragmento c3d de componente 3 de complemento. |
| US8940490B2 (en) | 2010-11-29 | 2015-01-27 | Novelmed Therapeutics, Inc. | Neoantibodies for diagnosing tissue injury |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| WO2013152024A1 (en) * | 2012-04-03 | 2013-10-10 | Novelmed Therapeutics, Inc | Humanized and chimeric anti-factor c3 antibodies and uses thereof |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| AU2014209350B8 (en) * | 2013-01-23 | 2019-04-18 | Department Of Veterans Affairs (Us) | Targeting constructs based on natural antibodies and uses thereof |
| KR102192596B1 (ko) | 2013-08-07 | 2020-12-18 | 알렉시온 파마슈티칼스, 인코포레이티드 | 비정형적 용혈성 요독증후군 (ahus) 바이오마커 단백질 |
| EP3086809A4 (en) * | 2013-12-24 | 2017-11-29 | NovelMed Therapeutics, Inc. | Compositions and methods of treating ocular diseases |
| BR112016019286B1 (pt) * | 2014-02-26 | 2024-02-20 | Allergan, Inc. | Anticorpo anti-c5 |
| JP6643244B2 (ja) | 2014-02-27 | 2020-02-12 | アラーガン、インコーポレイテッドAllergan,Incorporated | 補体因子Bb抗体 |
| PL3154561T3 (pl) | 2014-06-12 | 2019-12-31 | Ra Pharmaceuticals, Inc. | Modulowanie aktywności dopełniacza |
| IL250667B2 (en) * | 2014-08-20 | 2023-10-01 | Stichting Sanquin Bloedvoorziening | Factor h potentiating antibodies and uses thereof |
| HRP20211824T1 (hr) | 2015-01-28 | 2022-03-04 | Ra Pharmaceuticals, Inc. | Modulatori aktivnosti komplementa |
| RU2584582C1 (ru) * | 2015-03-16 | 2016-05-20 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Моноклональное антитело сс3-4 к конформационному эпитопу с3 человека, штамм гибридной днк мыши рккк(п)764д - продуцент моноклонального антитела сс3-4 |
| RS60134B1 (sr) | 2015-12-16 | 2020-05-29 | Ra Pharmaceuticals Inc | Modulatori aktivnosti komplementa |
| GB201608046D0 (en) * | 2016-05-09 | 2016-06-22 | Cambridge Entpr Ltd And Syndey Children S Hospitals Network Randwick And Westmead Incorporating The | Treatment of complement-mediated disorders |
| RU2630647C1 (ru) * | 2016-05-27 | 2017-09-11 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА |
| WO2018075474A1 (en) | 2016-10-17 | 2018-04-26 | Medical University Of South Carolina | Compositions and methods for treating central nervous system injury |
| BR112019011053A2 (pt) | 2016-12-07 | 2019-10-15 | Ra Pharmaceuticals Inc | moduladores da atividade do complemento |
| CN110494168B (zh) * | 2017-02-27 | 2023-02-03 | 再生元制药公司 | 肾病症和肝病症的人源化模型 |
| KR20200095485A (ko) | 2017-12-04 | 2020-08-10 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절인자 |
| GB201800620D0 (en) * | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| AR117565A1 (es) * | 2018-04-03 | 2021-08-18 | Ngm Biopharmaceuticals Inc | Agentes de unión a c3 y método de uso de los mismos |
| RU2687609C1 (ru) * | 2018-05-30 | 2019-05-15 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Гуманизированное антитело к конформационному эпитопу сз компонента комплемента человека |
| EP3801772A1 (en) | 2018-06-11 | 2021-04-14 | Aarhus Universitet | Single domain antibodies for complement regulation |
| GB2583560A (en) | 2018-12-11 | 2020-11-04 | Admirx Inc | Fusion protein constructs for complement associated disease |
| TW202100179A (zh) | 2019-03-08 | 2021-01-01 | 美商Ra製藥公司 | 補體活性之調節劑 |
| WO2020205501A1 (en) | 2019-03-29 | 2020-10-08 | Ra Pharmaceuticals, Inc. | Complement modulators and related methods |
| SG11202109837SA (en) | 2019-04-24 | 2021-10-28 | Ra Pharmaceuticals Inc | Compositions and methods for modulating complement activity |
| KR20220057530A (ko) | 2019-07-17 | 2022-05-09 | 제미니 테라퓨틱스 서브, 인코포레이티드 | 인자 h 강화 항체 및 이의 용도 |
| AR128065A1 (es) | 2021-12-22 | 2024-03-20 | Cdr Life Ag | Anticuerpos anti-c3 y fragmentos de unión al antígeno de estos y sus usos para tratar enfermedades oftálmicas u oculares |
| KR20230105972A (ko) * | 2022-01-05 | 2023-07-12 | 주식회사 카나프테라퓨틱스 | 혈관신생 억제제가 결합된 항-C3b 항체 또는 항-C5 항체 및 이의 용도 |
| CN119487063A (zh) * | 2022-04-29 | 2025-02-18 | 博闻生物有限责任公司 | 双特异性抗体以及治疗眼部疾病的方法 |
| CN117624347A (zh) | 2022-08-30 | 2024-03-01 | 天辰生物医药(苏州)有限公司 | 抗人补体c5抗体以及其融合蛋白 |
| EP4590697A2 (en) * | 2022-09-20 | 2025-07-30 | Visterra, Inc. | Treatment of complement mediated diseases and disorders with c3b-antibodies |
| CN118005802A (zh) | 2022-11-10 | 2024-05-10 | 天辰生物医药(苏州)有限公司 | 补体抑制杂合蛋白突变体及其抗体融合蛋白 |
| WO2024227154A1 (en) * | 2023-04-28 | 2024-10-31 | Broadwing Bio Llc | Complement component 3 (c3)-specific antibodies and uses thereof |
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| CN1214733A (zh) * | 1996-03-07 | 1999-04-21 | 艾姆特兰有限公司 | 负调节抗性c3转化酶 |
| CN1298308A (zh) * | 1998-02-20 | 2001-06-06 | 泰诺士公司 | 补体活化的抑制剂 |
| WO2006012621A2 (en) * | 2004-07-23 | 2006-02-02 | University Of Virginia Patent Foundation | Compositions and methods for regulating the alternative pathway of complement |
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