CN101779972A - Confocal microscope and rigid choledochoscope integrated system - Google Patents

Confocal microscope and rigid choledochoscope integrated system Download PDF

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Publication number
CN101779972A
CN101779972A CN201010116240A CN201010116240A CN101779972A CN 101779972 A CN101779972 A CN 101779972A CN 201010116240 A CN201010116240 A CN 201010116240A CN 201010116240 A CN201010116240 A CN 201010116240A CN 101779972 A CN101779972 A CN 101779972A
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CN
China
Prior art keywords
rigid
confocal microscope
choledochoscope
confocal
hard
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Pending
Application number
CN201010116240A
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Chinese (zh)
Inventor
乔铁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUANGZHOU CITY PANYU DISTRICT CHOLECYSTOPATHY RESEARCH INSTITUTE
Original Assignee
GUANGZHOU CITY PANYU DISTRICT CHOLECYSTOPATHY RESEARCH INSTITUTE
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Application filed by GUANGZHOU CITY PANYU DISTRICT CHOLECYSTOPATHY RESEARCH INSTITUTE filed Critical GUANGZHOU CITY PANYU DISTRICT CHOLECYSTOPATHY RESEARCH INSTITUTE
Priority to CN201010116240A priority Critical patent/CN101779972A/en
Publication of CN101779972A publication Critical patent/CN101779972A/en
Priority to PCT/CN2010/075583 priority patent/WO2011097870A1/en
Pending legal-status Critical Current

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Abstract

The invention belongs to the field of medical appliances and in particular discloses a confocal microscope and rigid choledochoscope integrated system. The system comprises a rigid choledochoscope. A rigid endoscope end is provided with a confocal microscope, confocal laser heads, a confocal microscope output connector end, a lightguide fiber and appliance channel exits. The confocal microscope, the confocal laser heads and the confocal microscope output connector end are integrated at the rigid endoscope end, and the rigid choledochoscope is designed into the integrated confocal microscope rigid choledochoscope. The system is characterized in that the confocal microscopy and the rigid choledochoscope are combined; the confocal microscope and the confocal micro laser heads are added in the structure of the rigid choledochoscope, and the blue laser beams of 488nm sent by the confocal micro laser heads interact with the fluorescein sodium of gallbladder mucosa to provide a tool for doctors to carry out real-time biopsy on the pathological changes of the gallbladder mucosa. The system introduces diagnosis of the gallbladder diseases and the knowledge of the gallbladders to a microworld and provides a powerful tool for knowing the gallbladders and the pathological changes of the gallbladders.

Description

Confocal microscope and rigid choledochoscope integrated system
Technical field
The invention belongs to field of medical appliances, be specifically related to modern medicine and carry out to protect a kind of core medical instrument that gallbladder is got stone (getting polyp) operation in a deep going way.
Prior art
Modern times carry out new-type hard gall bladder endoscope guarantor gallbladder and get in the process of stone operation, use the integrated single channel gall bladder endoscope (patent No.: ZL200820188854.7 that obtains national patent, notification number is CN201213821) or the integrated triple-channel vesicula fellis endoscope (patent No.: ZL200820188856.6, notification number is CN201213822) and system, the doctor can be by high-resolution image effect can naked eyes identification gallbladder wall some pathological changes, but be to use naked eyes to distinguish certain limitation is arranged, can not see the ultrastructure of cell exactly.Protect at present gallbladder and get in the stone operation for the case that can not make a definite diagnosis, the doctor often will get biopsy.Getting biopsy is exactly that the scope doctor observes pathological changes, by some pathological tissues of biopsy forceps gripping, delivers to Pathology Deparment, and that takes off is organized in Pathology Deparment by multiple working procedure, examines under a microscope the form and the structure of cell at last, to determine the character of pathological changes.The time that the cost of whole process need is long, and be difficult to accurately determine biopsy site when getting biopsy, be unfavorable for clinical timely diagnosis and treatment.
Get the further investigation of stone operation along with protecting gallbladder, must need a kind of new-type cholecystoscope system that can carry out real-time diagnosis active somatic cell.
Summary of the invention
The objective of the invention is to burnt microtechnique of copolymerization and hard gallbladder mirror are organically combined, by the Laser Scanning Confocal Microscope head gallbladder wall mucosa and polyp are carried out the microexamination diagnosis and treatment, a kind of confocal microscope and rigid choledochoscope integrated system is proposed, this confocal microscope and rigid choledochoscope integrated system can make the operator accurately determine biopsy site, observe the macroscopical situation and the microcosmic situation of mucous membrane of gallbladder simultaneously, in current operation and inspection, suspicious lesions is carried out instant analysis and detection, overcome the drawback that biopsy at random brings, help to improve clinical therapeutic effect and reduce medical treatment cost.
In order to reach above-mentioned technical purpose, the present invention is achieved through the following technical solutions:
Confocal microscope and rigid choledochoscope integrated system of the present invention, comprise hard gallbladder mirror, endoscopic cold light source main frame that is connected with hard gallbladder mirror and shooting main frame, described hard gallbladder mirror comprises hard scope end, the some instrument channel that are communicated with hard scope end, intake tunnel, exhalant canal, cold light source input and eyepiece input, described hard scope end is provided with the Laser Scanning Confocal Microscope head, the confocal laser head, the burnt micro-out splice going splice end of copolymerization, light-conductive optic fibre and instrument channel outlet are with the Laser Scanning Confocal Microscope head, the confocal laser head, the burnt micro-out splice going splice end of copolymerization is integrated in hard scope end hard gallbladder mirror is designed to integrated confocal microscopy hard gallbladder mirror.
In the present invention, the diameter of at least one instrument channel is 2.8mm or following, and hard scope end diameter is smaller or equal to 10mm, the long 250~300mm in end, and in addition, for fear of the damage mucosal tissue, hard scope elder generation end becomes blunt shape design.
In the present invention, hard gallbladder mirror adopts the 2.8mm optical lens, eyepiece input and hard scope end in line, Laser Scanning Confocal Microscope out splice going splice end and eyepiece input are at 45, scope integral body is gun type of gas burner, gripability and stability when improving operation technique.
The burnt hard gallbladder of described integrated copolymerization mirror, its shank place is provided with control unit, so that the doctor carries out the burnt micro-control of copolymerization, this control unit includes the burnt micro-unlatching switch of copolymerization, the freeze frame switch, amplify minification by-pass cock etc., control unit adopts high temperature resistant and the waterproof material design.
As the further improvement of above-mentioned technology, be connected with two medical monitors on the described integrated confocal microscopy hard gallbladder mirror, show the burnt micro-image of endoscopic image and copolymerization respectively; Also comprise with hard gallbladder mirror main frame and be connected the keyboard of being convenient to operate.
Compared with prior art, the invention has the beneficial effects as follows:
Confocal microscope and rigid choledochoscope integrated system of the present invention, burnt microtechnique of copolymerization and hard gallbladder mirror are organically combined, under the effect of fluorescein sodium, the doctor presses close to mucous membrane of gallbladder by operating integrated confocal microscopy hard gallbladder mirror, can be intracellular dynamically with 30 frame/seconds (fps) or above speed record, the burnt micro-main frame of copolymerization can be with 230fps or above speed photographic images, pass through confocal microscope and rigid choledochoscope integrated system, the doctor can observe the macroscopical situation and the microcosmic situation of mucous membrane of gallbladder simultaneously, provides new platform for the doctor carries out real-time cell biopsy.
Description of drawings
Fig. 1 is a confocal microscope and rigid choledochoscope integrated system sketch map of the present invention.
Fig. 2 is an integrated confocal microscopy hard gallbladder mirror structural representation of the present invention.
Fig. 3 is the end view of integrated confocal microscopy hard gallbladder mirror of the present invention.
Fig. 4 is the operation sketch map of confocal microscope and rigid choledochoscope integrated system of the present invention.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing:
As shown in Figure 1, confocal microscope and rigid choledochoscope integrated system of the present invention comprises integrated confocal microscopy hard gallbladder mirror 1, light source main frame 2, the burnt micro-main frame 3 of copolymerization, shooting main frame 4, keyboard 5, the burnt micro-monitor 7 of hard gallbladder mirror monitor 6 and copolymerization is formed.
Fig. 2, Fig. 3 is the structure and the end view of the integrated confocal microscopy hard gallbladder mirror 1 among the present invention, integrated confocal microscopy hard gallbladder mirror 1 comprises hard scope end 11, light source joint 12, Laser Scanning Confocal Microscope out splice going splice end 13, eyepiece input 16, control unit 17, two diameters are 2.8mm or following instrument channel 14,15, integrated confocal microscopy hard gallbladder mirror 1 adopts the optical lens of 2.8mm, eyepiece input 16 and hard scope end 11 are in line, Laser Scanning Confocal Microscope out splice going splice end 13 and eyepiece input 16 angles at 45, integrated confocal microscopy hard gallbladder mirror 1 integral body is gun type of gas burner, has improved gripability and the stability in the operative process effectively.The end of integrated confocal microscopy hard gallbladder mirror 1 is provided with Laser Scanning Confocal Microscope head 131, optical lens 161, the burnt main frame laser head 132 of 121, two copolymerization of light-conductive optic fibre and two 2.8mm or following instrument channel outlet 141 and 151.Control unit 17 makes things convenient for the doctor to carry out the burnt micro-control of copolymerization, and control unit 17 includes the burnt micro-unlatching switch of copolymerization, and the freeze frame switch amplifies minification by-pass cock etc., and control unit adopts high temperature resistant and the waterproof material design.
Fig. 4 is the operation sketch map of integrated confocal microscopy hard gallbladder mirror 1 of the present invention.Before the art, the doctor at first needs the patient is carried out the intravenous injection fluorescein sodium.In the art, do a miniature incision in gallbladder 8 bottoms, integrated then confocal microscopy hard gallbladder mirror 1 enters the gallbladder intracavity, and integrated confocal microscopy hard gallbladder mirror 1 can be obtained the calculus of gallbladder intracavity completely; In operation, the doctor can produce wavelength 488nm blue laser beam by the burnt micro-main frame 3 of operation control unit 17 control copolymerization, by the observed mucous membrane of gallbladder tissue of burnt main frame laser head 132 shootings of copolymerization, then the Laser Scanning Confocal Microscope head 131 of integrated confocal microscopy hard gallbladder mirror 1 is pressed close to the mucous membrane of gallbladder tissue, the signal that fluorescein sodium produces under the exciting of laser beam in the tissue is detected by Laser Scanning Confocal Microscope head 131 and is input to the burnt micro-main frame 3 of copolymerization by Laser Scanning Confocal Microscope out splice going splice end 13, the burnt micro-monitor 7 of copolymerization produces micro-image, helps the doctor that the character of patient's mucous membrane of gallbladder is made diagnosis.

Claims (5)

1. confocal microscope and rigid choledochoscope integrated system, comprise hard gallbladder mirror, endoscopic cold light source main frame that is connected with hard gallbladder mirror and shooting main frame, described hard gallbladder mirror comprises hard scope end, the some instrument channel that are communicated with hard scope end, intake tunnel, exhalant canal, cold light source input and eyepiece input, it is characterized in that: described hard scope end is provided with the Laser Scanning Confocal Microscope head, the confocal laser head, the burnt micro-out splice going splice end of copolymerization, light-conductive optic fibre and instrument channel outlet are with the Laser Scanning Confocal Microscope head, the confocal laser head, the burnt micro-out splice going splice end of copolymerization is integrated in hard scope end hard gallbladder mirror is designed to integrated confocal microscopy hard gallbladder mirror.
2. confocal microscope and rigid choledochoscope integrated system according to claim 1 is characterized in that: the diameter of at least one instrument channel is 2.8mm or following in the described instrument channel.
3. confocal microscope and rigid choledochoscope integrated system according to claim 1 is characterized in that: described hard scope end diameter is smaller or equal to 10mm, and 250~300mm is grown in the end.
4. confocal microscope and rigid choledochoscope integrated system according to claim 1, it is characterized in that: hard gallbladder mirror adopts the 2.8mm optical lens, eyepiece input and hard scope end are in line, Laser Scanning Confocal Microscope out splice going splice end and eyepiece input are at 45, and scope integral body is gun type of gas burner.
5. confocal microscope and rigid choledochoscope integrated system according to claim 1, it is characterized in that: the shank of described integrated confocal microscopy hard gallbladder mirror is provided with the control unit that makes things convenient for the doctor to carry out the burnt micro-control of copolymerization, described control unit includes the burnt micro-unlatching switch of copolymerization, freeze frame switch and amplifies the minification by-pass cock, and control unit adopts high temperature resistant and the waterproof material design.
CN201010116240A 2010-02-12 2010-02-12 Confocal microscope and rigid choledochoscope integrated system Pending CN101779972A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201010116240A CN101779972A (en) 2010-02-12 2010-02-12 Confocal microscope and rigid choledochoscope integrated system
PCT/CN2010/075583 WO2011097870A1 (en) 2010-02-12 2010-07-30 Integrated confocal microscopic hard endoscope system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201010116240A CN101779972A (en) 2010-02-12 2010-02-12 Confocal microscope and rigid choledochoscope integrated system

Publications (1)

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CN101779972A true CN101779972A (en) 2010-07-21

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101947099A (en) * 2010-09-17 2011-01-19 杨柳青 Integrated confocal microscopic rigid laryngoscope system
WO2011097870A1 (en) * 2010-02-12 2011-08-18 广州市番禺区胆囊病研究所 Integrated confocal microscopic hard endoscope system

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011097870A1 (en) * 2010-02-12 2011-08-18 广州市番禺区胆囊病研究所 Integrated confocal microscopic hard endoscope system
CN101947099A (en) * 2010-09-17 2011-01-19 杨柳青 Integrated confocal microscopic rigid laryngoscope system

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Open date: 20100721