CN107050657A - Photodynamic therapy system with organization chart picture and hot spot boundary visualization function - Google Patents

Photodynamic therapy system with organization chart picture and hot spot boundary visualization function Download PDF

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Publication number
CN107050657A
CN107050657A CN201710219692.2A CN201710219692A CN107050657A CN 107050657 A CN107050657 A CN 107050657A CN 201710219692 A CN201710219692 A CN 201710219692A CN 107050657 A CN107050657 A CN 107050657A
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CN
China
Prior art keywords
light
treatment
organization chart
chart picture
hot spot
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CN201710219692.2A
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Chinese (zh)
Inventor
邵永红
顾瑛
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中国人民解放军总医院
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Priority to CN201710219692.2A priority Critical patent/CN107050657A/en
Publication of CN107050657A publication Critical patent/CN107050657A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002Operational features of endoscopes
    • A61B1/00004Operational features of endoscopes characterised by electronic signal processing
    • A61B1/00009Operational features of endoscopes characterised by electronic signal processing of image signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00131Accessories for endoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/012Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/042Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by a proximal camera, e.g. a CCD camera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/07Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0626Monitoring, verifying, controlling systems and methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0632Constructional aspects of the apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0664Details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/067Radiation therapy using light using laser light

Abstract

The present invention is applied to optical dynamic therapy technical field, there is provided a kind of photodynamic therapy system with organization chart picture and hot spot boundary visualization function, on the one hand, electronic CCD or CMOS optical systems in video image dendoscope is while illumination light is received, blocking reflected is scattered back the treatment laser come, so as to can realize that organization chart picture is visual;On the other hand, treatment laser and instruction light are coupled by coupler and exported jointly to human lesion tissue via video image dendoscope by output optical fibre, because the instruction light is identical with the luminous zone of the treatment laser, treatment facula position can be determined by the instruction hot spot for indicating light formation for reflecting or scattering, so as to indicate that hot spot border shows treatment hot spot border in real time by recognizing, providing a width for doctor has the organization chart picture on treatment hot spot border;Image fidelity is visual during the photodynamic therapy system that the present invention is provided realizes optical dynamic therapy, and enables the clinician to accurately see the position relationship for the treatment of hot spot and pathological tissues.

Description

Photodynamic therapy system with organization chart picture and hot spot boundary visualization function

Technical field

There is organization chart picture and hot spot boundary visualization work(the invention belongs to optical dynamic therapy technical field, more particularly to one kind The photodynamic therapy system of energy.

Background technology

,, can be to patient's body because operation need to open chest if taking operative treatment in current treatment method on cancer There is larger wound;If taking chemicotherapy treatment method, because chemicotherapy whole body toxic side effect is strong, body normal immunological can be reduced Function, poor life quality after patient's treatment, and long term survival rate is still undesirable.In face of the current treatment status of malignant tumour, compel to be essential Develop targeted therapy new technology small to body wound, that toxic side effect is small.

Optical dynamic therapy (Photodynamic therapy, PDT) is that one kind meets 21 century oncotherapy developing direction The new technology of (targeting, part, individuation), has the advantages that targeting, local treatment, personalized treatment, with operation, chemotherapy, Radiotherapy is listed as four kinds of main methods of oncotherapy, has been successfully applied to the oncotherapy of a variety of Microendoscopics.But, light is moved Power treatment light source is 610-650nm wave band of laser, and power output is higher, causes endoscope CCD (Charge-coupled Device, charge coupled cell) saturation, display screen is in that brilliant white is a piece of.Doctor is in blind regarding state, nothing in whole therapeutic process Method intuitively sees position of the hot spot in cavity of organization chart picture and treatment optical fiber, and can not real-time judge focal reaction, this It is the common problem that PDT faces under current all fujinon electronic video endoscopes;So as to greatly reduce the accuracy and security for the treatment of, increase Add operation risk, also increase research dose-effect relationship and the difficulty of injectivity optimizing.

The content of the invention

The technical problems to be solved by the invention are to provide a kind of with organization chart picture and hot spot boundary visualization function Photodynamic therapy system, it is intended to solve, because photodynamic therapy light source power output is higher, to cause display screen a piece of in brilliant white, from And cause doctor can not intuitively see organization chart picture in whole therapeutic process and treat position of the hot spot of optical fiber in cavity, And can not real-time judge focal reaction, greatly reduce the accuracy and security for the treatment of, the problem of adding operation risk.

The invention provides a kind of photodynamic therapy system with organization chart picture and hot spot boundary visualization function, the light Dynamic therapy system includes:Optical dynamic therapy laser system, light multiplexing module and video image dendoscope system;

The optical dynamic therapy laser system includes optical dynamic therapy LASER Light Source and output optical fibre, the light multiplexing module Including indicating light source and photo-coupler, the first input end of the photo-coupler is connected with the optical dynamic therapy LASER Light Source, Second input is connected with the instruction light source, and output end is connected with the output optical fibre;The photo-coupler is used for will be described The treatment laser of optical dynamic therapy LASER Light Source output and the instruction optical coupling of the instruction light source output, and export to described defeated Go out optical fiber;

The video image dendoscope system includes video image dendoscope and scope monitor, and the video image dendoscope includes instrument channel and soft Matter scope end, the front end of the soft scope end includes instrument channel and exports and illuminate light exit, the output optical fibre from The instrument channel entrance penetrate and from the instrument channel outlet pass, for by the treatment laser of coupling and indicate light Exported via the video image dendoscope to human lesion tissue;

The illumination light exit is used to export illumination light, the front end of the soft scope end also comprising electronic CCD or CMOS optical systems, the electronic CCD or CMOS optical systems are used to end reflection or are scattered back the treatment laser come, and are used for Receive reflection or be scattered back the illumination light come and indicate light, and obtain according to the illumination light organization chart in therapeutic process in real time Hot spot border is treated as data, and according to the instruction light extract real-time;The scope monitor is used to show to be controlled comprising described Treat the organization chart picture on hot spot border.

Further, the video image dendoscope system also includes cold light source host and shooting main frame, and the video image dendoscope is also wrapped Data connector is included, the cold light source host is connected by the data connector with the video image dendoscope, for providing lighting source, To export illumination light from the illumination light exit;The shooting main frame is connected with the scope monitor, and passes through the number It is connected according to joint with the video image dendoscope, for the organization chart picture data according to the electronic CCD or the acquisition of CMOS optical systems The organization chart picture with treatment hot spot border is formed, and the organization chart picture is handled, and by the organization chart picture after processing Export to the scope monitor.

Further, the electronic CCD or CCD or CMOS in CMOS optical systems are provided with optical filter or the electronics CCD or CMOS optical systems are coated with band resistance light filter film, for ending reflection or being scattered back the treatment laser come.

Further, the photodynamic therapy system also includes a mode selection switch, for switching non-optical dynamic therapy Pattern and optical dynamic therapy pattern;Under the non-optical dynamic therapy pattern, the scope monitor is used to show non-smooth power The lower organization chart picture presented for the treatment of;Under the optical dynamic therapy pattern, the scope monitor is used to show optical dynamic therapy During the organization chart picture for including treatment hot spot border that presents.

Further, the shooting main frame is also equipped with image processing software, under non-optical dynamic therapy pattern, the figure As processing software is used to carry out real-time color correction to the organization chart picture of formation, so that the organization chart picture of display is without colour cast;In light Under dynamic therapy pattern, the organization chart picture progress with treatment hot spot border that described image processing software is used for formation is real-time Color correction, so that the organization chart picture of display is visual without the treatment hot spot border high definition in colour cast and organization chart picture.

Further, under optical dynamic therapy pattern, described image processing software is used to utilize formula I0=(k+1) IRIt is right The organization chart picture of formation carries out color correction;

Wherein, IRRepresent the red color intensity extracted from the organization chart picture got in real time, I0Represent canonical red intensity, k =Iloss/IR, k is characterized than parameter, IlossRepresent missing intensity.

Further, the treatment laser wavelength range of the optical dynamic therapy LASER Light Source output is 610nm-650nm, defeated Go out power bracket for 0W-3W;The output optical fibre be end face output optical fibre or side output optical fibre, the side output optical fibre Light extraction zone length is 10mm-200mm.

Further, the instruction light is green glow or blue light, and the output wavelength scope of the instruction light is 430nm- 580nm, output spectral width scope is 0nm-50nm, and output power range is 0mW-100mW.

Further, the optical filter is not more than 10% to the transmitance for treating laser, electronic CCD or CMOS optical systems Diameter be not more than 5.0mm, chip size≤1/4 of the CCD or CMOS ", the valid pixel of the CCD or CMOS are not less than 480000, the angle of view of the CCD or CMOS are not less than 100 °.

Further, the material of the soft scope end is flexible material, its bendable front end;The instrument channel Diameter is not more than 5mm.

Compared with prior art, beneficial effect is the present invention:One kind that the present invention is provided has organization chart picture and hot spot Spectrum shut-off technology and Optical multiplexing technology are incorporated into optical dynamic therapy by the photodynamic therapy system of boundary visualization function, the system System, enabling utilize the spectrum cutoff function cut-off reflection or scattered of the electronic CCD in video image dendoscope or CMOS optical systems The treatment laser penetrated, while receiving the illumination photoimaging of reflection or scattering, realizes that organization chart picture is visual, and by using light multiplexing Photo-coupler coupling treatment laser and instruction light in module, and by output optical fibre is by the treatment laser of coupling and indicates that light passes through Video image dendoscope is exported to human lesion tissue, can be by anti-because the treatment laser after coupling is identical with the luminous zone for indicating light That penetrates or scatter indicates the treatment position for indicating hot spot determination treatment laser of light formation, so as to indicate hot spot border by recognizing Display treatment hot spot border, is that doctor provides the organization chart picture with treatment hot spot border in real time in real time;Realize optical dynamic therapy During image fidelity it is visual, and enable the clinician to intuitively see the position pass of organization chart picture and treatment facula position and pathological tissues System, it is to avoid the blind operation of doctor by rule of thumb, improves therapeutic effect, and avoid excessive radiation, underexposure or irradiate inaccurate etc. ask Topic.

Brief description of the drawings

Fig. 1 is a kind of optical dynamic therapy with organization chart picture and hot spot boundary visualization function provided in an embodiment of the present invention The structural representation of system;

Fig. 2 is the structural representation of video image dendoscope provided in an embodiment of the present invention;

Fig. 3 is the structural representation of the front end of the soft scope end of video image dendoscope provided in an embodiment of the present invention;

Fig. 4 is the curve of spectrum schematic diagram of electronic CCD provided in an embodiment of the present invention or CMOS optical systems;

Fig. 5 is the schematic diagram of light multiplexing module provided in an embodiment of the present invention;

Fig. 6 is that the annexation of optical dynamic therapy laser system provided in an embodiment of the present invention and light multiplexing module is illustrated Figure;

Fig. 7 is the schematic diagram provided in an embodiment of the present invention for stomach detect treatment using video image dendoscope;

Fig. 8 a are that the video image dendoscope of traditional photodynamic therapy system provided in an embodiment of the present invention carries out treatment laser irradiation Preceding image;

Fig. 8 b are that the video image dendoscope of traditional photodynamic therapy system provided in an embodiment of the present invention carries out treatment laser irradiation Image;

Fig. 8 c are that the video image dendoscope of photodynamic therapy system provided in an embodiment of the present invention carries out the figure for the treatment of laser irradiation Picture.

Embodiment

In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and It is not used in the restriction present invention.

The main of the present invention realizes that thought is:A kind of light power with organization chart picture and hot spot boundary visualization function is provided Treatment system, the system is cut by the way that spectrum shut-off technology and Optical multiplexing technology are incorporated into photodynamic therapy system using spectrum Only technology prevents electronic CCD or CMOS optical systems receive reflection or are scattered back the treatment laser come, and electronics is come from while receiving Scope front end illuminates imaging, realizes that organization chart picture is visual;And couple treatment by using the photo-coupler in light multiplexing module Laser and instruction light, and by output optical fibre is by the treatment laser of coupling and indicates that light is exported to human lesion group by video image dendoscope Knit, wherein, luminous zone when indicating light with treatment laser irradiation tissue is identical, indicates that light is used to indicate treatment laser irradiation area Domain, Tissue reflectance or the instruction light being scattered back are received by electronic CCD or CMOS optical systems, are passed through and are recognized instruction hot spot border Display treatment hot spot border, with reference to software correction and backoff algorithm, realizes the group that display in real time includes treatment hot spot border in real time Knit image.

Lower mask body introduces this photodynamic therapy system with organization chart picture and hot spot boundary visualization function, such as Fig. 1 With shown in Fig. 5, the photodynamic therapy system includes:Optical dynamic therapy laser system, light multiplexing module and video image dendoscope system;

The optical dynamic therapy laser system includes optical dynamic therapy LASER Light Source 1 and output optical fibre 2, the light multiplexing mould Block 3 includes photo-coupler 301 and indicates light source 302, and the optical dynamic therapy LASER Light Source 1 passes through the first of photo-coupler 301 Input 3011 is connected with the photo-coupler 301, instruction second input of the light source 302 by photo-coupler 301 3012 are connected with the photo-coupler 301, output end 3013 and the optocoupler that the output optical fibre 2 passes through photo-coupler 301 Clutch 301 is connected, and the photo-coupler 301 is used for the treatment laser for exporting the optical dynamic therapy LASER Light Source 1 and described The instruction optical coupling that light source 302 is exported is indicated, and is exported to the output optical fibre 2.

Specifically, the treatment laser wavelength range that the optical dynamic therapy LASER Light Source 1 is exported is 610nm-650nm, defeated Go out power bracket for 0W-3W;The output optical fibre 2 is end face output optical fibre or side output optical fibre, the side output optical fibre Light extraction zone length be 10mm-200mm.

Specifically, the instruction light is green glow or blue light, and the output wavelength scope of the instruction light is 430nm-580nm, Output spectral width scope is 0nm-50nm, and output power range is 0mW-100mW.

The video image dendoscope system includes video image dendoscope 4, cold light source host 5, shooting main frame 6 and scope monitor 7;As schemed Shown in 2, the video image dendoscope 4 includes soft scope end 401, instrument channel 402, operation handle 403 and data connector 404; As shown in figure 3, the front end of the soft scope end 401 includes illumination light exit 4011 and instrument channel outlet 4012, also pacify Equipped with electronic CCD or CMOS optical systems 4013;The output optical fibre 2 is penetrated by the entrance of instrument channel 402 and from described Instrument channel outlet 4012 is passed, for the treatment laser and instruction light to be exported to human lesion via the video image dendoscope Tissue.

Specifically, the diameter of instrument channel 402 is not more than 5mm, and the material of the soft scope end 401 is soft material Material, its bendable front end;It is that the front end of the soft scope end 401 is imported into human body, treatment when carrying out optical dynamic therapy Laser and instruction light are exported from the output optical fibre 2.

Specifically, the cold light source host 5 is connected by the data connector 404 with the video image dendoscope 4, for providing Lighting source;More specifically, the lighting source that the cold light source host 5 is provided inputs institute from illumination light entrance (not shown) State after video image dendoscope 4, export, pass through between the illumination light entrance and illumination light exit 4011 from the illumination light exit 4011 Optical fiber transmits illumination light.

Specifically, video image dendoscope 4 provided in an embodiment of the present invention has two illumination light exits 4011.

Further, the electronic CCD (Charge-coupled Device, charge coupled cell) or CMOS In (Complementary Metal Oxide Semiconductor, complementary metal oxide semiconductor) optical system 4013 CCD or CMOS is provided with optical filter or the electronic CCD or CMOS optical systems are coated with band resistance light filter film, it is anti-for ending The treatment laser come is penetrated or is scattered back, the electronic CCD or CMOS optical systems 4013 are used to receive reflection or are scattered back what is come Illumination light and light is indicated, and obtain according to the illumination light organization chart picture data in therapeutic process in real time, and referred to according to described Show light extract real-time treatment hot spot border;The scope monitor 7 is used to show the organization chart for including the treatment hot spot border Picture.

Specifically, the optical filter is not more than 10% to the transmitance for treating laser, electronic CCD or CMOS optical systems Diameter is not more than 5mm, chip size≤1/4 of the CCD or CMOS ", and the valid pixel of the CCD or CMOS are not less than 48 Ten thousand, the angle of view of the CCD or CMOS are not less than 100 °.

Specifically, it is described shooting main frame 6 be connected with the scope monitor 7, and by the data connector 404 with it is described Video image dendoscope 4 is connected;More specifically, the shooting main frame 6 passes through the data connector 404 and the electronics of the video image dendoscope 4 CCD or CMOS optical systems 4013 are connected;The shooting main frame 6 is used for according to the electronic CCD or CMOS optical systems 4013 Organization chart picture of the organization chart picture data formation with treatment hot spot border of acquisition, and the organization chart picture is handled, and Organization chart picture after processing is exported to the scope monitor 7;The scope monitor 7, which is used to show, includes the treatment light The organization chart picture on spot border.

The photodynamic therapy system includes two kinds of mode of operations, i.e., non-optical dynamic therapy pattern and optical dynamic therapy mould Formula, wherein, non-optical dynamic therapy pattern refers to not start optical dynamic therapy laser system and the work of light multiplexing module, video image dendoscope Electronic CCD or CMOS optical systems in system only receive Tissue reflectance or are scattered back the illumination light come and the feelings being imaged Condition, under non-optical dynamic therapy pattern, the scope monitor in video image dendoscope system is used to show to be presented under non-optical dynamic therapy Tissue high-definition image;Optical dynamic therapy pattern refers to start optical dynamic therapy laser system and the work of light multiplexing module, electronics Electronic CCD or the cut-off of CMOS optical systems in endoscope system reflect or are scattered back the treatment laser come, and receive reflection or dissipate The situation for being emitted back towards the illumination light come and instruction light to be imaged;It is interior in video image dendoscope system under optical dynamic therapy pattern Mirror monitor is used to show the tissue high-definition image for including treatment hot spot border presented during optical dynamic therapy, both of which It can be switched by mode selection switch.The shooting main frame is also equipped with image processing software, in non-optical dynamic therapy pattern Under, image processing software has the red function of compensating and be cut off automatically;Under optical dynamic therapy pattern, image processing software The function with hot spot Boundary Recognition is compensated with auto color.

Specifically, under non-optical dynamic therapy pattern, image processing software can be according to organization chart of the red light intensity to formation As carrying out color correction, the high-definition image without colour cast of display normal electrical scope is reached.Bearing calibration is included for red strong Degree is multiplied by correction coefficient, or passes through the side such as standard sample normalization algorithm and the optimization of image processing algorithm combination calibration parameter Method.

Specifically, under optical dynamic therapy pattern, in terms of color real time correction, in order to reduce the mistake school of tissue color Just, this technology is used to the organization chart picture of formation using image processing software and carries out dynamic calibration, specific method than parametric technique: Red color intensity I is determined by standard color cardRWith missing intensity Iloss, calculate aspect ratio parameter k=Iloss/IR;Define canonical red Intensity I0=IR+Iloss;Then I0=(k+1) IR.Due to being approximately constant than parameter k, so, this method can pass through direct basis The image zooming-out red color intensity I got in real timeR, primary color correction can be completed by carrying out linear change, with simple and quick Feature.

Lower mask body introduces the operation principle of this photodynamic therapy system:Video image dendoscope system is used to obtain in real time and aobvious Show that electronic CCD or CMOS optical systems 4013 in tissue high-definition image, video image dendoscope 4 have special spectrum cutoff function, Blocking reflected or the treatment laser come can be scattered back reach CCD or cmos detector, to treat the transmitance of laser≤ 10%, its curve of spectrum shape are as shown in figure 4, but parameter is not limited to the parameter of curve;And due to the treatment laser after coupling and Indicate that the luminous zone of light is identical, even if being cut off so treating laser, can also pass through the instruction light formation of reflection or scattering Indicate that hot spot determines the treatment position for the treatment of laser, so as to indicate that hot spot border shows treatment hot spot border in real time by recognizing.

Above is the core operating principle of the present invention, is specifically introduced under optical dynamic therapy pattern with reference to Fig. 6 and Fig. 7 The specific work process of photodynamic therapy system, the output wavelength of optical dynamic therapy LASER Light Source 1 is the treatment between 610-630nm Laser, power output can be adjustable with 0-3W, and the treatment laser that optical dynamic therapy LASER Light Source 1 is exported is by the of photo-coupler 301 One input 3011 enters photo-coupler 301, indicates the instruction light (green glow or blue light) of the output of light source 302 through photo-coupler 301 Route output end 3013 is exported altogether together with treatment laser, and into output optical fibre 2, output end 3013 connects with optical fiber joint end 201 Connect;The output optical fibre 2 is penetrated by instrument channel 402 and passed from instrument channel outlet 4012, so that the treatment laser Exported with instruction light via video image dendoscope 4 to human lesion tissue.It is illustrated in figure 7 and stomach 8 is examined using video image dendoscope The schematic diagram for the treatment of is surveyed, video image dendoscope uses electronic CCD or CMOS optical systems 4013, the electronic CCD or CMOS optical systems The cut-off of system 4013 reflection is scattered back the treatment laser come, receives reflection or is scattered back the illumination light come and indicates light, and in real time The tissue high-definition image data in therapeutic process are obtained, so as to form tissue high-definition image, the high-definition image mainly includes group Knit information and indicate optical information, by indicating that hot spot determines treatment facula position, using indicating that light intensity distributions Real time identification goes out Hot spot border is indicated, the pseudo- color curve in hot spot border is shown in real time on high-definition image, to realize that border is high-visible in real time, this When, indicate that the color curve of puppet on hot spot border represents treatment hot spot border, can be determined to treat the position of laser according to its border, Be conducive to improving the accuracy for the treatment of laser irradiation, and carry out color correction to reduce the height of no colour cast by image processing software Clear image and treatment hot spot border is shown, realize that tissue and hot spot border real-time high-definition are visual in therapeutic process.

As shown by figures 8 a-8 c, Fig. 8 a carry out treating prelaser for the video image dendoscope of traditional photodynamic therapy system Image, Fig. 8 b are that the video image dendoscope of traditional photodynamic therapy system carries out the image for the treatment of laser irradiation, and Fig. 8 c carry for this patent The video image dendoscope of the photodynamic therapy system of confession carries out the image for the treatment of laser irradiation.It can be seen that utilizing the system When carrying out optical dynamic therapy, the organization chart picture for including treatment hot spot border can be shown.

A kind of photodynamic therapy system with organization chart picture and hot spot boundary visualization function that the present invention is provided, in electronics Being introduced in scope can stop that treatment laser reaches the electronic CCD or CMOS optical systems of CCD or cmos detector, and light power is controlled During treatment, on the one hand, electronic CCD or CMOS optical systems receive illumination light, and described controlling of coming of blocking reflected or be scattered back Treat laser so that scope monitor can show organization chart picture;On the other hand, photo-coupler coupling treatment laser and instruction light, And by output optical fibre is by the treatment laser of coupling and indicates that light is exported to human lesion tissue by video image dendoscope, refer to due to described Show that light is identical with the luminous zone of the treatment laser, treatment light is determined by the instruction hot spot for indicating light formation for reflecting or scattering Spot position, so as to indicate that hot spot border shows treatment hot spot border in real time by recognizing, is realized real in the organization chart picture of display When show treatment hot spot border;There is provided a width for doctor has the organization chart picture on treatment hot spot border, realizes optical dynamic therapy mistake Image fidelity is visual in journey, and enables the clinician to intuitively see that the position of organization chart picture and treatment facula position and pathological tissues is closed System, it is to avoid the blind operation of doctor by rule of thumb, improves therapeutic effect, and avoid excessive radiation, underexposure or irradiate inaccurate etc. ask Topic.

The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.

Claims (10)

1. a kind of photodynamic therapy system with organization chart picture and hot spot boundary visualization function, it is characterised in that the light is moved Power treatment system includes:Optical dynamic therapy laser system, light multiplexing module and video image dendoscope system;
The optical dynamic therapy laser system includes optical dynamic therapy LASER Light Source and output optical fibre, and the light multiplexing module includes Light source and photo-coupler are indicated, the first input end of the photo-coupler is connected with the optical dynamic therapy LASER Light Source, second Input is connected with the instruction light source, and output end is connected with the output optical fibre;The photo-coupler is used to move the light The treatment laser of power treatment LASER Light Source output and the instruction optical coupling of the instruction light source output, and export to the output light It is fine;
The video image dendoscope system includes video image dendoscope and scope monitor, and the video image dendoscope includes instrument channel and soft interior Mirror end, the front end of the soft scope end includes instrument channel and exports and illuminate light exit, and the output optical fibre is from described Instrument channel entrance penetrate and from the instrument channel outlet pass, for by the treatment laser of coupling and indicate light via The video image dendoscope is exported to human lesion tissue;
The illumination light exit is used to export illumination light, and the front end of the soft scope end also includes electronic CCD or CMOS light System, the electronic CCD or CMOS optical systems are used to end reflection or are scattered back the treatment laser come, and anti-for receiving Penetrate or be scattered back the illumination light come and indicate light, and obtain according to the illumination light organization chart picture number in therapeutic process in real time According to, and according to the instruction light extract real-time treatment hot spot border;The scope monitor, which is used to show, includes the treatment light The organization chart picture on spot border.
2. photodynamic therapy system as claimed in claim 1, it is characterised in that the video image dendoscope system also includes cold light source Main frame and shooting main frame, the video image dendoscope also include data connector, and the cold light source host passes through the data connector and institute Video image dendoscope connection is stated, for providing lighting source, to export illumination light from the illumination light exit;It is described shooting main frame with Scope monitor connection, and being connected by the data connector with the video image dendoscope, for according to the electronic CCD or Organization chart picture of the organization chart picture data formation with treatment hot spot border that CMOS optical systems are obtained, and to the organization chart picture Handled, and the organization chart picture after processing is exported to the scope monitor.
3. photodynamic therapy system as claimed in claim 1, it is characterised in that in the electronic CCD or CMOS optical systems CCD or CMOS is provided with optical filter or the electronic CCD or CMOS optical systems are coated with band resistance light filter film, it is anti-for ending Penetrate or be scattered back the treatment laser come.
4. the photodynamic therapy system as described in any one of claims 1 to 3, it is characterised in that the photodynamic therapy system Also include a mode selection switch, for switching non-optical dynamic therapy pattern and optical dynamic therapy pattern;In the non-smooth power Under Therapeutic mode, the scope monitor is used to show the organization chart picture presented under non-optical dynamic therapy;Controlled in the smooth power Under treatment pattern, the scope monitor is used to show the organization chart for including treatment hot spot border presented during optical dynamic therapy Picture.
5. photodynamic therapy system as claimed in claim 4, it is characterised in that the shooting main frame is also equipped with image procossing Software, under non-optical dynamic therapy pattern, described image processing software is used to carry out real-time color school to the organization chart picture of formation Just, so that the organization chart picture of display is without colour cast;Under optical dynamic therapy pattern, described image processing software is used for the tool to formation The organization chart picture for having treatment hot spot border carries out real-time color correction, so that the organization chart picture of display is without colour cast and organization chart picture In treatment hot spot border high definition it is visual.
6. photodynamic therapy system as claimed in claim 5, it is characterised in that under optical dynamic therapy pattern, described image Handling software is used to utilize formula I0=(k+1) IROrganization chart picture to formation carries out color correction;
Wherein, IRRepresent the red color intensity extracted from the organization chart picture got in real time, I0Represent canonical red intensity, k= Iloss/IR, k is characterized than parameter, IlossRepresent missing intensity.
7. photodynamic therapy system as claimed in claim 1, it is characterised in that the optical dynamic therapy LASER Light Source output Treatment laser wavelength range is 610nm-650nm, and output power range is 0W-3W;The output optical fibre is end face output optical fibre Or side output optical fibre, the light extraction zone length of the side output optical fibre is 10mm-200mm.
8. photodynamic therapy system as claimed in claim 1, it is characterised in that the instruction light is green glow or blue light, described The output wavelength scope for indicating light is 430nm-580nm, and output spectral width scope is 0nm-50nm, and output power range is 0mW-100mW。
9. photodynamic therapy system as claimed in claim 3, it is characterised in that transmitance of the optical filter to treatment laser No more than 10%, the diameter of electronic CCD or CMOS optical systems is not more than 5.0mm, chip size≤1/ of the CCD or CMOS 4 ", the valid pixel of the CCD or CMOS are not less than 480,000, and the angle of view of the CCD or CMOS are not less than 100 °.
10. photodynamic therapy system as claimed in claim 2, it is characterised in that the material of the soft scope end is soft Property material, its bendable front end;The diameter of the instrument channel is not more than 5mm.
CN201710219692.2A 2017-04-06 2017-04-06 Photodynamic therapy system with organization chart picture and hot spot boundary visualization function CN107050657A (en)

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