CN101803900A - Integrated confocal micro-rigid hysteroscope system - Google Patents
Integrated confocal micro-rigid hysteroscope system Download PDFInfo
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- CN101803900A CN101803900A CN201010116274A CN201010116274A CN101803900A CN 101803900 A CN101803900 A CN 101803900A CN 201010116274 A CN201010116274 A CN 201010116274A CN 201010116274 A CN201010116274 A CN 201010116274A CN 101803900 A CN101803900 A CN 101803900A
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- hysteroscope
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- 238000007334 copolymerization reaction Methods 0.000 claims description 28
- 230000003287 optical effect Effects 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000001574 biopsy Methods 0.000 abstract description 9
- 238000003745 diagnosis Methods 0.000 abstract description 7
- 210000004877 mucosa Anatomy 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000003902 lesion Effects 0.000 abstract description 3
- 238000004624 confocal microscopy Methods 0.000 abstract 1
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 abstract 1
- 239000013307 optical fiber Substances 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 3
- 229940020947 fluorescein sodium Drugs 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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Abstract
The invention belongs to the field of medical devices and particularly discloses an integrated confocal micro-rigid hysteroscope system which comprises a rigid hysteroscope and a light source host and a camera host connected with the rigid hysteroscope, wherein the rigid hysteroscope comprises a main body endoscope part and a hysteroscope sheath tube part connected with the main body endoscope part, a confocal micro-lens, a confocal laser head, a confocal micro-output joint end, a light guide optical fiber and a device channel outlet are arranged at a rigid endoscope end part, and the confocal micro-lens, the confocal laser head and the confocal micro-output joint end are integrated at the rigid endoscope end part, thereby designing the rigid hysteroscope into the integrated confocal micro-rigid hysteroscope. The system is combined with the confocal microscopy and the rigid hysteroscope, further increases the confocal micro-lens and the confocal micro-laser head in the structure of the rigid hysteroscope and leads a blue laser beam of 488nm emitted by the confocal micro-laser head to be reacted with sodium fluorescein of mucosa of the uterine wall, thereby providing a tool for real-time biopsy of lesions of the mucosa of the uterine wall for doctors. The appearance of the integrated confocal micro-rigid hysteroscope system can introduce the diagnosis of gynecological diseases into the microscopic world, and provide a powerful tool for understanding the uterine cavity and the lesions thereof.
Description
Technical field
The invention belongs to field of medical appliances, particularly modern medicine is carried out a kind of core medical instrument of gynecilogical operation, specifically is integrated confocal micro-rigid hysteroscope system.
Prior art
At present, hysteroscope and hysteroscope technology are widely used clinically, it is the important tool of gynecology examination and treatment disease, but the existing hysteroscope that is used for the intrauterine disease diagnosis and treatment can be determined the focus of uterine cavity, but can't understand the variation of each layer of uterine cavity and surrounding organ, there is the insufficient hidden danger of diagnostic accuracy, though can use and declare the ultrasonic hysteroscope that uses novel patent, adopt the miniature ultrasonic technology that uterine cavity is carried out ultrasonic scanning, but also do not have a kind of under the situation of live body uterine cavity mucomembranous cell to its technology of diagnosing.Implement gynecilogical operation at present, for the case that can not make a definite diagnosis, the doctor often will get biopsy.Getting biopsy is exactly that the scope doctor observes pathological changes, by some pathological tissues of biopsy forceps gripping, delivers to Pathology Deparment, and that takes off is organized in Pathology Deparment by multiple working procedure, examines under a microscope the form and the structure of cell at last, to determine the character of pathological changes.The time that the cost of whole process need is long, and be difficult to accurately determine biopsy site when getting biopsy, be unfavorable for clinical timely diagnosis and treatment.
Along with the further investigation of modern gynecilogical operation, must need a kind of new-type hard hysteroscope system that can carry out real-time diagnosis to active somatic cell.Still the equipment that does not have at present the burnt microtechnique of hysteroscope technology and copolymerization to organically combine.
Summary of the invention
The objective of the invention is to burnt microtechnique of copolymerization and hard hysteroscope are organically combined, by the burnt micro-probe of copolymerization cavity of uterus wall mucosa is carried out the microexamination diagnosis and treatment, a kind of integrated confocal micro-rigid hysteroscope system is proposed, can make the operator accurately determine biopsy site by integrated confocal micro-rigid hysteroscope system, observe intrauterine macroscopical situation and microcosmic situation simultaneously, in current operation and inspection, suspicious lesions is carried out instant analysis and detection, overcome the drawback that biopsy at random brings, help to improve clinical therapeutic effect and reduce medical treatment cost.
In order to reach above-mentioned technical purpose, the present invention is achieved through the following technical solutions:
Integrated confocal micro-rigid hysteroscope system of the present invention comprises hard hysteroscope and the light source main frame that is connected with the hard hysteroscope, shooting main frame; The hysteroscope sheath tube portion that described hard hysteroscope comprises the main body endoscope part, is connected with the main body endoscope part; Described main body endoscope part comprises hard scope end, the some instrument channel, eyepiece input, the cold light source input that are connected with hard scope end; Described hysteroscope sheath tube portion comprises sheath tube body, the intake tunnel, the exhalant canal that are communicated with the sheath tube body and is arranged at the sheath tube end of sheath tube body front end; Described hard scope end is provided with Laser Scanning Confocal Microscope head, confocal laser head, the burnt micro-out splice going splice end of copolymerization, light-conductive optic fibre and instrument channel outlet, and Laser Scanning Confocal Microscope head, confocal laser head, the burnt micro-out splice going splice end of copolymerization are integrated in hard scope end the hard hysteroscope is designed to integrated confocal micro-rigid hysteroscope.
In the present invention, described sheath tube end internal diameter and hard scope outer end diameter adapt to, and its external diameter is smaller or equal to 12mm; Described hard scope end diameter is smaller or equal to 10mm, the long 250～300mm in end, and the front end of its hard scope end becomes blunt shape design, avoids damaging tissue.
In addition, in the described instrument channel diameter of at least one instrument channel smaller or equal to 2.8mm.
In the present invention, described main body endoscope part adopts 2.8mm or following optical lens, eyepiece input and hard scope end in line, Laser Scanning Confocal Microscope out splice going splice end and eyepiece input are at 45, scope integral body is gun type of gas burner, gripability when being convenient to operation technique and stability.
The main body endoscope part of the burnt hard hysteroscope of described integrated copolymerization, its shank place is provided with control unit, so that the doctor carries out the burnt micro-control of copolymerization, control unit includes the burnt micro-unlatching switch of copolymerization, the freeze frame switch, amplify minification by-pass cock etc., control unit adopts high temperature resistant and the waterproof material design.
As the further improvement of above-mentioned technology, be connected with two medical monitors on the described integrated confocal micro-rigid hysteroscope, show the burnt micro-image of endoscopic image and copolymerization respectively; Also comprise with hard hysteroscope main frame and be connected the keyboard of being convenient to operate.
Compared with prior art, the invention has the beneficial effects as follows:
Integrated confocal micro-rigid hysteroscope system of the present invention, burnt microtechnique of copolymerization and hard hysteroscope are organically combined, at the wavelength that the burnt micro laser hair of the copolymerization of scope goes out is under the combined effect of the blue laser of 488nm and fluorescein sodium, the doctor presses close to Uterus wall by the operation integrated confocal micro-rigid hysteroscope, can be intracellular dynamically with 30 frame/seconds (fps) or above speed record, the burnt micro-main frame of copolymerization can be with 230fps or above speed photographic images, pass through integrated confocal micro-rigid hysteroscope system, the doctor can observe endometrial macroscopical situation and microcosmic situation simultaneously, provides new platform for the doctor carries out real-time cell biopsy.
Description of drawings
Fig. 1 is an integrated confocal micro-rigid hysteroscope system sketch map of the present invention.
Fig. 2 is the structural representation of integrated confocal micro-rigid hysteroscope of the present invention.
Fig. 3 is the end view of integrated confocal micro-rigid hysteroscope of the present invention.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing:
As shown in Figure 1, integrated confocal micro-rigid hysteroscope system of the present invention comprises integrated confocal micro-rigid hysteroscope 1, light source main frame 2, the burnt micro-main frame 3 of copolymerization, shooting main frame 4, keyboard 5, the burnt micro-monitor 7 of scope monitor 6 and copolymerization is respectively applied for the scope and the burnt micro-image of copolymerization that show integrated confocal micro-rigid hysteroscope 1.
As Fig. 2, shown in Figure 3, integrated confocal micro-rigid hysteroscope 1 is divided into sheath tube portion 12 and main body endoscope part 11 among the present invention.Described main body endoscope part 11 comprises the burnt micro-out splice going splice end 113 in hard scope end 116, light source input 111, copolymerization, eyepiece input 115, control unit 116, two instrument channel 112 and 114, its internal diameter is smaller or equal to 2.8mm, described hard scope end 116 diameters are smaller or equal to 10mm, and it grows 250～300mm; In addition, avoid damaging tissue, the front end of hard scope end 116 becomes blunt shape design.In the present invention, the eyepiece input 115 of integrated confocal micro-rigid hysteroscope 1 and the end 116 of scope are in line, Laser Scanning Confocal Microscope out splice going splice end 113 is at 45 with eyepiece input 115, and scope integral body is gun type of gas burner, so that the gripability of operative process and stability. Described hysteroscope sheath tube portion 12 comprises sheath tube body, the intake tunnel, the exhalant canal that are communicated with the sheath tube body and is arranged at the sheath tube end 121 of sheath tube body front end, described sheath tube end 121 internal diameter depend on the outer end diameter of main body endoscope part 11, external diameter is smaller or equal to 12cm.Control unit 116 makes things convenient for the doctor to carry out the burnt micro-control of copolymerization, and control unit 116 includes the burnt micro-unlatching switch of copolymerization, and the freeze frame switch amplifies minification by-pass cock etc., and control unit adopts high temperature resistant and the waterproof material design.
Be illustrated in figure 3 as the end view of the main body endoscope part 1 of integrated confocal micro-rigid hysteroscope, 116 designs of end, hard scope end have Laser Scanning Confocal Microscope head 1131, the burnt main frame laser head 1132 of copolymerization, the instrument channel 1121 of optical system lens 1151, at least one 2.8mm and 1131 and light-conductive optic fibre 1111.The optical system of integrated confocal micro-rigid hysteroscope 1 adopts 2.8mm or following optical lens 1151.
The operation method of integrated confocal micro-rigid hysteroscope system of the present invention is: the doctor at first needs the patient is carried out the intravenous injection fluorescein sodium.In the art, integrated confocal micro-rigid hysteroscope enters in the cavity of uterus by orifice of uterus, the doctor is by operation control unit 116, make the burnt micro-main frame 3 of copolymerization produce wavelength 488nm blue laser beam, by 1132 observed Uterus wall mucosal tissues of shooting of the burnt main frame laser of copolymerization, then the Laser Scanning Confocal Microscope head 1131 of integrated confocal micro-rigid hysteroscope 1 is pressed close to the Uterus wall mucosal tissue, the signal that fluorescein sodium produces under the exciting of laser beam in the tissue is detected by Laser Scanning Confocal Microscope head 1131 and is input to the burnt micro-main frame 3 of copolymerization by Laser Scanning Confocal Microscope out splice going splice end 113, the burnt micro-main frame 3 of copolymerization can be intracellular dynamic with 30 frame/seconds (fps) or above speed record, with 230fps or above speed photographic images, help the doctor that the character of patient's Uterus wall mucosa infection is made diagnosis.
Claims (7)
1. integrated confocal micro-rigid hysteroscope system comprises hard hysteroscope and the light source main frame that is connected with the hard hysteroscope, shooting main frame; The hysteroscope sheath tube portion that described hard hysteroscope comprises the main body endoscope part, is connected with the main body endoscope part; Described hard hysteroscope comprises hard scope end, the some instrument channel, eyepiece input, the cold light source input that are connected with hard scope end; Described hysteroscope sheath tube portion comprises sheath tube body, the intake tunnel, the exhalant canal that are communicated with the sheath tube body and is arranged at the sheath tube end of sheath tube body front end; It is characterized in that: described hard scope end is provided with Laser Scanning Confocal Microscope head, confocal laser head, the burnt micro-out splice going splice end of copolymerization, light-conductive optic fibre and instrument channel outlet, and Laser Scanning Confocal Microscope head, confocal laser head, the burnt micro-out splice going splice end of copolymerization are integrated in hard scope end the hard hysteroscope is designed to integrated confocal micro-rigid hysteroscope.
2. integrated confocal micro-rigid hysteroscope system according to claim 1 is characterized in that: described sheath tube end internal diameter and hard scope outer end diameter adapt to, and its external diameter is smaller or equal to 12mm.
3. integrated confocal micro-rigid hysteroscope system according to claim 2 is characterized in that: described hard scope end diameter is smaller or equal to 10mm, and 250～300mm is grown in hard scope end, and the front end of its hard scope end becomes blunt shape design.
4. integrated confocal micro-rigid hysteroscope system according to claim 3 is characterized in that: the diameter of at least one instrument channel is smaller or equal to 2.8mm in the described instrument channel.
5. integrated confocal micro-rigid hysteroscope system according to claim 4, it is characterized in that: the hard hysteroscope adopts 2.8mm or following optical lens, eyepiece input and hard scope end are in line, Laser Scanning Confocal Microscope out splice going splice end and eyepiece input are at 45, and scope integral body is gun type of gas burner.
6. integrated confocal micro-rigid hysteroscope system according to claim 1, it is characterized in that: the main body endoscope part of described integrated confocal micro-rigid hysteroscope is provided with the control unit that makes things convenient for the doctor to carry out the burnt micro-control of copolymerization, described control unit includes the burnt micro-unlatching switch of copolymerization, freeze frame switch, amplifies the minification by-pass cock, and control unit adopts high temperature resistant and the waterproof material design.
7. integrated confocal micro-rigid hysteroscope system according to claim 1 is characterized in that: be connected with two medical monitors on the described integrated confocal micro-rigid hysteroscope, show the burnt micro-image of endoscopic image and copolymerization respectively; Also comprise with hard hysteroscope main frame and be connected the keyboard of being convenient to operate.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010116274A CN101803900A (en) | 2010-02-12 | 2010-02-12 | Integrated confocal micro-rigid hysteroscope system |
| PCT/CN2010/075583 WO2011097870A1 (en) | 2010-02-12 | 2010-07-30 | Integrated confocal microscopic hard endoscope system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010116274A CN101803900A (en) | 2010-02-12 | 2010-02-12 | Integrated confocal micro-rigid hysteroscope system |
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| Publication Number | Publication Date |
|---|---|
| CN101803900A true CN101803900A (en) | 2010-08-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010116274A Pending CN101803900A (en) | 2010-02-12 | 2010-02-12 | Integrated confocal micro-rigid hysteroscope system |
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| CN (1) | CN101803900A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940465A (en) * | 2010-09-17 | 2011-01-12 | 乔景亮 | Hard confocal microscopic bronchoscope system |
| CN101947099A (en) * | 2010-09-17 | 2011-01-19 | 杨柳青 | Integrated confocal microscopic rigid laryngoscope system |
| CN102100532A (en) * | 2010-12-10 | 2011-06-22 | 广州宝胆医疗器械科技有限公司 | Integrated infrared thermally scanning colposcope system |
| WO2012075712A1 (en) * | 2010-12-10 | 2012-06-14 | 广州宝胆医疗器械科技有限公司 | Hysteroscope system integrated with function of infrared thermal scanning |
| WO2012075698A1 (en) * | 2010-12-10 | 2012-06-14 | 广州宝胆医疗器械科技有限公司 | Hysteroscope system with infrared thermal scanning function |
| CN103690136A (en) * | 2013-12-11 | 2014-04-02 | 宋伯根 | Intrinsic fluorescence diagnostic endoscope system |
| CN104586345A (en) * | 2015-01-19 | 2015-05-06 | 上海侃瑞仪器设备有限公司 | Inherent fluorescent precancerous lesion hysteroscopy diagnostic system |
| US10441144B2 (en) | 2013-08-31 | 2019-10-15 | Mor Research Applications Ltd. | Endoscope with shared working channel |
| CN112370005A (en) * | 2020-07-08 | 2021-02-19 | 浙江百安医疗科技有限公司 | Visual flexible hysteroscope |
-
2010
- 2010-02-12 CN CN201010116274A patent/CN101803900A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940465A (en) * | 2010-09-17 | 2011-01-12 | 乔景亮 | Hard confocal microscopic bronchoscope system |
| CN101947099A (en) * | 2010-09-17 | 2011-01-19 | 杨柳青 | Integrated confocal microscopic rigid laryngoscope system |
| CN102100532A (en) * | 2010-12-10 | 2011-06-22 | 广州宝胆医疗器械科技有限公司 | Integrated infrared thermally scanning colposcope system |
| WO2012075712A1 (en) * | 2010-12-10 | 2012-06-14 | 广州宝胆医疗器械科技有限公司 | Hysteroscope system integrated with function of infrared thermal scanning |
| WO2012075711A1 (en) * | 2010-12-10 | 2012-06-14 | 广州宝胆医疗器械科技有限公司 | Colposcope system integrated with infrared thermal scanner |
| WO2012075698A1 (en) * | 2010-12-10 | 2012-06-14 | 广州宝胆医疗器械科技有限公司 | Hysteroscope system with infrared thermal scanning function |
| US10441144B2 (en) | 2013-08-31 | 2019-10-15 | Mor Research Applications Ltd. | Endoscope with shared working channel |
| CN103690136A (en) * | 2013-12-11 | 2014-04-02 | 宋伯根 | Intrinsic fluorescence diagnostic endoscope system |
| CN103690136B (en) * | 2013-12-11 | 2015-07-29 | 宋伯根 | Intrinsic fluorescence diagnostic endoscope system |
| CN104586345A (en) * | 2015-01-19 | 2015-05-06 | 上海侃瑞仪器设备有限公司 | Inherent fluorescent precancerous lesion hysteroscopy diagnostic system |
| CN112370005A (en) * | 2020-07-08 | 2021-02-19 | 浙江百安医疗科技有限公司 | Visual flexible hysteroscope |
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Open date: 20100818 |