CN101779946B - Confocal microscopic hard cystoscope system - Google Patents
Confocal microscopic hard cystoscope system Download PDFInfo
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- CN101779946B CN101779946B CN2010101087606A CN201010108760A CN101779946B CN 101779946 B CN101779946 B CN 101779946B CN 2010101087606 A CN2010101087606 A CN 2010101087606A CN 201010108760 A CN201010108760 A CN 201010108760A CN 101779946 B CN101779946 B CN 101779946B
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- Prior art keywords
- probe
- cystoscope
- hard
- copolymerization
- hard cystoscope
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- 239000000523 sample Substances 0.000 claims abstract description 37
- 238000007334 copolymerization reaction Methods 0.000 claims description 33
- 230000035515 penetration Effects 0.000 claims description 3
- 210000003932 urinary bladder Anatomy 0.000 abstract description 24
- 238000003745 diagnosis Methods 0.000 abstract description 7
- 210000001519 tissue Anatomy 0.000 abstract description 5
- 210000004877 mucosa Anatomy 0.000 abstract description 4
- 238000001356 surgical procedure Methods 0.000 abstract description 3
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 231100000915 pathological change Toxicity 0.000 description 6
- 230000036285 pathological change Effects 0.000 description 6
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 208000029162 bladder disease Diseases 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 229940020947 fluorescein sodium Drugs 0.000 description 2
- 210000001082 somatic cell Anatomy 0.000 description 2
- 210000003708 urethra Anatomy 0.000 description 2
- 208000026533 urinary bladder disease Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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Abstract
The invention belongs to the field of medical instruments, in particular discloses a confocal microscopic hard cystoscope system which comprises a hard cystoscope and a confocal microscopic probe. The hard cystoscope comprises a main body endoscope part and a cystoscope sheathing canal part connected with the main body endoscope part and at least is provided with a linear instrument channel, the confocal microscopic probe comprises a working end part and an interface, and the end part of the confocal microscopic probe penetrates through the linear instrument channel and combines the hard cystoscope and the confocal microscopic probe. In the system, the advanced confocal laser scanning microscopic technology is introduced into the diagnosis of urinary surgery operations, the confocal microscopic probe enters the urinary bladder cavity by the instrument channel and can amplify the tissue by more than 500 times under the coaction of obiturin so that the fine structures of the bladder mucosa or the polyps and the like can be clearly observed, accurately positioned and qualitatively checked, and the in-vivo tissue can be pathologically diagnosed. The invention introduces the diagnosis and the recognition to the bladder into a microscopic world, provides a more forceful tool for recognizing the bladder mucosa and the lesions thereof and provides a reliable basis for treatment and research.
Description
Technical field
The invention belongs to field of medical appliances, be specifically related to a kind of core medical instrument that modern medicine is carried out the Urology Surgery operation.
Prior art
At present, cystoscope and cystoscope technology are widely used clinically, it is the important tool of Urology Surgery diagnosis and treatment disease, but the existing cystoscope that is used for the bladder disease diagnosis and treatment can be determined the focus of bladder, but can't understand the variation of each layer of bladder and surrounding organ, there is the insufficient hidden danger of diagnostic accuracy, though can use and declare the ultrasonic cystoscope that uses novel patent, adopt the miniature ultrasonic technology that bladder is carried out ultrasonic scanning, but also do not have a kind of under the situation of live body mucous membrane of urinary bladder cell to its technology of diagnosing.
The burnt microtechnique of copolymerization can provide the cyto-architectural details of mucosal wall interbed clearly as a kind of brand-new imaging technique, clearly shows the surface structure of mucous layer, positions biopsy.Laser Scanning Confocal Microscope is used widely in biological study, application expands in the research work of subjects such as cytology, microbiology, developmental biology, hereditism, neurobiology, physiology and pathology at present, becomes the important tool of modern biology microexamination
Still the equipment that does not have at present the combination of the burnt microtechnique of cystoscope technology and copolymerization.
Summary of the invention
In order to overcome the deficiencies in the prior art, the objective of the invention is to burnt microtechnique of copolymerization and hard cystoscope are organically combined, by the burnt micro-probe of copolymerization the wall of urinary bladder mucosa is carried out the microexamination diagnosis and treatment, a kind of confocal microscopic hard cystoscope system is proposed, this endoscope system has been brought up to microcosmos with the understanding of bladder pathological changes, thereby to active somatic cell make the location and etiologic diagnosis, for the treatment and research reliable basis is provided.
For realizing above-mentioned technical purpose, the present invention is achieved through the following technical solutions:
Confocal microscopic hard cystoscope system of the present invention, comprise hard cystoscope and the cold light source main frame that is connected with the hard cystoscope, shooting main frame, described hard cystoscope comprises main body endoscope part, the cystoscope sheath tube portion that is connected with the main body endoscope part, described hard cystoscope comprises hard scope end, the instrument channel, eyepiece input, the cold light source input that are connected with hard scope end, described cystoscope sheath tube portion comprise sheath tube body, the intake tunnel, the exhalant canal that are communicated with the sheath tube body and are arranged at the sheath tube end of sheath tube body front end; Also comprise burnt micro-probe of copolymerization and the burnt micro-probe system main frame of copolymerization; Described hard cystoscope is provided with straight line type instrument channel at least; The burnt micro-probe of described copolymerization comprises work end and interface; The work end of the burnt micro-probe of described copolymerization is passed this linear type instrument channel the hard cystoscope is focused on micro-probe combination together.
In the present invention, the described linear type instrument channel diameter that is used for passing to the work work end of the burnt micro-probe of copolymerization is smaller or equal to 3.0mm.
In addition, the diameter of the work work end of the burnt micro-probe of described copolymerization is smaller or equal to 3.0mm, its length is less than 2000mm, work end penetration depth of penetrate tissue in bladder cavity of the burnt micro-probe of described copolymerization is 30 to 80 μ m, the width of its maximum observation field range is 325 μ m, lateral resolution 3.5 μ m, the burnt micro-probe system of copolymerization can amplify more than 500 times to observed object.
As the further improvement of above-mentioned technology, be connected with burnt main frame of copolymerization and medical monitor on the burnt micro-probe of described copolymerization, so that operation and supervision; Described hard cystoscope also is connected with medical monitor; Also comprise with each medical monitor and be connected the keyboard of being convenient to operate.
Compared with prior art, the invention has the beneficial effects as follows:
Confocal microscopic hard cystoscope system of the present invention be the basis of ultrasonic cystoscope on, introduce the burnt micro-probe of advanced copolymerization, the burnt micro-probe of copolymerization is that platform enters in the bladder cavity by the linear type instrument channel of the cystoscopic special use of hard, under the combined effect of fluorescein sodium, amplify more than 500 times to mucous membrane of urinary bladder and pathological changes thereof, the understanding of bladder pathological changes has been brought up to microcosmos, thus to active somatic cell make the location and etiologic diagnosis, for the treatment and research reliable basis is provided.
Description of drawings
Fig. 1 is a confocal microscopic hard cystoscope system sketch map of the present invention.
Fig. 2 is a hard cystoscope sketch map of the present invention.
Fig. 3 is the burnt micro-probe sketch map of copolymerization of the present invention.
Fig. 4 is that sketch map is used in focusing microscopic hard cystoscope system operation of the present invention.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing:
As shown in Figure 1, confocal microscopic hard cystoscope system hard cystoscope 1 of the present invention, endoscopic cold light source main frame 3, shooting main frame 4, the burnt micro-probe 2 of copolymerization, the burnt micro-probe system main frame 5 of copolymerization and keyboard 6, two medical monitors 7 and 8 show the image of the burnt micro-probe 2 of hard cystoscope 1 and copolymerization respectively.
Fig. 2 is the sketch map of hard cystoscope 1 among the present invention, and hard cystoscope 1 is divided into two parts, is respectively sheath tube portion 11 and main body endoscope part 12.Sheath tube portion 11 is the parts that enter bladder cavity through urethra, cystoscope sheath tube portion 11 comprises sheath tube body, the intake tunnel, the exhalant canal that are communicated with the sheath tube body and is arranged at the sheath tube end of sheath tube body front end, in order to protect urethra and bladder, its first end 111 is designed to blunt shape;
Described hard cystoscope 12 comprises hard scope end, the instrument channel, eyepiece input, the cold light source input that are connected with hard scope end; Described hard cystoscope 1 is provided with straight line type instrument channel 121 at least, and its internal diameter is smaller or equal to 3.0mm.
Fig. 3 is the structure diagram of the burnt micro-probe 2 of copolymerization among the present invention.The burnt micro-probe of copolymerization is divided into work end 21 and interface 22, work end 21 diameters of the burnt micro-probe of copolymerization are smaller or equal to 3.0mm, its length is less than 2000mm, work end penetration depth of penetrate tissue in bladder cavity of the burnt micro-probe of described copolymerization is 30 to 80 μ m, the width of its maximum observation field range is 325 μ m, lateral resolution 3.5 μ m, it can amplify more than 500 times to mucous membrane of urinary bladder and pathological tissues thereof, the work end 21 of the burnt micro-probe 2 of described copolymerization is passed this linear type instrument channel 121 the hard cystoscope is focused on micro-probe 2 combinations together, and the understanding of bladder and bladder disease is brought up to microcosmos.
As Fig. 4, in conjunction with shown in Figure 1, the operation sketch map of confocal microscopic hard cystoscope system of the present invention, the doctor at first needs the patient is carried out the intravenous injection fluorescein sodium before the art, hard cystoscope 1 enters in the bladder cavity 9 from patient's urethral orifice, the doctor can clearly observe the pathological changes situation of bladder cavity 9 by the medical grade monitor 7 of hard cystoscope 1, the burnt micro-probe 2 of copolymerization is a platform by the instrument channel 121 of hard cystoscope 1, enter in the bladder cavity 9, can amplify more than 500 times to bladder cavity 9 mucosas or pathological changes, carry out live body and detect, the doctor can diagnose mucous membrane of urinary bladder or pathological changes etc. and treat immediately.
Claims (2)
1. confocal microscopic hard cystoscope system, comprise hard cystoscope and the cold light source main frame that is connected with the hard cystoscope, the shooting main frame, described hard cystoscope comprises the main body endoscope part, the cystoscope sheath tube portion that is connected with the main body endoscope part, described hard cystoscope comprises hard scope end, the instrument channel that is connected with hard scope end, the eyepiece input, the cold light source input, described cystoscope sheath tube portion comprises the sheath tube body, the intake tunnel that is communicated with the sheath tube body, exhalant canal and be arranged at the sheath tube end of sheath tube body front end is characterized in that: also comprise burnt micro-probe of copolymerization and the burnt micro-probe system main frame of copolymerization; Described hard cystoscope is provided with straight line type instrument channel at least; The burnt micro-probe of described copolymerization comprises work end and interface; The work end of the burnt micro-probe of described copolymerization is passed this linear type instrument channel the hard cystoscope is focused on micro-probe combination together; The diameter of the work end of the burnt micro-probe of described copolymerization is smaller or equal to 3.0mm, its length is less than 2000mm, work end penetration depth of penetrate tissue in bladder cavity of the burnt micro-probe of described copolymerization is 30 to 80 μ m, the width of its maximum observation field range is 325 μ m, lateral resolution 3.5 μ m.
2. confocal microscopic hard cystoscope system according to claim 1 is characterized in that: the linear type instrument channel diameter that is used for passing to the work end of the burnt micro-probe of copolymerization is smaller or equal to 3.0mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101087606A CN101779946B (en) | 2010-02-04 | 2010-02-04 | Confocal microscopic hard cystoscope system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101087606A CN101779946B (en) | 2010-02-04 | 2010-02-04 | Confocal microscopic hard cystoscope system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101779946A CN101779946A (en) | 2010-07-21 |
| CN101779946B true CN101779946B (en) | 2011-08-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101087606A Expired - Fee Related CN101779946B (en) | 2010-02-04 | 2010-02-04 | Confocal microscopic hard cystoscope system |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011097870A1 (en) * | 2010-02-12 | 2011-08-18 | 广州市番禺区胆囊病研究所 | Integrated confocal microscopic hard endoscope system |
| WO2012006767A1 (en) * | 2010-07-15 | 2012-01-19 | 广州宝胆医疗器械科技有限公司 | Therapeutic and diagnostic confocal microscopic rigid endoscope system |
| CN101940465A (en) * | 2010-09-17 | 2011-01-12 | 乔景亮 | Hard confocal microscopic bronchoscope system |
| CN102100535A (en) * | 2010-12-10 | 2011-06-22 | 广州宝胆医疗器械科技有限公司 | Cystoscope system with infrared thermally scanning function |
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2010
- 2010-02-04 CN CN2010101087606A patent/CN101779946B/en not_active Expired - Fee Related
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| CN101779946A (en) | 2010-07-21 |
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Granted publication date: 20110810 |