CN104586345A - Inherent fluorescent precancerous lesion hysteroscopy diagnostic system - Google Patents
Inherent fluorescent precancerous lesion hysteroscopy diagnostic system Download PDFInfo
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- CN104586345A CN104586345A CN201510024546.5A CN201510024546A CN104586345A CN 104586345 A CN104586345 A CN 104586345A CN 201510024546 A CN201510024546 A CN 201510024546A CN 104586345 A CN104586345 A CN 104586345A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
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Abstract
The invention discloses an inherent fluorescent precancerous lesion hysteroscopy diagnostic system. The inherent fluorescent precancerous lesion hysteroscopy diagnostic system comprises a main machine, a beam guiding system, a computer and an output device; the inherent fluorescent precancerous lesion hysteroscopy diagnostic system is particularly characterized in that the beam guiding system comprises a cavity inlet light guide, an external cavity light guide and a control device, the cavity inlet light guide is integrally formed by a white light guide, ultraviolet excitation fiber (or LED (Light Emitting Diode) light excitation fiber) and fluorescent feedback fiber which are integrated into the white light guide, a biopsy pipeline, a water injection pipeline and a liquid pumping pipeline; the external cavity light guide is integrally formed by the white light guide, ultraviolet light (or LED light) and fluorescent fiber which are integrated into the white light guide, the water injection pipeline and the liquid pumping pipeline. The inherent fluorescent precancerous lesion hysteroscopy diagnostic system disclosed by the invention not only has the function of a common hysteroscopy, but also has the functions of diagnosing early cancer in endometrium and cervical canal by inherent fluorescence, and more effective and more convenient diagnosis can be provided for a patient.
Description
Technical field
The present invention relates to hysteroscope system, particularly a kind of primary fluorescence precancerous lesion hysteroscopic diagnosis system, for the early diagnosis of carcinoma of endometrium and carcinoma canalis cervicis etc. and the diagnosis of precancerous lesion of clinical medicine.
Background technology
Experiment and clinical research all confirm that primary fluorescence has the function of tentative diagnosis early-stage cancer and precancerous lesion.Current fujinon electronic video endoscope adopts white light beam, directly observes the exception finding mucosa form, infantile tumour is not yet formed to unconspicuous pathological changes and the precancerous lesion of tumor block, do not have diagnostic function.Primary fluorescence hysteroscopic diagnosis system by fluorescence diagnosis combine with technique in hysteroscopy technology.
The concept of primary fluorescence: primary fluorescence does not need by means of other fluorescent material, but irradiate tissue, the fluorescence reflected after tissue resorption with the laser (referred to as LED light) that the light of certain wavelength exports as ultraviolet light (340nm) or laser diode.
The principle of Intrinsic fluorescence diagnostic mucosal carcinoma and precancerous lesion:
It is that in molecular structure, the change of quantum state causes that fluorescence produces, and in the color of fluorescence and molecular structure, quantum state has special relation.If quantum state plays change in molecular structure, color, the wavelength of the primary fluorescence reflected will be different.Because in the molecular structure of precancerous lesion, cancerous tissue, quantum state plays change, different from normal structure, the primary fluorescence color sent is just different from normal structure with wavelength, therefore just can differentiate precancerous lesion and cancerous tissue.Under the exciting of ultraviolet light or LED light, normal structure sends blue fluorescence, and cancerous tissue and Precancerous Lesion then send purple or hepatic fluorescence.So just can carry out Differential Diagnosis to the pathological changes of mucosal tissue, therefore be called as " optical biopsy ".As shown in Figure 1.Figure upper right side is the different wave modes of normal structure and abnormal structure, and figure lower right is white light and primary fluorescence image.
The early cancer of Intrinsic fluorescence diagnostic mucosa and the technology of precancerous lesion are only limitted to the position in short cavity road at present, as cervix uteri, also do not stretch into the Intrinsic fluorescence diagnostic of cavity of uterus.Primary fluorescence also needs signal amplifying system at the cancer diagnosis of deep tract mucosa and accepts analytical system technology.Current panoramic hysteroscope does not possess the function of Intrinsic fluorescence diagnostic early cancer, in the past in preliminary clinical trial, the biopsy hole of primary fluorescence fibre system from scope is imported, need again optical fiber to be extracted out during biopsy, again biopsy forceps is inserted biopsy hole, due to the wriggling of hollow organ, the position of suspicious lesions may be moved.Have impact on the application of Intrinsic fluorescence diagnostic tumor technology.But the primary fluorescence hysteroscope also not having Intrinsic fluorescence diagnostic to be integrated in the world at present.
Summary of the invention
The object of the present invention is to provide a kind of primary fluorescence precancerous lesion hysteroscopic diagnosis system, this system described to enter outside chamber light guide bundles and chamber in light guide bundles original white light light guide bundles and ultraviolet light (or LED light) excitation fiber and primary fluorescence feedback optical fiber are integrated, therefore both there is the function of panoramic hysteroscope, there is again the function of Intrinsic fluorescence diagnostic early cancer, and it is easy to use, simple to operate, save operating time and the misery that alleviates when patient checks.
Technical solution of the present invention is as follows:
A kind of primary fluorescence precancerous lesion hysteroscopic diagnosis system, comprises main frame, leads beam system, computer and outut device, and its feature is:
Described main frame comprises white light source, ultraviolet source (or LED light source), white light imaging system, primary fluorescence signal amplifying system, primary fluorescence Signal Analysis System, HPI, water injecting pump and drawing liquid pump, this HPI respectively with described white light source, ultraviolet source (or LED light source), white light imaging system, primary fluorescence signal amplifying system is connected, the first input end of the computer described in output termination of described white light imaging system, the outfan of described primary fluorescence signal amplifying system is connected with the second input of described computer through described primary fluorescence Signal Analysis System, the input of the outut device described in output termination of described computer,
Described beam system of leading comprises and leads bundle into chamber, bundle and actuation means is led outside chamber, described enter chamber and lead bundle and feed back optical fiber by white light light guide bundles and ultraviolet light (or LED light) excitation fiber be incorporated in this white light light guide bundles and fluorescence, biopsy pipeline, filling pipe, drawing liquid pipeline one is formed, lead bundle outside described chamber and feed back optical fiber by white light light guide bundles and ultraviolet light (or LED light) excitation fiber be incorporated in white light light guide bundles and fluorescence, filling pipe, drawing liquid pipeline one is formed, described actuation means comprises manipulation hands wheel, the biopsy hole communicated with described biopsy pipeline, the water injection hole communicated with described filling pipe, the drawing liquid hole communicated with described drawing liquid pipeline, described enter chamber and lead the white light light guide bundles of bundle and ultraviolet light (or LED light) and fluorescence optical fiber and lead the white light light guide bundles of bundle and ultraviolet light (or LED light) and fluorescence optical fiber outside described chamber and communicate respectively, the described filling pipe entering chamber light guide bundles, drawing liquid pipeline communicates with the filling pipe of light guide bundles outside described chamber and drawing liquid pipeline respectively, the white light light guide bundles of leading bundle outside described chamber is connected with the input of white light imaging system with the outfan of described white light source by described HPI with the other end of ultraviolet light (or LED light) and fluorescence optical fiber, described ultraviolet light (or LED light) and the other end of fluorescence optical fiber are connected with the input of primary fluorescence signal amplifying system with the outfan of described ultraviolet source (or LED light source), described filling pipe is connected with described water injecting pump, described drawing liquid pipeline is connected with described drawing liquid pump.
Technology beneficial effect of the present invention:
Primary fluorescence precancerous lesion hysteroscopic diagnosis system of the present invention, enter chamber and lead to lead outside bundle and chamber described and intrafascicular original white light light guide bundles and ultraviolet light (or LED light) excitation fiber and primary fluorescence feedback optical fiber to be integrated, both there is the function of conventional endoscope, there is again the function of Intrinsic fluorescence diagnostic early cancer, and it is easy to use, simple to operate, save operating time and the misery that alleviates when patient checks.
The most effective measures of current raising tumor survival rate are exactly early diagnosis and early treatment.For gastric cancer, if at cancer early detection, Post operation 5 years survival rates can reach more than 90%.Primary fluorescence detects and is especially suitable for mucous epithelium the early cancer even diagnosis of precancerous lesion, therefore has great importance to the incidence rate and mortality rate that reduce some common mucous epithelium cancers, and has great social benefit.
The hysteroscope that the present invention with the addition of primary fluorescence early cancerous diagnose specific function is that manufacturer enjoys market and adds competitive strength, has great economic benefit.
The present invention to the sensitivity of cervical canal and endometrial precancer and early stage cancerous diagnose comparatively common detection methods improve 4-6 doubly; Verification and measurement ratio comparatively conventional method improves 3-5 doubly; Specificity reaches 90%-95%.
Accompanying drawing explanation
Fig. 1 is " optical biopsy " principle schematic
Fig. 2 is the structural representation of primary fluorescence precancerous lesion hysteroscopic diagnosis system of the present invention:
In figure:
1-enters chamber to be led bundle 2-and enters chamber light guide bundles section 3-white light light guide bundles 4-biopsy pipeline 5-ultraviolet light (or LED light source) and to import and primary fluorescence accepts optical fiber 6-filling pipe 7-drawing liquid pipeline 8-biopsy hole 9-water injection hole 10-drawing liquid hole 11-and operates the outer light guide bundles section 14-same 5 in outer light guide bundles 13-chamber, handwheel 12-chamber, and ultraviolet light (or LED light) importing and primary fluorescence accept optical fiber 15-filling pipe 16-drawing liquid pipeline 17-HPI 18-main frame 19-white light source 20-ultraviolet source (or LED light source) 21-white light imaging system 22-primary fluorescence signal amplifying system 23-primary fluorescence Signal Analysis System 24-computer 25-print system
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the invention will be further described, but should not limit the scope of the invention with this.
First refer to Fig. 2, Fig. 2 is the structural representation of primary fluorescence hysteroscope system of the present invention, and as seen from the figure, Intrinsic fluorescence diagnostic hysteroscope system of the present invention, comprises main frame 18, leads beam system, computer 24 and outut device 25,
Described main frame 18 comprises white light source 19, ultraviolet source (or LED light source) 20, white light imaging system 21, primary fluorescence signal amplifying system 22, primary fluorescence Signal Analysis System 23, HPI 17, water injecting pump and drawing liquid pump (not shown), this HPI 17 respectively with described white light source 19, ultraviolet source (or LED light source) 20, white light imaging system 21, primary fluorescence signal amplifying system 22 is connected, the first input end of the computer 24 described in output termination of described white light imaging system 21, the outfan of described primary fluorescence signal amplifying system 22 is connected through second input of described primary fluorescence Signal Analysis System 23 with described computer 24, the input of the outut device 25 described in output termination of described computer 24,
Described beam system of leading comprises and leads bundle 1 into chamber, bundle 12 and actuation means is led outside chamber, described enter chamber and lead bundle 1 and feed back optical fiber 5 by white light light guide bundles 3 and ultraviolet light (or LED light) excitation fiber be incorporated in this white light light guide bundles 3 and fluorescence, biopsy pipeline 4, filling pipe 6, drawing liquid pipeline 7 one is formed, bundle 12 is led by white light light guide bundles 3 and the ultraviolet light (or LED light) be incorporated in white light light guide bundles 3 and fluorescence optical fiber 14 outside described chamber, filling pipe 15, drawing liquid pipeline 16 one is formed, described actuation means comprises manipulation handwheel 11, the biopsy hole 8 communicated with described biopsy pipeline 4, the water injection hole 9 communicated with described filling pipe 15, the drawing liquid hole 10 communicated with described drawing liquid pipeline 16, described enter chamber and lead the white light light guide bundles 3 of bundle 1 and ultraviolet light (or LED light) and fluorescence optical fiber 5 and lead the white light light guide bundles 3 of bundle 12 and ultraviolet light (or LED light) and fluorescence optical fiber 14 outside described chamber and communicate respectively, described enters the filling pipe 6 that bundle 1 is led in chamber, drawing liquid pipeline 7 communicates with the filling pipe 15 and drawing liquid pipeline 16 of leading bundle 12 outside described chamber respectively, the white light light guide bundles 3 of leading bundle 12 outside described chamber is connected with main frame 18 by described HPI 17 with the other end of ultraviolet light (or LED light) and fluorescence optical fiber 14, described white light light guide bundles 3 is connected with the input of white light imaging system 21 with the outfan of described white light source 19, described ultraviolet light (or LED light) and the other end of fluorescence optical fiber 14 are connected with the input of primary fluorescence signal amplifying system 22 with the outfan of described ultraviolet source (or LED light source) 20, described filling pipe 15 is connected with described water injecting pump, described drawing liquid pipeline 16 is connected with described drawing liquid pump.
Enter 14 outside 5 and 13 chambeies in the image guide bundles profile of chamber in light guide bundles profile and comprise the excitation fiber importing ultraviolet light (or LED light) and the feedback optical fiber of deriving primary fluorescence.(being the same group of optical fiber having integrated one)
Described HPI 17 is the same with conventional electrical endoscope, is Active Interface, departs from ordinary times, be connected when clinical manipulation with main frame with main frame.
Primary fluorescence acquisition system comprises primary fluorescence signal amplifying system; Described primary fluorescence analytical system is rapid fluorescence spectrophotometer.
Operational applications of the present invention
1, HPI 17 is connected with main frame.
2, chamber will be entered lead bundle 1 and insert tract that patient examines, as cavity of uterus.
3, give cavity of uterus water filling as required or extract uterus intracavity liquid, being convenient to observe.
4, first do overview with white light source, after finding suspicious lesions, white light source is closed, open ultraviolet source (or LED light source), show peculiar abnormal primary fluorescence, get biopsy in lesion.As white light source is not closed only to observe judgement by the wave mode of primary fluorescence
5, result judges
The primary fluorescence of normal endometrium or benign lesion is blue or blue and white fluorescence; Precancerous lesion (intraepithelial neoplasia) and cancerous tissue are the fluorescence of purple;
The display of computer can show the difference special wave mode of benign lesion and precancerous lesion (intraepithelial neoplasia) and cancerous tissue.
Primary fluorescence precancerous lesion hysteroscopic diagnosis system of the present invention is entered chamber and is led to lead outside bundle and chamber described and intrafascicular original white light light guide bundles and ultraviolet light (or LED light) excitation fiber and primary fluorescence feedback optical fiber are integrated one, the function of existing conventional endoscope can be realized, there is again the function of Intrinsic fluorescence diagnostic early cancer.
Claims (2)
1. a primary fluorescence precancerous lesion hysteroscopic diagnosis system, comprises main frame (18), leads beam system, computer (24) and outut device (25), it is characterized in that:
Described main frame (18) comprises white light source (19), ultraviolet source (20), white light imaging system (21), primary fluorescence signal amplifying system (22), primary fluorescence Signal Analysis System (23), HPI (17), water injecting pump and drawing liquid pump, this HPI (17) respectively with described white light source (19), ultraviolet source (20), white light imaging system (21), primary fluorescence signal amplifying system (22) is connected, the first input end of the computer (24) described in output termination of described white light imaging system (21), the outfan of described primary fluorescence signal amplifying system (22) is connected with the second input of described computer (24) through described primary fluorescence Signal Analysis System (23), the input of the outut device (25) described in output termination of described computer (24),
Described beam system of leading comprises and leads bundle (1) into chamber, bundle (12) and actuation means is led outside chamber, described enter chamber and lead bundle (1) by white light light guide bundles (3) and the ultraviolet light be incorporated in this white light light guide bundles (3) and fluorescence optical fiber (5), biopsy pipeline (4), filling pipe (6), drawing liquid pipeline (7) one is formed, bundle (12) is led by white light light guide bundles (3) and the ultraviolet light be incorporated in white light light guide bundles (3) and fluorescence optical fiber (14) outside described chamber, filling pipe (15), drawing liquid pipeline (16) one is formed, described actuation means comprises biopsy hole (8), water injection hole (9), drawing liquid hole (10) and manipulation handwheel (11), described biopsy hole (8) communicates with described biopsy pipeline (4), described water injection hole (9) communicates with described filling pipe (15), described drawing liquid hole (10) communicates with described drawing liquid pipeline (16), described enter chamber and lead the white light light guide bundles (3) of the white light light guide bundles (3) of bundle (1) and ultraviolet light and fluorescence optical fiber (5) and light guide bundles (12) outside described chamber and ultraviolet light and fluorescence optical fiber (14) and communicate respectively, the described filling pipe (6) entering chamber light guide bundles (1), drawing liquid pipeline (7) communicates with the filling pipe (15) of light guide bundles (12) outside described chamber and drawing liquid pipeline (16) respectively, outside described chamber, the white light light guide bundles (13) of light guide bundles (12) is connected with described main frame (18) by described HPI (17) with the other end of ultraviolet light and fluorescence optical fiber (14), described white light light guide bundles (3) is connected with the input of white light imaging system (21) with the outfan of described white light source (19) respectively, the other end of described ultraviolet light and fluorescence optical fiber (14) is connected with the input of primary fluorescence signal amplifying system (22) with the outfan of described ultraviolet source (20), described filling pipe (15) is connected with described water injecting pump, described drawing liquid pipeline (16) is connected with described drawing liquid pump.
2. primary fluorescence precancerous lesion hysteroscopic diagnosis system according to claim 1, is characterized in that: described burst of ultraviolel light source is 340nm excitation source or white light laser diode, output>=1.0 × 10 of 340nm excitation source
-2w/cm
2; The room temperature of white light laser diode is 5000K ± 400K, and brightness is 5 ~ 15Lx.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510024546.5A CN104586345A (en) | 2015-01-19 | 2015-01-19 | Inherent fluorescent precancerous lesion hysteroscopy diagnostic system |
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| CN201510024546.5A CN104586345A (en) | 2015-01-19 | 2015-01-19 | Inherent fluorescent precancerous lesion hysteroscopy diagnostic system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854109A (en) * | 2017-12-16 | 2018-03-30 | 上海交通大学 | Medical ultraviolet photoelectron endoscope light source unit |
| CN111839469A (en) * | 2020-08-20 | 2020-10-30 | 上海思坦德医疗科技有限公司 | Method and system for collecting autofluorescence staring image of mucosa tissue by using specific wave strong light for cancer diagnosis |
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|---|---|---|---|---|
| US6697666B1 (en) * | 1999-06-22 | 2004-02-24 | Board Of Regents, The University Of Texas System | Apparatus for the characterization of tissue of epithelial lined viscus |
| US20070273877A1 (en) * | 2004-03-31 | 2007-11-29 | Yoshihiro Kawano | Examination Apparatus, Fluoroscopy Apparatus, Examination Method, And Experimental Method |
| CN101322644A (en) * | 2008-06-13 | 2008-12-17 | 曾堃 | Portable cervical cancer precancerosis diagnostic equipment |
| US20090234234A1 (en) * | 2005-10-12 | 2009-09-17 | Ryo Machida | Biodiagnosis Apparatus |
| CN101803900A (en) * | 2010-02-12 | 2010-08-18 | 广州市番禺区胆囊病研究所 | Integrated confocal micro-rigid hysteroscope system |
-
2015
- 2015-01-19 CN CN201510024546.5A patent/CN104586345A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6697666B1 (en) * | 1999-06-22 | 2004-02-24 | Board Of Regents, The University Of Texas System | Apparatus for the characterization of tissue of epithelial lined viscus |
| US20070273877A1 (en) * | 2004-03-31 | 2007-11-29 | Yoshihiro Kawano | Examination Apparatus, Fluoroscopy Apparatus, Examination Method, And Experimental Method |
| US20090234234A1 (en) * | 2005-10-12 | 2009-09-17 | Ryo Machida | Biodiagnosis Apparatus |
| CN101322644A (en) * | 2008-06-13 | 2008-12-17 | 曾堃 | Portable cervical cancer precancerosis diagnostic equipment |
| CN101803900A (en) * | 2010-02-12 | 2010-08-18 | 广州市番禺区胆囊病研究所 | Integrated confocal micro-rigid hysteroscope system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854109A (en) * | 2017-12-16 | 2018-03-30 | 上海交通大学 | Medical ultraviolet photoelectron endoscope light source unit |
| CN111839469A (en) * | 2020-08-20 | 2020-10-30 | 上海思坦德医疗科技有限公司 | Method and system for collecting autofluorescence staring image of mucosa tissue by using specific wave strong light for cancer diagnosis |
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Application publication date: 20150506 |